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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | 基于逻辑回归模型的泥石流易发性评价与检验:以金沙江上游奔子栏—昌波河段为例显示文摘基于地理信息系统(Arc GIS10.0)平台和小流域单元,采用逻辑回归(LR)模型对金沙江上游(奔子栏—昌波河段)干热河谷区进行泥石流易发性评价,并对预测结果进行总体检验与随机个案检验。评价与检验结果表明,得到的最优指标组合下LR评价模型的AUC值为82.7%;预测的极高易发区、高易发区面积合占全区面积的35.98%,实发泥石流面积占泥石流总面积的65.03%;在个案检验中,位于各等级分区的检验组样本实发泥石流比例随着分区易发性等级降低,依次为91.7%(极高)、75.0%(高)、36.4%(中等)、16.7%(低)、0(极低),表明评价效果良好。研究区泥石流集中发育于金沙江沿岸的东北部、中部和西南部,主导性的评价指标依次为距主干道路距离、岩性、距断裂带距离、雨季月平均降雨量。人类活动与季节性降雨为研究区干热河谷泥石流的主要诱发条件。基于逻辑回归模型的泥石流易发性评价方法提高了泥石流发生可能性的预测精度,可为干热河谷区泥石流预测预警和防治提供参考依据。 | 吴赛儿 陈剑 ZHOU Wendy 高玉欣 徐能雄 | 2018 | 现代地质2018，32，3： | 14 |
| 3 | Effectiveness of predicting tunneling-induced ground settlements using machine learning methods with small datasets显示文摘Prediction of tunneling-induced ground settlements is an essential task,particularly for tunneling in urban settings.Ground settlements should be limited within a tolerable threshold to avoid damages to aboveground structures.Machine learning(ML)methods are becoming popular in many fields,including tunneling and underground excavations,as a powerful learning and predicting technique.However,the available datasets collected from a tunneling project are usually small from the perspective of applying ML methods.Can ML algorithms effectively predict tunneling-induced ground settlements when the available datasets are small?In this study,seven ML methods are utilized to predict tunneling-induced ground settlement using 14 contributing factors measured before or during tunnel excavation.These methods include multiple linear regression(MLR),decision tree(DT),random forest(RF),gradient boosting(GB),support vector regression(SVR),back-propagation neural network(BPNN),and permutation importancebased BPNN(PI-BPNN)models.All methods except BPNN and PI-BPNN are shallow-structure ML methods.The effectiveness of these seven ML approaches on small datasets is evaluated using model accuracy and stability.The model accuracy is measured by the coefficient of determination(R2)of training and testing datasets,and the stability of a learning algorithm indicates robust predictive performance.Also,the quantile error(QE)criterion is introduced to assess model predictive performance considering underpredictions and overpredictions.Our study reveals that the RF algorithm outperforms all the other models with the highest model prediction accuracy(0.9)and stability(3.0210^(-27)).Deep-structure ML models do not perform well for small datasets with relatively low model accuracy(0.59)and stability(5.76).The PI-BPNN architecture is proposed and designed for small datasets,showing better performance than typical BPNN.Six important contributing factors of ground settlements are identified,including tunnel depth,the distance between tunnel face and surface monitoring points(DTM),weighted average soil compressibility modulus(ACM),grouting pressure,penetrating rate and thrust force. | Linan Liu Wendy Zhou Marte Gutierrez | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，4： | 5 |
| 4 | Self-management interventions for adults with stroke:A scoping review显示文摘Background:Stroke is a principal cause of mortality and disability globally.Numerous studies have contributed to the knowledge base regarding self-management interventions among chronic disease patients,but there are few such studies for patients with stroke.Therefore,it is necessary to analyze self-management interventions among stroke patients.This scoping review aimed to systematically identify and describe randomized controlled trials(RCTs)of self-management interventions for adults with stroke.Methods:A review team carried out a scoping review on stroke and self-management interventions based on the methodology of Arksey and O’Malley,following the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews(PRISMA-ScR).PubMed,Embase,Web of Science,CINAHL Plus Full