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| 1 | Recent advances in friction and lubrication of graphene and other 2D materials:Mechanisms and applications显示文摘Two-dimensional materials having a layered structure comprise a monolayer or multilayers of atomic thickness and ultra-low shear strength.Their high specific surface area,in-plane strength,weak layer-layer interaction,and surface chemical stability result in remarkably low friction and wear-resisting properties.Thus,2D materials have attracted considerable attention.In recent years,great advances have been made in the scientific research and industrial applications of anti-friction,anti-wear,and lubrication of 2D materials.In this article,the basic nanoscale friction mechanisms of 2D materials including interfacial friction and surface friction mechanisms are summarized.This paper also includes a review of reports on lubrication mechanisms based on the film-formation,self-healing,and ball bearing mechanisms and applications based on lubricant additives,nanoscale lubricating films,and space lubrication materials of 2D materials in detail.Finally,the challenges and potential applications of 2D materials in the field of lubrication were also presented. | Lincong LIU Ming ZHOU Long JIN Liangchuan LI Youtang MO Guoshi SU Xiao LI Hongwei ZHU Yu TIAN | 2019 | Friction2019，7，3： | 29 |
| 2 | Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats显示文摘瞄准:在可勃起的功能和氮的氧化物 synthase (NOS ) 的表达式上调查 icariin 的效果在阉割的老鼠的 isoforms。方法:32 只成年男 Wistar 老鼠随机被划分成一假冒操作组(A) ,三阉割了组(B, C 和 D ) 。在外科以后的一个星期,老鼠与生理盐水(组 A 和 B ) 或口头的 icariin 被对待(1 mg/[kg.day ] 为组 C 和 5 mg/[kg.day ] 为组 D ) 为 4 个星期。一星期术后疗法,老鼠的可勃起的功能被在 cavernosal 神经的电镀物品刺激期间测量 intracavernosal 压力(ICP ) 估计。浆液睾丸激素(圣)层次,在小梁的织物的平滑肌( PSM )的百分比,和 mRNA 的表示和神经元的氮的氧化物 synthase ( nNOS )的蛋白质,可诱导的氮的氧化物 synthase ( i NOS ),内皮的氮的氧化物 synthase ( eNOS )和在阴茎海绵体( CC )的磷酸二酯酶 V ( PDE5 )也被评估。结果:ICP, PSM,圣和 nNOS, i NOS, eNOS 和 PDE5 的表示显著地在组 A (P 0.01 ) 与那些相比在组 B 被减少。然而, ICP, PSM 和 nNOS 和 i NOS 的表示在组 B (P 0.05 ) 与那些相比在组 C 和 D 被增加。在圣和 eNOS 和 PDE5 的表示的变化不是重要的(P 0.05 ) 在组 C 和 D 与那些相比在组 B。结论:有为 4 个星期的 icariin (98.6 % 纯净) 的口头的处理潜在地改进可勃起的功能。这效果随阉割的老鼠的 CC 的 PSM 和某些 NOS 的表示的增加被相关。这些结果建议 icariin 可以在可勃起的机能障碍上有治疗学的效果。 | Wu-Jiang Liu Zhong-Cheng Xin Hua Xin Yi-Ming Yuan Long Tian Ying-Lu Guo | 2005 | Asian Journal of Andrology2005，7，4： | 22 |
| 3 | Effectiveness of Different Waist Circumference Cut-off Values in Predicting Metabolic Syndrome Prevalence and Risk Factors in Adults in China显示文摘Objective To study the effectiveness of waist circumference cut-off values in predicting the prevalence of metabolic syndrome(MetS) and risk factors in adults in China. Methods A cross-sectional survey was condcuted in 14 provinces(autonomous region, municipality) in China. A total of 47 325 adults aged ≥20 years were selected by multistage stratified sampling, and questionnaire survey and physical and clinical examination were conducted among them. MetS was defined according to the International Diabetes Federation(IDF) criteria and modified IDF criteria.Results The age-standardized prevalence of MetS was 24.2%(22.1% in men and 25.8% in women) and 19.5%(22.1% in men and 18.0% in women) according to the IDF criteria and modified IDF criteria respectively. The age-standardized prevalence of pre-MetS was 8.1%(8.6% in men and 7.8% in women) according to the modified IDF criteria. The prevalence of MetS was higher in urban residents than rural residents and in northern China residents than in southern China residents. The prevalence of central obesity was about 30% in both men and women according to the ethnicity-specific cut-off values of waist circumference for central obesity(90 cm for men and 85 cm for women). Multivariate regression analysis revealed no significant difference in risk factors between the two MetS definitions. Conclusion Using both the modified IDF criteria and ethnicity-specific cut-off values of waist circumference can provide more useful information about the prevalence of MetS in China. | ZHOU Hai Cheng LAI Ya Xin SHAN Zhong Yan JIA Wei Ping YANG Wen Ying LU Ju Ming WENG Jian Ping JI Li Nong LIU Jie TIAN Hao Ming JI Qiu He ZHU Da Long CHEN Li GUO Xiao Hui ZHAO Zhi Gang Li Qiang ZHOU Zhi Guang GE Jia Pu SHAN Guang Liang | 2014 | Biomedical and Environmental Sciences2014，27，5： | 17 |
