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| 1 | Stable classi?cation with limited sample: transferring a 30-m resolution sample set collected in 2015 to mapping 10-m resolution global land cover in 2017显示文摘As the world strives to reduce the impact of population growth, urbanization, agricultural expansion, and climate change on food security, energy and water shortage, resource over-exploration, biodiversity loss, environmental pollution, and ultimately human health, timely and higher resolution land cover information is urgently needed to achieve the sustainable development goals of the United Nations. | Peng Gong Han Liu Meinan Zhang Congcong Li Jie Wang Huabing Huang Nicholas Clinton Luyan Ji Wenyu Li Yuqi Bai Bin Chen Bing Xu Zhiliang Zhu Cui Yuan Hoi Ping Suen Jing Guo Nan Xu Weijia Li Yuanyuan Zhao Jun Yang Chaoqing Yu Xi Wang Haohuan Fu Le Yu Iryna Dronova Fengming Hui Xiao Cheng Xueli Shi Fengjin Xiao Qiufeng Liu Lianchun Song | 2019 | Science Bulletin2019，64，6： | 166 |
| 2 | Effect of Boschniakia rossica on expression of GSTP,p53 and p21^(ras)proteins in early stage of chemical hepatocarcinogenesis and its anti-inflammatory activities in rats显示文摘AIM To investigate the effect of Boschniakiarossica(BR)extract on expression of GST-P,p53 and p21rasproteins in early stage of chemicalhepatocarcinogenesis in rats and its anti-inflammatory activities.METHODS The expression of tumor marker-placental form glutathione S-transferase(GST-P),p53 and p21rasproteins were investigated byimmunohistochemical techniques and ABCmethod.Anti-inflammatory activities of BR werestudied by xylene and croton oil-induced mouseear edema,carrageenin,histamine and hotscald-induced rat pow edema,adjuvant-inducedrat arthritis and cotton pellet-induced mousegranuloma formation methods.RESULTS The 500 mg/kg of BR-H2O extractfractionated from BR-Methanol extract hadinhibitory effect on the formation of DEN-inducedGST-P-positive foci in rat liver(GST-P stainingwas 78% positive in DEN+AAF group vs 20%positive in DEN+AAF+BR group,P<0.05)andthe expression of mutant p53 and p21rasproteinwas lower than that of hepatic preneoplasticlesions(33% and 22% positive respectively inDEN+AAF group vs negative in DEN+AAF+BRgroup).Both CH2Cl2 and H2O extracts from BRhad anti-inflamatory effect in xylene and crotonoil-induced mouse ear edema(inhibitory rateswere 26%-29% and 35%-59%,respectively). BR-H2O extract exhibited inhibitory effect incarrageenin,histamine and hot scald-inducedhind paw edema and adjuvant-induced arthritis inrats and cotton pellet-induced granulomaformation in mice.CONCLUSION BR extract exhibited inhibitory effect on formation of preneoplastic hepatic foci in early stage of rat chemical hepato-carcinogenesis. Both CH2CI2 and H2O extracts from BR exerted anti-inflammatory effect in rats and mice. | Zong Zhu Yin Hai Ling Jin Xue Zhe Yin Tian Zhu Li Ji Shu Quan Zeng Nan Jin Institute for Cancer Research,Yanbian University College of Medicine,Yanji 133000,Jilin Province,China | 2000 | World Journal of Gastroenterology2000，6，6： | 33 |
| 3 | Nutritional and medicinal characteristics of Chinese giant salamander (Andrias davidianus) for applications in healthcare industry by artificial cultivation: A review显示文摘Andrias davidianus,i.e.Chinese giant salamander(CGS),is one of the largest and oldest amphibians existing in the world and is also one of the valuable biological resources of China.Wild CGS has been threatened with extinction in the past decades due to over capturing,deterioration of natural environment,the slow breeding and growth of the wild species in nature.However,in the past twenty years,with the breakthrough and progress of artificial breeding technology by artificial insemination,the number of artificially cultivated CGS has increased rapidly.Artificially cultivated CGS can either be released to the CGS living environment to