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| 1 | Domain structure and defects of highly ordered Bi_4Si_3O_(12) micro-crystals显示文摘Highly ordered Bi4Si3O12 micro-crystals were prepared at normal atmosphere. Phase identification of the prepared crystals was accomplished by X-ray diffractometer (XRD). Domain structure and defects were characterized by environmental scanning electron microscopy (ESEM). XRD shows that the obtained micro-crystals are of eulytite structure with chemical formulation of Bi4Si3O12. A highly ordered growth pattern is confirmed due to the faster growth of the {124} faces than that of the {204} faces by ESEM. The growing process of the domain structure is of pollen parent and filial generation pattern. The filial generations of Bi4Si3O12 crystals are generated from the pollen parent. Cracks generate from the defect areas and propagate along the {124} faces due to their lower binding energy under a proper temperature gradient, contributing to the total transcrystalline fracture. It is confirmed that the generation and development of the voids in the crystal grains can be developed when unmatched dimensions of the two opposite faces are formed. And the development of the voids is dependent on the dimensions and orientations of the two opposite faces. | TIAN QingQuan, WANG XiuFeng, YU ChengLong, JIANG HongTao, ZHANG ZhengGuang, WANG Yan & LIN SheBao School of Materials Science and Engineering, Shaanxi University of Science & Technology, Xi’an 710021, China | 2009 | Science China(Technological Sciences)2009，52，8： | 8 |
| 2 | Five-year follow-up of 23 asymmetrical Parkinson's disease patients treated with unilateral subthalamic nucleus stimulation显示文摘In this study, 23 asymmetrical Parkinson's disease patients were treated with unilateral deep brain stimulation of the subthalamic nucleus and followed up for 5 years. At 5 years after stimulation treatment, Unified Parkinson's Disease Rating Scale II, III and axial symptom scores in the off-drug condition were significantly increased compared those at baseline. However, total Unified Parkinson's Disease Rating Scale II, III and axial symptom scores were significantly lower with stimulation-on compared with the synchronous stimulation-off state in off-drug condition, and the motor symptoms of contralateral side limbs were effectively controlled. Only low Hoehn-Yahr stage was correlated with good long-term postoperative improvement in motor symptoms. The mean levodopa-equivalent daily dose after stimulation treatment was significantly lower than that before treatment, but dyskinesias became worse. Our experimental findings indicate that unilateral deep brain stimulation of the subthalamic nucleus is an effective treatment for improving motor symptoms in well selected asymmetrical Parkinson's disease patients presenting no severe axial symptoms and dyskinesias. | Jinchuan Liang Xiaowu Hu Xiaoping Zhou Xiufeng Jiang Yiqun Cao Laixing Wang Aiguo Jin Jianmin Liu | 2012 | Neural Regeneration Research2012，7，18： | 3 |
| 3 | Escape from abluminal LRP1-mediated clearance for boosted nanoparticle brain delivery and brain metastasis treatment显示文摘Breast cancer brain metastases(BCBMs)are one of the most difficult malignancies to treat due to the intracranial location and multifocal growth.Chemotherapy and molecular targeted therapy are extremely ineffective for BCBMs due to the inept brain accumulation because of the formidable bloodbrain barrier(BBB).Accumulation studies prove that low density lipoprotein receptor-related protein 1(LRP1)is promising target for BBB transcytosis.However,as the primary clearance receptor for amyloid beta and tissue plasminogen activator,LRP1 at abluminal side of BBB can clear LRP1-targeting therapeutics.Matrix metalloproteinase-1(MMP1)is highly enriched in metastatic niche to promote growth of BCBMs.Herein,it is reported that nanoparticles(NPs-K-s-A)tethered with MMP1-sensitive fusion peptide containing HER2-targeting K and LRP1-targeting angiopep-2(A),can surmount the BBB and escape LRP1-mediated clearance in metastatic niche.NPs-K-s-A revealed infinitely superior brain accumulation to angiopep-2-decorated NPs-A in BCBMs bearing mice,while comparable brain accumulation in normal mice.The delivered doxorubicin and lapatinib synergistically inhibit BCBMs growth and prolongs survival of mice bearing BCBMs.Due to the efficient BBB penetration,special and remarkable clearance escape,and facilitated therapeutic outcome,the fusion peptide-based drug delivery strategy may serve as a potential approach for clinical management of BCBMs. | Naveed Ullah Khan Jiang Ni Xiufeng Ju Tongtong Miao Haiyan Chen Liang Han | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 3 |