| 4 | Expression and localization of CKLFSF2 in human spermatogenesis显示文摘瞄准:调查表示并且代替细胞的本地化象 ofchemokine 一样因素总科 2 (CKLFSF2 ) 在在精子发生的人的睾丸和它的潜在的角色。方法:对 CKLFSF2 的特定的 polyclonal 抗体被提起。表示和在生精的小管的 CKLFSF2 的细胞的本地化是检查 byimmu-nohistochemistry 方法。另外,在 situ,杂交被使用本地化 mRNAdistribution。EGFP-CKLFSF2 熔化蛋白质在 COS-7 房间被表示在 vitro 本地化 itssubcellular 地点。另外,在有男不孕的病人的睾丸的 CKLFSF2 的反常表示是由反向的抄写聚合酶链反应(RT-PCR ) 的 assayed andimmunohistochemistry 方法。结果:与精子发生有靠近的关联背叛, CKLFSF2 明确地在 meiotic 和 post-meiotic 细菌房间被表示,它对 endoplasmic 蜂窝胃局部性(嗯) 在 Golgi 仪器附近。结论:CKLFSF2 能在成熟分裂和精子形式的过程起重要作用,并且可能在 endoplasmic 蜂窝胃涉及小囊的运输或膜并置事件。 | Gang Liu Zhong-Cheng Xin Liang Chen Long Tian Yi-Ming Yuan Wei-Dong Song Xue-Jun Jiang Ying-Lu Guo | 2007 | Asian Journal of Andrology2007，9，2： | 16 |
| 5 | Mesenchymal stem cells transplantation mildly ameliorates experimental diabetic nephropathy in rats显示文摘背景糖尿病的 nephropathy 是学习试图探索间充质的干细胞( MSC )移植是否能在收到的试验性的糖尿病的 rats.Methods Sprague-Dawley 老鼠稀释糖尿病的 nephropathy 的糖尿病 mellitus.This 的普通复杂并发症 streptozotocin ( STZ )( 60 mg/kg )的单个 intraperitoneal 注射 .Diabetic 老鼠被使随机化到四个 groups:diabetes 控制组( DC ), ciclosporin A 组( CsA ), MSC 组,和 MSC+CsA 组( MSCA ) .Bone 髓间充质的严厉房间是有教养的, | ZHOU Hong TIAN Hao-ming LONG Yang ZHANG Xiang-xun ZHONG Li DENG Li CHEN Xiao-he LI Xiu-qun | 2009 | Chinese Medical Journal2009，，21： | 15 |
| 6 | Cox7a2 mediates steroidogenesis in TM3 mouse Leydig cells显示文摘瞄准:为了在 steroidogenesis 和机制上调查 Cox7a2 的规章的功能,在 TM3 老鼠 Leydig 房间包含了。方法:Cox7a2 的 cDNA 从 TM3 老鼠 Leydig 房间被克隆。它是短暂基因 transfection 在表达式上为 Cox7a2 克隆到回来的 pDsRed-Express-N1 和 transfected 进 TM3 鼠标 Leydig 房间的潜水艇。Steroidogenesis 影响了由在表示 Cox7a2 上被 ELISA 学习。得到这效果的机制, steroidogenic 的表示尖锐规章(星) 蛋白质和反应的氧种类(ROS ) 被西方的污点和氟量计分别地检验。结果:Cox7a2 (249 bp ) 的 cDNA 从 Leydig 房间被克隆并且由定序的 DNA 证实了。在构造 pDsRed-Express-N1-Cox7a2 是回来的 transfected 进 TM3 老鼠 Leydig 房间以后, Cox7a2 禁止了导致的 luteinizing (LH ) 不仅睾丸激素的分泌物而且星蛋白质的表示。同时, Cox7a2 在 TM3 老鼠 Leydig 房间增加了 ROS 的活动。结论:Cox7a2 禁止了导致 LH 的星蛋白质表示,和作为结果的睾丸激素生产,至少部分地,由在 TM3 鼠标 Leydig 房间增加 ROS 活动。 | Liang Chen Zhong-Cheng Xin Xin Li Long Tian Yi-Ming Yuan Gang Liu Xue-Jun Jiang Ying-Lu Guo | 2006 | Asian Journal of Andrology2006，8，5： | 13 |
| 7 | Ginsenoside-Rg_6, a Novel Triterpenoid Saponin from the Stem-Leaves of Panax ginseng C. A. Mey.显示文摘A novel dammarane-type triterpene oligoglycoside, named ginsenoside-Rg6 3, was isolated from the stem-leaves of Panax ginseng C. A. Mey., together with two known ones, 20(S)-ginsenoside-Rg2 1 and 20(R)-ginsenoside-Rg2 2. On the basis of chemical and physicochemical evidence , the structure of ginsenoside-Rg6 have been elucidated as 6-O-(-L-rhamnosyl-(1?2)-(-D-glucopyranosyl-dammarane-(E)-20(22), 24-diene-3(, 6(, 12(-triol. | Xiu Wei YANG, Long Yun LI, Jian Ming TIAN, Zhi Wei ZHANG, Jin Mei YE, Wei Fang Gu (National Research Laboratory of Natural & Biomimetic Drugs, Peking University, Beijing 100083) (Academy of Chinese Traditional Medicine and Materia Medica of Jilin Provinc | 2000 | Chinese Chemical Letters2000，11，10： | 12 |
