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| 1 | Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts' consensus statement显示文摘Since the outbreak of 2019 novel coronavirus infection (2019-nCoV) in Wuhan City,China,by January 30,2020,a total of 9692 confirmed cases and 15,238 suspected cases have been reported around 31 provinces or cities in China.Among the confirmed cases,1527 were severe cases,171 had recovered and been discharged at home,and 213 died.And among these cases,a total of 28 children aged from 1 month to 17 years have been reported in China.For standardizing prevention and management of 2019-nCoV infections in children,we called up an experts' committee to formulate this experts' consensus statement.This statement is based on the Novel Coronavirus Infection Pneumonia Diagnosis and Treatment Standards (the fourth edition) (National Health Committee) and other previous diagnosis and treatment strategies for pediatric virus infections.The present consensus statement summarizes current strategies on diagnosis,treatment,and prevention of 2019-nCoV infection in children. | Kunling Shen Yonghong Yang Tianyou Wang Dongchi Zhao Yi Jiang Runming Jin Yuejie Zheng Baoping Xu Zhengde Xie Likai Lin Yunxiao Shang Xiaoxia Lu Sainan Shu Yan Bai Jikui Deng Min Lu Leping Ye Xuefeng Wang Yongyan Wang Liwei Gao | 2020 | World Journal of Pediatrics2020，16，3： | 56 |
| 2 | Automatic analytical approach for the determination of 12 illicit drugs and nicotine metabolites in wastewater using on-line SPE-UHPLC-MS/MS显示文摘In this study,we developed a novel on-line solid phase extraction(SPE)-ultra-high-performance liquid chromatography tandem mass spectrometry(UHPLC-MS/MS)-based analytical method for simultaneously quantifying 12 illicit drugs and metabolites(methamphetamine,amphetamine,morphine,codeine,6-monoacetylmorphine,benzoylecgonine,3,4-methylenedioxymethamphetamine,3,4-methylenedioxyamphetamine,cocaine,ketamine,norketamine,and methcathinone)and cotinine(COT)in wastewater samples.The analysis was performed by loading 2 m L of the sample onto an Oasis hydrophilic-lipophilic balance cartridge and using a cleanup step(5%methanol)to eliminate interference with a total run time of 13 min.The isotope-labeled internal standard method was used to quantify the target substances and correct for unavoidable losses and matrix effects during the on-line SPE process.Typical analytical characteristics used for method validation were sensitivity,linearity,precision,repeatability,recovery,and matrix effects.The limit of detection(LOD)and limit of quantification(LOQ)of each target were set at 0.20 ng/L and 0.50 ng/L,respectively.The linearity was between 0.5 ng/L and250 ng/L,except for that of COT.The intra-and inter-day precisions were<10.45%and 25.64%,respectively,and the relative recovery ranged from 83.74%to 162.26%.The method was used to analyze various wastewater samples from 33 cities in China,and the results were compared with the experimental results of identical samples analyzed using off-line SPE.The difference rate was between 19.91%and-20.44%,and the error range could be considered acceptable.These findings showed that on-line SPE is a suitable alternative to off-line SPE for the analysis of illicit drugs in samples. | Jingyuan Wang Likai Qia Chenzhi Hou Tingting Zhang Mengyi Chen Haitao Meng Mengxiang Su Hui Xu Zhendong Hua Youmei Wang Bin Di | 2021 | Journal of Pharmaceutical Analysis2021，11，6： | 5 |
| 3 | Global analysis of lysine succinylation in patchouli plant leaves显示文摘Lysine succinylation is a novel,naturally occurring posttranslational modification(PTM)in living organisms.Global lysine succinylation identification has been performed at the proteomic level in various species;however,the study of lysine succinylation in plant species is relatively limited.Patchouli plant(P.cablin(Blanco)Benth.,Lamiaceae)is a globally important industrial plant and medicinal herb.In the present study,lysine succinylome analysis was carried out in patchouli plants to determine the potential regulatory role of lysine succinylation in patchouli growth,development,and physiology.The global succinylation sites and proteins in patchouli plants were screened with an immunoprecipitation affinity enrichment technique and advanced mass spectrometry-based proteomics.Several bioinformatic analyses,such as function classification and enrichment,subcellular location predication,metabolic pathway enrichment and protein−protein interaction networking,were conducted to characterize the functions of the identified sites and proteins.In total,1097 succinylation sites in 493 proteins were detected in patchouli plants,among which 466 succinylation sites in 241 proteins were repeatedly identified within three independent experiments.The functional characterization of these proteins indicated that the tricarboxylic acid(TCA)cycle,oxidative phosphorylation,photosynthesis processes,and amino acid biosynthesis may be regulated by lysine succinylation.In addition,these succinylated proteins showed a wide subcellular location distribution,although the chloroplast and cytoplasm were the top two preferred cellular components.Our study suggested the important role of lysine succinylation in patchouli plant physiology and biology and could serve as a useful reference for succinylation studies in other medicinal plants. | Xiaobing Wang Xiuzhen Chen Junren Li Xuanxuan Zhou Yanting Liu Liting Zhong Yun Tang Hai Zheng Jiyun Liu Ruoting Zhan Likai Chen | 2019 | Horticulture Research2019，6，1： | 2 |
