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| 1 | Preparation and evaluation of poly(L-histidine) based pH-sensitive micelles for intracellular delivery of doxorubicin against MCF-7/ADR cells显示文摘In this study, a p H-sensitive micelle self-assembled from poly(L-histidine) based triblock copolymers of poly(ethylene glycol)–poly(D,L-lactide)–poly(L-histidine)(mPEG-PLA-PHis) was prepared and used as the intracellular doxorubicin(Dox) delivery for cancer chemotherapy. Dox was loaded into the micelles by thin-film hydration method and a Box–Behnken design for three factors at three levels was used to optimize the preparations. The optimized mPEG-PLA-Phis/Dox micelles exhibited good encapsulation efficiency of 91.12%,a mean diameter of 45 nm and narrow size distribution with polydispersity index of 0.256.In vitro drug release studies demonstrated that Dox was released from the micelles in a p Hdependent manner. Furthermore, the cellular evaluation of Dox loaded micelles displayed that the micelles possessed high antitumor activity in vitro with an IC50 of 35.30 μg/ml against MCF-7/ADR cells. The confocal microscopy and flow cytometry experiments indicated that m PEG-PLA-Phis micelles mediated efficient cytoplasmic delivery of Dox with the aid of poly(Lhistidine) mediated endosomal escape. In addition, blank m PEG-PLA-Phis micelles were shown to be nontoxic to MCF-7/ADR cells even at a high concentration of 200 μg/ml. The pHsensitive mPEG-PLA-PHis micelles have been demonstrated to be a promising nanosystem for the intracellular delivery of Dox for MDR reversal. | Nan Jia Yuqing Ye Qi Wang Xiuli Zhao Haiyang Hu Dawei Chen Mingxi Qiao | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，5： | 6 |
| 2 | Bistratal Au@Bi2S3 nanobones for excellent NIR-triggered/multimodal imaging-guided synergistic therapy for liver cancer显示文摘To fabricate a highly biocompatible nanoplatform enabling synergistic therapy and real-time imaging,novel Au@Bi2S3 core shell nanobones(NBs)(Au@Bi2S3 NBs)with Au nanorods as cores were synthesized.The combination of Au nanorods with Bi2S3 film made the Au@Bi2S3 NBs exhibit ultrahigh photothermal(PT)conversion efficiency,remarkable photoacoustic(PA)imaging and high computed tomography(CT)performance;these Au@Bi2S3 NBs thus are a promising nanotheranostic agent for PT/PA/CT imaging.Subsequently,poly(N-vinylpyrrolidone)-modified Au@Bi2S3 NBs(Au@Bi2S3-PVP NBs)were successfully loaded with the anticancer drug doxorubicin(DOX),and a satisfactory pH sensitive release profile was achieved,thus revealing the great potential of Au@Bi2S3-PVP NBs in chemotherapy as a drug carrier to deliver DOX into cancer cells.Both in vitro and in vivo investigations demonstrated that the Au@Bi2S3-PVP NBs possessed multiple desired features for cancer therapy,including extremely low toxicity,good biocompatibility,high drug loading ability,precise tumor targeting and effective accumulation.Highly efficient ablation of the human liver cancer cell HepG2 was achieved through Au@Bi2S3-PVP NB-mediated photothermal therapy(PTT).As both a contrast enhancement probe and therapeutic agent,Au@Bi2S3-PVP NBs provided outstanding NIR-triggered multi-modal PT/PA/CT imaging-guided PTT and effectively inhibited the growth of HepG2 liver cancer cells via synergistic chemo/PT therapy. | Ruizhuo Ouyang Penghui Cao Pengpeng Jia Hui Wang Tianyu Zong Chenyu Dai Jie Yuan Yuhao Li Dong Sun Ning Guo Yuqing Miao Shuang Zhou | 2021 | Bioactive Materials2021，6，2： | 5 |