increase the population in nature or legally applied in food and medicinal industry as a feedstock due to the unique nutritional and medicinal values of CGS as recorded historically.In this review,the nutritional components,bioactive components and medicinal activities of the artificially cultivated CGS will be summarized.The mucus,skin,meat and bone of CGS contain many different bioactive substances thereby having various medicinal activities including anti-aging,anti-fatigue,anti-tumor,therapy of burn and anti-infection and other physiological functions.This paper will further discuss the potential applications of the artificially cultivated CGS in healthcare industry and prospects of future technological development. | Dong He Wenming Zhu Wen Zenga Jun Lin Yang Ji Yi Wang Chong Zhang Yuan Lu Daoquan Zhao Nan Su Xin-Hui Xing | 2018 | Food Science and Human Wellness2018，7，1： | 28 |
| 4 | MAXIMUM PRINCIPLE FOR OPTIMAL CONTROLPROBLEM OF FULLY COUPLEDFORWARD-BACKWARD STOCHASTIC SYSTEMS显示文摘The optimal control problem of fully coupled forward-backward stochastic systems is put forward. A necessary condition, called maximum principle, for an optimal control of the problem with the control domain being convex is proved. | WU Zhen(College of Mathematics and System Sciences, Shandong University, Ji’nan 250100, China) | 1998 | Systems Science and Mathematical Sciences1998，11，3： | 21 |
| 5 | Meteorological mechanism for a large-scale persistent severe ozone pollution event over eastern China in 2017显示文摘An intensive and persistent regional ozone pollution event occurred over eastern China from 25 June to 5 July 2017.73 out of 96 selected cities,most located in the Beijing-TianjinHebei and the surrounding area(BTHS),suffered severe ozone pollution.A north-south contrast ozone distribution,with higher ozone(199±33μg/m3)in the BTHS and lower ozone(118±25μg/m^3)in the Yangtze River Delta(YRD),was found to be dominated by the position of the West Pacific Subtropical High(WPSH)and mid-high latitude wave activities.In the BTHS,the positive anomalies of geopotential height at 500 hPa and temperature at the surface indicated favorable meteorological conditions for local ozone formation.Prevailing northwesterly winds in the mid-high troposphere and warm advection induced by weak southerly winds in the low troposphere resulted in low-moderate relative humidity(RH),less total cloud cover(TGC),strong solar radiation and high temperatures.Moreover,southerly winds prevailing over the BTHS aggravated the pollution due to regional transportation of O3 and its precursors.On one hand,the deep sinking motion and inversion layer suppressed the dispersion of pollutants.On the other hand,O3-rich air in the upper layer was maintained at night due to temperature inversion,which facilitated O3 vertical transport to the surface in the next-day morning due to elevated convection.Generally,temperature,UV radiation,and RH showed good correlations with O3 in the BTHS,with rates of 8.51(μg/m^3)/℃(within the temperature range of 20-38℃),59.54(μg/m^3)/(MJ/m^2)and-1.93(μg/m^3)/%,respectively. | Jia Mao Lili Wang Chuhan Lu Jingda Liu Mingge Li Guiqian Tang Dongsheng Ji Nan Zhang Yuesi Wang | 2020 | Journal of Environmental Sciences2020，32，6： | 18 |
| 6 | Radial shock wave therapy in the treatment of chronic constriction injury model in rats: a preliminary study显示文摘 | Fu Miao Cheng Hao Li Duoyi Yu Xiaotong Ji Nan Luo Fang | 2014 | Chinese Medical Journal2014，，5： | 13 |
| 7 | POSITIVE SOLUTIONS OF SINGULAR SUBLINEAR SECOND ORDER BOUNDARY VALUE PROBLEMS显示文摘This paper mainly studies the existence of positive solutions of singular sub-linear boundary value problems concerning the generalized Emden-Fowler equations. Anecessary and sufficient condition for the existence of positive solutions to this problemhas been obtained by using the method of lower and upper solutions with the fixed poilltt heorems. | WEI Zhongli(Department of Fundamental Courses, Shandong Arehitectuml andCivil Engineering Institute, Ji’nan 250014, China) | 1998 | Systems Science and Mathematical Sciences1998，11，1： | 12 |