| 8 | Casticin induces caspase-mediated apoptosis via activation of mitochondrial pathway and upregulation of DR5 in human lung cancer cells显示文摘Objective:To assess if casticin induces caspase-mediated apoptosis via activation of mitochondrial pathway and upregulation of DR5 in human lung cancer ceils.Methods:Human non-small-cell lung carcinoma cell lines H460,AS49 and H157 were cultured in vitro.The cytotoxic activities were determined using MTT assay.The apoptotic cells death was examined by flow cytometry using PI staining and DMA agarose gel electrophoresis.The activities of caspase-3, -8 and -9 were measured via ELISA.Cellular fractionation was determined by flow cytometry to assess release of cytochrome c and the mitochondrial transmembrane potential.Bcl-2/Bcl-XL/ XIAP/Bid/ DR5 and DR4 proteins were analyzed using western blot.Results:The concentrations required for a 50%decrease in cell growth(IC50) ranged from 1.8 to 3.2 Jt M.Casticin induced rapid apoptosis and triggered a series of effects associated with apoptosis by way of mitochondrial pathway,including the depolarization of the mitochondrial membrane,release of cytochrome c from mitochondria,activation of procaspase-9 and -3,and increase of DNA fragments.Moreover, the pan caspase inhibitor zVAD-FMK and the caspase-3 inhibitor zOEVD-FMK suppressed casticin-induced apoptosis.In addition,casticin induced XIAP and Bcl-XL down-regulation, Bax upregulation and Bid clearage.In H157 cell line,casticin increased expression of DRS at protein levels but not affect the expression of DR4.The prelreatmenl with DR5/Fc chimera protein effectively attenuated casticin-induced apoptosis in H157 cells.No correlation was found between cell sensitivity to casticin and that to p53 status,suggesting that casticin induce a p53- independent apoptosis.Conclusions:Our results demonstrate that casticin induces caspase-mediated apoptosis via activation of mitochondrial pathway and upregulation of DRS in human lung cancer cells. | Yuan Zhou Yi Peng Qi-Qi Mao Xia Li Ming-Wu Chen Ting Su Li Tian Nai-Quan Mao Ling-Zhi Long Mei-Fang Quan Fei Liu Su-Fang Zhou Yong-Xiang Zhao | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，5： | 11 |
| 9 | Major advances in studies of the physical geography and living environment of China during the past 70 years and future prospects显示文摘The natural environment provides material essentials for human survival and development. The characteristics,processes, regional differentiation and forcing mechanisms of the elements of the natural environment(e.g. geomorphology,climate, hydrology, soil, etc.) are the main objects of research in physical geography. China has a complex natural environment and huge regional differentiation and therefore it provides outstanding reserach opportunities in physical geography. This review summarizes the most important developments and the main contributions of research in the physical geography and human living environment in China during the past 70 years. The major topics addressed are the uplift of the Tibetan Plateau and the evolution of its cryosphere, the development of fluvial systems, the acidification of the vast arid region of the Asian interior, variations in the monsoon and westerly climate systems on multiple timescales, the development of lakes and wetlands, the watershed system model, soil erosion, past human-environment interactions, biogeography, and physical geographic zonality. After briefly introducing international research developments, we review the history of research in physical geography in China, focusing on the major achievements and major academic debates, and finally we summarize the status of current research and the future prospects. We propose that in the context of the national demand for the construction of an ecological civilization, we should make full use of the research findings of physical geography, and determine the patterns and mechanisms of natural environmental processes in order to continue to promote the continued contribution of physical geography to national development strategies, and to further contribute to the theory of physical geography from a global perspective. | Fahu CHEN Bojie FU Jun XIA Duo WU Shaohong WU Yili ZHANG Hang SUN Yu LIU Xiaomin FANG Boqiang QIN Xin LI Tingjun ZHANG Baoyuan LIU Zhibao DONG Shugui HOU Lide TIAN Baiqing XU Guanghui DONG Jingyun ZHENG Wei YANG Xin WANG Zaijun LI Fei Wang Zhenbo HU Jie WANG Jianbao LIU Jianhui CHEN Wei HUANG Juzhi HOU Qiufang CAI Hao LONG Ming JIANG Yaxian HU Xiaoming FENG Xingguo MO Xiaoyan YANG Dongju ZHANG Xiuhong WANG Yunhe YIN Xiaochen LIU | 2019 | Science China Earth Sciences2019，62，11： | 11 |
