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| 1 | Characterization of focal liver lesions with SonoVue~-enhanced sonography: International multicenter-study in comparison to CT and MRI显示文摘AIM: To evaluate in a multicenter study whether the sonographic characterization of focal liver lesions can be improved using SonoVueüà-enhancement; and to compare this method with computed tomography (CT) and magnetic resonance imaging (MRI). METHODS: One hundred and thirty four patients with one focal liver lesion detected in baseline ultrasound (US) were examined with conventional US, contrastenhanced US (n = 134), contrast-enhanced CT (n = 115) and/or dynamic contrast-enhanced MRI (n = 70). The lesions were classified as malignant, benign or indeterminate and the type of lesion was determined. The f inal diagnosis based on the combined information of all imaging examinations, clinical information and histology (n = 32) was used. Comparisons were made to see whether the addition of contrast-enhanced US led to the improvement of the characterization of doubtful focal liver lesions. RESULTS: In comparison with unenhanced US, SonoVue markedly improves sensitivity and specificity for the characterization (malignant/benign) of focal liver lesions. In comparison with CT and/or dynamic MRI, SonoVueüà -enhanced sonography applied for characterization of focal liver lesions was 30.2% more sensitive in the recognition of malignancy and 16.1% more specific in the exclusion of malignancy and overall 22.9% more accurate. In the subgroup with confirmative histology available (n = 30), sensitivity was 95.5% (CEUS), 72.2% (CT) and 81.8% (MRI), and specif icity was 75.0% (CEUS), 37.5% (CT) and 42.9% (MRI). The sensitivity and specif icity of CEUS for the identif ication of focal nodular hyperplasia (FNH) and hemangiomas was 100% and 87%, resulting in an accuracy of 94.5%. CONCLUSION: SonoVueüà-enhanced sonography emerges as the most sensitive, most specif ic and thus most accurate imaging modality for the characterization of focal liver lesions. | Hervé Trillaud Jean-Michel Bruel Pierre-Jean Valette Valérie Vilgrain Gérard Schmutz Raymond Oyen Wieslaw Jakubowski Jan Danes Vlastimil Valek Christian Greis | 2009 | World Journal of Gastroenterology2009，15，30： | 34 |
| 2 | Contrast-enhanced ultrasonography in the evaluation of incidental focal liver lesions: A cost-effectiveness analysis显示文摘AIM To determine whether contrast-enhanced ultrasonography(CEUS) as the first-line method is more costeffective in evaluating incidentally discovered focal liver lesions(FLLs) than is computed tomography(CT) and magnetic resonance imaging(MRI). METHODS Between 2010 and 2015, our prospective study enrolled 459 patients with incidentally found FLLs. The biological nature of FLLs was assessed by CEUS in all patients. CT or MRI examinations were added in unclear cases. The sensitivity and specificity of CEUS were calculated. The total costs of CEUS examinations and of the added examinations performed in inconclusive cases were calculated. Afterwards, the theoretical expenses for evaluating incidentally discovered FLLs using CT or MRI as the first-line method were calculated. The resultswere compared. RESULTS The total cost of the diagnostic process using CEUS for all enrolled patients with FLLs was 75884 USD. When the expenses for additional CT and MRI examinations performed in inconclusive cases were added, the total cost was 90540 US dollar(USD). If all patients had been examined by CT or MR as the first-line method, the costs would have been 78897 USD or 384235 USD, respectively. The difference between the cost of CT and CEUS was 3013 USD(4%) and that between MRI and CEUS was 308352 USD(406.3%). We correctly described 97.06% of benign or malignant lesions, with 96.99% sensitivity and 97.09% specificity. Positive predictive value was 94.16% and negative predictive value was 98.52%. In cases with 4 and more lesions, malignancy is significantly more frequent and inconclusive findings significantly less frequent(P < 0.001).CONCLUSION While the costs of CEUS and CT in evaluating FLLs are comparable, CEUS examination is far more costeffective in comparison to MRI. | Miriama Smajerova Hana Petrasova Jirina Little Petra Ovesna Tomas Andrasina Vlastimil Valek Eva Nemcova Barbora Miklosova | 2016 | World Journal of Gastroenterology2016，22，38： | 4 |