| 3 | Trithiocyanuric acid derived g-C3N4 for anchoring the polysulfide in Li-S batteries application显示文摘Lithium-sulfur (Li-S) batteries have great potential as an electrochemical energy storage system because of the high theoretical energy density and acceptable cost of financial and environment.However,the shuttle effect leads to severe capacity fading and low coulombic efficiency.Here,graphitic carbon nitride(g-C3N4) is designed and prepared via a feasible and simple method from trithiocyanuric acid (TTCA) to anchor the polysulfides and suppress the shuttle effect.The obtained g-C3N4 exhibits strong chemical interaction with polysulfides due to its high N-doping of 56.87 at%,which is beneficial to improve the cycling stability of Li-S batteries.Moreover,the novel porous framework and high specific surface area of g-C3N4 also provide fast ion transport and broad reaction interface of sulfur cathode,facilitating high capacity output and superior rate performance of Li-S batteries.As a result,Li-S batteries assembled with g-C3N4 can achieve high discharge capacity of 1200 mAh/g at 0.2 C and over 800 mAh/g is remained after 100 cycles with a coulombic efficiency more than 99.5%.When the C-rate rises to 5 C,the reversible capacity of Li-S batteries can still maintain at 607mAh/g. | Ziyang Jia Hongzhang Zhang Ying Yu Yuqing Chen Jingwang Yan Xianfeng Li Huamin Zhang | 2020 | Journal of Energy Chemistry2020，29，4： | 4 |
| 4 | Model Test of Deformation Evolution and Multi Factor Prediction of Anchorage Slope Stability under Rainfall Condition显示文摘The stability of the anchorage slope on the Baiyang Yangtze River Highway Bridge in Yichang,China,was investigated under different rainfall conditions using model test,numerical simulation,and factor analysis.The results of the study are as follows:(1)with the increase of rainfall intensity,the change of earth pressure can be divided into three stages.However,when the rainfall intensity was larger than a certain value,the change of earth pressure of cut slope became two stages;with the increase of rainfall intensity,pore water pressure increased with the increase of rainfall time,while at a certain stage after the rainfall,the pore water pressure in the cut slope did not decrease immediately,but increased for a period of time.(2)When the rainfall stopped,the stability coefficient of the anchorage slope continued to decrease,then slowly increased,and finally tended to be gentle.Meanwhile,when the rainstorm reached a certain intensity,the main factor that restricted the rainfall infiltration rate became the geotechnical permeability coefficient of the cut slope,which was no longer the rainfall intensity.(3)Factor analysis shows that the rainfall intensity and rainfall duration were the most important factors for anchorage slope stability,while earth pressure,pore water pressure and slope displacement were much less significant. | Tingyao Wu Jianhong Jia Nan Jiang Chuanbo Zhou Xuedong Luo Yuqing Xia | 2020 | Journal of Earth Science2020，31，6： | 3 |
| 5 | Preparation and Evaluation of Electrospun Zein/HA Fibers Based on Two Methods of Adding HA Nanoparticles显示文摘 | Mei Zhang Yongjia Liu Yuqing Jia Hongshuang Han Dahui Sun | 2014 | Journal of Bionic Engineering2014，11，1： | 2 |
| 6 | Study on Anti-infection Effect of Polysaccharide from Agaricus blazei Murrill on Mice显示文摘In order to study the anti-infection effect of phoshporylated Agaricus blazei polysaccharide on mice,mice were drenched phoshporylated A. blazei polysaccharide for 14 d,and an A. blazei polysaccharide control group and a blank control group were also set. The mice in all the three groups were infected with Escherichia coli on the 15^(th)day and the 29^(th)day of the experiment,the body weight of the mice in each group was recorded,as well as the spleen index on the 29^(th)day of infection and the 36^(th)day of the experiment,and the anti-E. coli titer in serum was also detected. The results showed that phoshporylated A. blazei polysaccharide could promote and maintain the development of spleen,and improve the immune response of organisms,thereby resisting bacterial infection. Furthermore,phoshporylated A. blazei polysaccharide has better immunoregulation and anti-infection effects than A. blazei polysaccharide,and could play an important role in veterinary clinical treatment and prevention and control of diseases as a immunologic adjuvant or immunopotentiator. | Chao REN Yuqing ZHOU Shuifeng XIAN Jie LI Deliang WEI Yao LU Nina JIA Shunzi YUAN | 2018 | Agricultural Biotechnology2018，7，4： | 2 |
