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| 1 | Regulated upon activation,normal T cell expressed and secreted(RANTES)levels in the peripheral blood of patients with Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is the most common type of dementia,but it is very difficult to diagnose with certainty,so many AD studies have attempted to find early and relevant diagnostic markers.Regulated upon activation,normal T cell expressed and secreted(RANTES,also known as C-C chemokine ligand)is a chemokine involved in the migration of T cells and other lymphoid cells.Changes in RANTES levels and its expression in blood or in cerebrospinal fluid have been reported in some neurodegenerative diseases,such as Parkinson’s disease and multiple sclerosis,but also in metabolic diseases in which inflammation plays a role.The aim of this observational study was to assess RANTES levels in peripheral blood as clinical indicators of AD.Plasma levels of RANTES were investigated in 85 AD patients in a relatively early phase of AD(median 8.5 months after diagnosis;39 men and 46 women;average age 75.7 years),and in 78 control subjects(24 men and 54 women;average age 66 years).We found much higher plasma levels of RANTES in AD patients compared to controls.A negative correlation of RANTES levels with age,disease duration,Fazekas scale score,and the medial temporal lobe atrophy(MTA)score(Scheltens’s scale)was found in AD patients,i.e.,the higher levels corresponded to earlier stages of the disease.Plasma RANTES levels were not correlated with cognitive scores.In AD patients,RANTES levels were positively correlated with the levels of pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-α,which is consistent with the wellknown fact that AD is associated with inflammatory processes.RANTES levels were also positively correlated with insulin levels in AD patients,with insulin resistance(HOMA-R)and pancreatic beta cell function(HOMA-F).This study evaluated several clinical and metabolic factors that may affect plasma levels of RANTES,but these factors could not explain the increases in RANTES levels observed in AD patients.Plasma levels of RANTES appear to be an interesting peripheral marker for early stages of AD.The study was approved by the Ethics Committee of Institute of Endocrinology,Prague,Czech Republic on July 22,2011. | Gabriela Vacínová Daniela Vejražkova Robert Rusina Iva Holmerová Hana Vaňková Eva Jarolímová Josef Včelák Běla Bendlová Markéta Vaňková | 2021 | Neural Regeneration Research2021，16，4： | 3 |
| 2 | 2-Phenylindoles relationship between structure,estrogen receptor affinity,and mammary tumor inhibiting activity in the rat显示文摘 | Jelica P Josef S Erwin V A | 1984 | Journal of Medicinal Chemistry1984，27，： | 1 |
| 3 | Reduction and immobilization of hexavalent chromium with coal-and humate-based sorbents显示文摘 | Pave1 Jano Václav H?la Petra Bradnová Věra Pila?ová Josef?edlbauer | | 0，，06： | 1 |
| 4 | Plasma resistin,adiponectin and leptin levels in lean and obese subjects:correlations with insulin resistance显示文摘 | Josef V Silha Michal Krsek Jan V Skrha | 2003 | European Journal of Endocrinology2003，149，4： | 1 |
| 5 | Magnetic Resonance Diffusion Tensor Imaging in Patients With Cervical Spondylotic Spinal Cord Compression: Correlations Between Clinical and Electrophysiological Findings显示文摘 | Milo? Kerkovsky Josef Bednarík Ladislav Du?ek Andrea ?prláková-Puková Igor Urbánek Marek Mechl Vlastimil Válek Zdenek Kadanka | 2012 | Spine2012，，1： | 1 |
| 6 | The usage of frequence swept: signals for metal detection 显示文摘 | JAKUB S JOSEF V | 2012 | IEEE Transactions on Magnetics2012，48，4： | 1 |
| 7 | Plasma resistin,adiponectin and leptin levels in lean and obese subjects:correlations with insulin resistance显示文摘 | Josef V Silha Michal Krsek Jan V Skrha | 2003 | European Joumal of Endocrinology2003，149，4： | 1 |
| 8 | The phloroglucinols of Dryopteris aitoniana pichi serm (Dryopteridaceae, Pteridophyta) 显示文摘 | Josef V E Tadeus R Wid6n C J | 1985 | Helv Chim Aeta1985，68，5： | 1 |
| 9 | Postnatal passive immunization of neonatal macaques with a triple combination of human monoclonal antibodies against oral simian-human immunodeficiency virus challenge 显示文摘 | Josef V Robert A | 2001 | Journal of Virology2001，75，16： | 1 |
| 10 | Interactions between soil development, vegetation and soil fauna during spontaneous succession in post mining sites显示文摘 | Jan Frouz Karel Prach Václav Pi?l Ladislav Háněl Josef Stary Karel Tajovsky Jan Materna Vladimír Balík Ji?í Kal?ík Klára ?ehounková | 2007 | European Journal of Soil Biology2007，，1： | 1 |
| 11 | Calcific aortic aortic stenosis is independently associated with increase parathormone and decreased vitamin D levels in coronary artery disease patients显示文摘 | Katerina L Josef V Gabriela S | 2007 | Circulation2007，116，16： | 1 |
| 12 | Molecular variability of the capsid protein of the prune dwarf virus显示文摘 | Dana V Petrzik K Josef S | 2000 | European Journal of Plant Pathology2000，106，： | 1 |
| 13 | Effect of acute hyperglycemia on erythrocyte membrane ion transport in offspring of hypertensive parents 显示文摘 | Gabriela S Zuzana V Josef Z | 2003 | J Hypertens2003，21，7： | 1 |
| 14 | Assessment of multipathway exposure of small children to PAH显示文摘 | Adolf Vyskocil Zdenek Fiala Véronique Chénier Ladislav Krajak Eva Ettlerova Josef Bukac Claude Viau Stanislav Emminger | 2000 | Environmental Toxicology and Pharmacology2000，，2： | 1 |
| 15 | Scoring variability of micronuclei in binudeated human lymphocytes in a case control study 显示文摘 | BRENDA P G JOSEF H DOMINIC V | 2006 | Mutagenesis2006，21，： | 1 |
| 16 | The phloroglucinols of Dryopteris aetoniana Pichi Serm 显示文摘 | Josef V E Tadeus R Widen C J | 1985 | Helv Chim Acta1985，68，： | 1 |
| 17 | Parathyroid hor- mone and vitamin D levels are independently associated with calcific aortic stenosis显示文摘 | Katerina L Josef V Gabrieta S | 2008 | Circ J2008，72，： | 1 |
| 18 | Langmuir probe measurements of plasma parameters in a planar magnetron with additional plasma confinement显示文摘 | Spatenka P Jaroslav V Josef B | 1999 | Vacuum1999，55，： | 1 |
| 19 | PPARγ agonists upregulate sphingosine 1-phosphate (S1P) receptor 1 expression, which in turn reduces S1P-induced [Ca 2+ ] i increases in renal mesangial cells显示文摘 | Alexander Koch Anja V?lzke Bianca Puff Kira Blankenbach Dagmar Meyer zu Heringdorf Andrea Huwiler Josef Pfeilschifter | 2013 | BBA - Molecular and Cell Biology of Lipids2013，，： | 1 |
| 20 | Parathyroid hormone and vitamin D levels are independently associated with ealcific aortic stenosis 显示文摘 | Katerina L Josef V Gabriela S | 2008 | Cite J2008，72，： | 1 |
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