|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cytoplasmic expression of p27^(kip1) is associated with a favourable prognosis in colorectal cancer patients显示文摘AIM: To evaluate the prognostic significance of p27kip1 in colorectal cancer patients. METHODS: Cytoplasmic and nuclear p27kip1 expression was evaluated in 418 colorectal cancers using tissue microarrays. Data were associated with known patient and tumor variables and long-term patient outcomes, providing further insight into the mechanisms by which p27kip1 may influence tumor development. RESULTS: Nuclear and cytoplasmic p27Kip1 expressions were detected in 59% and 19% of tumors respectively. Cytoplasmic p27Kip1 was almost invariably associated with positive nuclear p27Kip1 expression. Neither case correlat- ed with known clinical or pathological variables, includ- ing tumor stage, grade or extramural vascular invasion. Furthermore, nuclear p27kip1 expression had no impact on survival. However, we identified a significant correla- tion between expression of cytoplasmic p27kip1 and longer disease-specific survival times. On multivariate analysis, TNM stage and extramural vascular invasion were highly significant independent prognostic factors, with positive cytoplasmic p27 expression showing a trend towards im- proved patient survival (P = 0.059).CONCLUSION: These findings support the recent evi- dence that cytoplasmic p27kip1 has a distinct and impor- tant biological role that can influence tumor outcome. | Nicholas FS Watson Lindy G Durrant John H Scholefield Zahra Madjd Duncan Scrimgeour Ian Spendlove Ian O Ellis Poulam M Patel | 2006 | World Journal of Gastroenterology2006，12，39： | 3 |
| 2 | Arithmetic Coding for Data Compression 显示文摘 | Neal Radford M Cleary John G | 1987 | Communications of the ACM1987，30，6： | 1 |
| 3 | Arithmetic coding for data compression 显示文摘 | Witten Ian H Neal Radford M Cleary John G | 1987 | Communications of the Association for Computing Machinery1987，30，6： | 1 |
| 4 | Functional motor neurons differentiating from mouse multipotent spinal cord precursor cells in culture and after transplantation into transected sciatic nerve 显示文摘 | Stephen C Ian G Shawn H | 2003 | J Neurosurg2003，98，： | 1 |
| 5 | On the Physics of Harmonic Injection in a Travelling Wave Tube显示文摘 | Wφhlbier John G Booske John H Dobson Ian | 2004 | IEEE Trans Plasma Science2004，32，3： | 1 |
| 6 | Top management team diversity, group process, and strategic consensus 显示文摘 | KN IGHTD PEARCE C L SMITH K G OL IAN J D SIMS H P SMITH K A FLOOD P | 1999 | Strategic Management Journal1999，20，3： | 1 |
| 7 | Improved filter design in internal model control 显示文摘 | IAN G H JEFFERY R A CHRISTOPHER J G | 1996 | Industrial Engineering Chemistry Research1996，35，10： | 1 |
| 8 | Volumetric reductions in the subgenual anterior cingulate cortex in adolescents with bipolar I disorder显示文摘 | Manpreet K Singh Kiki D Chang Michael C Chen Ryan G Kelley Amy Garrett Myles M Mitsunaga Layla Bararpour Meghan Howe Allan L Reiss Ian H Gotlib | 2012 | Bipolar Disorders2012，，6： | 1 |
| 9 | Magnetotelluric response and geoelectric structure of the Great Slave Lake zone 显示文摘 | WU X H IAN J F ALAN G J | 2002 | Earth and Planetary Science Letters2002，196，： | 1 |
| 10 | Investigating driver fatigue in truck crashes: trial of a systematic methodology 显示文摘 | PHILIPA H G NATHNIEL S M IAN J | 2006 | Transportation Research Part F2006，9，1： | 1 |
| 11 | Solid phase synthesis of purines from pyrimidines显示文摘 | Raffaella D L Ian H G Christopher D F | 2000 | J Comb Chem2000，2，3： | 1 |
| 12 | Dicarboximide resistance in field isolates of Alternaria alternatais mediated by a mutation in a two-component histidine kinase gene显示文摘 | Ian B D Khor H Y Hutton D G | 2004 | Fungal Genetic and Biology2004，41，： | 1 |
| 13 | Overexpression of polygalacturonase in transgenic apple trees leads to a range of novel phenotypes involving changes in cell adhesion显示文摘 | ROSS G A ROSWITHA S IAN C H DANIDL C ELSPETH A M | 2002 | Plant Physiology2002，129，： | 1 |
| 14 | Production of calmodulin-tagged proteins in Drosophila Schneider S2 cells:A novel system for antigen production and phage antibody isolation显示文摘 | Jennings N S Smethurst P A Knight C G O'Connor M N Korhonen L J Stafford P Stephens J Stephen F G Ian J H Richard W F Nicholas A W Willem H O | | 0，，： | 1 |
| 15 | A computer code for gas turbine engine weight and disk life estimation显示文摘 | Michael T T Ian H Louis J G | 2004 | Journal of Engineering for Gas Turbines and Power2004，126，2： | 1 |
| 16 | Magnetotelluric response and geoe-lectric structure of the Great Slave Lake shear zone显示文摘 | Wu X H Ian J F Alan G J | 2002 | Earthand Planetary Science Letters2002，196，： | 1 |
| 17 | Probing synergy between two catalytic strategies in the glycoside hydrolase O-glcNAcase using multiple linear free energy relationships显示文摘 | Ian R G Matthew S Ian H | 2009 | Journal of the American Chemical Society2009，131，13： | 1 |
| 18 | Stool DNA Testing for Screening Detection of Colorectal Neoplasia in Alaska Native People显示文摘 | Diana G Redwood Elvin D Asay Ian D Blake Pamela E Sacco Claudia M Christensen Frank D Sacco James J Tiesinga Mary E Devens Steven R Alberts Douglas W Mahoney Tracy C Yab Patrick H Foote Thomas C Smyrk Ellen M Provost David A Ahlquist | 2016 | Mayo Clinic Proceedings2016，，： | 1 |
| 19 | Influence of channel stoichio- metry on zinc indium oxide thin-film transistor perfor- mance 显示文摘 | Matthew G M Ian G H | 2009 | IEEE Transactions on Electron Devices2009，56，2： | 1 |
| 20 | Treatment of corebinding-factor in acute myelogenous leukemia with fludarabine, cytarabine, and granulocyte colony-stimulating factor results in imp roved event-free survival显示文摘 | Borthakur G KANTARJ IAN H WANG X | 2008 | Cancer2008，113，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员