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| 1 | Function of apoptosis and expression of the proteins Bcl-2,p53 and C-myc in the development of gastric cancer显示文摘INTRODUCTIONIn China ,the incidence and mortality of gastric cancer rank the second among all cancers. Recent development of cancer [1-20].The aim of this study was investigat the insight of apoptosis and bcl-2, p53 and C-myc protein expression in the development of gastric cancer . | An Gao Xu Shao Guang Li Ji Hong Liu Ai Hua Gan Research Laboratory of Digestive Disease,Huizhou Central People’s Hospital,Huizhou 516001,Guangdong Province,ChinaDr.An Gao Xu graduated from Guangdong Medical College in 1984.He is an associate physician-in-chief,specializing in the research and treatment of gastrointestinal and liver tumors.He has published 24 papers and 1 book. | 2001 | World Journal of Gastroenterology2001，7，3： | 91 |
| 2 | The prognostic value of preoperative serum levels of CEA,CA19-9 and CA72-4 in patients with colorectal cancer显示文摘INTRODUCTIONCarcinoembryonic antigen ( CEA) , originally described by Gold and Freedman [1] in 1965, is now an acknowledged member of immunoglobulin superfamily[2],with a role as an intracellular adhesion molecule[3].Carbohydrate antigen 19-9(CA19-9), obtained with a monoclonal antibody produced by immunizing a monoclonal antibody produced by immunizing a mouse with a colonic cancer cell line in 1979[4],is a ligand for E-selectin that plays an important role in the addhesion of cancer cells to endothelial cells [5,6]. | Chao Xu Zheng~1 Wen Hua Zhan~1 Ji Zong Zhao~2 Dong Zheng~3 Dong Ping Wang~1 Yu Long He~1 Zhang Qing Zheng~1 ~1Department of General Surgery,~2Laboratory of Surgery,~3Department of Medicine,First Affiliated Hospital,Sun Yat-Sen University of Medical Sciences,Guangzhou 510080,Guangdong Province,ChinaDr.Chao Xu Zheng now working as a surgeon and lecturer in the Department of General Surgery,First Affiliated Hospital,Sun Yat-Sen University of Medical Sciences,who is a Ph.D.student,having 7 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 25 |
| 3 | Multipliers on Dirichlet Type Spaces | Peng Yan HU Department of Mathematics. Normal College of Shenzhen University. Shenzhen. Guangdong 518060. P. R. China Ji Huai SHI Department of Mathematics. University of Science and Technology of China. Hefei. Anhui 230026, P. R. China | 2001 | Acta Mathematica Sinica,English Series2001，17，2： | 23 |
| 4 | Protochordate amphioxus is an emerging model organism for comparative immunology显示文摘Protochordate amphioxus is an extant invertebrate regarded quite recently as a basal chordate. It has a vertebrate-like body plan including a circulation system with an organization similar to that of vertebrates. However, amphioxus is less complex than vertebrates for having a genome uncomplicated by extensive genomic duplication, and lacking lymphoid organs and free circulating blood cells. Recent studies on immunity have demonstrated the presence in amphioxus of both the constituent elements of key molecules involved in adaptive immunity such as proto-major histocompatibility complex (proto-MHC), V region-containing chitin-binding protein (VCBP) and V and C domain-bearing protein (VCP), and the complement system operating via the alternative and lectin pathways resembling those seen in vertebrates. In addition, the acute phase response profile in amphioxus has been shown to be similar to that observed in vertebrates. These findings together with the relative structural and genomic simplicity make amphioxus an ideal organism for gaining insights into the origin and evolution of the vertebrate immune system, especially adaptive immunity, and the composition and mech- anisms of the vertebrate innate immunity. | Shicui Zhang Yujun Liang Guangdong Ji Zhimeng Zhuang | 2009 | Progress in Natural Science:Materials International2009，19，8： | 1 |