| 4 | Evidence of ceased programmed cell death in metaphloem sieve elements in the developing caryopsis of Triticum aestivum L.显示文摘 | Likai Wang Zhuqing Zhou Xuefang Song Jiwei Li Xiangyi Deng Fangzhu Mei | 2008 | Protoplasma (-)2008，，14： | 1 |
| 5 | A facile route to Ce3+-doped Y3Al5O12phosphors and their photoluminescent properties显示文摘 | WANG Likai ZHAO Fenghua ZHUANG Jianle | 2014 | Materials Letters2014，120，： | 1 |
| 6 | Exploring the synergy of building massing and façade design through evolutionary optimization显示文摘In performance-based architectural design optimization, the design of building massings and façades is commonly separated, which weakens the effectiveness in performance improvement. In response, this study proposes a hybrid massing-façade integrated design generation and optimization workflow to integrate the two elements in an evolutionary design process. Compared with the existing approaches, the proposed workflow emphasizes the diversity of building design generation, with which various combinations of building massing forms and façade patterns can be systematically explored. Two case studies and a corresponding comparison study are presented to demonstrate the efficacy of the proposed workflow. Results show that the optimization can produce designs coupling the potential of building massings and façades in performance improvement. In addition, the optimization can provide information that supports early-stage architectural design exploration. Such information also enables the architect to understand the performance implications associated with the synergy of building massing and façade design. | Likai Wang Han Zhang Xuehan Liu Guohua Ji | 2022 | Frontiers of Architectural Research2022，11，4： | 1 |
| 7 | Microstructure and properties of laser direct deposited nickel base superalloy 显示文摘 | Zhang Yongzhong Gao Shiyou Shi Likai Wang Dianwu | 2007 | Journal of Advanced Materials2007，，2： | 1 |
| 8 | Geometrical odeling of leaf shape based on image processing and feature points detection 显示文摘 | Su Likai Wang Xiaoming | 2009 | Journel of Sorth China Normal University: Natural Science Edition2009，，4： | 1 |
| 9 | Tridecanuclear Gd(III)-silsesquioxane:Synthesis,structure,and magnetic property显示文摘Polynuclear metal clusters,particularly those with aesthetically appealing structures,are of increasing interest.In this study,by employing C 4 symmetrical macrocyclic silsesquioxane ligand,a novel tridecanuclear Gd(III)cluster(Gd13)with a{Gd 13 O 8}core featuring unprecedent body-centered Archimedean cuboctahedron conformation is realized using an efficient solvothermal method instead of conventional Schlenk techniques.To the best of our knowledge,Gd13 cluster is thus far the highest nuclearity of lanthanide-silsesquioxane.Moreover,a magnetic study reveals a weak antiferromagnetic interaction between adjacent Gd ions in the cluster.In addition,Gd13 exhibits cryogenic magnetocaloric effects with a maximum−ΔS M value of 20 J kg^(−1) K^(−1) at 2 K andΔH=7.0 T. | Kai Sheng Ran Wang Alexey Bilyachenko Victor Khrustalev Marko Jagodič Zvonko Jagličić Zhaoyang Li Likai Wang Chenho Tung Di Sun | 2022 | ChemPhysMater2022，1，4： | 0 |
| 10 | Exploration on Charge Transfer and Absorption Spectra of Spiro[fluorene-9,90-xanthene]-based Polyoxometalate Hybrids Toward High Performance Dye-sensitized Solar Cell显示文摘 | WANG Shuo GAO Yu SU Xiaofang YAN Likai | 2018 | Chemical Research in Chinese Universities2018，34，5： | 0 |
