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| 1 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 2 | Validation of real-time three-dimensional echocardiography for quantifying left ventricular volumes in the presence of a left ventricular aneurysm: in vitro and in vivo studies显示文摘 | Jian Xin Qin Michael Jones Takahiro Shiota Neil L Greenberg Hiroyuki Tsujino Michael S Firstenberg Pankaj C Gupta Arthur D Zetts Yong Xu Jing Ping Sun Lisa A Cardon Jill A Odabashian Scott D Flamm Richard D White Julio A Panza James D Thomas | 2000 | Journal of the American College of Cardiology2000，，3： | 1 |
| 3 | Damage in hot rolling work rolls显示文摘 | Rafael Colás Jorge Ram??rez Ignacio Sandoval Julio C Morales Luis A Leduc | 1999 | Wear1999，，1： | 1 |
| 4 | The role of consumption patterns,demand and technological factors on the recent evolution of CO2emissions in a group of advanced economies显示文摘 | Duarte R Mainar A Julio S C | 2013 | Ecological Economics2013，96，12： | 1 |
| 5 | Effects of diet supplementation with three soluble polysaccharides on serum lipid levels of hypercholesterolemic rats 显示文摘 | INAR A C JULIO T MARCIA L | 2003 | Food Chemistry2003，80，3： | 1 |
| 6 | Health professionals for a new cen- tre-y: transforming education to strengthen health systems in an interde- pendent wodd显示文摘 | Julio F Lincoln C Zu]fiqar A B | 2010 | Laneet2010，9756，376： | 1 |
| 7 | Processing of spent platinum-based catalysts via fusion with potassium hydrogenosulfate显示文摘 | Sebastiao G Batista J Julio C A | 2010 | Journal of Hazardous Materials2010，184，13： | 1 |
| 8 | Ryanodine receptor calcium release channels显示文摘 | Michael F Julio A C | 2002 | Physiological Reviews2002，82，： | 1 |
| 9 | Health professionals for a new century: transforming education to strengthen health systems in an inter- dependent world 显示文摘 | Julio F Lincoln C Zulfiqar A B | 2010 | Lancet2010，，376： | 1 |
| 10 | The influence of disuse on bone microstructure and mechanics assessed by HR-pQCT显示文摘 | Galateia J Kazakia Willy Tjong Jasmine A Nirody Andrew J Burghardt Julio Carballido-Gamio Janina M Patsch Thomas Link Brian T Feeley C Benjamin Ma | 2014 | Bone2014，63，： | 1 |
| 11 | A study of the effect of flow maldistribution on heat transfer performance in evaporators显示文摘 | Julio C Pacio Carlos A Dorao | 2010 | Nuclear Engineering and Design2010，240，11： | 1 |
| 12 | Risk of fracture in celiac disease:Gender,dietary compliance,or both?显示文摘AIM:To determine the incidence of peripheral fractures in patients with celiac disease (CD) and the effect of treatment on fracture risk.METHODS:We compared the incidence and risk of peripheral fractures before and after diagnosis between a cohort of 265 patients who had been diagnosed with CD at least 5 years before study entry and a cohort of 530 age-and sex-matched controls who had been diagnosed with functional gastrointestinal disorders.Data were collected through in-person interviews with an investigator.The overall assessment window for patients was 9843 patient-years (2815 patient-years after diagnosis).RESULTS:Compared with the control group,the CD cohort showed significantly higher incidence rate and risk of first peripheral fracture before diagnosis [adjusted hazard ratio (HR):1.78,95% CI:1.23-2.56,P < 0.002] and in men (HR:2.67,95% CI:1.37-5.22,P < 0.004).Fracture risk was significantly associated with the classic CD presentation with gastrointestinal symptoms (P < 0.003).In the time period after diagnosis,the risk of fractures was comparable between the CD cohort and controls in both sexes (HR:1.08,95% CI:0.55-2.10 for women;HR:1.57,95% CI:0.57-4.26 for men).CONCLUSION:CD patients have higher prevalence of fractures in the peripheral skeleton before diagnosis.This is associated with male sex and classic clinical presentation.The fracture risk was reduced after the treatment. | María Inés Pinto Sánchez Adriana Mohaidle Andrea Baistrocchi Dolores Matoso Horacio Vázquez Andrea González Roberto Mazure Evangelina Maffei Guillermina Ferrari Edgardo Smecuol Adriana Crivelli Juan Andrés de Paula Juan C Gómez Silvia Pedreira Eduardo Maurio Julio César Bai | 2011 | World Journal of Gastroenterology2011，17，25： | 1 |