| 7 | Involucre fossils of Carpinus,a northern temperate element,from the Miocene of China and the evolution of its species diversity in East Asia显示文摘East Asia has long been recognized as a major center for temperate woody plants diversity.Although several theories have been proposed to explain how the diversity of these temperate elements accumulated in the region,the specific process remains unclear.Here we describe six species of Carpinus,a typical northern hemisphere temperate woody plant,from the early Miocene of the Maguan Basin,southwestern China,southern East Asia.This constitutes the southernmost,and the earliest occurrence that shows a high species diversity of the genus.Together with other Carpinus fossil records from East Asia,we show that the genus had achieved a high diversity in East Asia at least by the middle Miocene.Of the six species here described,three have become extinct,indicating that the genus has experienced apparent species loss during its evolutionary history in East Asia.In contrast,the remaining three species closely resemble extant species,raising the possibility that these species may have persisted in East Asia at least since the early Miocene.These findings indicate that the accumulation of species diversity of Carpinus in East Asia is a complex process involving extinction,persistence,and possible subsequent speciation. | Li Xue Linbo Jia Gi-soo Nam Yongjiang Huang Shitao Zhang Yuqing Wang Zhuo Zhou Yongsheng Chen | 2020 | Plant Diversity2020，42，3： | 2 |
| 8 | Testing universality of Feynman-Tan relation in interacting Bose gases using high-order Bragg spectra显示文摘The Feynman-Tan relation,obtained by combining the Feynman energy relation with the Tan’s two-body contact,can explain the excitation spectra of strongly interacting 39K Bose-Einstein condensate(BEC).Since the shift of excitation resonance in the Feynman-Tan relation is inversely proportional to atomic mass,the test of whether this relation is universal for other atomic systems is significant for describing the effect of interaction in strongly correlated Bose gases.Here we measure the high-momentum excitation spectra of 133Cs BEC with widely tunable interactions by using the second-and third-order Bragg spectra.We observe the backbending of frequency shift of excitation resonance with increasing interaction,and even the shift changes its sign under the strong interactions in the high-order Bragg spectra.Our finding shows good agreement with the prediction based on the Feynman-Tan relation.Our results provide significant insights for understanding the profound properties of strongly interacting Bose gases. | Yunfei Wang Huiying Du Yuqing Li Feng Mei Ying Hu Liantuan Xiao Jie Ma Suotang Jia | 2023 | Light(Science & Applications)2023，12，3： | 2 |
| 9 | Kernel partial robust Mregression as a flexible robust nonlinear modeling technique 显示文摘 | Jia Runda Mao Zhizhong Chang Yuqing | 2010 | Chemometrics and Intelligent Laboratory Systems2010，100，2： | 1 |
| 10 | Soil respiration in a mixed urban forest in China in relation to soil temperature and water content显示文摘 | Wenjing Chen Xin Jia Tianshan Zha Bin Wu Yuqing Zhang Chunyi Li Xiaoping Wang Guimei He Haiqun Yu Guopeng Chen | 2013 | European Journal of Soil Biology2013，，： | 1 |
| 11 | Cryptotanshinone induces cell cycle arrest and apoptosis of multidrug resistant human chronic myeloid leukemia cells by inhibiting the activity of eukaryotic initiation factor 4E显示文摘 | Yuqing Ge Rubin Cheng Yuhong Zhou Jianping Shen Laijun Peng Xiaofeng Xu Qun Dai Pei Liu Haibing Wang Xiaoqiong Ma Jia Jia Zhe Chen | 2012 | Molecular and Cellular Biochemistry2012，，1： | 1 |
