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| 1 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 2 | Long-term outcomes of autoimmune pancreatitis: a multicentre, international analysis显示文摘 | Phil A Hart Terumi Kamisawa William R Brugge Jae Bock Chung Emma L Culver László Czakó Luca Frulloni Vay Liang W Go Thomas M Gress Myung-Hwan Kim Shigeyuki Kawa Kyu Taek Lee Markus M Lerch Wei-Chih Liao Matthias L?hr Kazuichi Okazaki Ji Kon Ryu Nicolas Sc | 2013 | Gut2013，，12： | 2 |
| 3 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 4 | Psychological treatments for chronic post-traumatic stress disorder:Systematic review and Meta-analysis显示文摘 | Bisson JI Ehlers A Matthews R | 2007 | Br J Psychiatry2007，190，： | 1 |
| 5 | Cloning and expression of the poreine obese gene显示文摘 | BIDWELL C A JI S FRANK G R | 1997 | Anim Bioteeh1997，8，2： | 1 |
| 6 | Conditioned place preference reveals tonic pain in an animal model of central pain显示文摘 | Davoody L Quiton R.L Lucas J.M Ji Y.D Keller A & Masri R | | 0，，： | 1 |
| 7 | Multi-laboratory validation of a standard method for quantifying proanthocyanidins in cranberry powders显示文摘 | Prior R L Fan E Ji H P Howell A Nio C Payne M J Reed J | 2010 | Journal of the Science of Food and Agriculture2010，90，9： | 1 |
| 8 | Efficiency droop due to electron spill-over and limited hole injection in Ⅲ-nitride visible light-emitting diodes employing lattice-matched InAlN electron blocking layers显示文摘 | Choi S Ji M H Kim J Kim H J Satter M M Yoder P D Ryou J H Dupuis R D Fischer A M Ponce F A | | 0，，16： | 1 |
| 9 | Novel Syntheses of 2, 3 - Disubstituted Benzofurans 显示文摘 | Katritzky A R Ji Yu Fang Yun - feng | 2001 | J Org Chem2001，66，： | 1 |
| 10 | C-erbB-2/HER-2 upregulates fascin,an actin-bundling protein associated with cell motility,in human breast cancer cell lines显示文摘 | GROTHEY A HASHIZUME R JI H | 2000 | Oncogene2000，19，42： | 1 |
| 11 | Sorption of a branched nonylphenol and perfluorooctanoic acid on Yangtze river sediments and their model components显示文摘 | Li CL Ji R Schaffer A Sequaris JM Amelung W Vereeckena H Klumpp E | 2012 | Journal of Environmental Monitor2012，14，10： | 1 |
| 12 | Isolation and characteristics of bacteri- ocin-preducing bacteria from the intestine of duck for probioties 显示文摘 | SHIN M S HAN S K JI A R | 2007 | Jour- nal of animal science and technology2007，49，5： | 1 |
| 13 | Disparity for the minor histocompatibility antigen HA-1 is associated with an increased risk of acute graft-versus-host disease(GvHD)but it does not affect chronic GvHD incidence,disease-free survival or overall survival after allogeneic human leucocyte antigen-identical sibling donor transplantation显示文摘 | Arostegui JI Balas A Torres A Caballero D Carreras E Brunet S Jimenez A Mataix R Serrano D Vallejo C Sanz G Solano C Rodriguez-Luaces M Marin J Baro J Sanz C Roman J Gonzalez M Martorell J Sierra J Martin C de la Camara R Granena A | 2001 | Br J Haematol2001，114，4： | 1 |
| 14 | Abiotic association of soil-borne monomeric phenols with humic acids显示文摘 | VINKEN R SCHAFFER A JI Rong | 2005 | Organic Geochemistry2005，36，4： | 1 |
| 15 | Development and validation of the tinnitus primary function questionnaire显示文摘 | TYLER R JI H PERREAU A | 2014 | Am J Audiol2014，23，： | 1 |
| 16 | Effect of low-molecular-weight organic anions on surface charge of variable charge soils显示文摘 | XU R K ZHAO A Z JI G L | 2003 | J Colloid Interface Sci2003，264，： | 1 |
| 17 | Novel syntheses of 2,3-disubstituted benzofurans显示文摘 | KATRITZKY A R JI Yu FANG Yu | 2001 | J Org Chem2001，66，16： | 1 |
| 18 | One-step production of alkoxylated ethyl acetate with narrow adduct distribution 显示文摘 | XIA Y M SHEN Y A JI S R | 2007 | J Chem Technol Biotechnol2007，82，： | 1 |
| 19 | C-erbB-2/HER-2 upergulates fas- cin, an actin-bunding protein associated with cell motility, in human breast cancer cell lines 显示文摘 | Grothey A Hashizume R Ji H | 2000 | Oncegene2000，19，42： | 1 |
| 20 | Cultivation of microal- gae species in tertiary municipal wastewater supplemented with CO2 for nutrient removal and biomass production显示文摘 | Ji M K Abou-Shanab R A I Kim S H | 2013 | Ecol Eng2013，58，： | 1 |
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