Text,Medline Plus Full Text,and Cochrane Central Register of Controlled Trials were searched from inception to July 2020.Results:Fifty-four RCTs were included.The most popular study design is comparing a self-management intervention to usual care or waitlist control condition.Physical activity is the most common intervention topic,and interventions were mainly delivered face to face.The majority of interventions were located in inpatient and multiple settings.Interventions were conducted by various providers,with nurses the most common provider group.Symptom management was the most frequently reported outcome domain that improved.Conclusions:Self-management interventions benefit the symptom management of stroke patients a lot.The reasonable time for intervention is at least 6-12 months.Multifarious intervention topics,delivery formats,and providers are adopted mostly to meet the multiple needs of this population.Physical activity was the most popular topic currently.Studies comparing the effect of different types of self-management interventions are required in the future. | Suebsarn Ruksakulpiwat Wendie Zhou | 2021 | Chronic Diseases and Translational Medicine2021，7，3： | 2 |
| 5 | Taking the pulse of COVID-19:a spatiotemporal perspective显示文摘The sudden outbreak of the Coronavirus disease(COVID-19)swept across the world in early 2020,triggering the lockdowns of several billion people across many countries,including China,Spain,India,the U.K.,Italy,France,Germany,Brazil,Russia,and the U.S.The transmission of the virus accelerated rapidly with the most confirmed cases in the U.S.,India,Russia,and Brazil.In response to this national and global emergency,the NSF Spatiotemporal Innovation Center brought together a taskforce of international researchers and assembled implementation strategies to rapidly respond to this crisis,for supporting research,saving lives,and protecting the health of global citizens.This perspective paper presents our collective view on the global health emergency and our effort in collecting,analyzing,and sharing relevant data on global policy and government responses,human mobility,environmental impact,socioeconomical impact;in developing research capabilities and mitigation measures with global scientists,promoting collaborative research on outbreak dynamics,and reflecting on the dynamic responses from human societies. | Chaowei Yang Dexuan Sha Qian Liu Yun Li Hai Lan Weihe Wendy Guan Tao Hu Zhenlong Li Zhiran Zhang John Hoot Thompson Zifu Wang David Wong Shiyang Ruan Manzhu Yu Douglas Richardson Luyao Zhang Ruizhi Hou You Zhoua Cheng Zhong Yifei Tian Fayez Beaini Kyla Carte Colin Flynn Wei Liu Dieter Pfoser Shuming Bao Mei Li Haoyuan Zhang Chunbo Liu Jie Jiang Shihong Du Liang Zhao Mingyue Lu Lin Li Huan Zhou Andrew Ding | 2020 | International Journal of Digital Earth2020，13，10： | 2 |
| 6 | Osteoblasts directly control lineage commitment of mesenchymal progenitor cells through Wnt signaling显示文摘 | Hong Zhou Wendy Mak Yu Zheng | 2007 | 283:19362007，283，： | 1 |
| 7 | Brain-targeting,acid-responsive antioxidant nanoparticles for stroke treatment and drug delivery显示文摘Stroke is the leading cause of death and disability.Currently,there is no effective pharmacological treatment for this disease,which can be partially attributed to the inability to efficiently deliver therapeutics to the brain.Here we report the development of natural compound-derived nanoparticles(NPs),which function both as a potent therapeutic agent for stroke treatment and as an efficient carrier for drug delivery to the ischemic brain.First,we screened a collection of natural nanomaterials and identified betulinic acid(BA)as one of the most potent antioxidants for stroke treatment.Next,we engineered BA NPs for preferential drug release in acidic ischemic tissue through chemically converting BA to betulinic amine(BAM)and for targeted drug delivery