| 12 | Laser intensity induced transparency in atom-molecular transition process显示文摘We propose a new transparency mechanism,which is based on photoassociation(PA)laser intensity induced transitional frequency shift for ultracold cesium molecules formed in PA scheme.The PA laser intensity is supposed to change before the atom-molecule resonance.Thus,a remarkable transparent effect for PA laser is expected to appear in the vicinity of original resonant transitional line,where the variation of PA laser intensity induces the shift of the excited molecular levels.The mechanism is different from electromagnetically induced transparency effect and interesting for further research on the scattering length for cesium atomic condensate. | Jie Ma Yuqing Li Jizhou Wu Liantuan Xiao Suotang Jia | 2014 | Chinese Science Bulletin2014，59，22： | 1 |
| 13 | A dual-regulation strategy of B/N codoped CNT-encapsulated Ni nanoparticles as a catalytic host and separator coating promises high-performance Li-S batteries显示文摘A dual-regulation strategy of adopting B/N codoped carbon nanotube-encapsulated nickel nanoparticles(Ni@BNCNT) as a sulfur host and separator coating is proposed for high-performance Li-S batteries. On the cathode side, the 3D conductive network structure of Ni@BNCNT is favorable for high sulfur utilization, and the collaboration between polar metal Ni nanoparticles(NPs) and doped B/N elements facilitates the chemical adsorption of Li polysulfides(Li PSs). In addition, these metal Ni NPs exhibit a satisfactory catalytic effect on the polysulfide conversion. Moreover, using the Ni@BNCNT interlayer can further capture the soluble Li PSs, make them convert quickly, and prevent them from diffusing toward the anode side. The Li-S batteries simultaneously equipped with a S/Ni@BNCNT cathode and Ni@BNCNT interlayer show high reversible capacity and good cycle stability. Additionally, even at a sulfur loading of 3.5 mg cm;and an electrolyte/sulfur ratio of 3 μL mg;, excellent battery performance can be achieved. We believe that this work offers a new strategy based on combining a catalytic host and separator coating to construct high-efficiency Li-S batteries. | XIONG DongGen XU Ling XU Jian ZHANG XiangXiang LI Jia XU YuQing ZHANG Ze YU Ji YANG ZhenYu | 2022 | Science China(Technological Sciences)2022，65，7： | 1 |
| 14 | Phase Regulation and Defect Passivation Enabled by Phosphoryl Chloride Molecules for Efficient Quasi‑2D Perovskite Light‑Emitting Diodes显示文摘Quasi-2D perovskites have attracted tremendous interest for application as lightemission layers in light-emitting diodes(LEDs).However,the heterogeneous n phase and non-uniform distribution still severely limit the further development of quasi-2D perovskite LEDs(Pero-LEDs).Meanwhile,the increased defect density caused by the reduced dimension and grain size induces non-radiative recombination and further deteriorates the device performance.Here,we found that a series of molecules containing phosphoryl chloride functional groups have noticeable enhancement effects on the device performance of quasi-2D Pero-LEDs.Then,we studied the modification mechanism by focusing on the bis(2-oxo-3-oxazolidinyl)phosphinic chloride(BOPCl).It is concluded that the BOPCl can not only regulate the phase distribution by decreasing the crystallization rate but also remain in the grain boundaries and passivate the defects.As a result,the corresponding quasi-2D Pero-LEDs obtained a maximum external quantum efficiency(EQE_(max))of 20.82%and an average EQE(EQE_(ave))of around 20%on the optimal 50 devices,proving excellent reproducibility.Our work provides a new selection of molecular types for regulating the crystallization and passivating the defects of quasi-2D perovskite films. | Mingliang Li Yaping Zhao Jia Guo Xiangqian Qin Qin Zhang Chengbo Tian Peng Xu Yuqing Li Wanjia Tian Xiaojia Zheng Guichuan Xing Wen‑Hua Zhang Zhanhua Wei | 2023 | Nano-Micro Letters2023，15，8： | 1 |
| 15 | Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression显示文摘 | Haixia Dang Ying Chen Xinmin Liu Qiong Wang Liwei Wang William Jia Yuqing Wang | 2009 | Progress in Neuropsychopharmacology & Biological Psychiatry2009，，8： | 1 |
| 16 | Soft-sensor for copper extraction process in cobalt hydrometallurgy based onadaptive hybrid model 显示文摘 | Jia Runda Mao Zhizhong Chang Yuqing | 2011 | Chemical Engineering Research and Design2011，89，6： | 1 |