| 11 | Virome diversity of ticks feeding on domestic mammals in China显示文摘Ticks are considered the second most common pathogen vectors transmitting a broad range of vital human and veterinary viruses.From 2017 to 2018,640 ticks were collected in eight different provinces in central and western China.Six species were detected,including H.longicornis,De.everestianus,Rh.microplus,Rh.turanicus,Rh.sanguineous,and Hy.asiaticum.Sixty-four viral metagenomic libraries were constructed on the MiSeq Illumina platform,resulting in 13.44 G(5.88×10^(7))of 250-bp-end reads,in which 2,437,941 are viral reads.We found 27 nearly complete genome sequences,including 16 genome sequences encoding entire protein-coding regions(lack of 30 or 50 end non-coding regions)and complete viral genomes,distributed in the arboviral family(Chuviridae,Rhabdoviridae,Nairoviridae,Phenuiviridae,Flaviviridae,Iflaviridae)as well as Parvoviridae and Polyomaviridae that cause disease in mammals and even humans.In addition,13 virus sequences found in Chuviridae,Nairoviridae,Flaviviridae,Iflaviridae,Hepeviridae,Parvoviridae,and Polyomaviridae were identified as belonging to a new virus species in the identified viral genera.Besides,an epidemiological survey shows a high prevalence(9.38%and 15.63%)of two viruses(Ovine Copiparvovirus and Bovine parvovirus 2)in the tick cohort. | Zijun Yang Hao Wang Shixing Yang Xiaochun Wang Quan Shen Likai Ji Jian Zeng Wen Zhang Haiyan Gong Tongling Shan | 2023 | Virologica Sinica2023，38，2： | 0 |
| 12 | Whole-genome methylation analysis reveals epigenetic variation between wild-type and nontransgenic cloned,ASMT transgenic cloned dairy goats generated by the somatic cell nuclear transfer显示文摘Background:SCNT(somatic cell nuclear transfer)is of great significance to biological research and also to the livestock breeding.However,the survival rate of the SCNT cloned animals is relatively low compared to other transgenic methods.This indicates the potential epigenetic variations between them.DNA methylation is a key marker of mammalian epigenetics and its alterations will lead to phenotypic differences.In this study,ASMT(acetylserotonin-Omethyltransferase)ovarian overexpression transgenic goat was produced by using SCNT.To investigate whether there are epigenetic differences between cloned and WT(wild type)goats,WGBS(whole-genome bisulfite sequencing)was used to measure the whole-genome methylation of these animals.Results:It is observed that the different m Cp G sites are mainly present in the intergenic and intronic regions between cloned and WT animals,and their CG-type methylation sites are strongly correlated.DMR(differentially methylated region)lengths are located around 1000 bp,mainly distributed in the exonic,intergenic and intronic functional domains.A total of 56 and 36 DMGs(differentially methylated genes)were identified by GO and KEGG databases,respectively.Functional annotation showed that DMGs were enriched in biological-process,cellularcomponent,molecular-function and other signaling pathways.A total of 10 identical genes related to growth and development were identified in GO and KEGG databases.Conclusion:The differences in methylation genes among the tested animals have been identified.A total of 10 DMGs associated with growth and development were identified between cloned and WT animals.The results indicate that the differential patterns of DNA methylation between the cloned and WT goats are probably caused by the SCNT.These novel observations will help us to further identify the unveiled mechanisms of somatic cell cloning technology,particularly in goats. | Hao Wu Wendi Zhou Haijun Liu Xudai Cui Wenkui Ma Haixin Wu Guangdong Li Likai Wang Jinlong Zhang Xiaosheng Zhang Pengyun Ji Zhengxing Lian Guoshi Liu | 2023 | Journal of Animal Science and Biotechnology2023，14，1： | 0 |
| 13 | Atomically precise metal nanoclusters for(photo)electroreduction of CO_(2): Recent advances, challenges and opportunities显示文摘To alleviate the global warming by removing excess CO_(2) and converting them into value-added chemicals,(photo)electrochemical reduction has been recognized as a promising strategy.As the CO_(2) reduction reaction(CO_(2) RR) is involved with multiple electrons and multiple products,plus the complexity of the surface chemical environment of the catalyst,it is extremely challenging to establish the structure/function relationship.Atomically precise metal nanoclusters(NCs),with crystallographically resolved structure,molecule-like characters and strong quantum confinement effects,have been emerging as a new type of catalyst for CO_(2) RR,and more importantly,they can provide an ideal platform to unravel the comprehensive mechanistic insights and establish the structure/function relationship eventually.In this review,the recent advances regarding employing molecular metal NCs with well-defined structure including Au NCs,Au-based alloy NCs,Ag NCs,Cu NCs for CO_(2) RR and relevant mechanistic studies are discussed,and the opportunities and challenges are proposed at the end for paving the development of CO_(2) RR by using atomically precise metal NCs. | Lubing Qin Guanyu Ma Likai Wang Zhenghua Tang | 2021 | Journal of Energy Chemistry2021，30，6： | 0 |