through surface conjugation of AMD3100,a CXCR4 antagonist.The resulting AMD3100-conjugated BAM NPs,or A-BAM NPs,were then assessed as a therapeutic agent for stroke treatment and as a carrier for delivery of NA1,a neuroprotective peptide.We show that intravenous administration of A-BAM NPs effectively improved recovery from stroke and its efficacy was further enhanced when NA1 was encapsulated.Due to their multifunctionality and significant efficacy,we anticipate that A-BAM NPs have the potential to be translated both as a therapeutic agent and as a drug carrier to improve the treatment of stroke. | Shenqi Zhang Bin Peng Zeming Chen Jiang Yu Gang Deng Youmei Bao Chao Ma Fengyi Du Wendy C.Sheu W.Taylor Kimberly J.Marc Simard Daniel Coman Qianxue Chen Fahmeed Hyder Jiangbing Zhou Kevin N.Sheth | 2022 | Bioactive Materials2022，7，10： | 1 |
| 8 | Maintenance of highly interfacial shear strength by diblock copolymer between carbon fiber and epoxy resin in hostile environment显示文摘 | Deng Shuanghui Ma Wendi Zhou Xiaodong | 2012 | Composite Interfaces2012，19，8： | 1 |
| 9 | Self-antigen-Driven Activation Induces Instability of Regulatory T Cells during an Inflammatory Autoimmune Response显示文摘 | Samantha L. Bailey-Bucktrout Marc Martinez-Llordella Xuyu Zhou Bryan Anthony Wendy Rosenthal Herve Luche Hans J. Fehling Jeffrey A. Bluestone | 2013 | Immunity2013，，5： | 1 |
| 10 | An international examination of assurance practices on carbon emissions disclosures 显示文摘 | Wendy Green Shan Zhou | 2013 | Aus- tralian Accounting ILeview2013，，1： | 1 |
| 11 | Natural history of esophageal and gastric cardia precursor by repetitive endoscope screening with 425 adults in a high-risk area in China显示文摘 | Deng Gui Wen Shi Jie Wang Li Wei Zhang Wendi Zhou Wei Fang Yu Xiao Ling Wang | 2009 | Cancer Epidemiology2009，，2： | 1 |
| 12 | A positive family history of esophageal/gastric cardia cancer with gastric cardia adenocarcinoma is associated with a younger age at onset and more likely with another synchronous esophageal/gastric cardia cancer in a Chinese high-risk area显示文摘 | Denggui Wen Baoen Shan Shijie Wang Liwei Zhang Lizhen Wei Wendi Zhou Qing Peng | 2010 | European Journal of Medical Genetics2010，，5： | 1 |
| 13 | Percutaneous Radiologic, Surgical Endoscopic, and Percutaneous Endoscopic Gastrostomy/Gastrojejunostomy: Comparative Study and Cost Analysis显示文摘 | Jeffrey M. Barkmeier Scott O. Trerotola Eric A. Wiebke Stuart Sherman Veronica J. Harris John J. Snidow Matthew S. Johnson Wendy J. Rogers Xiao-Hua Zhou | 1998 | CardioVascular and Interventional Radiology1998，，4： | 1 |
| 14 | Therapeutic effect of Qinghuayin(清化饮)against chronic atrophic gastritis through the inhibition of toll or interleukin-1 receptor domain-containing adaptor inducing interferon-β signaling pathway显示文摘OBJECTIVE:To examine the efficacy of Qinghuayin(清化饮,QHY)in rat chronic atrophic gastritis(CAG)models and explored the molecular mechanism of QHY in treating CAG.METHODS:In total,65 Wistar rats were randomly divided into the control(n=10)and CAG groups(n=55).CAG model rats were further divided into five groups:model(n=10),vitacoenzyme(n=10),low-dose QHY(n=10),medium-dose QHY(n=10),and high-dose QHY groups(n=10).We analyzed histopathological changes using hematoxylin and eosin staining and measured interleukin(IL)-6 and IL-8 levels in serum using enzyme-linked immunosorbent assay(ELISA)(Boster Bio,Pleasanton,USA).In addition,gastrin(GAS),pepsinogen I(PGI),and PGII expressions were evaluated using ELISA.The protein and m RNA expression of toll-like receptor 4(TLR4)and toll or interleukin-1 receptor domaincontaining adaptor inducing interferon-β(TRIF)was detected by Western blotting and quantitative reverse transcription-polymerase chain reaction,respectively.RESULTS:Our results revealed that histopathological changes in CAG model rates could be restored by low-,medium-,and high-dose QHY.The changes in