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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Genetic and Epigenetic Silencing of MicroRNA-203 Enhances ABL1 and BCR-ABL1 Oncogene Expression显示文摘 | María J. Bueno Ignacio Pérez de Castro Marta Gómez de Cedrón Javier Santos George A. Calin Juan C. Cigudosa Carlo M. Croce José Fernández-Piqueras Marcos Malumbres | 2008 | Cancer Cell2008，，： | 2 |
| 3 | N-acetyl-L-cysteine combined with mesalamine in the treatment of ulcerative colitis: Randomized,placebo-controlled pilot study显示文摘AIM: To evaluate the effectiveness and safety of oral N-acetyl-L-cysteine (NAC) co-administration with mesalamine in ulcerative colitis (UC) patients. METHODS: Thirty seven patients with mild to moderate UC were randomized to receive a four-wk course of oral mesalamine (2.4 g/d) plus N-acetyl-L-cysteine (0.8 g/d) (group A) or mesalamine plus placebo (group B). Patients were monitored using the Modified Truelove-Witts Severity Index (MTWSI). The primary endpoint was clinical remission (MTWSI ≤ 2) at 4 wk. Secondary endpoints were clinical response (defined as a reduction from baseline in the MTWSI of ≥ 2 points) and drug safety. The serum TNF-α, interleukin-6, interleukin-8 and MCP-1 were evaluated at baseline and at 4 wk of treatment. RESULTS: Analysis per-protocol criteria showed clinical remission rates of 63% and 50% after 4 wk treatment with mesalamine plus N-acetyl-L-cysteine (group A) and mesalamine plus placebo (group B) respectively (OR = 1.71; 95% CI: 0.46 to 6.36; P = 0.19; NNT = 7.7). Analysis of variance (ANOVA) of data indicated a significant reduction of MTWSI in group A (P = 0.046) with respect to basal condition without significant changes in the group B (P = 0.735) during treatment. Clinical responses were 66% (group A) vs 44% (group B) after 4 wk of treatment (OR = 2.5; 95% CI: 0.64 to 9.65; P = 0.11; NNT = 4.5). Clinical improvement in group A correlated with a decrease of IL-8 and MCP-1. Rates of adverse events did not differ significantly between both groups. CONCLUSION: In group A (oral NAC combined with mesalamine) contrarily to group B (mesalamine alone), the clinical improvement correlates with a decrease of chemokines such as MCP-1 and IL-8. NAC addition not produced any side effects. | Luis G Guijarro Jose Mate Javier P Gisbert Jose Luis Perez-Calle Ignacio Marín-Jimenez Encarna Arriaza Tomás Olleros Mario Delgado Maria S Castillejo David Prieto-Merino Venancio Gonzalez Lara Amado Salvador Pea | 2008 | World Journal of Gastroenterology2008，14，18： | 2 |
| 4 | Growth hormone reduces mortality and bacterial translocation in irradiated rats显示文摘 | Ignacio A Isabel P Antonio G | 1998 | Acta Oncologica1998，37，： | 1 |
| 5 | Growth hormone reduces mortality and bacterial translocation in irradiated rats显示文摘 | Ignacio A Isabel P Antonio G | 1998 | Acta Oncologica1998，37，1： | 1 |
| 6 | Negative heat capacity of sodium clusters 显示文摘 | Reyes-nava J A Ignacio L G | 2003 | Phys Rev2003，67，16： | 1 |
| 7 | Regulatory and Functional Connection of Microphthalmia-Associated Transcription Factor and Anti-Metastatic Pigment Epithelium Derived Factor in Melanoma显示文摘 | Asunción Fernández-Barral Jose Luis Orgaz Pablo Baquero Zaheer Ali Alberto Moreno María Tiana Valentí Gómez Erica Riveiro-Falkenbach Carmen Ca?adas Sandra Zazo Corine Bertolotto Irwin Davidson Jose Luis Rodríguez-Peralto Ignacio Palmero Federico Rojo Lass | 2014 | Neoplasia2014，，： | 1 |
| 8 | Determination of tin and titanium in soils,sediments and sludges using electrothermal atomic absorption spectrometry with slurry sample introduction显示文摘 | Ignacio L G Isabel A J Natalia C | 2004 | Talanta2004，62，： | 1 |