| 17 | Common Apolipoprotein E Gene Mutations Contribute to Lipoprotein Glomerulopathy in China 显示文摘 | Jia H Yongli P Yuqing C | 2010 | Nephron Clin Pract2010，114，： | 1 |
| 18 | Kernel partial robust M-regression as a flexible robust nonlinear modelingtechnique 显示文摘 | Jia Runda Mao Zhizhong Chang Yuqing | 2010 | Chemometrics and Intelligent Laboratory Systems2010，100，2： | 1 |
| 19 | Genome degradation promotes Salmonella pathoadaptation by remodeling fimbriae-mediated proinflammatory response显示文摘Understanding changes in pathogen behavior(e.g.increased virulence,a shift in transmission channel)is critical for the public health management of emerging infectious diseases.Genome degradation via gene depletion or inactivation is recognized as a pathoadaptive feature of the pathogen evolving with the host.However,little is known about the exact role of genome degradation in affecting pathogenic behavior,and the underlying molecular detail has yet to be examined.Using large-scale global avian-restricted Salmonella genomes spanning more than a century,we projected the genetic diversity of Salmonella Pullorum(bvSP)by showing increasingly antimicrobial-resistant ST92 prevalent in Chinese flocks.The phylogenomic analysis identified three lineages in bvSP,with an enhancement of virulence in the two recently emerged lineages(L2/L3),as evidenced in chicken and embryo infection assays.Notably,the ancestor L1 lineage resembles the Salmonella serovars with higher metabolic flexibilities and more robust environmental tolerance,indicating stepwise evolutionary trajectories towards avian-restricted lineages.Pan-genome analysis pinpointed fimbrial degradation from a virulent lineage.The later engineeredfim-deletion mutant,and all other five fimbrial systems,revealed behavior switching that restricted horizontal fecal-oral transmission but boosted virulence in chicks.By depleting fimbrial appendages,bvSP established persistent replication with less proinflammation in chick macrophages and adopted vertical transovarial transmission,accompanied by ever-increasing intensification in the poultry industry.Together,we uncovered a previously unseen paradigm for remodeling bacterial surface appendages that supplements virulence-enhanced evolution with increased vertical transmission. | Xiao Zhou Xiamei Kang Jiaqi Chen Yan Song Chenghao Jia Lin Teng Yanting Tang Zhijie Jiang Xianqi Peng Xiaoxi Tao Yiwei Xu Linlin Huang Xuebin Xu Yaohui Xu Tengfei Zhang Shenye Yu Jiansen Gong Shaohui Wang Yuqing Liu Guoqiang Zhu Corinna Kehrenberg Franois-Xavier Weill Paul Barrow Yan Li Guoping Zhao Min Yue | 2023 | National Science Review2023，10，10： | 0 |
| 20 | Bioconversion of lignocellulosic biomass into bacterial nanocellulose:challenges and perspectives显示文摘Nanocellulose has various outstanding properties and great potential for replacing petrochemical products.The utilization of lignocellulose to produce nanocellulose is of great significance to the sustainable development of the economy and society.However,the direct extraction of nanocellulose from lignocellulose by chemical method is challenged by toxic chemicals utilization,energy and time consumption,and waste water generation.Therefore,this paper addressed the conversion of lignocellulosic biomass into bacterial nanocellulose(BNC)by the biological method.Moreover,this article highlights the recent advances in potentials and challenges of lignocellulosic biomass for BNC production through the bioconversion process,including biomass pretreatment,enzymatic hydrolysis,glucose and xylose fermentation,GA accumulation,and inhibitor tolerant.The development in metabolic and evolutionary engineering to enhance the production capacity of BNC-producing strain is also discussed.It is expected to provide guidance on the effective bioproduction of nanocellulose from lignocellulosic biomass. | Wenchao Li Yuqing Shen Huan Liu Xinxin Huang Bin Xu Cheng Zhong Shiru Jia | 2023 | Green Chemical Engineering2023，4，2： | 0 |
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