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| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | Towards a structure-function analysis of bovine lactoferricin and related tryptophan and argini-necontaining peptides 显示文摘 | Vogel H J Schibli D J Jing W G | 2002 | Biochemistry and Cell Biology2002，80，1： | 1 |
| 3 | Studies on prediction of separation per- cent in electrodialysis process via BP neural networks and im- proved BP algorithms显示文摘 | JING G DU W GUO Y | 2012 | Desalination2012，291，： | 1 |
| 4 | Experimental study of the prediction of the ventilation flow rate through solar chimney with large gap- to-height ratios 显示文摘 | Jing H W Chen Z D Li A G | 2015 | Building and Environment2015，89，： | 1 |
| 5 | Towards a structurefunction analysis of bovine lacoferricin and related tryptophan and argiminecontaining pepficlcs显示文摘 | VOGEL H J SCHIBLE D J JING W G | 2002 | Biochem Cell Biol2002，80，1： | 1 |
| 6 | Carbon nano-LiFePO4 @ C cathode material with superior high-rate and low-temperature performances for lithium-ion batteries 显示文摘 | XING L W YU G G JING S | 2013 | Adv Eng Mater2013，3，9： | 1 |
| 7 | Recovery of cobalt and lithium from spent lithium ion batteries using organic citric acid as leachant 显示文摘 | LI L JING G FENG W | 2010 | Journal of Hazardous Materials2010，176，： | 1 |
| 8 | Priori-ty- Based Traffic Scheduling and Utility Optimization for Cognitive Radio Communication Infrastructure-Based Smart Grid 显示文摘 | JING F H HONG G W YI Q A | 2013 | IEEE Transactions on Smart Grid2013，4，1： | 1 |
| 9 | Surface tuning for oxide- based nanomaterials as efficient photocatalysts 显示文摘 | Jing L Zhou W Tian G | 2013 | Chemi- cal Society Reviews2013，42，24： | 1 |
| 10 | Surface tuning for oxide-based nanomaterials as efficient photocatalysts 显示文摘 | Jing L Q Zhou W Tian G H | 2013 | Chem Soe Rev2013，42，： | 1 |
| 11 | Determination of atrazine, deethylatrazine and simazine in water at parts-per-triflion levels using solid-phase extraction and gas chromatography/ion trap mas spectrometry显示文摘 | Ma W T Cai Z Jing G B | 2003 | Rapid Commu Mass Sp2003，17，24： | 1 |
| 12 | The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1显示文摘 | Liang G Jing W | 2008 | Cell Metabolism2008，7，： | 1 |
| 13 | 查看详情显示文摘 | Kang W L Jing G L Zhang H Y Li M Y Wu Z Y | | 0，，： | 1 |
| 14 | The characteristics of hydrolysis of triolein catalyzed by wheat germ lipase in water-in-oil microemulsions 显示文摘 | JING F AN X Q SHEN W G | 2003 | Journal of Molecular Catalysis B: Enzymatic2003，2425，： | 1 |
| 15 | A fully coupled thermo-hydro-mechanical model for simulating multiphase flow, deformation and heat transfer in buffer material and rock masses 显示文摘 | Tong F G Jing L R Zimmerman R W | 2010 | Int J Rock Mech Min Sci2010，47，2： | 1 |
| 16 | 显示文摘 | Tang Z Y Jing W G Wang E K | 2000 | Langmuir2000，16，： | 1 |
| 17 | Spatial variations of dimethylsulfide and dimethylsulfoniopropionate in the surface microlayer and in the subsurface waters of the South China Sea during springtime 显示文摘 | Yang G P Jing W W Kang Z Q | 2008 | Marine Environmental Research2008，65，： | 1 |
| 18 | Crude extracts of Solanum lyratum protect endothelial cells against oxidized low - density lipoprotein - induced injury by direct antioxidant action 显示文摘 | Wei W K Chih Y H Jing G C | 2009 | BASIC RESEARCH STUDIES2009，4，50： | 1 |
| 19 | Photoinduced charge property of nanosized perovskite-type LaFeO_3 and its relationships with photocatalytic activity under visible irradiation显示文摘 | Li S D Jing L Q Fu W Yang L B Xin B F Fu H G | | 0，，02： | 1 |
| 20 | Beamforming in non-regenerative MIMO broadcast relay networks 显示文摘 | Okeke G Krzymien W Jing Y | 2012 | IEEE Transactions on Signal Processing2012，60，12： | 1 |
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