|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Chemical screen identifies a geroprotective role of quercetin in premature aging显示文摘Aging increases the risk of various diseases. The main goal of aging research is to find therapies that attenuate aging and alleviate aging-related diseases. In this study, we screened a natural product library for geroprotective compounds using Werner syndrome (WS) human mesenchymal stem cells (hMSCs), a premature aging model that we recently established. Ten candidate compounds were identified and quercetin was investigated in detail due to its leading effects. Mechanistic studies revealed that quercetin alleviated senescence via the enhancement of cell proliferation and restoration of heterochromatin architecture in WS hMSCs. RNA-sequencing analysis revealed the transcriptional commonalities and differences in the geroprotective effects by quercetin and Vitamin C. Besides WS hMSCs, quercetin also attenuated cellular senescence in Hutchinson-Gilford progeria syndrome (HGPS) and physiological-aging hMSCs. Taken together, our study identifies quercetin as a geroprotective agent against accelerated and natural aging in hMSCs, providing a potential therapeutic intervention for treating age-associated disorders. | Lingling Geng Zunpeng Liu Weiqi Zhang Wei Li Zeming Wu Wei Wang Ruotong Ren Yao Su Peichang Wang Liang Sun Zhenyu Ju Piu Chan Moshi Song Jing Qu Guang-Hui Liu | 2019 | Protein & Cell2019，10，6： | 13 |
| 2 | Enrichment of heavy metal elements and their adsorption on iron oxides during carbonate rock weathering process显示文摘Analysis of trace elements in the Lower Palaeozoic carbonate rock strata of the Beijing area shows that the Cr, Zn, Cd and Pb contents increase from primary carbonate rocks to weathered carbonate rocks and from primary carbonate rocks to the soil coexisting with carbonate rock. Distributions of Cr, Zn, Cd and Pb have the same trends as that of Fe2O3. Iron oxides play different roles at different stages of weathering of carbonate rock. The adsorption of Cr, Zn, Cd and Pb on Fe2O3 is greater than on FeO in soil. However, FeO, as a main component of clay mineral, is a better adsorbent of Cr, Zn, Cd and Pb than Fe2O3 in weathered and primary carbonate rocks. According to R-type clustering analysis, the main components of carbonate rock are divided into marine and continental sediments. Correlation analysis shows that heavy metal elements mainly exist in continental substances. | Shanqin Ni Yiwen Ju Quanlin Hou Shijie Wang Qing Liu Yudong Wu Lingling Xiao | 2009 | Progress in Natural Science:Materials International2009，19，9： | 8 |
| 3 | Visualization of aging-associated chromatin alterations with an engineered TALE system显示文摘在实时房间的特定的 genomic loci 的可视化在多样的生物过程期间是为在染色质建筑学的动态变化的调查的一个前提,例如细胞的老化。然而,当前的精确 genomic 成像方法被缺乏妨碍荧光灯有高特性和 signal-to-noise 的探针形成对照。我们发现那常规抄写像使活跃之物的受动器(故事) 趋于形成蛋白质总数,从而在成像应用程序损害他们的性能。通过屏蔽,我们发现有故事的那熔化 thioredoxin 阻止了总数形成,开基于故事的 genomic 成像的完整的力量。用熔化 thioredoxin 的故事(TTALE ) ,我们在各种各样的 genomic loci 完成了高质量的成像并且观察联系老化(epi ) 在在人和老鼠早衰模型的 telomeres 和着丝点的 genomic 改变。重要地,我们鉴别 ribosomal DNA 的摩擦为人的老化作为一个分子的标记重复。我们的学习为精确在 vitro 并且在 vivo 监视染色质动力学建立一个简单、柔韧的成像方法。 | Ruotong Ren Liping Deng Yanhong Xue Keiichiro Suzuki Weiqi Zhang Yang Yu Jun Wu Liang Sun Xiaojun Gong Huiqin Luan Fan Yang Zhenyu Ju Xiaoqing Ren Si Wang Hong Tang Lingling Geng Weizhou Zhang Jian Li Jie Qiao Tao Xu Jing Qu Guang-Hui Liu | 2017 | Cell Research2017，27，4： | 4 |
| 4 | Efficacy of hyperbaric oxygen treatment for depression in the convalescentstage following cerebral hemorrhage显示文摘 | Hua Cao Keju Ju Lingling Zhong Tao Meng | 2013 | Experimental and Therapeutic Medicine2013，，6： | 1 |
| 5 | Six novel single-nucleotide polymorphisms in SPAG11 gene and their association with sperm quality traits in Chinese Holstein bulls显示文摘 | Xinyan Liu Zhihua Ju Lingling Wang Yan Zhang Jingmin Huang Qiuling Li Jianbin Li Jifeng Zhong Liguo An Changfa Wang | 2011 | Animal Reproduction Science2011，，1： | 1 |