| 10 | Parallel Planning:A New Motion Planning Framework for Autonomous Driving显示文摘Motion planning is one of the most significant technologies for autonomous driving. To make motion planning models able to learn from the environment and to deal with emergency situations, a new motion planning framework called as'parallel planning' is proposed in this paper. In order to generate sufficient and various training samples, artificial traffic scenes are firstly constructed based on the knowledge from the reality.A deep planning model which combines a convolutional neural network(CNN) with the Long Short-Term Memory module(LSTM) is developed to make planning decisions in an end-toend mode. This model can learn from both real and artificial traffic scenes and imitate the driving style of human drivers.Moreover, a parallel deep reinforcement learning approach is also presented to improve the robustness of planning model and reduce the error rate. To handle emergency situations, a hybrid generative model including a variational auto-encoder(VAE) and a generative adversarial network(GAN) is utilized to learn from virtual emergencies generated in artificial traffic scenes. While an autonomous vehicle is moving, the hybrid generative model generates multiple video clips in parallel, which correspond to different potential emergency scenarios. Simultaneously, the deep planning model makes planning decisions for both virtual and current real scenes. The final planning decision is determined by analysis of real observations. Leveraging the parallel planning approach, the planner is able to make rational decisions without heavy calculation burden when an emergency occurs. | Long Chen Xuemin Hu Wei Tian Hong Wang Dongpu Cao Fei-Yue Wang | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，1： | 9 |
| 11 | Genome of Plant Maca (Lepidium meyenil) Illuminates Genomic Basis for High-Altitude Adaptation in the Central Andes显示文摘Maca (Lepidium meyenii Walp, 2n = 8x = 64 ) ,属于 Brassicaceae 家庭,经济植物在秘鲁(4000-4500 m ) 在中央安第斯山脉岭被栽培。认为快速中央安第斯山脉高举发生 5-10 百万年以前(妈) ,一个进化问题关于象 maca 那样的植物怎么在一个短地质的时期以内获得高高度的改编产生。这里,我们报导 maca 的高质量的染色体集会,在里面它二仔细 spaced maca 特定的整个染色体的复制(WGD;6.7 妈) 被识别。在 maca 和密切相关的 Brassicaceae 种类之间的比较 genomic 分析揭示了经由 WGD 涉及不能生活的压力反应,荷尔蒙发信号小径,和第二等的代谢物生合成的 maca 基因和基因家庭的扩大。保留和许多复制基因的随后的功能的分叉可以说明词法、生理的变化(即,小叶形状和自我富饶) 在在高高度的环境的 maca。另外,一些复制 maca 基因在词法改编与功能被识别(即,叶卷应答) 并且不能生活的压力反应(即, GLYCINE 富有的 RNA 有约束力的蛋白质和 DNA-DAMAGE-REPAIR/TOLERATION 2 ) 在积极选择下面。一起, maca 染色体提供有用信息在安第斯山脉在植物的高高度的改编理解 WGD 的重要角色。 | Jing Zhang Yang Tian Liang Yan GuanghuiZhang Xiao Wang Yan Zeng Jiajin Zhang Xiao Ma Yuntao Tan Ni Long Yangzi Wang Yujin Ma Yuqi He Yu Xue Shumei Hao Shengchao Yang Wen Wang Liangsheng Zhang Yang Dong Wei Chen Jun Sheng | 2016 | Molecular Plant2016，9，7： | 9 |