| 3 | Percutaneous Intraductal Radiofrequency Ablation is a Safe Treatment for Malignant Biliary Obstruction: Feasibility and Early Results显示文摘 | Malkhaz Mizandari Madhava Pai Feng Xi Vlastimil Valek Andrasina Tomas Pietro Quaretti Rita Golfieri Cristina Mosconi Ao Guokun Charis Kyriakides Robert Dickinson Joanna Nicholls Nagy Habib | 2013 | CardioVascular and Interventional Radiology2013，，3： | 3 |
| 4 | Percutaneous Intraductal Radiofrequency Ablation for Clearance of Occluded Metal Stent in Malignant Biliary Obstruction: Feasibility and Early Results显示文摘 | Madhava Pai Vlastimil Valek Andrasina Tomas Attila Doros Pietro Quaretti Rita Golfieri Cristina Mosconi Nagy Habib | 2014 | CardioVascular and Interventional Radiology2014，，1： | 2 |
| 5 | Relevance of miR-21 and miR-143 expression in tissue samples of colorectal carcinoma and its liver metastases显示文摘 | Vlastimil Kulda Martin Pesta Ondrej Topolcan Vaclav Liska Vladislav Treska Alan Sutnar Karel Rupert Marie Ludvikova Vaclav Babuska Lubos Holubec Radim Cerny | 2010 | Cancer Genetics and Cytogenetics2010，，： | 2 |
| 6 | Determination of warm-cool feeling of various fibrous polymers through thermal absorbtivity显示文摘 | Lubos Hes Vlastimil Hybil Bhaskar N bandyopadhyay | 1991 | Indian Journal of Fiber & Textile Research1991，16，9： | 1 |
| 7 | The centrosome and cell proliferation显示文摘 | Vlastimil S Andreas M | 2006 | Cell Div2006，16，1： | 1 |
| 8 | Tunnels in Hash Functions:MD5 Collisions Within a Minute显示文摘 | Vlastimil Klima | 2006 | IACR ePrint archive2006，105，： | 1 |
| 9 | Investigation of the sensitivity of PCS fibers to changes of light absorption coefficient of the cladding:Photonics,Devices,and Systems Ⅱ显示文摘 | Chomat Miroslav Mrazek Jan Matejec Vlastimil | 2003 | Proceedings of the SPIE2003，5036，： | 1 |
| 10 | Liquid chromatographic - - cold vapour atomic fluorescence spectrometric determination of mercury species显示文摘 | Houserova Pavlina Matejicek David Kuban Vlastimil | 2006 | Journal of separation science2006，29，2： | 1 |
| 11 | 复数在平面几何中的魅力显示文摘复数和平面几何的密切关系是丰富中学数学教育的一个非常重要的,有趣的和令人惊讶的课题,复数这一概念有一个复杂的历史.它甚至导出数学中很多深刻的问题,几乎近于神奇.同时,依照当代数学的观点,复数作为一个数域,以一个从线到平面的非常自然的方式延展了实数域.此外,用复数可阐释很多数学中的基本事实,例如,乘法运算的本质. | Vlastimil Dlab 陈学庆 | 2011 | 数学通报2011，50，7： | 1 |
| 12 | Tunnels in Hash Functions tMD5 Collisions Within a Minute显示文摘 | Vlastimil Klima | 2006 | IACR ePrint archive2006，105，1： | 1 |
| 13 | Enhancing sensitivity of liquid chromatographic/ion- trap tandem mass spectrometric determination of estrogens by on-line pre-column derivatization 显示文摘 | DAVID M VLASTIMIL K | 2008 | Journal of Chromatography A2008，1192，： | 1 |
| 14 | Relevance of miR-21 and miR-143 expression in tissue samples of colorectal carcinoma and its liver metastases显示文摘 | Vlastimil Kulda Martin Pesta Ondrej Topolcan Vaclav Liska Vladislav Treska Alan Sutnar Karel Rupert Marie Ludvikova Vaclav Babuska Lubos Holubec Radim Cerny | 2010 | Cancer Genetics and Cytogenetics2010，，2： | 1 |
| 15 | High performance liquid chromatography/ion-trap mass spectrometry for separation and simultaneous determination of ethynylestradiol, gestodene, levonorgestrel, cyproterone acetate and desogestrel显示文摘 | David MatVej' iVcek Vlastimil Kub' av | 2007 | Analytica Chimica Acta2007，588，2： | 1 |
| 16 | Optical fiber with novel geometry for evanescent-wave sensing显示文摘 | Vlastimil Matejec Miroslav Chomat Marie Pospisilova | 1995 | Sensors and Actuators B1995，29，： | 1 |
| 17 | A class of balanced non-uniserial rings显示文摘 | Vlastimil Dlab Claus Michael Ringel | 1971 | Mathematische Annalen1971，，2： | 1 |
| 18 | Voltammetric determination of insecticide thiamethoxam on silver solidamalgam electrode显示文摘 | Parthena C Jan F Vlastimil V | 2014 | Electrochimica Acta2014，140，： | 1 |
| 19 | Magnetic Resonance Diffusion Tensor Imaging in Patients With Cervical Spondylotic Spinal Cord Compression: Correlations Between Clinical and Electrophysiological Findings显示文摘 | Milo? Kerkovsky Josef Bednarík Ladislav Du?ek Andrea ?prláková-Puková Igor Urbánek Marek Mechl Vlastimil Válek Zdenek Kadanka | 2012 | Spine2012，，1： | 1 |
| 20 | Relevance of miR-21 and miR-143 expression in tissue samples of colorectal carcinoma and its liver metastases显示文摘 | Vlastimil Kulda Martin Pesta Ondrej Topolcan Vaclav Liska Vladislav Treska Alan Sutnar Karel Rupert Marie Ludvikova Vaclav Babuska Lubos Holubec Radim Cerny | 2010 | Cancer Genetics and Cytogenetics2010，，2： | 1 |
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