| 4 | Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study显示文摘Emerging evidence suggests that children conceived through assisted reproductive technology(ART)have a higher risk of congenital heart defects(CHDs)even when there is no family history.De novo mutation(DNM)is a well-known cause of sporadic congenital diseases;however,whether ART procedures increase the number of germline DNM(gDNM)has not yet been well studied.Here,we performed whole-genome sequencing of 1137 individuals from 160 families conceived through ART and 205 families conceived spontaneously.Children conceived via ART carried 4.59 more gDNMs than children conceived spontaneously,including 332 paternal and 1.26 maternal DNMs,after correcting for parental age at conception,cigarette smoking,alcohol drinking,and exercise behaviors.Paternal DNMs in offspring conceived via ART are characterized by C>T substitutions at CpG sites,which potentially affect protein-coding genes and are significantly associated with the increased risk of CHD.In addition,the accumulation of non-coding functional mutations was independently associated with CHD and 87.9% of the mutations were originated from the father.Among ART offspring,infertility of the father was associated with elevated paternal DNMs;usage of both recombinant and urinary follicle-stimulating hormone and high-dosage human chorionic gonadotropin trigger was associated with an increase of maternal DNMs.In sum,the increased gDNMs in offspring conceived by ART were primarily originated from fathers,indicating that ART itself may not be a major reason for the accumulation of gDNMs.Our findings emphasize the importance of evaluating the germline status of the fathers in families with the use of ART. | Cheng Wang Hong Lv Xiufeng Ling Hong Li Feiyang Diao Juncheng Dai Jiangbo Du Ting Chen Qi Xi Yang Zhao Kun Zhou Bo Xu Xiumei Han Xiaoyu Liu Meijuan Peng Congcong Chen Shiyao Tao Lei Huang Cong Liu Mingyang Wen Yangqian Jiang Tao Jiang Chuncheng Lu Wei Wu Di Wu Minjian Chen Yuan Lin Xuejiang Guo Ran Huo Jiayin Liu Hongxia Ma Guangfu Jin Yankai Xia Jiahao Sha Hongbing Shen Zhibin Hu | 2021 | Cell Research2021，31，8： | 2 |
| 5 | Mechanical properties and influence mechanism of confined concrete arches in high-stress tunnels显示文摘Deep underground projects(e.g., coal mines), are often faced with complex conditions such as high stress and extremely soft rock. The strength and rigidity of the traditional support system are often insufficient,which makes it difficult to meet the requirements of ground control under complex conditions. As a new support form with high strength and rigidity, the confined concrete arch plays an important role in controlling the rock deformation under complex conditions. The section shape of the tunnel has an important impact on the mechanical properties and design of the support system. However, studies on the mechanical properties and influence mechanism of the new confined concrete arch are rarely reported. To this end, the mechanical properties of traditional U-shaped steel and new confined concrete arches are compared and comparative tests on arches of circular and straight-leg semicircular shapes in deep tunnels are conducted. A large mechanical testing system for underground engineering support structure is developed. The mechanical properties and influence mechanism of confined concrete arches with different section shapes under different loading modes and cross-section parameters are systematically studied. Test results show that the bearing capacity of the confined concrete arch is 2.10 times that of the U-shaped steel arch, and the bearing capacity of the circular confined concrete arch is 2.27 times that of the straight-leg semicircular arch. Among the various influencing factors and their engineering parameters,the lateral stress coefficient has the greatest impact on the bearing capacity of the confined concrete arch,followed by the steel pipe wall thickness, steel strength, and core concrete strength. Subsequently, the economic index of bearing capacity and cost is established, and the optimization design method for the confined concrete arch is proposed. Finally, this design method is applied to a high-stress tunnel under complex conditions, and the deformation of the surrounding rock is effectively controlled. | Bei Jiang Zhongxin Xin Xiufeng Zhang Yusong Deng Mingzi Wang Shidong Li Wentao Ren | 2023 | International Journal of Mining Science and Technology2023，33，7： | 2 |
