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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | The impact of household consumption patterns on emissions in Spain显示文摘 | Rosa D Alfredo M Julio S | 2010 | Energy Economics2010，32，1： | 1 |
| 3 | Validation of real-time three-dimensional echocardiography for quantifying left ventricular volumes in the presence of a left ventricular aneurysm: in vitro and in vivo studies显示文摘 | Jian Xin Qin Michael Jones Takahiro Shiota Neil L Greenberg Hiroyuki Tsujino Michael S Firstenberg Pankaj C Gupta Arthur D Zetts Yong Xu Jing Ping Sun Lisa A Cardon Jill A Odabashian Scott D Flamm Richard D White Julio A Panza James D Thomas | 2000 | Journal of the American College of Cardiology2000，，3： | 1 |
| 4 | Mechanisms of karyotype differentiation in Cassidinae sensu lato (Coleoptera, Polyphaga, Chrysomelidae) based on seven species of the Brazilian fauna and an overview of the cytogenetic data显示文摘 | JULIO M D FEMANDES F R COSTA C | 2010 | Micron2010，41，1： | 1 |
| 5 | Blow up and global existence for a semilinear reaction 2 diffusion system in a bounded domain 显示文摘 | JULIO D R NOEMI W | 1995 | Partial Diffusion Equations1995，20，1112： | 1 |
| 6 | Chronic intermittent hypoxia enhances cat chemosensory and ventilatory responses to hypoxi显示文摘 | SERGIO R RODRIGO D R JULIO A | 2004 | J Physiol2004，560，2： | 1 |
| 7 | Gastric and Duodenal Stents: Follow-Up and Complications显示文摘 | Isabel Teresa Pinto Pabón Laura Paúl Díaz Juan Carlos Ruiz de Adana Julio López Herrero | 2001 | Cardiovascular and Interventional Radiology2001，，3： | 1 |
| 8 | DNAadenine methylase is essential for viability and plays a role in the pathognesis of Yersinia Pseudotuberculosis and Vibrio Cholerae显示文摘 | Julio S M Heithoff D M Provenzano D | 2001 | Infect Immun2001，69，12： | 1 |
| 9 | PSFGA:A Parallel Genetic Algorithmfor Multi objective Optimization显示文摘 | Julio Ortega Javier Fernández Antonio Díaz | | IEEE Computer Society0，2002，： | 1 |
| 10 | A luminal epithelial stem cell that is a cell of origin for prostatecancer显示文摘 | WANG X KRUITHOF-DE JULIO M ECONOMIDES K D | 2009 | Nature2009，461，7263： | 1 |
| 11 | Reducing the content of nornicotine in tobacco via targeted mutation breeding显示文摘 | Emilie Julio Frédéric Laporte Stéphanie Reis Christophe Rothan Fran?ois Dorlhac de Borne | 2008 | Molecular Breeding2008，，3： | 1 |
| 12 | Reduced progression of experimental osteoarthritis in vivo by selective inhibition of inducible nitric oxide sythase显示文摘 | Pelletier JP Jovanovic D Julio C | 1998 | J Athritis Rheum1998，41，6： | 1 |
| 13 | Formal contracts in fresh produce markets 显示文摘 | Poole N D Del Campo Gomis F J JuliO Igual J F et a| | 1998 | Food Policy1998，23，2： | 1 |
| 14 | A state-of-the-art review on shear-friction 显示文摘 | SANTOS P M D JULIO E N B S | 2012 | Engineering Structures2012，45，： | 1 |
| 15 | Multimodal analgesia without parenteral narcotics for total knee arthroplasty 显示文摘 | LAWRENCE D D JULIO R WILLIAM T L | 2008 | J Arthro2008，123，4： | 1 |
| 16 | Reduced progression of experimental osteoarthritis in vivo by selective inhibition of inducible nitric oxide synthase显示文摘 | Pelletier JP Jovanovic D Julio C | 1998 | Arthritis Rheum1998，41，7： | 1 |
| 17 | Imaging quality of multifocal intraocular lenses: automated assessment setup显示文摘 | Arnau Calatayud Laura Remón Julio Martos Walter D Furlan Juan A Monsoriu | 2013 | Ophthalmic Physiol Opt2013，，4： | 1 |
| 18 | Antioxidant and metal chelating activities of Phaseolus vulgaris L. var. Jamapa protein isolates, phaseolin and lectin hydrolysates显示文摘 | Janet Carrasco-Castilla Alan Javier Hernández-álvarez Cristian Jiménez-Martínez Carmen Jacinto-Hernández Manuel Alaiz Julio Girón-Calle Javier Vioque Gloria Dávila-Ortiz | 2011 | Food Chemistry2011，，4： | 1 |
| 19 | DNA adenine methylase is essential for viability and plays role in the pathogenesis of Yersinia Pseudotuberculosis and Vibrio cholerae显示文摘 | Heithoff D M Provenzano D Klose K E Sinsheimer R L Low D A Mahan M J | 2001 | Infect Immun2001，69，12： | 1 |
| 20 | Frequency of cognitive im-pairment without dementia in patients with stroke a two -year fol - low - up study 显示文摘 | Soledad S Julio D Elena R G | 2007 | J Stroke2007，38，： | 1 |
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