| 13 | A study of the effect of flow maldistribution on heat transfer performance in evaporators 显示文摘 | Pacio Julio C Dorao Carlos A | 2010 | Nuclear Engineering and Design2010，240，： | 1 |
| 14 | Gluten immunogenic peptide excretion detects dietary transgressions in treated celiac disease patients显示文摘BACKGROUND Life-long removal of gluten from the diet is currently the only way to manage celiac disease(CeD). Until now, no objective test has proven useful to objectively detect ingested gluten in clinical practice. Recently, tests that determine consumption of gluten by assessing excretion of gluten immunogenic peptides(GIP) in stool and urine have been developed. Their utility, in comparison with conventional dietary and analytical follow-up strategies, has not been fully established.AIM To assess the performance of enzyme-linked immunosorbent assay(ELISA) and point-of-care tests(PoCTs) for GIP excretion in CeD patients on gluten-free diet(GFD).METHODS We conducted an observational, prospective, cross-sectional study in patients following a GFD for at least two years. Using the Gastrointestinal Symptom Rating Scale questionnaire, patients were classified at enrollment as asymptomatic or symptomatic. Gluten consumption was assessed twice by 3-d dietary recall and GIP excretion(by ELISA in stool and PoCTs(commercial kits for stool and urine) in two consecutive samples. These samples and dietary reports were obtained 10 day apart one from the other. Patients were encouraged to follow their usual GFD during the study period.RESULTS Forty-four patients were enrolled, of which 19(43.2%) were symptomatic despite being on a GFD. Overall, 83 sets of stool and/or urine samples were collected.Eleven out of 44 patients(25.0%) had at least one positive GIP test. The occurrence of at least one positive test was 32% in asymptomatic patients compared with 15.8% in symptomatic patients. GIP was concordant with dietary reports in 65.9% of cases(Cohen′s kappa: 0.317). PoCT detected dietary indiscretions. Both ELISA and PoCT in stool were concordant(concomitantly positive or negative) in 67 out of 74(90.5%) samples. Excretion of GIP was detected in 7(8.4%) stool and/or urine samples from patients considered to be strictly compliant with the GFD by dietary reports.CONCLUSION GIP detects dietary transgressions in patients on long-term GFD, irrespective of the presence of symptoms. PoCT for GIP detection constitutes a simple homebased method for self-assessment of dietary indiscretions. | Ana Florencia Costa Emilia Sugai María de la Paz Temprano Sonia Isabel Niveloni Horacio Vázquez María Laura Moreno M.Remedios Domínguez-Flores Alba Mu?oz-Suano Edgardo Smecuol Juan Pablo Stefanolo Andrea F González Angel Cebolla-Ramirez Eduardo Mauri?o Elena F Verdú Julio César Bai | 2019 | World Journal of Gastroenterology2019，25，11： | 1 |
| 15 | Solving design equation system for animal cell cultures by two step sedimentation显示文摘 | Marya I C Julio A L Ricardo J G | 2001 | Journal of Biotechnology2001，84，： | 1 |
| 16 | Organic contanminants in sediments from San Quintin Bay, Baja California, Mexico显示文摘 | EFRAIN A G G JULIO A V C GILBERTO F M | 1996 | Marine Pollution Bulletin1996，32，4： | 1 |
| 17 | Extracting Comprehensible Rules from Neural Networks via Genetic Algorithm显示文摘 | RAUL T S JULIO C N ALEX A F | 2000 | IEEE2000，36，： | 1 |
| 18 | A study of the effect of flow maldistribution on heat transfer performance in evap- orators显示文摘 | Julio C P Carlos A D | 2010 | Nuclear Engineering and Design2010，240，11： | 1 |
| 19 | Detection and quantification adulteration via direct incorporation of syrups or bee-feeding: preliminary study honey sugar using high-performance anion exchange chromatography with pulsed amperometric detection ( HPAEC-PAD ) and ehemometrics 显示文摘 | Christophe C Julio SLT Milit a o Marie -Claude C | 2005 | Analy - tica Chimica Acta2005，531，： | 1 |
| 20 | A simple and robust adaptive controller for detuning correction in field-oriented induction machines 显示文摘 | Julio C Moreira Hung Kam Tim Lipo T A | 1992 | IEEE Trans on Ind App1992，，： | 1 |
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