| 12 | Combination of mild therapeutic hypothermia and adipose-derived stem cells for ischemic brain injury显示文摘Mild therapeutic hypothermia has been shown to mitigate cerebral ischemia, reduce cerebral edema, and improve the prognosis of patients with cerebral ischemia. Adipose-derived stem cell-based therapy can decrease neuronal death and infiltration of inflammatory cells, exerting a neuroprotective effect. We hypothesized that the combination of mild therapeutic hypothermia and adipose-derived stem cells would be neuroprotective for treatment of stroke. A rat model of transient middle cerebral artery occlusion was established using the nylon monofilament method. Mild therapeutic hypothermia(33°C) was induced after 2 hours of ischemia. Adipose-derived stem cells were administered through the femoral vein during reperfusion. The severity of neurological dysfunction was measured by a modified Neurological Severity Score Scaling System. The area of the infarct lesion was determined by 2,3,5-triphenyltetrazolium chloride staining. Apoptotic neurons were detected by terminal deoxynucleotidyl transferase-mediated d UTP-biotin nick end labeling(TUNEL) staining. The regeneration of microvessels and changes in the glial scar were detected by immunofluorescence staining. The inflammatory responses after ischemic brain injury were evaluated by in situ staining using markers of inflammatory cells. The expression of inflammatory cytokines was measured by reverse transcription-polymerase chain reaction. Compared with mild therapeutic hypothermia or adipose-derived stem cell treatment alone, their combination substantially improved neurological deficits and decreased infarct size. They synergistically reduced the number of TUNEL-positive cells and glial fibrillary acidic protein expression, increased vascular endothelial growth factor levels, effectively reduced inflammatory cell infiltration and down-regulated the m RNA expression of the proinflammatory cytokines interleukin-1β, tumor necrosis factor-α and interleukin-6. Our findings indicate that combined treatment is a better approach for treating stroke compared with mild therapeutic hypothermia or adipose-derived stem cells alone. | Kai Zhao Rui Li Sheng Bi Yu Li Long Liu Yu-Long Jia Peng Han Chang-Cong Gu Xi-Ze Guo Wan-Ping Zhang Chun Wang Chun-Ying Pei Lin-Lu Tian Li-Xian Li | 2018 | Neural Regeneration Research2018，13，10： | 9 |
| 13 | Effects of yeast and yeast cell wall polysaccharides supplementation on beef cattle growth performance, rumen microbial populations and lipopolysaccharides production显示文摘This experiment was conducted to investigate the effects of live yeast and yeast cell wall polysaccharides on growth performance,rumen function and plasma lipopolysaccharides(LPS) content and immunity parameters of beef cattle.Forty Qinchuan cattle were randomly assigned to one of four treatments with 10 replicates in each treatment.The dietary treatments were: control diet(CTR),CTR supplemented with 1 g live yeast(2×10^10 live cell g^-1 per cattle per day(YST1),CTR supplemented with 2 g live yeast per cattle per day(YST2) and CTR supplemented with 20 g of yeast cell wall polysaccharides(30.0%≤β-glucan≤35.0%,and 28.0%≤mannanoligosaccharide≤32.0%) per cattle per day(YCW).The average daily gain was higher(P=0.023) and feed conversion ratio was lower(P=0.042) for the YST2 than the CTR.The digestibility of neutral detergent fiber(P=0.039) and acid detergent fiber(P=0.016) were higher in yeast supplemented groups.The acetic acid:propionic acid of the YST2 was lower compared with the CTR(P=0.033).Plasma LPS(P=0.032),acute phase protein haptoglobin(P=0.033),plasma amyloid A(P=0.015) and histamine(P=0.038) were lower in the YST2 compared with the CTR.The copies of fibrolytic microbial populations such as Fibrobacter succinogenes S85,Ruminococcus albus 7 and Ruminococcus flavefaciens FD-1 of the YST2 were higher(P<0.001),while the copies of typical lactate producing bacteria Streptococcus bovis JB1 was lower(P<0.001) compared with the CTR.Little differences were observed between the CTR,YST1 and YCW in growth performance,ruminal fermentation characteristics,microbial populations,immunity indices and total tract nutrient digestibility.It is concluded that the YST2 could promote fibrolytic microbial populations,decrease starch-utilizing bacteria,reduce LPS production in the rumen and LPS absorption into plasma and decrease inflammatory parameters,which can lead to an improvement in growth performance in beef cattle. | PENG Quan-hui CHENG Long KANG Kun Tian Gang Mohammad Al-Mamun XUE Bai WANG Li-zhi ZOU Hua-wei Mathew Gitau Gicheha WANG Zhi-sheng | 2020 | Journal of Integrative Agriculture2020，19，3： | 9 |