| 8 | Singularity Analysis of a 3-RPS Parallel Manipulator Using Geometric Algebra显示文摘Singular configurations must be avoided in path planning and control of a parallel manipulator. However, most studies rarely focus on an overall singularity loci distribution of lower-mobility parallel mechanisms. Geometric algebra is employed in analysis of singularity of a 3-RPS parallel manipulator. Twist and wrench in screw theory are represented in geometric algebra. Linear dependency of twists and wrenches are described by outer product in geometric algebra. Reciprocity between twists and constraint wrenches are reflected by duality. To compute the positions of the three spherical joints of the 3-RPS parallel manipulator, Tilt-and-Torsion angles are used to describe the orientation of the moving platform. The outer product of twists and constraint wrenches is used as an index for closeness to singularity(ICS) of the 3-RPS parallel manipulator. An overall and thorough perspective of the singularity loci distribution of the 3-RPS parallel manipulator is disclosed, which is helpful to design, trajectory planning and control of this kind of parallel manipulator. | LI Qinchuan XIANG Ji'nan CHAI Xinxue WU Chuanyu | 2015 | Chinese Journal of Mechanical Engineering2015，28，6： | 12 |
| 9 | Effects of endotoxin on endothelin receptor in hepatic and intestinal tissues after endotoxemia in rats显示文摘INTRODUCTIONEndothelins(ETs) has a potent and sustainedvasoconstrictive effect on a variety of blood vessels.The vascular smooth muscle cell (VSMC)is thetarget for ETs.VSMC of the whole body containsendothelin receptor (ETR).A great number ofexperiments have shown that three distinctcomplementary DNAs of ETR have been identifiedi.e.,endothelin A receptor(ET_A receptor),endothelin B receptor(ET_B receptor) | Bao Hua Liu Hui Sun Chen Ji Hong Zhou Nan Xiao | 2000 | World Journal of Gastroenterology2000，6，2： | 12 |
| 10 | Research on crystal growth and properties of a new nonlinear optical crystal:Bismuth borate BiB_3O_6显示文摘BiB3O6 (BIBO) single crystals with sizes of 44 mm × 24 mm × 10 mm and weight of 24.7 g have been successfully grown by the top-seeded method. In this note, the preparation of seed, the growth of crystal and some problems encountered are reported. The lattice parameters of BIBO are a =7.1203(7)A, b = 4.9948(7)A, c = 6.5077(7)A, β= 105.586(8) ', V=222.93(5)A3, which were determined by BRUKER-P4 four-circle diffractometer. BIBO is biaxial crystal and the relative orientation of (X, Y, Z) with regard to (a, b, c) is: X|| b, (Y, c) =47.2°, (Z, a) = 31.6°, determined by the X-ray analysis combined with polarized microscopy. The second-harmonic-generation (SHG) conversion efficiency of the sample for 1.064 μm light is up to 67.7%. We have also obtained the third harmonic generation (THG) of 1.064 μm, namely, 1.064 μm + 0.532 μn →0.355 μm. BIBO crystal is free of moisture and hygroscopy. | TENG Bing, WANG Jiyang, WANG Zhengping, JIANG Huaidong, SONG Renbo, LIU Hong, HU Xiaobo, LIU Yaogang, WEI Jingqian & SHAO ZongshuState Key Laboratory of Crystal Materials, Shandong University, Ji’nan 250100, China | 2001 | Chinese Science Bulletin2001，46，21： | 10 |