| 9 | Aflatoxin (B1, B2, G1, and G2) Contamination in Rice of Mexico and Spain, from Local Sources or Imported显示文摘 | Elena Suárez‐Bonnet Magda Carvajal Ignacio Méndez‐Ramírez Pável Castillo‐Urueta Josefina Cortés‐Eslava Sandra Gómez‐Arroyo José María Melero‐Vara | 2013 | Journal of Food Science2013，，11： | 1 |
| 10 | Response to McAvoy and Tudor-Locke on their commentary on our manuscript:“Association of accelerometer-derived step volume and intensity with hospitalizations and mortality in older adults:A prospective cohort study”显示文摘Dear Editor,We have read with interest the commentary by McAvoy and Tudor-Locke on our article entitled 'Association of accelerometer-derived step volume and intensity with ho spitalizations and mortality in older adults:A prospective cohort study'. The authors expressed some concerns about our methodology used to define accelerometer-derived step intensity and the analytical approach applied in our study. | Asier Mañas Borja del Pozo Cruz Ulf Ekelund JoséLosa Reyna Irene Rodríguez Gómez JoséAntonio Carnicero Carreño Leocadio Rodríguez Mañas Francisco J.García García Ignacio Ara | 2022 | Journal of Sport and Health Science2022，11，6： | 1 |
| 11 | Cancer‐associated fibroblast and M 2 macrophage markers together predict outcome in colorectal cancer patients显示文摘 | Mercedes Herrera Alberto Herrera Gemma Domínguez Javier Silva Vanesa García José M. García Irene Gómez Beatriz Soldevilla Concepción Mu?oz Mariano Provencio Yolanda Campos‐Martin Antonio García de Herreros Ignacio Casal Félix Bonilla Cristina Pe?a | 2013 | Cancer Sci2013，，4： | 1 |
| 12 | Proton-Decoupled 31P MRS in untreated pediatric brain tumors显示文摘 | Mark J A Mark D K Ignacio G G | 2005 | Magnetic Resonance in Medicine2005，53，1： | 1 |
| 13 | Minor sesquiterpenes from Maytenus canariensis with insecticidal and antifeedant activity 显示文摘 | Antonio G G Ignacio A J Angel G R | 1993 | Tetrahedron1993，49，30： | 1 |
| 14 | Comprehensive Functional Assessment of MLH1 Variants of Unknown Significance显示文摘 | Ester Borràs Marta Pineda Angela Brieger Inga Hinrichsen Carolina Gómez Matilde Navarro Judit Balma?a Teresa Ramón y Cajal Asunción Torres Joan Brunet Ignacio Blanco Guido Plotz Conxi Lázaro Gabriel Capellá | 2012 | Human Mutation2012，，1： | 1 |
| 15 | Manage- ment innovation and leadership: the moderating role of organizational size 显示文摘 | Ignacio G V Justin J P J Frans A J V | 2012 | Journal of Management Studies2012，1，49： | 1 |
| 16 | Differences between carbon nanofibers produced using Fe and Ni catalysts in a floating catalyst reactor 显示文摘 | IGNACIO M G JOSE V JUAN A C JOSE L G | 2006 | Carbon2006，44，8： | 1 |
| 17 | Neutropenia and enterocolitis with docetaxel treatment显示文摘 | Alberto Oca?a Fernández Ignacio Martín González Amalia Gómez Bernal Juan Jesús Cruz Hernández | 2005 | Clinical and Translational Oncology2005，，2： | 1 |
| 18 | AC and DC technology in microgrids: A review显示文摘 | Estefanía Planas Jon Andreu José Ignacio Gárate I?igo Martínez de Alegría Edorta Ibarra | 2014 | Renewable and Sustainable Energy Reviews2014，，： | 1 |
| 19 | An analytical approach to the design of electrodes in high-power, fast-transverse-flow CO2 lasers 显示文摘 | Martin G G Ignacio J R Violeta D A | 2005 | Optics and Laser Technology2005，37，8： | 1 |
| 20 | Monitoring the degradation and solubilisation of butyitin compounds during in vitro gastrointestinal digestion using “triple spike” isotope dilution GC-ICP-MS显示文摘 | Pablo R G Jorge R E J Ignacio G A | 2005 | Anal Bioanal Chem2005，381，4： | 1 |
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