GAS and PGI/II expression demonstrated that QHY improved CAG.Serum IL-6 and IL-levels were decreased by QHY administration.TLR4 and TRIF were upregulated at the m RNA and protein levels in the model group but downregulated by QHY administration.CONCLUSION:We concluded that QHY could effectively improve the histopathological changes of the gastric mucosa induced by CAG in rats.The therapeutic mechanism of QHY may be related to inhibition of the inflammatory factors IL-6 and IL-8 and suppression of TLR4/TRIF m RNA and protein expression. | HE Youcheng YAO Xiaoling LI Sihan ZHOU Hongjian XU Ruoying ZHENG Rong XIAO Wendi SU Ning LIN Ping HUANG Minghan | 2022 | Journal of Traditional Chinese Medicine2022，42，2： | 1 |
| 15 | A prospective future towards bio/medical technology and bioelectronics based on 2D vdWs heterostructures显示文摘Nano-biotechnology research has become extremely important due to the possibilities in manipulation and characterization of biological molecules through nanodevices.Nanomaterials exhibit exciting electrical,optoelectronic,magnetic,mechanical and chemical properties that can be exploited to develop efficient biosensors or bio-probes.Those unique properties in nanomaterials can also be used in bioimaging and cancer therapeutics,where biomolecules influence the inherent properties in nanomaterials.Effective manipulation of nanomaterial properties can lead to many breakthroughs in nanotechnology applications.Nowadays,2D nanomaterials have emerged as viable materials for nanotechnology.Large cross-section area and functional availability of 2D or 1D quantum limit in these nanomaterials allow greater flexibility and better nanodevice performance.2D nanomaterials enable advanced bioelectronics to be more easily integrated due to their atomic thickness,biocompatibility,mechanical flexibility and conformity.Furthermore,with the development of 2D material heterostructures,enhanced material properties can be obtained which can directly influence bio-nanotechnology applications.This article firstly reviews the development of various types of 2D heterostructures in a wide variety of nano-biotechnology applications.Furthermore,future 2D heterostructure scopes in bioimaging,nanomedicine,bio-markers/therapy and bioelectronics are discussed.This paper can be an avenue for providing a wide scope for 2D van der Waals(vdWs)heterostructures in bio-and medical fields. | Guru Prakash Neupane Linglong Zhang Tanju Yildirim Kai Zhou Bowen Wang Yilin Tang Wendi Ma Yunzhou Xue Yuerui Lu | 2020 | Nano Research2020，13，1： | 1 |
| 16 | Whole-genome methylation analysis reveals epigenetic variation between wild-type and nontransgenic cloned,ASMT transgenic cloned dairy goats generated by the somatic cell nuclear transfer显示文摘Background:SCNT(somatic cell nuclear transfer)is of great significance to biological research and also to the livestock breeding.However,the survival rate of the SCNT cloned animals is relatively low compared to other transgenic methods.This indicates the potential epigenetic variations between them.DNA methylation is a key marker of mammalian epigenetics and its alterations will lead to phenotypic differences.In this study,ASMT(acetylserotonin-Omethyltransferase)ovarian overexpression transgenic goat was produced by using SCNT.To investigate whether there are epigenetic differences between cloned and WT(wild type)goats,WGBS(whole-genome bisulfite sequencing)was used to measure the whole-genome methylation of these animals.Results:It is observed that the different m Cp G sites are mainly present in the intergenic and intronic regions between cloned and WT animals,and their CG-type methylation sites are strongly correlated.DMR(differentially methylated region)lengths are located around 1000 bp,mainly distributed in the exonic,intergenic and intronic functional domains.A total of 56 and 36 DMGs(differentially methylated genes)were