| 14 | Impacts of ionospheric scintillation on geosynchronous SAR focusing: preliminary experiments and analysis显示文摘亲爱的编辑,同步合成孔径雷达(GEO SAR)具有显着的潜在危害和灾害监测应用时,由于其短重访时间约24小时,约1 / 3的地球表面[1,2],覆盖面广。然而,在L波段操作使它更容易受到电离层闪烁[2,3]。徐等。从理论上分析了电离层对星载SAR球形闪烁[ 3 ]的影响,这一现象也被观察到在低地球轨道(LEO SAR)SARS如ALOS PALSAR [ 4 ]。地理合成孔径雷达是更严重的影响电离层闪烁,因为信号传播路径覆盖整个电离层(超过1000公里以上的地面)[ 3 ]。相比之下,狮子座合成孔径雷达的轨道是几百公里。然而,研究人员很少分析电离层闪烁对L波段GEO SAR,或进行实验验证。 | LI YuanHao HU Cheng DONG XiChao TIAN WeiMing LONG Teng | 2015 | Science China(Information Sciences)2015，58，10： | 8 |
| 15 | Estimation of reproduction numbers of COVID-19 in typical countries and epidemic trends under different prevention and control scenarios显示文摘The coronavirus disease 2019(COVID-19)has become a life-threatening pandemic.The epidemic trends in different countries vary considerably due to different policy-making and resources mobilization.We calculated basic reproduction number(R0)and the time-varying estimate of the effective reproductive number(Rt)of COVID-19 by using the maximum likelihood method and the sequential Bayesian method,respectively.European and North American countries possessed higher (R0)and unsteady Rt fluctuations,whereas some heavily affected Asian countries showed relatively low (R0)and declining Rt now.The numbers of patients in Africa and Latin America are still low,but the potential risk of huge outbreaks cannot be ignored.Three scenarios were then simulated,generating distinct outcomes by using SEIR(susceptible,exposed,infectious,and removed)model.First,evidence-based prompt responses yield lower transmission rate followed by decreasing Rt.Second,implementation of effective control policies at a relatively late stage,in spite of huge casualties at early phase,can still achieve containment and mitigation.Third,wisely taking advantage of the time-window for developing countries in Africa and Latin America to adopt adequate measures can save more people’s life.Our mathematical modeling provides evidence for international communities to develop sound design of containment and mitigation policies for COVID-19. | Chen Xu Yinqiao Dong Xiaoyue Yu Huwen Wang Lhakpa Tsamlag Shuxian Zhang Ruijie Chang Zezhou Wang Yuelin Yu Rusi Long Ying Wang Gang Xu Tian Shen Suping Wang Xinxin Zhang Hui Wang Yong Cai | 2020 | Frontiers of Medicine2020，14，5： | 8 |
| 16 | Characteristics of dissolved organic matter in lakes with different eutrophic levels in southeastern Hubei Province,China显示文摘Dissolved organic matter(DOM)plays a crucial role in both the carbon cycle and geochemical cycles of other nutrient elements,which is of importance to the management and protection of the aquatic environments.To achieve a more comprehensive understanding the characteristics of DOM in the Changjiang(Yangtze)River basin,water samples from four natural lakes(Xiandao,Baoan,Daye,and Qingshan)in southeastern Hubei Province in China with different eutrophication levels were collected and analyzed.The optical characteristics were analyzed using ultraviolet-visible spectrophotometry and excitation-emission matrix spectroscopy coupled with parallel factor analysis.The results show that:(1)two humic-like components(C1 and C2)and two protein-like substances(C3 and C4)of DOM were identified in all waterbodies;(2)C3 originated primarily from the degradation of microalgae and contributed substantially to humic-like components during transformation.C4 was widely present in the Changjiang River basin and its formation was