| 11 | Investigation of the ultrastructural characteristics of foxtail and broomcorn millet during carbonization and its application in archaeobotany显示文摘Fossilized caryopses (or grains) of foxtail millet (Setaria italica) and broomcorn millet (Panicum miliaceum) are important archaeobotanical materials for the study of early human agricultural activities.The morphology and ultrastructural characteristics of carbonized modern millets caryopses treated in a drying oven and burning in a field were investigated at different temperatures to study how fossilized millets are formed.The caryopses shrank gradually at temperatures below 200°C,and starch granules in the endosperm retained their crystalline structure.At 250°C the foxtail millet caryopses expanded,whereas the broomcorn millet caryopses were greatly deformed.At this temperature,the structure of the starch granules of both millets became amorphous.At 300°C the caryopses partially turned to ash and became porous,and the ultrastructure of the starch granules was transformed into alveolate cavities.Fossil caryopses from the prehistoric storage cellar at the Beiniu Site retained their crystalline structure and were formed by the dehydrating effect of carbonization,indicating that water molecules were not involved in the starch crystallization.The results of a field burning experiment demonstrated that the ultrastructure of carbonized caryopses placed on the ground under the fire was amorphous.The amorphous ultrastructure of the carbonized caryopses recovered from the archaeological layers is consistent with the expected structure of caryopses that have been carbonized at 250°C.Therefore,we suggest that the recovered caryopses were formed at about 250°C by baking rather than by burning in an open fire. | YANG Qing LI XiaoQiang ZHOU XinYing ZHAO KeLiang JI Ming SUN Nan | 2011 | Chinese Science Bulletin2011，56，14： | 10 |
| 12 | Thermal Modeling and Cooling Analysis of High-power Lithium Ion Cells显示文摘The heat generation model and three-dimensional computational fluid dynamics model for lithium ion cells were established with boundary conditions defined.In order to provide a better insight about the behaviors of high-power lithium ion cells under realistic discharge conditions,the temperature difference of the cells and an active thermal management system with a pure air-cooling mode were analyzed and predicted with the factors affecting the unevenness of temperature field discussed.The results show a significant effect of the cooling flow rate on the temperature rise of the cells for all discharge rates.Average surface temperatures are relatively uniform at lower discharge rate that makes it easier to control the temperature of the pack.Cell temperatures are expected to rise significantly toward the end of discharge and they show non-uniformity at higher discharge rates.Adequate air flow rate of active cooling is required at high discharge rate and high ambient temperature for practical pack thermal management system. | Zhuqian Zhang Li Ji a Nan Zhao Lixin Yang | 2011 | Journal of Thermal Science2011，20，6： | 10 |
| 13 | Numerical simulation and application of three-dimensional oil resources migration-accumulation of fluid dynamics in porous media显示文摘Numerical simulation of oil migration and accumulation is to describe the history of oil migration and accumulation in basin evolution. It is of great value in evaluation of oil resources and determination of the location and amount of oil deposits. Based on such actual conditions as the effects of fluid mechanics in porous media and 3-dimensional geology characteristics,a kind of modified method of second order upwind finite difference fractional steps implicit interactive scheme was put forward. As for the actual problem of Dongying hollow,Huimin hollow,Tanhai region and Yangxin hollow in Shengli Petroleum Oil Field,a numerical simulation test was carried out,and the result is basically coincident with the actual conditions. For the model problem,optimal order estimates were derived. Thus the well-known problem on oil resources was solved. | YUAN YiRang1 & HAN YuJi2 1 Institute of Mathematics,Shandong University,Ji’nan 250100,China 2 Physical Exploration Institute of Shengli Petroleum Administration,Dongying 257022,China | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，8： | 10 |