identified by GO and KEGG databases,respectively.Functional annotation showed that DMGs were enriched in biological-process,cellularcomponent,molecular-function and other signaling pathways.A total of 10 identical genes related to growth and development were identified in GO and KEGG databases.Conclusion:The differences in methylation genes among the tested animals have been identified.A total of 10 DMGs associated with growth and development were identified between cloned and WT animals.The results indicate that the differential patterns of DNA methylation between the cloned and WT goats are probably caused by the SCNT.These novel observations will help us to further identify the unveiled mechanisms of somatic cell cloning technology,particularly in goats. | Hao Wu Wendi Zhou Haijun Liu Xudai Cui Wenkui Ma Haixin Wu Guangdong Li Likai Wang Jinlong Zhang Xiaosheng Zhang Pengyun Ji Zhengxing Lian Guoshi Liu | 2023 | Journal of Animal Science and Biotechnology2023，14，1： | 0 |
| 17 | New Discovery of Ca. 38 Ma Ultramafic–mafic Dyke Swarms in the Mitizi Area, Northwestern Tibetan Plateau显示文摘Objective The Tibetan Plateau, located in the eastern part of the Alpine Himalayan tectonic domain, is the youngest and the most spectacular of all continent-continent collisional belts in the world(Zhang et al., 2007;Xu et al., 2011;Zhu et al., 2012). | CHAO Wendi WANG Zuopeng LI Xiaojun ZHOU Yanlong | 2021 | Acta Geologica Sinica(English Edition)2021，95，4： | 0 |
| 18 | Adaptive evolution to the natural and anthropogenic environment in a global invasive crop pest,the cotton bollworm显示文摘The cotton bollworm,Helicoverpa armigera,is set to become the most economically devastating crop pest in the world,threatening food security and biosafety as its range expands across the globe.Key to understanding the eco-evolutionary dynamics of H.armigera,and thus its management,is an understanding of population connectivity and the adaptations that allow the pest to establish in unique environments.We assembled a chromosome-scale reference genome and re-sequenced 503 individuals spanning the species range to delineate global patterns of connectivity,uncovering a previously cryptic population structure. | Minghui Jin Henry L.North Yan Peng Hangwei Liu Bo Liu Ruiqing Pan Yan Zhou Weigang Zheng Kaiyu Liu Bo Yang Lei Zhang Qi Xu Samia Elfekih Wendy A.Valencia-Montoya Tom Walsh Peng Cui Yongfeng Zhou Kenneth Wilson Chris Jiggins Kongming Wu Yutao Xiao | 2023 | The Innovation2023，4，4： | 0 |
| 19 | Tracking Study at Circular Electron-positron Collider显示文摘The circular electron-positron collider(CEPC)is designed to study the property of Higgs bosonin depth.The baseline detector on CEPC uses time projection chamber(TPC)as main tracker.The raw data collected by detector should be reconstructed before studied by physicists.The reconstruction processes include the process from electronic signal to hit,the process from hit to track,and the process from track and calorimeter signal to particles.Reconstructing the tracks from the hits is an important and critical procedure in the reconstruction chain,which is called tracking. | ZHAO Mingrui RUAN Manqi HU Shouyang ZHOU Jing CHEN Lei LIU Wendi ZHI Yu LI Peiyu LI Xiaomei | 2018 | 中国原子能科学研究院年报2018，，1： | 0 |
| 20 | Development of PandaⅩⅢ Readout Module Test Platform显示文摘The goal of the PandaⅩⅢexperiment is to build the first Time Projection Chamber(TPC)of the 100kg class,high sensitivity and low-radio background gas in the world,which is capable to reconstruct the tracking of events by using TPC’s unique three-dimensional imaging principle and thereby study the non-neutrino double beta decay.China Institute of Atomic Energy is responsi- | HU Shouyang LI Xiaomei ZHOU Jing LI Xinglong CHEN Lei ZHI Yu LIU Wendi ZHAO Mingrui LI Peiyu | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
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