| 6 | Fuzzy SVM with a new fuzzy membership function显示文摘 | Jiang Xiufeng Yi Zhang Lv Jiancheng | 2006 | Neural Comput and Applic2006，，15： | 1 |
| 7 | Fuzzy SVM with anew fuzzy membership function显示文摘 | Xiufeng Jiang Zhang Yi Jian Cheng Lü | 2006 | Neural Computing andApplications2006，15，34： | 1 |
| 8 | Ethanol gas sensor based on CoFe2O4 nano-crystallines prepared by bydrothermal method显示文摘 | CHOU Xiufeng JIANG Dongli GUO Yu | 2006 | Sens Actuators B2006，120，： | 1 |
| 9 | Identification of serum metabolites enhancing inflammatory responses in COVID-19显示文摘Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is characterized by a strong production of inflammatory cytokines such as TNF and IL-6,which underlie the severity of the disease.However,the molecular mechanisms responsible for such a strong immune response remains unclear.Here,utilizing targeted tandem mass spectrometry to analyze serum metabolome and lipidome in COVID-19 patients at different temporal stages,we identified that 611 metabolites(of 1,039)were significantly altered in COVID-19 patients.Among them,two metabolites,agmatine and putrescine,were prominently elevated in the serum of patients;and 2-quinolinecarboxylate was changed in a biphasic manner,elevated during early COVID-19 infection but levelled off.When tested in mouse embryonic fibroblasts(MEFs)and macrophages,these 3 metabolites were found to activate the NF-κB pathway that plays a pivotal role in governing cytokine production.Importantly,these metabolites were each able to cause strong increase of TNF and IL-6 levels when administered to wildtype mice,but not in the mice lacking NF-κB.Intriguingly,these metabolites have little effects on the activation of interferon regulatory factors(IRFs)for the production of type I interferons(IFNs)for antiviral defenses.These data suggest that circulating metabolites resulting from COVID-19 infection may act as effectors to elicit the peculiar systemic inflammatory responses,exhibiting severely strong proinflammatory cytokine production with limited induction of the interferons.Our study may provide a rationale for development of drugs to alleviate inflammation in COVID-19 patients. | Chen-Song Zhang Bingchang Zhang Mengqi Li Xiaoyan Wei Kai Gong Zhiyong Li Xiangyang Yao Jianfeng Wu Cixiong Zhang Mingxia Zhu Lei Zhang Xiufeng Sun Yi-Hong Zhan Zhengye Jiang Wenpeng Zhao Wei Zhong Xinguo Zhuang Dawang Zhou Hai-Long Piao Sheng-Cai Lin Zhanxiang Wang | 2022 | Science China(Life Sciences)2022，65，10： | 1 |
| 10 | Fuzzy SVM with a new fuzzy membership function显示文摘 | JIANG Xiufeng ZHANG Yi LV Jiancheng | 2006 | Neural Computation and Application2006，3，15： | 1 |
| 11 | Evolutionary mechanism of b-oriented TS-1 film on porous α-Al_2O_3 supported chitosan surface in hydrothermal reactions显示文摘The acid-base titration,atomic force microscopy(AFM),contact angle technique,energy dispersive X-ray(EDX)and electron probe microanalysis(EPMA)were performed to check the existence of the gel-layer on the chitosan surface after it was dipped in aqueous TPAOH solution as well as in TS-1 synthesis solution.The evolution of TS-1 monolayer and multi-layered film on the chitosan surface was studied using SEM imaging at different stages during hydrothermal reactions.Experimental evidence for the formation mechanism of supported zeolite films and membranes revealed that a gel-layer enriched with TPA cations and TS-1 precursors was first formed on the chitosan surface,followed by the nucleation within the gel-layer especially on the chitosan surface.The nuclei formed on the chitosan surface were further transformed into crystalline particles and TS-1 crystal grains.The nuclei beyond the chitosan surface subsequently grew up,leading to the formation of multi-layered TS-1 film with preferential b-orientation.The result is significant for engineering the microstructure of supported zeolite films and membranes in hydrothermal reactions. | LIU XiuFeng WANG XiaoDong NA Ping JIANG HaiYang LANG Lin ZHAO HongShe ZHANG BaoQuan | 2010 | Chinese Science Bulletin2010，55，27： | 1 |
| 12 | Identification and developmental profiling of conserved and novel microRNAs in Manduca sexta显示文摘 | Xiufeng Zhang Yun Zheng Guru Jagadeeswaran Ren Ren Ramanjulu Sunkar Haobo Jiang | 2012 | Insect Biochemistry and Molecular Biology2012，，6： | 1 |
