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| 1 | 在 7T 的多原子的磁性的回声光谱学的应用显示文摘 AIM: To discuss the advantages of ultra-high field (7T) for 1H and 13C magnetic resonance spectroscopy (MRS) studies of metabolism.made at both 3 and 7T using 1H MRS. Measurements of glycogen and lipids in muscle were measured using 13C and 1H MRS respectively. RESULTS: In the brain, increased signal-to-noise ratio (SNR) and dispersion allows spectral separation of the amino-acids glutamate, glutamine and γ-aminobutyric acid (GABA), without the need for sophisticated editing sequences. Improved quantification of these me-tabolites is demonstrated at 7T relative to 3T. SNR was 36% higher, and measurement repeatability (% coefficients of variation) was 4%, 10% and 10% at 7T, vs 8%, 29% and 21% at 3T for glutamate, glutamine and GABA respectively. Measurements at 7T were used to compare metabolite levels in the anterior cingulate cortex (ACC) and insula. Creatine and glutamate levels were found to be significantly higher in the insula compared to the ACC (P < 0.05). In muscle, the increased SNR and spectral resolution at 7T enables interleaved studies of glycogen (13C) and intra-myocellular lipid (IMCL) and extra-myocellular lipid (EMCL) (1H) following exercise and refeeding. Glycogen levels were sig-nificantly decreased following exercise (-28% at 50% VO2 max; -58% at 75% VO2 max). Interestingly, levels of glycogen in the hamstrings followed those in the quadriceps, despite reduce exercise loading. No changes in IMCL and EMCL were found in the study. CONCLUSION: The demonstrated improvements in brain and muscle MRS measurements at 7T will increase the potential for use in investigating human metabolism and changes due to pathologies. | Mary C Stephenson Frances Gunner Antonio Napolitano Paul L Greenhaff Ian A MacDonald Nadeem Saeed William Vennart Susan T Francis Peter G Morris | 2011 | World Journal of Radiology2011，3，4： | 2 |
| 2 | Effects of yttrium on the sintering and microstructure of alumina-silicon carbide 'nanocomposites' 显示文摘 | ALEX M C IAN P S RICHARD I T STEVE G R | 2005 | J Am Ceram Soc2005，88，9： | 1 |
| 3 | Ethanol vaponr treat- ment alleviates postharvest decay and maintains fruit quality in Chinese bayberry显示文摘 | ZHANG W S LI X WANG X X WANG G Y ZHENG J T ABERSINGHE Don C FERGUSON Ian B | 2007 | Postharvest Biology and Technology2007，46，2： | 1 |
| 4 | Rates of starch hydrolysis and changes in viscosity in a range of common foods subject to simulated digestion in vitro 显示文摘 | Jennifer M G Ian T J | 1985 | Journal of Science Food Agriculture1985，36，： | 1 |
| 5 | Trans fer method for charactering the existence of m axm al elem ents of binary rehtions on oanpact or noncompact sets显示文摘 | G Q T ian | 1992 | SIAM J O ptim1992，2，3： | 1 |
| 6 | A video-based technique for mapping intertidal beach bathymetry 显示文摘 | Stefan G J Aaminkhof Ian L Turner Thomas D T Dronkers Mark Caljouw Leann Nipius | 2003 | Coastal Engineering2003，49，： | 1 |
| 7 | Correlation of micro -seismic and chemical properties of brittle deformation in locharbriggs sandstone 显示文摘 | Ira O Ojala Bryne T Ngwenya Ian G Main | 2003 | Journal of Geophysical Research2003，108，5： | 1 |
| 8 | Gas generation, transport, and extraction in landfill显示文摘 | SUMADHU G Arigala THEODORE T Tsotsis IAN A Webster JAMES J Kattapuram | 1995 | Journal of Environmental Engineering1995，121，1： | 1 |
| 9 | Novel biosynthetic routes to non- proteinogenic amino acids as chiral pharmaceutical intermediates显示文摘 | David J A Tao L David P P Richard F S Paul P T Ian G F | 2001 | J Mol Ca B:Enz2001，11，： | 1 |
| 10 | Floc Architecture in Wastewater and Natural Riverine Systems 显示文摘 | Steven N L Ian G D Derrick T F | 1996 | Environmental Sci-ence & Technology1996，30，： | 1 |
| 11 | Nortriptyline and gabapentin, alone and in combination for neuropathic pain: a double-blind, randomised controlled crossover trial 显示文摘 | IAN G JOAN MB DONGSHENG T | 2009 | Lancet2009，374，9697： | 1 |
| 12 | Emergence of fatal PRRSV variants: Unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark 显示文摘 | 'I'IAN K G YU X L ZHAO T Z | 2007 | PLo S One2007，2，6： | 1 |
| 13 | Zoledronic acid improves femoral head sphericity in a rat model of perthes disease显示文摘 | Little D G Donald M M Ian T | 2005 | Journal of Orthopaedic Research2005，23，4： | 1 |
| 14 | Posterior olecranon plat- ing biomechanical and clinical evaluation of a new operative tech- nique显示文摘 | Nirmal C T Ian R G Philip R W | 2002 | Bulletin Hospital for Joint Diseases2002，61，1： | 1 |
| 15 | A computer code for gas turbine engine weight and disk life estimation显示文摘 | Michael T T Ian H Louis J G | 2004 | Journal of Engineering for Gas Turbines and Power2004，126，2： | 1 |
| 16 | Spectral Imaging:Principles and Applications显示文摘 | Yuval G Ian T Y George M | 2006 | Cytometry Part A2006，69，8： | 1 |
| 17 | Association between functional polymorphism in EGF gene and malignant melanoma显示文摘 | Majid Shahbazi Vera Pravica Najma Nasreen Hana Fakhoury Anthony A Fryer Richard C Strange Peter E Hutchinson Joy E Osborne John T Lear Andrew G Smith Ian V Hutchinson | 2002 | The Lancet . 2002 (9304)2002，，9304： | 1 |
| 18 | Ferroelectric PZT thin films by Sol- Gel deposition显示文摘 | David V T Keith G B | 1998 | Sol- Gel Science and Technology1998，13，： | 1 |
| 19 | A Comparison of different focus functions for use in autofocus algorithms显示文摘 | GROEN F IAN T Y LIGHART G | 1985 | Cytometry1985，6，2： | 1 |
| 20 | Actvity of pancreatic endopeptidases towards luteinizing hormone-releasing hormones显示文摘 | Greg F W Robin L Ian G T | 2001 | International Journal of Pharmaceutics2001，23，： | 1 |
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