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| 1 | Effects of Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) medicated serum on chemotactic migration of alveolar macrophages and inters regions macrophages in rats显示文摘OBJECTIVE: To observe the effects of serum containing Mahuang(Herba Ephedra Sinica) or Wuweizi(Fructus Schisandrae Chinensis) on the migration of alveolar macrophages(AM) and interstitial macrophages(IM) from normal rats, and to analyze and compare the mechanisms leading to cell migration differences.METHODS: Rats were randomly divided into three groups: Mahuang(Herba Ephedra Sinica), Wuweizi(Fructus Schisandrae Chinensis), and blank serum. After treatment with the herbs, serum was extracted from the rats. AM and IM were isolated from normal rats and cultured. The effects of Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) medicated serum on normal rat AM and IM chemotactic migration were determined by transwell assays. The CC chemokine receptor(CCR) 2, CCR5, voltage-gated Kvl. 3 K^+channel(Kv1. 3), and voltage-gated Kvl. 5 K^+channel(Kv1. 5) protein levels were analyzed by western blotting.RESULTS: The migration quantities of AM and IM in the Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) medicated serum groups were significantly higher than those in the blank serum group(P < 0.01). Compared with the Wuweizi(Fructus Schisandrae Chinensis) medicated serum group, the migration quantity of cultured rat AM in the Mahuang(Herba Ephedra Sinica) medicated serum group was significantly increased(P <0.01). Meanwhile, compared with the Mahuang(Herba Ephedra Sinica) medicated serum group, the migration quantity of cultured rat IM in the Wuweizi(Fructus Schisandrae Chinensis) medicated serum group was significantly increased(P < 0.01).CCR2, CCR5, Kv1. 3, and Kv1. 5 proteins were expressed on the AM cell surface, and showed significantly higher expression in the Mahuang(Herba Ephedra Sinica) medicated serum group compared with the Wuweizi(Fructus Schisandrae Chinensis)medicated serum group. In contrast, CCR5, Kv1.3,and Kv1.5 proteins were expressed on the IM cell surface, and showed significantly higher expression in the Wuweizi(Fructus Schisandrae Chinensis)medicated serum group compared with the Mahuang(Herba Ephedra Sinica) medicated serum group.CONCLUSION: Mahuang(Herba Ephedra Sinica)and Wuweizi(Fructus Schisandrae Chinensis) can promote AM and IM migration ability, with Mahuang(Herba Ephedra Sinica) targeting AM more apparently and Wuweizi(Fructus Schisandrae Chinensis) targeting IM more apparently. The mechanism may be that, by stimulating cells, Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) promote expression of CCR2 and CCR5 receptors on the AM and IM cell surface,which pass signals to Kvl.3 and Kvl.5 ion channels,leading to changes in the cytoskeleton, and ultimately promoting chemotactic cell migration. | Yuan Yiping Zhai Huaqiang Zhang Tian Guo Zhaojuan Kong Liting Jia Xiaoyu Wang Ningning Dai Ying Liu Guoxiu Wang Yanping | 2017 | Journal of Traditional Chinese Medicine2017，37，5： | 3 |
| 2 | Experimental Study on Thermal Management of Cylindrical Li-ion Battery with Flexible Microchannel Plates显示文摘A novel thermal management system of cylindrical Li-ion battery with the liquid cooling in flexible microchannel plate was established in the study. The experiments were conducted with R141 b in flexible microchannel plates. The cooling system with the flexible aluminum microchannels can effectively transfer heat from battery to the cooling refrigerant R141 b based on flow boiling. A battery module with five cells along flow channel was chosen to study the effects of contact surface area and mass flux on the thermal performance and electrochemical characteristics in the experiments. Three types of structure with different contact areas were studied and their performances were compared with the experiments without cooling structures. The experiments were carried out at the same discharge rate with the inlet mass flow rates of 0–10 kg/h. For the inlet mass flow rate of 5.98 kg/h, the surface temperature and temperature uniformity of battery were the best, and the output voltage and capacity of batteries were higher than those under other mass flow rates. With given inlet mass flow rates, the five series cells exhibited different electrochemical performances, including output voltage and discharge capacity, due to the different refrigerant flow states in the microchannels. Finally, an optimal design was presented with thermal performances, macroscopic electrochemical characteristics, inlet mass flow rates and cooling performance taken into consideration. | WEI Liting JIA Li AN Zhoujian DANG Chao | 2020 | Journal of Thermal Science2020，29，4： | 3 |