| 14 | Homoleptic alkynyl-protected Ag_(32 )nanocluster with atomic precision: Probing the ligand effect toward CO_(2) electroreduction and 4-nitrophenol reduction显示文摘We report a superatomic homoleptic alkynyl-protected Ag_(32)L_(24)(L=3,5-bis(trifluoromethylbenzene)acetylide,Ag_(32) for short)nanocluster with atomic precision,which possesses eight free electrons.Ag_(32) is formed by an Ag17 core with C3 symmetry and the remaining 15 Ag atoms bond to each other and coordinate with the 24 surface ligands.When applied as electrocatalyst for CO_(2) reduction reaction(CO_(2)RR),Ag_(32) exhibited the highest Faradaic efficiency(FE)of CO up to 96.44%at−0.8 V with hydrogen evolution being significantly suppressed in a wide potential range,meanwhile it has a reaction rate constant of 0.242 min−1 at room temperature and an activation energy of 45.21 kJ·mol−1 in catalyzing the reduction of 4-nitrophenol,both markedly superior than the thiolate and phosphine ligand co-protected Ag_(32) nanocluster.Such strong ligand effect was further understood by density functional theory(DFT)calculations,as it revealed that,one single ligand stripping off from the intact cluster can create the undercoordinated Ag atom as the catalytically active site for both clusters,but alkynyl-protected Ag_(32) nanocluster possesses a smaller energy barrier for forming the key*COOH intermediate in CO_(2)RR,and favors the adsorption of 4-nitrophenol.This study not only discovers a new member of homoleptic alkynyl-protected Ag nanocluster,but also highlights the great potentials of employing alkynyl-protected Ag nanoclusters as bifunctional catalysts toward various reactions. | Leyi Chen Fang Sun Quanli Shen Lubing Qin Yonggang Liu Liang Qiao Qing Tang Likai Wang Zhenghua Tang | 2022 | Nano Research2022，15，10： | 0 |
| 15 | Blockchain data secure sharing protocol based on threshold Paillier algorithm显示文摘With the development of Internet technology,secure storage and secure sharing of data have become increasingly important.Traditional data sharing schemes exist a series of problems including lack of security and low efficiency.In this paper,we construct a secure and efficient data sharing scheme based on threshold Paillier algorithm and blockchain technology,which achieves secure data storage and sharing without a third-party institution.Firstly,we propose a(t,l)threshold Paillier blockchain data sharing scheme,which effectively prevents decryption failures caused by the loss of a single node’s private key.Secondly,we propose a combined on-chain and off-chain data storage scheme,we store the ciphertext on the cloud server and the ciphertext hash value on the blockchain,which not only ensures the integrity of the data but also solves the storage limitation problem on the blockchain.Finally,we use the simulation paradigm to prove the security of the scheme in the semi-honest model.The discussion results of the comparison and the analysis of performance show that the blockchain data security sharing scheme proposed in this paper has lower computational overhead and higher security than other similar schemes. | Likai Jia Xiubo Chen Luxi Liu Xiaoge Wang Ke Xiao Gang Xu | 2023 | High-Confidence Computing2023，3，4： | 0 |
| 16 | Preparation of biomass-derived carbon loaded with MnO_(2) as lithium-ion battery anode for improving its reversible capacity and cycling performance显示文摘Biomass-derived carbon materials for lithiumion batteries emerge as one of the most promising anodes from sustainable perspective.However,improving the reversible capacity and cycling performance remains a long-standing challenge.By combining the benefits of K2CO_(3) activation and KMnO_(4) hydrothermal treatment,this work proposes a two-step activation method to load MnO_(2) charge transfer onto biomass-derived carbon(KAC@MnO_(2)).Comprehensive analysis reveals that KAC@MnO_(2) has a micro-mesoporous coexistence structure and uniform surface distribution of MnO_(2),thus providing an improved electrochemical performance.Specifically,KAC@MnO_(2) exhibits an initial chargedischarge capacity of 847.3/1813.2 mAh·g^(-1) at 0.2 A·g^(-1),which is significantly higher than that of direct pyrolysis carbon and K2CO_(3) activated carbon,respectively.Furthermore,the KAC@MnO_(2) maintains a reversible capacity of 652.6 mAh·g^(-1) after 100 cycles.Even at a high current density of 1.0 A·g^(-1),KAC@MnO_(2) still exhibits excellent long-term cycling stability and maintains a stable reversible capacity of 306.7 mAh·g^(-1) after 500 cycles.Compared with reported biochar anode materials,the KAC@MnO_(2) prepared in this work shows superior reversible capacity and cycling performance.Additionally,the Li+insertion and de-insertion mechanisms are verified by ex situ X-ray diffraction analysis during the chargedischarge process,helping us better understand the energy storage mechanism of KAC@MnO_(2). | Likai Zhu Huaping Lin Wenli Zhang Qinhui Wang Yefeng Zhou | 2024 | Frontiers of Chemical Science and Engineering2024，18，1： | 0 |
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