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| 1 | Gastroenteropancreatic neuroendocrine tumours显示文摘 | Irvin M Modlin Kjell Oberg Daniel C Chung Robert T Jensen Wouter W de Herder Rajesh V Thakker Martyn Caplin Gianfranco Delle Fave Greg A Kaltsas Eric P Krenning Steven F Moss Ola Nilsson Guido Rindi Ramon Salazar Philippe Ruszniewski Anders Sundin | 2008 | Lancet Oncology2008，，1： | 8 |
| 2 | Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration显示文摘AIM:To develop a model of stress-induced senescence to study the hepatocyte senescence associated secretory phenotype(SASP).METHODS:Hydrogen peroxide treatment was used to induce senescence in the human Hep G2 hepatocyte cell line.Senescence was confirmed by cytochemical staining for a panel of markers including Ki67,p21,heterochromatin protein 1β,and senescence-associated-β-galactosidase activity.Senescent hepatocytes were characterised by gene expression arrays and quantitative polymerase chain reaction(q PCR),and conditioned media was used in proteomic analyses,a human chemokine protein array,and cell migration assays to characterise the composition and function of the hepatocyte SASP.RESULTS:Senescent hepatocytes induced classical markers of senescence(p21,heterochromatin protein1β,and senescence-associated-β-galactosidase activity);and downregulated the proliferation marker,Ki67.Hepatocyte senescence induced a 4.6-fold increase in total secreted protein(P=0.06)without major alterations in the protein profile.Senescence-induced genes were identified by microarray(Benjamini Hochbergcorrected P<0.05);and,consistent with the increase in secreted protein,gene ontology analysis revealed a significant enrichment of secreted proteins among inducible genes.The hepatocyte SASP included characteristic factors such as interleukin(IL)-8 and IL-6,as well as novel components such as SAA4,IL-32and Fibrinogen,which were validated by q PCR and/or chemokine protein array.Senescent hepatocyteconditioned medium elicited migration of inflammatory(granulocyte-macrophage colony stimulating factor,GM-CSF-derived),but not non-inflammatory(CSF-1-derived)human macrophages(P=0.022),which could contribute to a pro-inflammatory microenvironment in vivo,or facilitate the clearance of senescent cells.CONCLUSION:Our novel model of hepatocyte senescence provides insights into mechanisms by which senescent hepatocytes may promote chronic liver disease pathogenesis. | Katharine M Irvine Richard Skoien Nilesh J Bokil Michelle Melino Gethin P Thomas Dorothy Loo Brian Gabrielli Michelle M Hill Matthew J Sweet Andrew D Clouston Elizabeth E Powell | 2014 | World Journal of Gastroenterology2014，20，47： | 2 |
| 3 | 前蛋白转化酶枯草溶菌素9变异、低密度脂蛋白胆固醇与神经认知功能损害的关系显示文摘尽管之前的研究引发了对抑制前蛋白转化酶枯草溶菌素9(proprotein convertase subtilisin/kexintype9,PCSK9)造成神经认知功能损害事件的关注,但近期一个第3期随机试验并没有发现药物性PCSK9抑制与神经认知损害有关。 | 黄洁 叶鹏 Mefford MT Rosenson RS Cushman M Farkouh ME McClure LA Wadley VG Irvin MR Bittner VA Safford MM Somaratne R Monda KL Muntner P Levitan EB | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 4 | First-spike timing of auditory-nerve fibers and comparison with auditory cortex 显示文摘 | Heil P Irvine DR | 1997 | J Neurophysiol1997，78，5： | 1 |
| 5 | Hydrogen fertilizer bacteria or fungi?显示文摘 | IRVINE P SMITH M DONG Z | 2004 | Acta Hofliculturae2004，631，： | 1 |
| 6 | Pokeweed antiviral protein inactivates pokeweed ribosomes implications for the antiviral mechanism显示文摘 | BONNESS M S READY M P IRVIN J D | 1994 | Plant J1994，5，2： | 1 |
| 7 | Room-Tempera- ture Ferroeleetrieity in Strained SrTiO3 显示文摘 | Haeni J H Irvin P Chang W | 2004 | Nature2004，430，： | 1 |
| 8 | Implantable silk composite microneedles for programmable vaccine release ki- netics and enhanced immunogenicity in transcutaneous immu- nization显示文摘 | DEMUTH P C MIN Y IRVINE D J | 2014 | AdvHealthcMater2014，3，1： | 1 |
| 9 | DNA integrity in human spermatozoa : relationships with semen quality 显示文摘 | Irvine D S Twigg J P Gordon E L | 2000 | J Androl2000，21，1： | 1 |
| 10 | Hydrogen Titanates as Potential Proton Conducting Fuel Cell Electrolytes显示文摘 | Corcoran D J D Tunstall D P Irvine J T S | 2000 | Solid State Ionics2000，，： | 1 |
| 11 | Novel tin oxide-based an-odes for Li-ion batteries显示文摘 | Belliard F Connor P A Irvine J T S | 2000 | Solid State2000，135，14： | 1 |
| 12 | Production of in vitro matured oocytes from 6-week old calves显示文摘 | Earl C R Irvine B J Rowe J P | | 0，，： | 1 |
| 13 | Fractional metals in street dust of a mixed land use sewershed, Hamilton, Ontario 显示文摘 | Droppo I G Irvine K N Murphy T P | 1998 | Hydrology in a Changing Environment Ⅲ1998，，： | 1 |
| 14 | Monitoring the sensible heat flux over urban areas using large aperture scintillometry: Case study of Marseille city during the escompte experiment显示文摘 | Lagouarde J P M Irvine J M Bonnefond | 2006 | Boundary Layer Meteor2006，118，3： | 1 |
| 15 | Polymer latexes for cell-resistant and cell-interactive surfaces显示文摘 | BANERJEE P IRVINE D J MAYES A M | 2000 | Biomed Mater Res2000，50，3： | 1 |
| 16 | The effect of intermittent feeding on aerobic granule structure 显示文摘 | McSwain B S Irvine R L Wilderer P A | 2004 | Water Science and Technology2004，49，1112： | 1 |
| 17 | Functional gastrointestinal disorders in Canada:first population-based survey using Rome II criteria with suggestions for improving the questionnaire显示文摘 | Thompson WG Irvine EJ Pare P | | 0，，01： | 1 |
| 18 | The influence of settling time on the formation of aerobic granules显示文摘 | Mcswain B S Irvine R L Wilderer P A | 2005 | Water Science and Technology2005，50，10： | 1 |
| 19 | Sinterability of commercial 8mol % yttriastabilized zirconia powders and the effect of sintered density on the ionic conductivity 显示文摘 | Gibson I R Dransfield G P Irvine J T S | 1998 | J Mater Sci1998，33，17： | 1 |
| 20 | Health-related quality of life in functional GI disorders:focus on constipation and resource utilization显示文摘 | Irvine EJ Ferrazzi S Pare P | | 0，，08： | 1 |
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