| 3 | Outcome of aggressive B-cell lymphoma with TP53 alterations administered with CAR T-cell cocktail alone or in combination with ASCT显示文摘TP53 gene alteration confers inferior prognosis in refractory/relapse aggressive B-cell non-Hodgkin lymphoma(r/r B-NHL).From September 2016 to September 2020,257 r/r B-NHL patients were assessed for eligibility for two trials in our center,assessing anti-CD19 and anti-CD22 chimeric antigen receptor(CAR19/22)T-cell cocktail treatment alone or in combination with autologous stem cell transplantation(ASCT).TP53 alterations were screened in 123 enrolled patients and confirmed in 60.CAR19/22 T-cell administration resulted in best objective(ORR)and complete(CRR)response rate of 87.1%and 45.2%in patients with TP53 alterations. | Jia Wei Min Xiao Zekai Mao Na Wang Yang Cao Yi Xiao Fankai Meng Weimin Sun Ying Wang Xingcheng Yang Liting Chen Yicheng Zhang Haichuan Zhu Shangkun Zhang Tongcun Zhang Jianfeng Zhou Liang Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 2 |
| 4 | Treatment with carnosine reduces hypoxia-ischemia brain damage in a neonatal rat model显示文摘 | Huizhen Zhang Shang Guo Linlin Zhang Liting Jia Zhan Zhang Hongbao Duan Jingbin Zhang Jingyan Liu Weidong Zhang | 2014 | European Journal of Pharmacology2014，，： | 1 |
| 5 | Age- and sex-specific reference intervals for blood copper, zinc, calcium, magnesium, iron, lead, and cadmium in infants and children显示文摘 | Junjie Liu Enwu Yuan Zhan Zhang Liting Jia Zhiqiang Yin Xiangying Meng Hongmei Du | 2012 | Clinical Biochemistry2012，，6： | 1 |
| 6 | Polymorphism of HLA-A and HLA-B in preeclampsia显示文摘 | Zhang Zhan Jia Liting Zhang Linlin | 2009 | Beijing Da Xue Xue Bao2009，41，： | 1 |
| 7 | Facile Synthesis of Lumi- nescent Silver Nanoparticles and Fluorescence Interactions with Blue-Emitting Polyarylene Ether Nitrile 显示文摘 | Jia Kun Wang Pan Yuan Liting | 2015 | Journal of Materials Chemistry C2015，3，： | 1 |
| 8 | Post-TACE Combination Therapy of Heparin and Octreotide Results in Decreased Tumor Metastasis in Extrahepatic Tumorigenesis显示文摘 | Weidong Jia Kehai Feng Pingsheng Fan Gaofei Fan Shoumei Yang Tengyue Zhang Qiang Wei Liting Qian | 2012 | Cell Biochemistry and Biophysics2012，，1： | 1 |
| 9 | Rice Storage Proteins:Focus on Composition,Distribution,Genetic Improvement and Effects on Rice Quality显示文摘Rice storage proteins(RSPs)are plant proteins with high nutritional quality.As the second largest type of storage substance in rice,it is the main source of protein intake for people who consume rice as a staple food.The content and type of RSPs affect the appearance,processing quality and eating quality of rice.These effects involve the distribution of RSPs in rice grains as well as the interactions of RSPs with other components such as starch in rice grains.In the past two decades,some progress has been made in the genetic improvement of RSPs.However,the determination mechanism of protein content and composition in rice is still unclear,and the mechanism of the effect of RSPs on rice quality has not been elucidated.In this review,the composition,biosynthesis and distribution of RSPs,and quantitative trait loci mapping and cloning of RSP genes are summarized,the research progress of the influence of RSPs and their components on rice quality are reviewed,and the research directions in the future are proposed. | LONG Xinkang GUAN Chunmin WANG Lin JIA Liting FU Xiangjin LIN Qinlu HUANG Zhengyu LIU Chun | 2023 | Rice science2023，30，3： | 0 |