related to microbial activity,rather than algal blooms or seasons.Influenced by the water mixing,the protein-like components were more likely to be transformed by microorganism,whereas humic-like components were more easily to be photobleached;(3)the concentration of DOM and the fluorescence intensity of humic-like components gradually increased with rising lake eutrophication levels.With respect to protein-like components,only C3 showed changes along the eutrophication gradients;(4)DOM showed a high affinity with permanganate index(COD Mn)and chlorophyll a(chl a)while the relationship was variable with phosphorus.This study helps us systematically understand the DOM characteristics,microbial activities,and pollutant transformation in the Changjiang River basin and provides reference to the ecological restoration of aquatic environments. | Weixiang REN Xiaodong WU Xuguang GE Guiying LIN Mengdie ZHOU Zijie LONG Xinhui YU Wei TIAN | 2021 | Journal of Oceanology and Limnology2021，39，4： | 8 |
| 17 | Detection of serum IgM and IgG for COVID-19 diagnosis显示文摘Dear Editor,Infection with the novel coronavirus(SARS-CoV-2,which is the virus responsible for the coronavirus disease 2019(COVID-19))was first reported in Wuhan,China on December 31,2019.The outbreak of COVID-19 remains ongoing and was linked to more than 80,000 infected patients and more than 3,000 deaths in China as of March 7,2020(Holshue et al.,2020). | Ling Zhong Junlan Chuan Bo Gong Ping Shuai Yu Zhou Yi Zhang Zhilin Jiang Dingding Zhang Xiaoqi Liu Shi Ma Yi Huang He Lin Qingwei Wang Lulin Huang Dan Jiang Fang Hao Juan Tang Chunqi Zheng Hua Yu Zhibin Wang Qi Jiang Tao Zeng Mei Luo Fanwei Zeng Fanxin Zeng Jianghai Liu Junxi Tian Yu Xu Tengxiang Long Kaiju Xu Xingxiang Yang Yuping Liu Yi Shi Li Jiang Zhenglin Yang | 2020 | Science China(Life Sciences)2020，63，5： | 8 |
| 18 | Liver stiffness and serum markers for excluding high-risk varices in patients who do not meet Baveno VI criteria显示文摘BACKGROUND The Baveno VI criteria for predicting esophageal varices, i.e., liver stiffness measurement (LSM)< 20 kPa and platelet (PLT) count > 150 × 109/L, identify patients who can safely avoid gastroscopy screening. However, they require further refinement. AIM To evaluate the utility of LSM and serum markers of liver fibrosis in ruling out high-risk varices (HRV) in patients who do not meet Baveno VI criteria. METHODS Data from 132 patients with hepatitis B virus (HBV)-related compensated liver cirrhosis who did not meet the Baveno VI criteria were retrospectively reviewed. MedCalc 15.8 was used to calculate receiver operating characteristic (ROC) curves, and the accuracy of LSM, PLT count, aspartate aminotransferase (AST)- to-PLT ratio index, Fibrosis-4, and the Lok index in predicting HRV were evaluated according to the area under each ROC curve (AUROC). The utility of LSM, PLT, and serum markers of liver fibrosis stratified by alanine transaminase (ALT) and total bilirubin (TBil) levels was evaluated for ruling out HRV. RESULTS In all patients who did not meet the Baveno VI criteria, the independent risk factors for HRV were LSM and ALT. Only the AUROC of Lok index was above 0.7 for predicting HRV, and at a cutoff value of 0.4531 it could further spare 24.2% of gastroscopies without missing HRVs. The prevalence of HRV was significantly lower in patients with ALT or TBil ≥ 2 upper limit of normal (ULN)(14.3%) than in patients with both ALT and TBil < 2 ULN (34.1%)(P = 0.018). In the 41 patients with ALT and TBil < 2 ULN, LSM had an AUROC for predicting HRV of 0.821. LSM < 20.6 kPa spared 39.0% of gastroscopies without missing HRVs. In the 91 patients with ALT or TBiL ≥ 2 ULN, the Lok index and PLT had AUROCs of 0.814 and 0.741, respectively. Lok index ≤ 0.5596 or PLT > 100 × 109/L further spared 39.6% and 43.9% of gastroscopies, respectively, without missing HRVs. CONCLUSION In HBV-related compensated cirrhosis patients who do not meet Baveno VI criteria, the LSM, PLT, or Lok index cutoff stratified by ALT and TBil accurately identifies more patients without HRV. | Hong Zhou Jun Long Han Hu Cai-Yun Tian Shi-De Lin | 2019 | World Journal of Gastroenterology2019，25，35： | 7 |