| 5 | Administration of Yeast Glucan on Immunity of Offspring in Turbot Scophthalmus maximus: A Trans-Generational Immune-Enhancing Effect显示文摘β-glucan has been shown to increase immunity and survival in various juvenile and adult fish both in freshwater and marine aquaculture species as well as in marine fish larvae. However, information about the trans-generational immune-enhancing effects of β-glucan remains rather limited. Here we clearly show that dietary intake of β-glucan enhanced the levels of C3, Bf and lysozyme in the serum of turbot as well as in their eggs released. We also show that yeast glucan induced a significant increase in lysozyme activity in both the serum and eggs. Moreover, the embryos derived from yeast glucan-treated turbot were more resistant to bacterial challenge than control embryos. By contrast, the administration of yeast glucan on female turbots had little influence on the egg development and embryonic development. Collectively, these data indicate that yeast glucan can be safely used to promote the non-specific trans-generational immunity in offspring of turbot. | JIANG Chengyan WANG Peng LIU Shousheng WANG Yanfeng LI Jun JI Guangdong | 2019 | Journal of Ocean University of China2019，18，4： | 1 |
| 6 | Whole-genome methylation analysis reveals epigenetic variation between wild-type and nontransgenic cloned,ASMT transgenic cloned dairy goats generated by the somatic cell nuclear transfer显示文摘Background:SCNT(somatic cell nuclear transfer)is of great significance to biological research and also to the livestock breeding.However,the survival rate of the SCNT cloned animals is relatively low compared to other transgenic methods.This indicates the potential epigenetic variations between them.DNA methylation is a key marker of mammalian epigenetics and its alterations will lead to phenotypic differences.In this study,ASMT(acetylserotonin-Omethyltransferase)ovarian overexpression transgenic goat was produced by using SCNT.To investigate whether there are epigenetic differences between cloned and WT(wild type)goats,WGBS(whole-genome bisulfite sequencing)was used to measure the whole-genome methylation of these animals.Results:It is observed that the different m Cp G sites are mainly present in the intergenic and intronic regions between cloned and WT animals,and their CG-type methylation sites are strongly correlated.DMR(differentially methylated region)lengths are located around 1000 bp,mainly distributed in the exonic,intergenic and intronic functional domains.A total of 56 and 36 DMGs(differentially methylated genes)were identified by GO and KEGG databases,respectively.Functional annotation showed that DMGs were enriched in biological-process,cellularcomponent,molecular-function and other signaling pathways.A total of 10 identical genes related to growth and development were identified in GO and KEGG databases.Conclusion:The differences in methylation genes among the tested animals have been identified.A total of 10 DMGs associated with growth and development were identified between cloned and WT animals.The results indicate that the differential patterns of DNA methylation between the cloned and WT goats are probably caused by the SCNT.These novel observations will help us to further identify the unveiled mechanisms of somatic cell cloning technology,particularly in goats. | Hao Wu Wendi Zhou Haijun Liu Xudai Cui Wenkui Ma Haixin Wu Guangdong Li Likai Wang Jinlong Zhang Xiaosheng Zhang Pengyun Ji Zhengxing Lian Guoshi Liu | 2023 | Journal of Animal Science and Biotechnology2023，14，1： | 0 |