| 10 | Carrageenan Fiber Prepared by a New Process Route of Ba^(2+)Ion Pre-Crosslinking in the Spinning Solution显示文摘Ba^(2+)pre-crosslinked carrageenan fiber(Ba/CAF)was prepared by adding a small amount of Ba2+to the carrageenan(CA)solution as the spinning solution.Ba/CAF-n/A,Ba/CAF-n/B and Ba/CAF-n/C were prepared with ethanol solution(combine A),high concentration BaCl_(2)solution(combine B)and low concentration BaCl_(2)solution(combine C),as coagulation bath and stretch bath,respectively.The combination of coagulation bath and stretch bath suitable for Ba2+pre-crosslinking wet spinning was screened.The results showed that Ba2+can induce the birefringence of the CA molecular chain,and the Ba2+pre-crosslinking effect is the best when the CA mass fraction is 8.0 wt%.From the perspective of production safety,fiber performance and spinning cost,the coagulation bath of 3.5 wt%BaCl_(2)solution and stretch bath of 1.7 wt%BaCl_(2)solution,that is,combination C with low concentration BaCl_(2)solution,is the best choice.Ba/CAF-8.0/C was obtained under the best conditions.The linear intensity,water absorption and flame retardancy study showed that the breaking strength of Ba/CAF-8.0/C is as high as 1.61 cN/dtex,the water absorption was 649.2%and 574.3%,in deionized water and normal saline,respectively,and the LOI value reached 32. | Liting Jia Xiao Han Cuixia Qiao Gang Zhao Yanzhi Xia Zhixin Xue | 2024 | Journal of Renewable Materials2024，12，3： | 0 |
| 11 | Rab蛋白家族的蛋白相互作用组研究揭示树突状细胞Rab32蛋白复合体防御细菌感染机制显示文摘树突状细胞发挥功能依赖胞内广泛存在的Rab蛋白介导的复杂膜转运系统。 | Yuanyuan Li Yu Wang Liyun Zou Xiangyu Tang Yi Yang Li Ma Qingzhu Jia Qingshan Ni Siqi Liu Lizhang Tang Regina Lin Elizabeth Wong Wei Sun Liting Wang Quanfang Wei Haiying Ran Liqun Zhang Hengning Lian Wei Huang Yuzhang Wu 李启靖 万瑛 | 2017 | 科学新闻2017，19，4： | 0 |
| 12 | Assembling ionic liquid into porous molecular filler of mixed matrix membrane to trigger high gas permeability,selectivity,and stability for CO_(2)/CH_(4) separation显示文摘As an emerging zero-dimensional nano crystalline porous material,porous organic cages(POCs)with soluble properties in organic solvents,are promising candidates as molecular fillers in mixed matrix membranes(MMMs).The pore structure of POCs should be adjusted to trigger efficient gas separation performance,and the interaction between filler and matrix should be optimized.In this work,ionic liquid(IL)was introduced into the molecular fillers of CC3,to construct the IL@CC3/PIM-1 membrane to effectively separate CO_(2) from CH_(4).The advantages of doping IL include:(1)narrowing the cavity size of POCs from 4.4 to 3.9Åto enhance the diffusion selectivity,(2)strengthening the CO_(2) solubility to heighten the gas permeability,and(3)improving the compatibility between filler and matrix to upgrade membrane stability.After the optimization of the membrane composite,the IL@CC3/PIM-1-10%membrane possesses the CO_(2) permeability of 7868 Barrer and the CO_(2)/CH_(4) selectivity of 73.4,which compared to the CC3/PIM-1-10%membrane,improved by 15.9%and 106.2%,respectively.Furthermore,the membrane has maintained a stable separation performance at varied temperatures and pressures during the long-term test.The proposed method offers an efficient way to improve the performance of POCs-based MMMs in gas separation. | Liting Yu Liqin Hao Yang Feng Jia Pang Mengwei Guo Liangjun Li Weidong Fan Lili Fan Rongming Wang Zixi Kang Daofeng Sun | 2024 | Nano Research2024，17，5： | 0 |
| 13 | Understanding the separator pore size inhibition effect on lithium dendrite via phase-field simulations显示文摘Dendrite growth in lithium-ion batteries may bring thermal run-away especially at high current densities,which remains the major bottleneck to implement safe and fast charging for portable electronic devices or electronical vehicles.Designing dendrite inhibition separators with proper pore size is considered to be one of the most promising strategies to guarantee the battery safety.However,due to the impossible observation of lithium-ion distribution under separator by experiments,the underlying dendrite inhibition mechanism is still not fully understood.Here,we apply the phase-field model,which takes the separator phase into account to construct the electrochemical system total free energy,to study the ion re-distribution behavior of porous separator and understand the pore size inhibition effect on lithium dendrite.The numerical results indicate that separator with smaller pore size is beneficial to smoother electrodeposition,since the lithium-ion concentration on the electrode surface is more uniform under denser separator pores,when their sizes is larger than the critical nucleus.The proposed model could capture the physicochemical process of electrodeposition under multiphase structures,so it could also be used to explore dendrite growth under composite electrodes and composite solid electrolytes. | Yajie Li Geng Zhang Bin Chen Wei Zhao Liting Sha Da Wang Jia Yu Siqi Shi | 2022 | Chinese Chemical Letters2022，33，6： | 0 |
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