| 14 | Risk factors and pain status due to diabetic neuropathy in chronic long-term diabetic patients in a Chinese urban population显示文摘 | JI Na ZHANG Nan REN Zhan-jie JIA Ke-bao WANG Li NI Jia-xiang MA Jun | 2012 | Chinese Medical Journal2012，，23： | 10 |
| 15 | Ginsenoside Rg1 protects mouse podocytes from aldosterone-induced injury in vitro显示文摘 | Nan MAO Yuan CHENG Xin-li SHI Li WANG Ji WEN Qiong ZHANG Qiong-dan HU Jun-ming FAN | 2014 | Acta Pharmacologica Sinica2014，35，4： | 10 |
| 16 | Danshen protects endothelial progenitor cells from oxidized low-density lipoprotein induced impairment显示文摘In this study,we examined the protective effects of Danshen both on endothelial progenitor cells(EPCs) in patients with hypercholesterolemia and on in-vitro EPCs of healthy volunteers.In the clinical study,we randomly divided 24 subjects with hypercholesterolemia into two groups(the control group and the Danshen-treated group).At the end of two weeks of treatment,the EPC cellular functions of both groups were tested.The results indicated that,compared to the control group,EPCs in the Danshen-treated group showed significantly better cellular functions,which was manifested in the cloning number,the proliferation capacity,the number of EPC adhesions,and cell migration.In the subsequent in-vitro experiments,EPCs were treated with vehicle,oxidized low-density lipoprotein(Ox-LDL,100 μg/ml),or Ox-LDL(100 μg/ml) plus different concentrations of Danshen(Danshensu 2,10,or 50 μg/ml,respectively) for 24 h.The results showed that Danshen treatments can prevent the detrimental effects of Ox-LDL on EPC cellular functions measured by proliferation capacity(0.24±0.08,0.37±0.11,0.30±0.04 vs.0.13±0.02,P<0.05,P<0.01,and P<0.01,respectively),and adhesion ability(63.00±11.60,70.00±10.80,85.50±11.41 vs.40.50±6.85,all P<0.01).Compared to the group treated with Ox-LDL alone,Danshen treatment significantly decreased the lipid peroxidation end product malondialdehyde(MDA) [(4.34±0.54),(3.98±0.47),(3.46±0.31) vs.(5.57±0.64) nmol/ml,all P<0.01],increased the production of superoxide dismutase(SOD) [(29.74±0.71),(31.09±0.83),(30.41±0.65) vs.(14.76±3.99) U/ml,all P<0.01],and lowered the expression of interleukin-6(IL-6) [(24.62±7.69),(27.04±3.14),(33.38±18.86) vs.(230.67±33.53) pg/ml,all P<0.01] and tumor necrosis factor-α(TNF-α) [(41.72±6.10),(17.02±6.82),(3.73±2.26) vs.(228.71±41.53) pg/ml,all P<0.01] in Ox-LDL treated EPCs.These results suggest that Danshen may exert a protective effect through its antioxidant and anti-inflammatory features. | Kang-ting JI Jun-de CHAI Cheng XING Jin-liang NAN Peng-lin YANG Ji-fei TANG | 2010 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010，11，8： | 9 |
| 17 | Effect of Pulsed Radiofrequency on Rat Sciatic Nerve Chronic Constriction Injury: A Preliminary Study显示文摘 | Duo-Yi Li Lan Meng Nan Ji Fang Luo | 2015 | Chinese Medical Journal2015，，4： | 9 |
| 18 | Prognostic values of the integrated model incorporating the volume of metastatic regional cervical lymph node and pretreatment serum Epstein-Barr virus DNA copy number in predicting distant metastasis in patients with N1 nasopharyngeal carcinoma显示文摘Background: According to the 7 th edition of the American Joint Committee on Cancer(AJCC) staging system, over50% of patients with nasopharyngeal carcinoma(NPC) have N1 disease at initial diagnosis. However, patients with N1 NPC are relatively under-researched, and the metastasis risk of this group is not well-stratified. This study aimed to evaluate the prognostic values of gross tumor volume of metastatic regional lymph node(GTVnd) and pretreatment serum copy number of Epstein-Barr virus(EBV) DNA in predicting distant metastasis of patients with N1 NPC, and to develop an integrated prognostic model that incorporates GTVnd and EBV DNA copy number for this group of patients.Methods: The medical records of 787 newly diagnosed patients