| 13 | Body weight and mortality among men and women in china显示文摘 | Gu Dongfeng He Jiang Duan Xiufeng | 2006 | Jama2006，295，： | 1 |
| 14 | Fuzzy SVM with a new fuzzy membership function显示文摘 | JIANG XIUFENG YI ZHANG LV JIANCHENG | 2006 | Neural Computing and Applications2006，15，34： | 1 |
| 15 | Fuzzy SVM with a new fuzzy membership function显示文摘 | Xiufeng Jiang Zhang Yi Jian Cheng Lv | 2006 | Neural Computing and Applications (-)2006，，3： | 1 |
| 16 | Electro-elastic features of YBa3(PO_(4))3 and YbBa3(PO_(4))3 crystals with pure face-shear mode for acoustic wave sensor applications显示文摘The fundamental shear horizontal(SH0)waves have been proved to be a very useful method for nondestructive testing due to their non-dispersive characteristics.Currently,although several methods have been proposed to generate SH0 waves,it is still a challenge to obtain pure SH0 wave mode efficiently.Herein,in this study,non-centrosymmetric YBa3(PO_(4))3(YBP)and YbBa3(PO_(4))3(YbBP)crystals with pure face-shear mode were grown via the traditional Czochralski pulling method at temperatures above 1800℃.High resolution X-ray diffraction was carried out to evaluate the crystalline quality.Results showed that the YBP and YbBP crystals were of good quality,with the full width at half-maxima being on the order of 42.500 and 52.300,respectively.Moreover,the full set of electro-elastic constants for the YBP and YbBP crystals were determined and collated using a combination of impedance and pulse-echo methods.The piezoelectric coefficient(d14)of the YBP and YbBP crystals were determined to be 10.6 pC/N and 11.4 pC/N,respectively,corresponding to the electromechanical coupling coefficient(k14)equal to 15.4%and 15.9%,exhibiting large and pure face-shear vibration mode.Collectively,these results indicate that the YBP and YbBP crystals are promising for acoustic wave sensing application. | Guangda Wu Lingkai Kong Mengdi Fan Fapeng Yu Chao Jiang Xiufeng Cheng Xian Zhao | 2021 | Journal of Materiomics2021，7，4： | 0 |
| 17 | Deep brain stimulation of the subthalamic nucleus treats Parkinson's disease through enhancing metabolic activity of the corpus striatum Verification by single photon emission computed tomography and positron emission tomography显示文摘BACKGROUND:Subthalamic nucleus deep brain stimulation (STN DBS) for Parkinson's disease (PD) has achieved good effects,but to date the mechanism of STN DBS remains poorly understood. STN DBS may increase dopamine levels or metabolic activity of the corpus striatum. OBJECTIVE:To validate the effects of STN DBS on dopamine metabolism and glucose metabolism in the corpus striatum of hemiparkinsonian monkeys using single photon emission computed tomography (SPECT) and position emission tomography (PET). DESIGN,TIME AND SETTING:A controlled animal study was performed at the Neurosurgery Laboratory,Changhai Hospital of the Second Military Medical University of Chinese PLA between January 2004 and December 2007. METHODS:Hemiparkinsonism was induced in adult Rhesus Macaque monkeys,which exhibit similar characteristics of PD in humans,through unilateral internal carotid artery infusion of 1-methy-4-phenyl-1,2,3,6-tetrahydropyrindine. Following model establishment,stimulation electrodes were implanted in the right STN,and chronic high-frequency stimulation (60 μs pulse width,130 Hz frequency,and 1.5-2.0 V pressure) was performed. MAIN OUTCOME MEASURES:The changes in dopamine transporter (DAT),D2 receptor (D2R),and glucose metabolism in the corpus striatum following STN DBS were observed using SPECT and PET. RESULTS:SPECT examination showed that DAT specific binding in the right corpus striatum was increased at 3 months after DBS compared with prior to stimulation,and D2R specific binding in the right corpus striatum gradually decreased near levels on the left (non-electrode-implanted) side within 3 months after DBS. PET examination showed that the glucose metabolism in the right corpus striatum was markedly increased at 3 months after effective DBS. Hemiparkinsonism monkeys showed improved left limb rigidity,increased activities,and stable gait under chronic high-frequency stimulation. CONCLUSION:STN DBS increased striatal DAT,decreased D2R,and enhanced glucose metabolism,suggesting that chronic,high-frequency STN stimulation enhanced the metabolic activity of the corpus striatum,a mechanism for improving the PD symptoms of hemiparkinsonian monkeys. | Yiqun Cao Xiaoping Zhou Zhifeng Zhang Xiaowu Hu Xiufeng Jiang | 2010 | Neural Regeneration Research2010，5，6： | 0 |
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