| 6 | Migration and enrichment of trace elements of Lower Palaeozoic carbonate rock strata in Beijing显示文摘Analyses of trace elements of the Lower Palaeozoic carbonate rock strata in Beijing show that the contents of As, Hg, F increase from primary carbonate rocks to weathered carbonate rocks and from primary carbonate rocks to the soil coexisting with carbonate rocks, but the distribution regularity of S is not obvious. In the whole weathered stages, the sorption of As is mainly affected by Fe2O3. In soil Fe2O3 is also the main affecting factor of Hg enrichment. The main existing forms of Hg in primary carbonate rocks should simply be physical adsorption, coprecipitation and false isomorphous form between surface of carbonate rock and Hg. In soil the enrichment of F has little relationship with sul-fides and Fe2O3. In primary carbonate rocks, F is mainly absorbed by sulfides and clay minerals, etc. Weathered samples have closer genetic relationships with primary carbonate rocks. This also implies that weathered carbonate rocks have the close existing forms to that of primary carbonate rocks. In primary carbonate rocks FeS2 and FeS are the main forms of S, and sulfides have fixation effect on some heavy metals, whereas in weathered carbonate rocks and soil the fixation effect is weakened. | NI ShanQin HOU QuanLin JU YiWen XIAO LingLing WU YuDong LIU Qing | 2008 | Science China Earth Sciences2008，51，12： | 1 |
| 7 | Six novel single- nucleotide polymorphisms in SPAG11 gene and their association with sperm quality traits in Chinese Holstein bulls显示文摘 | Liu Xinyan Ju Zhihua Wang Lingling | 2011 | Animal Reproduction Science2011，129，： | 1 |
| 8 | Research on the Model of Performance Evaluation of the Industry Cluster Brand显示文摘 | WANG Xiaoyan LIU Hanyan JU Lingling HU Shouzhong | 2016 | International English Education Research2016，，2： | 0 |
| 9 | Spherical cationic polymer networks with porphyrin photosensitizer for sustainable and efficient photocatalysis显示文摘The continuous and sustainable photo-activity on micro-or nano-carriers has always been a key stepping stone in the industrialization of photo-catalysis,photo-synthesis,and photo-degradation.Herein,we report a new series of positively charged hollow microspheres carrying porphyrin moieties.Such hollow spheres are formed through crosslinking of well-ordered porous thin laminates,initiated by co-assembly of regular monomers and those decorated with porphyrin moieties.On the surface of an individual sphere,densely distributed positive sites attract anionic reactants.The superficial porphyrin decomposes the accumulated reactants under 1 Sun.After degradation and release of products,the photoactive sites are thereby renewed.We demonstrate that polymer network(1:10)exhibited superior sustainable photocatalytic performance with complete degradation of methyl orange(MO)in 40 min with no observable performance deterioration after six cycles.The established close loop of adsorption-reaction-release cycle makes possible many efficient and continuous photo-catalytic processes. | Lingling Zhang Liwei Wu Junhui Bao Longhui Li Zejun Liu Feng Bai Jie Ju Xi Yao | 2024 | Nano Research2024，17，5： | 0 |
| 10 | Hepatic microRNA-126 deficiency restrains liver regeneration through p53 pathway in mice显示文摘Dear Editor,Emerging evidences show close associations between miRNAs and liver regeneration.MiR-126 is known as a governor of vascular integrity and angiogenesis.MiR-126 is involved in the self-renewal of hematopoietic stem cells(HSCS)and leukemia stem cells.1,2 MiR-126 also plays a vital role in hepatocellular carcinogenesis,however,the functions of miR-126 in liver regeneration were still unclear. | Lingling Zhang Yugang Qiu Fan Yang Jiyuan Yao Ying Wang Yang Qin Hanchuan Mou Qing Jing Leiming Liu Zhenyu Ju | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员