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| 1 | Metabolic syndrome does not affect sustained virologic response of direct-acting antivirals while hepatitis C clearance improves hemoglobin A1c显示文摘AIM To determine whether successful treatment with direc-tacting antivirals(DAA) is associated with improvements in hemoglobin A1 c(HbA1 c) and if type 2 diabetes mellitus(T2 DM) or metabolic syndrome affects sustained virologic response(SVR).METHODS We performed a retrospective analysis of all hepatitis C virus(HCV) patients at the VA Greater Los Angeles Healthcare System treated with varying DAA therapy between 2014-2016. Separate multivariable logistic regression was performed to determine predictors of HbA1 c decrease ≥ 0.5 after DAA treatment and predictors of SVR 12-wk post treatment(SVR12).RESULTS A total of 1068 patients were treated with DAA therapy between 2014-2016. The presence of T2 DM or metabolic syndrome did not adversely affect SVR12. 106 patients had both HCV and T2 DM. Within that cohort,patients who achieved SVR12 had lower mean HbA1 c pre treatment(7.35 vs 8.60,P = 0.02),and lower mean HbA1 c post-treatment compared to non-responders(6.55 vs 8.61,P = 0.01). The mean reduction in HbA1 c after treatment was greater for those who achieved SVR12 than for non-responders(0.79 vs 0.01,P = 0.03). In adjusted models,patients that achieved SVR12 were more likely to have a HbA1 c decrease of ≥ 0.5 than those that did not achieve SVR12(adjusted OR = 7.24,95%CI: 1.22-42.94). CONCLUSION In HCV patients with T2 DM,successful treatment with DAA was associated with a significant reduction in HbA1 c suggesting that DAA may have a role in improving insulin sensitivity. Furthermore,the presence of T2 DM or metabolic syndrome does not adversely affect SVR12 rates in patients treated with DAA. | Tien S Dong Elizabeth S Aby Jihane N Benhammou Jenna Kawamoto Steven-Huy Han Folasade P May Joseph R Pisegna | 2018 | World Journal of Hepatology2018，10，9： | 4 |
| 2 | Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Joseph P Costantino Takamaru Ashikaga Donald L Weaver Eleftherios P Mamounas Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Norman Wolmark | 2010 | Lancet Oncology2010，，10： | 3 |
| 3 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 4 | Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia–reperfusion: Therapeutic potential of mitochondrially targeted antioxidants显示文摘 | Partha Mukhopadhyay B?la Horváth Zsuzsanna Zsengell?r Sándor Bátkai Zongxian Cao Malek Kechrid Eileen Holovac Katalin Erd?lyi Galin Tanchian Lucas Liaudet Isaac E. Stillman Joy Joseph Balaraman Kalyanaraman Pál Pacher | 2012 | Free Radical Biology and Medicine2012，，5： | 2 |
| 5 | IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality显示文摘 | Zhang Hong Neuh?fer Patrick Song Liang Rabe Bj?rn Lesina Marina Kurkowski Magdalena U Treiber Matthias Wartmann Thomas Regnér Sara Thorlacius Henrik Saur Dieter Weirich Gregor Yoshimura Akihiko Halangk Walter Mizgerd Joseph P Schmid Roland | 2013 | Journal of Clinical Investigation2013，，3： | 2 |
| 6 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 7 | Mode of action of the COR15a gene on the freezing tolerance of Arabidopsis thaliana 显示文摘 | STEPONKUS P L UEMURA M JOSEPH R A | 1998 | Proc Nail Acad Sci USA1998，95，14： | 1 |
| 8 | Cold Acclimation of Arabidopsis Thalian 显示文摘 | M Uemura R A Joseph and P L Steponkus | 1995 | Plant Physiol1995，，109： | 1 |
| 9 | Aluminm alloy 2519 in military vehicles显示文摘 | James J F Lawrence S K Joseph R P | 2002 | Advanced Materials and Processes2002，160，9： | 1 |
| 10 | Virtual Corporations: Recipe for Success 显示文摘 | P M Joseph R R Levary | 1998 | Industrial Management1998，40，4： | 1 |
| 11 | Aluminum alloy 2519 in military vehicles显示文摘 | James J F Lawrence S K Joseph R P | 2002 | Advanced Materials and Processes2002，160，9： | 1 |
| 12 | Studies on polyisobuty- lene bound paraphenylene diamine antioxidant in natural rubber 显示文摘 | Sulekha P B Joseph R George K E | 1999 | Polym Degrad Stab1999，63，2： | 1 |
| 13 | Synthesis and character- ization of chlorinated paraffin wax-bound paraphenylenediamine antioxidant and its application in natural rubber 显示文摘 | Sulekha P B Joseph R Prathapan S | 2001 | J Appl Polym Sci2001，81，9： | 1 |
| 14 | The social endocrinology of dominance: Basal testosterone predicts cortisol changes and behavior following victory and defeat显示文摘 | MEHTA P H JONES A C JOSEPHS R A | 2008 | Journal of Personality & Social Psychology2008，，94： | 1 |
| 15 | Thermal degradation and flammability characteristics of some polystyrenes and poly(methyl methacrylate)s chemically modified with silicon-containing groups 显示文摘 | EBDON J R HUNT B J JOSEPH P | 2004 | Polymer Degradation and Stability2004，83，1： | 1 |
| 16 | Understanding the Influence of National Culture on the Development of Trust显示文摘 | PATRICIA M DONEY JOSEPH P CANNON MICHAEL R MULLEN | 1998 | The Academy of Management Review1998，23，3： | 1 |
| 17 | Blockade of the renin-angiotensin- aldosterene system (RAAS) for primary prevention of non-valvular atri- al fibrillation :a systematic review and meta analysis of randomized controlled trials 显示文摘 | Khatib R Joseph P Briel M | 2012 | Nt J Cardio12012，13，： | 1 |
| 18 | Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding显示文摘 | Joseph L Kim Kurt A Morgenstern James P Griffith Maureen D Dwyer John A Thomson Mark A Murcko Chao Lin Paul R Caron | 1998 | Structure1998，，1： | 1 |
| 19 | Cold acclimation of Arabidopsis thaliana:Effect on plasma membrane composition and freezing induced lesions显示文摘 | UEMURA M JOSEPH R A STEPONDUS P L | 1995 | Plant Physiol1995，109，： | 1 |
| 20 | Atrazine and Cancer Incidence Among Pesticide Applicators in the Agricultural Health Study (1994-2007)显示文摘 | Beane Freeman Laura E Rusiecki Jennifer A Hoppin Jane A Lubin Jay H Koutros Stella Andreotti Gabriella Zahm Sheila Hoar Hines Cynthia J Coble Joseph B Barone-Adesi Francesco Sloan Jennifer Sandler Dale P Blair Aaron Alavanja Michael C R | 2011 | Environmental Health Perspectives2011，，9： | 1 |
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