with nonmetastatic, histologically proven N1 NPC who were treated at Sun Yat-sen University Cancer Center between November 2009 and February 2012 were analyzed. Computed tomography-derived GTVnd was measured using the summation-of-area technique. Blood samples were collected before treatment to quantify plasma EBV DNA. The receiver operating characteristic(ROC) curve analysis was used to evaluate the cut-off point for GTVnd, and the area under the ROC curve was used to assess the predicted validity of GTVnd. The survival rates were assessed by Kaplan-Meier analysis, and the survival curves were compared using a log-rank test. Multivariate analysis was conducted using the Cox proportional hazard regression model.Results: The 5-year distant metastasis-free survival(DMFS) rates for patients with GTVnd > 18.9 vs.≤ 18.9 mL were82.2% vs. 93.2%(P < 0.001), and for patients with EBV DNA copy number > 4000 vs. < 4000 copies/mL were 83.5% vs.93.9%(P < 0.001). After adjusting for GTVnd, EBV DNA copy number, and T category in the Cox regression model, both GTVnd > 18.9 mL and EBV DNA copy number > 4000 copies/mL were significantly associated with poor prognosis(both P < 0.05). According to combination of GTVnd and EBV DNA copy number, all patients were divided into low-,moderate-, and high-risk groups, with the 5-year DMFS rates of 96.1,87.4, and 73.8%, respectively(P < 0.001). Multivariate analysis confirmed the prognostic value of this model for distant metastatic risk stratification(hazard ratio [HR],4.17; 95% confidence interval [CI] 2.34-7.59; P < 0.001).Conclusions: GTVnd and serum EBV DNA copy number are independent prognostic factors for predicting distant metastasis in NPC patients with N1 disease. The prognostic model incorporating GTVnd and EBV DNA copy number may improve metastatic risk stratification for this group of patients. | Ji‑Jin Yao Guan‑Qun Zhou Ya‑Qin Wang Si‑Yang Wang Wang‑Jian Zhang Ya‑Nan Jin Fan Zhang Li Li Li‑Zhi Liu Zhi‑Bin Cheng Jun Ma Zhen‑Yu Qi | 2017 | Chinese Journal of Cancer2017，36，12： | 9 |
| 19 | A prospective study to evaluate the efficacy of an intracardiac electrogram-based atrioventricular and interventricular intervals optimization method in cardiac resynchronization therapy显示文摘有 biventricular 踱步的背景心脏的再同步治疗( CRT )与学习试图评估基于的 intracardiac 电记录图( IEGM )的功效的心 failure.The 电流改进在选择病人的生活的心脏的功能,功能的能力和质量优化方法, QuickOptTM ,在与 CRT.Methods 大动脉的时间对待的中国病人,速度积分( AVTI )完成了在察觉到心房与心室( AV ),在 AV 和两 Qu 推荐的 interventricular ( VV ) | Hua Wei Wang Dong-mei Cai Lin Sun Chao-feng Fu Guo-sheng Wang Yu-tang Yan Ji Luo Zhi-ling Xu Jing Wang Zhi-yong Xu Geng Shen Fa-rong Xu Wei Wang Jing-feng Ren Xue-jun Jin Wei Zhang, Nan Lau, Elizabeth Oi-Yan Zhang Shu | 2012 | Chinese Medical Journal2012，，3： | 8 |
| 20 | Lactulose enhances neuroplasticity to improve cognitive function in early hepatic encephalopathy显示文摘Lactulose is known to improve cognitive function in patients with early hepatic encephalopathy; however, the underlying mechanism remains poorly understood. In the present study, we investigated the behavioral and neurochemical effects of lactulose in a rat model of early hepatic encephalopathy induced by carbon tetrachloride. Immunohistochemistry showed that lactulose treatment promoted neurogenesis and increased the number of neurons and astrocytes in the hippocampus. Moreover, lactulose-treated rats showed shorter escape latencies than model rats in the Morris water maze, indicating that lactulose improved the cognitive impairments caused by hepatic encephalopathy. The present findings suggest that lactulose effectively improves cognitive function by enhancing neuroplasticity in a rat model of early hepatic encephalopathy. | Nan Yang He Liu Yao Jiang Ji Zheng Dong-mei Li Chao Ji Yan-yong Liu Ping-ping Zuo | 2015 | Neural Regeneration Research2015，10，9： | 8 |
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