| 19 | Building a sequence map of the pig pan-genome from multiple de novo assemblies and Hi-C data显示文摘Pigs were domesticated independently in the Near East and China,indicating that a single reference genome from one individual is unable to represent the full spectrum of divergent sequences in pigs worldwide.Therefore,12 de novo pig assemblies from Eurasia were compared in this study to identify the missing sequences from the reference genome.As a result,72.5 Mb of nonredundant sequences(~3% of the genome)were found to be absent from the reference genome(Sscrofa11.1)and were defined as pan-sequences.Of the pan-sequences,9.0 Mb were dominant in Chinese pigs,in contrast with their low frequency in European pigs.One sequence dominant in Chinese pigs contained the complete genic region of the tazarotene-induced gene 3(TIG3)gene which is involved in fatty acid metabolism.Using flanking sequences and Hi-C based methods,27.7% of the sequences could be anchored to the reference genome.The supplementation of these sequences could contribute to the accurate interpretation of the 3D chromatin structure.A web-based pan-genome database was further provided to serve as a primary resource for exploration of genetic diversity and promote pig breeding and biomedical research. | Xiaomeng Tian Ran Li Weiwei Fu Yan Li Xihong Wang Ming Li Duo Du Qianzi Tang Yudong Cai Yiming Long Yue Zhao Mingzhou Li Yu Jiang | 2020 | Science China(Life Sciences)2020，63，5： | 7 |
| 20 | MmNet:Identifying Mikania micrantha Kunth in the wild via a deep Convolutional Neural Network显示文摘Mikania micrantha Kunth is an invasive alien weed and known as a plant killer around the world.Accurately and rapidly identifying M.micrantha in the wild is important for monitoring its growth status,as this helps management officials to take the necessary steps to devise a comprehensive strategy to control the invasive weed in the identified area.However,this approach still mainly depends on satellite remote sensing and manual inspection.The cost is high and the accuracy rate and efficiency are low.We acquired color images of the monitoring area in the wild environment using an Unmanned Aerial Vehicle(UAV)and proposed a novel network-MmNet-based on a deep Convolutional Neural Network(CNN)to identify M.micrantha in the images.The network consists of AlexNet Local Response Normalization(LRN),along with the GoogLeNet and continuous convolution of VGG inception models.After training and testing,the identification of 400 testing samples by MmNet is very good,with accuracy of 94.50%and time cost of 10.369 s.Moreover,in quantitative comparative analysis,the proposed MmNet not only has high accuracy and efficiency but also simple construction and outstanding repeatability.Compared with recently popular CNNs,MmNet is more suitable for the identification of M.micrantha in the wild.However,to meet the challenge of wild environments,more M.micrantha images need to be acquired for MmNet training.In addition,the classification labels need to be sorted in more detail.Altogether,this research provides some theoretical and scientific basis for the development of intelligent monitoring and early warning systems for M.micrantha and other invasive species. | QIAO Xi LI Yan-zhou SU Guang-yuan TIAN Hong-kun ZHANG Shuo SUN Zhong-yu YANG Long WAN Fang-hao QIAN Wan-qiang | 2020 | Journal of Integrative Agriculture2020，19，5： | 7 |
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