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| 1 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 2 | Token+constraint systems for tangible interaction with digital information 显示文摘 | Ullmer B Ishii H Jacob R J K | 2005 | A CM Transactions on Computer Human Interaction2005，12，1： | 1 |
| 3 | Evidence for the nature of true Lewis sites in faujasite - type zeolites显示文摘 | JACOBS P A H K BEYER | 1979 | J Phys Chem1979，83，9： | 1 |
| 4 | Dynamicsand structure formation in thin polymer melt films 显示文摘 | Seemann R Herminghaus S Neto C Schlagowski S Podzimek D Konrad R Mantz H Jacobs K | 2005 | Journal of Physics2005，17，9： | 1 |
| 5 | Dietary fat and incidence of type 2 diabetes in older women显示文摘 | Meyer K A Jacobs D R Kushi L H | 2011 | Diabetes Care2011，24，2： | 1 |
| 6 | Stereotactic breast biopsy in a community hospital setting显示文摘 | Klem D Jacobs H K Jorgensen R | 1999 | Am Surg1999，65，8： | 1 |
| 7 | Optimal inventory policy显示文摘 | ARROW K H HARRIS T JACOB M | 1951 | Econometrica1951，19，3： | 1 |
| 8 | Genome sequence and analysis of the tuber crop potato显示文摘 | Xu X Pan S Cheng S Zhang B Mu D Ni P Zhang G Yang S Li R Wang J Orjeda G Guzman F Tones M Lnzano R Ponce O Martinez D De la Cruz G Chakrabarti S K Patil V U Skryabin K G Kuznetsov B B Ravin N V Kolganova T V Beletsky A V Mardanov A V Di Genova A Bolser D M Martin D M Li G Yang Y Kuang H Hu Q Xiong X Bishop G J Sagredo B Mejia N Zagorski W Gromadka R Gawor J Szczesny P Huang S Zhang Z Liang C He J Li Y He Y Xu J Zhang Y Xie B Du Y Qu D Bonierbale M Ghislain M Herrera Mdel R Giuliano G Pietrella M Perrotta G Faeella P O 'Brien K Feingold S E Barreiro L E Massa G A Diambra L Whitty B R Vaillancourt B Lin H Massa A N Geoffroy M Lundback S DellaPenna D Buell C R Sharma S K Marshall D F Waugh R Bryan G J Destefanis M Nagy I Milbourne D Thomson S J Fiefs M Jacobs J M Nielsen K L Sonderkaer M Iovene M Tortes G A Jiang J Veilleux R E Bachem C W de Boer J Bonn T Kloosterman B van Eck H Datema E Hekkert B Goverse A van Ham R C Visser R G | 2011 | Nature2011，475，7355： | 1 |
| 9 | Classitocation systems as boundary objects in diverse information ecologies 显示文摘 | Albrechtsen H Jacob E K | 1998 | Advances in Classification Research1998，8，1： | 1 |
| 10 | Carbohydrates, dietary fiber, and incident type 2 diabetes in older women 显示文摘 | Meyer K A Kushi L H Jacobs D R J Slavin J Sellers T A Folsom A R | 2000 | The American Journal of Clinical Nutrition2000，71，4： | 1 |
| 11 | Dietary fat and incidence of type 2 diabetes in older Iowa women显示文摘 | MEYER K A KUSHI L H JACOBS D R Jr | 2001 | Diabetes Care2001，24，： | 1 |
| 12 | Molecular epidemi- ology of subgroup C avian pneumoviruses isolated in the United States and comparison with subgroup A and B viruses显示文摘 | Shin H J Cameron K T Jacobs J A | 2002 | J Clin Micobiol2002，5，： | 1 |
| 13 | A comparison and test of various site response estimation techniques,including three that are non reference-site dependent显示文摘 | Field E H Jacob K H | 1995 | Bull Seism Soc Amer1995，85，4： | 1 |
| 14 | The importance of chill rate whencharacterising colour change of lamb meat during retail display显示文摘 | Jacob R H Thomson K L | 2012 | Meat Science2012，90，2： | 1 |
| 15 | Heterogeneous beliefs and the non-linear cobweb model显示文摘 | Jacob K G Cars H H | 2000 | J of Economic Dynamics and Control2000，24，： | 1 |
| 16 | Association studies of Parkinson's disease and parkin polymorphisms 显示文摘 | Klein C Schumacher K Jacobs H | 2000 | Ann Neurol2000，48，1： | 1 |
| 17 | Exergy analysis on the simulation of a small-scale hydrogen liquefaction test rig with a multi-component refrigerant refrigeration system 显示文摘 | SONGWUT K JACOB H S PETTER N | 2010 | International Journal of Hydrogen Energy2010，35，5： | 1 |
| 18 | 显示文摘 | Jacob K T Dasgupta N Niife H Aldinger F | 2000 | Mater Res2000，15，12： | 1 |
| 19 | Advanced forecasting of cost and yield 显示文摘 | NAG P K MALY W JACOBS H | 1998 | Semiconductor International1998，21，8： | 1 |
| 20 | Molecular Epide- miology of Subgroup C Avian Pneumoviruses Isolated in the United States and comparison with Subgroup A and B Viruses 显示文摘 | Shin H J Cameron K T Jacobs J A | 2002 | J Clin Micobiology2002，5，： | 1 |
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