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| 1 | Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy显示文摘Although PD-L1/PD-1 blockade therapy has been approved to treat many types of cancers,the majority of patients with solid tumors do not respond well,but the underlying reason remains unclear.Here,we studied ovarian cancer(OvCa),a tumor type generally resistant to current immunotherapies,to investigate PD-1-independent immunosuppression.We found that PD-L1 was not highly expressed in the tumor microenvironment(TME)of human OvCa.Instead,B7-H3,another checkpoint molecule,was highly expressed by both tumor cells and tumor-infiltrating antigen-presenting cells(APCs),which correlated with T-cell exhaustion in patients.Using ID8 OvCa mouse models,we found that B7-H3 expressed on tumor cells,but not host cells,had a dominant role in suppressing antitumor immunity.Therapeutically,B7-H3 blockade,but not PD-1 blockade,prolonged the survival of ID8 tumorbearing mice.Collectively,our results demonstrate that tumor-expressed B7-H3 inhibits the function of CD8^(+)T cells and suggest that B7-H3 may be a target in patients who are not responsive to PD-L1/PD-1 inhibition,particularly OvCa patients. | Dongli Cai Jiaming Li Dingfeng Liu Shanjuan Hong Qin Qiao Qinli Sun Pingping Li Nanan Lyu Tiantian Sun Shan Xie Li Guo Ling Ni Liping Jin Chen Dong | 2020 | Cellular & Molecular Immunology2020，17，3： | 8 |
| 2 | Dimethyl Ether Synthesis via Methanol and Syngas over Rare Earth Metals Modified Zeolite Y and Dual Cu-Mn-Zn Catalysts显示文摘 | JIN Dingfeng ZHU Bing HOU Zhaoyin | 2007 | Fuel2007，86，17： | 1 |
| 3 | Analytical optimization for field emission of carbon nanotube array显示文摘To optimize field emission (FE) property of carbon nanotube (CNT) array on a planar cathode surface, the Fowler-Nordheim formula has been used to discuss the maximum of the emission current density with the floating sphere model in this paper. The emission current density is dominating as the analytical Fowler-Nordheim function of the intertube distance, and the maximum of the emission current density is deduced and discussed. The results indicate that the intertube distance in CNT array critically affects the field enhancement factor and the emission current density, whose maximum occurs at the intertube distance approximating a tenth of the tube height. Considering the emission current density and the field enhancement factor, the FE can be optimized analytically when the intertube distance is about a tenth of the tube height. | WANG XinQing LI Liang CHEN Min JIN HongXiao JIN DingFeng PENG Min GE HongLiang | 2009 | Chinese Science Bulletin2009，54，10： | 1 |
| 4 | Magnetic properties of SBA-15 mesoporous nanocomposites with CoFe 2 O 4 nanoparticles显示文摘 | Xinqing Wang Min Chen Liang Li Dingfeng Jin Hongxiao Jin Hongliang Ge | 2010 | Materials Letters2010，，： | 1 |
| 5 | Lrrc34 Is Highly Expressed in SSCs and Is Necessary for SSC Expansi on In Vitro显示文摘Objective To discover critical genes contributing to the sternness and maintenance of spermatogonial stem cells(SSCs)and provide new insights into the function of the leucine-rich repeat(LRR)family member Lrrc34(leudne-rich repeat-containing 34)in SSCs from mice.Methods Bioinformatic methods,including differentially expressed gene(DEG),gene ontology(GO)enrichment and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analyses,were used to uncover latent pluripotency-related genes.Reverse transcription-polymerase chain reaction(RT-PCR)and immunofluorescence analyses were utilized to verify the mRNA and protein expression levels,respectively.RNA interference of Lrrc34 using siRNA was performed to detect its transient impact on SSCs.Results Eight DEGs between ID4-EGFP+(G)and ID4-EGFP+/TSPAN8Hig11(TH),eight DEGs between G and ID4-EGFP+/TSPAN8Uw(TL)and eleven DEGs between TH and TL were discovered,and eleven proteinprotein interaction(PPI)modules were found to be significant in the PPI network of DEGs.One of the DEGs,Lrrc34,was selected as a potential pluripotency?related gene due to its differential expression among ID4-EGFP+spermatogonia subsets and its interaction with fibroblast growth factor 2 in the fifth module.Immunofluorescence experiments exhibited specific expression of Lrrc34 in a subpopulation of undifferentiated spermatogonia marked by LIN28A,and RT-PCR experiments confirmed the high expression of Lrrc34 in SSCs from P7 and adult mice.The transient knockdown of Lrrc34 in SSCs resulted in reduced colony sizes and significant changes in the transcriptome and apoptotic pathways.Conclusion Lrrc34 is highly expressed in mouse SSCs and is required for SSC proliferation in vitro through effects on transcriptome and signaling transduction pathways. | Jinhuan Ou Yiran Li Zhipeng Wang Cheng Jin Kai Li Yan Lu Dingfeng Zou Pengyu Li Mengzhen Li Shiying Miao Linfang Wang Wei Song | 2020 | Chinese Medical Sciences Journal2020，35，1： | 0 |
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