| 7 | The structural characterization of some palladium (Ⅱ) complexes of 1,10-phenanthroline and amino acids by NMR spectroscopy显示文摘The complexes [Pd(phen)(aa)]Cl.3H2O, where phen is 1,10-phenanthroline and aa is the anion of glycine (gly), .DL-alanine (ala), DL-serine (ser) or DL-asparagine (asn), were synthesized and characterized by spectroscopies. The NMR signals were assigned completely on the basis of the double irradiation, 1H-1H COSY and 1H-13C COSY techniques. In the 1H NMR spectra of phen in the complexes, the signals of 2-H and 9-H show upfield shifts 0.8-1 ppm, while the signals of 4-H and 3-H show downfield shifts or almost no shift, as compared to the free phen ligand, and the signal of 4-H appears in the lowest field. The signals of ring B which is trans to the carboxyl group show significant upfield shifts as compared to those of ring A. The probable structures were described on the basis of a metal-non-bonded hydrogen interaction, trons effect and ligand-ligand interaction. There may exist three conformation isomers in the [Pd(phen)(asn)]Cl.3H2O complex at room temperature. The preferred conformation isomer is | YE, Bao-Hui ZENG, Tian-Xian JI, Liang-NianChemistry Department, Zhongshan University, Guangzhou, Guangdong 510275, China | 1995 | Chinese Journal of Chemistry1995，13，3： | 0 |
| 8 | Characterization, Evolution and Tissue-specific Expression of AmphiCalbin, a Novel Gene Encoding EF-hand Calcium-binding Protein in Amphioxus Branchiostoma belcheri显示文摘一条文昌鱼全身的 cDNA , AmphiCalbin ,编码新奇EF手钙绑定蛋白质( EFCaBP ),从文昌鱼 Branchiostoma belcheri.It 的内脏 cDNA 图书馆被孤立与 636 bp 由 1321 bp 组成与种系发生的分析为二有趣的推论提供的约 24.5 kDa.The 的一个分子的团编码 211 氨基酸的蛋白质的开的读框架。首先,有被区分开来与其它的一组未命名的 EFCaBPs 的 AmphiCalbin 簇识别了 EFCaBPs.Second,在脊椎动物的底的 AmphiCalbin 下降未命名的 EFCaBPs clade,可能代表他们的原型。这被 AmphiCalbin 有与脊椎动物的相同的一个 exon-intron 组织的事实也支持未命名的 EFCaBP 基因。在 situ 杂交的两织物节并且在 situ 杂交整个山证明 AmphiCalbin 的一个织物特定的表达式模式,与在消化系统和性腺的表示的高水平。AmphiCalbin 可能在消化系统和性腺起一个作用,这被建议。这些观察为未命名的 EFCaBPs 的函数的进一步的理解打了基础。 | Jing LUAN Shicui ZHANG Zhenhui LIU Chunxin FAN Guangdong JI Lei LI | 2007 | Acta Biochimica et Biophysica Sinica2007，39，11： | 0 |
| 9 | THE INTRAMOLECULAR STACKING INTERACTION IN TERNARY COMPLEXES FORMED BY AND HETEROAROMATIC N-BASE LIGANDS显示文摘THE INTRAMOLECULAR STACKING INTERACTION IN TERNARY COMPLEXES FORMED BY AND HETEROAROMATIC N-BASE LIGANDSTHEINTRAMOLECULARSTAC... | Fu Hai WU Xue Yi LE Fen Yun SONG Liang Nian JI(Department of Chemistry. Zhongshan University, University,Guangzhou. 510275)(State Key Laboratory of Coordination Chemistry, Nanjing University,Nanjing,210008)Guangdong Pharmaceutical College | 1996 | Chinese Chemical Letters1996，7，8： | 0 |
| 10 | Presence of a long nuclear-localization signal sequence in homeodomain transcription factor Nkx 1.2显示文摘Homeodomains,a 60-amino acid sequence encoded by 180 nucleotides,are highly conserved DNA-binding motifs that are present in a variety of transcription factors in species ranging from yeast to humans.The NKX proteins belong to the homeodomain(HD)-containing transcription factor family.They play vital roles in the regulation of morphogenesis.NKX1-2 is one member of the NKX subfamily.At present,information about its nuclear localization signal(NLS)sequence is limited.We studied the NLS sequence of zebrafish Nkx1.2 by introducing sequence changes such as deletion,mutation,and truncation,and identified an NLS motif(QNRRTKWKKQ)that is localized at the C-terminus of the homeodomain.Moreover,the deletion of two amino acid residues(RR)in this NLS motif prevents Nkx1.2 from entering the nucleus,indicating that the two amino acids are essential for Nkx1.2 nuclear localization.However,the NLS motif alone is unable to target cytoplasmic protein glutathione S-transferase(GST)to the nucleus.An intact homeodomain is necessary for mediating the complete nuclear transport of cytoplasmic protein.Unlike most nuclear import proteins with short NLS sequences,a long NLS is present in zebrafish Nkx1.2.We also demonstrated that the sequences of homeodomain of NKX1.2 are well conserved among different species.This study is informative to verify the function of the NKX1.2 protein. | Xinyi LI Lihui CHEN Xinyuan WANG Chen SUN Guangdong JI Guobin HU Zhenhui LIU | 2024 | Journal of Oceanology and Limnology2024，42，2： | 0 |
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