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| 1 | Anti-HBc screening in Indian blood donors:Still an unresolved issue显示文摘AIM:To study the seroprevalence of antibody to hepatitis B core antigen (anti-HBc) in healthy blood donors negative for HBsAg and to evaluate whether anti-HBc detection could be adopted in India as a screening assay for HBV in addition to HBsAg. METHODS: A total of 1700 serum samples collected from HBsAg-negative healthy blood donors were tested for the presence of anti-HBc antibody (IgM + IgG). All samples reactive for anti-HBc antibody were then investigated for presence of anti-HBs and for liver function tests (LFTs). One hundred serum samples reactive for anti-HBc were tested for HBV DNA by PCR method. RESULTS: Out of 1700 samples tested, 142 (8.4%) blood samples were found to be reactive for anti-HBc. It was signif icantly lower in voluntary (6.9%) as compared to replacement donors (10.4%, P = 0.011). Seventy- two (50.7%) anti-HBc reactive samples were also reactive for anti-HBs with levels > 10 mIU/mL and 70 (49.3%) samples were non-reactive for anti-HBs, these units were labeled as anti-HBc-only. These 142 anti-HBc reactive units were also tested for liver function test. HBV DNA was detected in only 1 of 100 samples tested. CONCLUSION: Keeping in view that 8%-18% of donor population in India is anti-HBc reactive, inclusion of anti- HBc testing will lead to high discard rate. Anti-HBs as proposed previously does not seem to predict clearance of the virus. Cost effectiveness of introducing universalanti-HBc screening and discarding large number of blood units versus considering ID NAT (Individual donor nuclic acid testing) needs to be assessed. | Hari Krishan Dhawan Neelam Marwaha Ratti Ram Sharma Yogesh Chawla Beenu Thakral Karan Saluja Sanjeev Kumar Sharma Manish K Thakur Ashish Jain | 2008 | World Journal of Gastroenterology2008，14，34： | 8 |
| 2 | Hoffa fracture associated with femoral shaft and proxi-mal tibial fractures: report of two cases显示文摘独居的花冠砍大腿骨的髁的破裂例如 Hoffa’s 骨折,通常与 supracondylar 或腿节的 intercondylar 破裂被联系。这些破裂在导致多重损害的高精力机制的上下文稀罕、看见;因此,病人的彻底的 workup 被要求排除另外的重要损害。Hoffa’与大腿骨的柄联系的 s 骨折和近似胫骨的破裂是极其稀罕的,没有如此的损害以前被报导了。我们报导与标准起作用的固定技术被管理并且示威的二个如此的案例对在一年的后续以后的优秀功能的结果好。这份报告强调怀疑的那个高索引为这些损害的诊断被要求,彻底的 workup 是强制的排除另外的联系损害。我们也建议损害的可能的机制。 | Anuj Jain Prakash Agrawal Manish Chadha Amite Pankaj | 2012 | Chinese Journal of Traumatology2012，15，6： | 5 |
| 3 | Adansonia digitata L.(baobab):a review of traditional information and taxonomic description显示文摘Adansonia digitata L.(Malvaceae) is commonly known as baobab tree native to Africa.Baobab is a multi-purpose tree which offers protection and provides food,clothing and medicine as well as raw material for many useful items.The fruit pulp,seeds,leaves,flowers.roots,and bark of baobab are edible and they have been studied by scientists for their useful properties.The fruit pulp have very high vitamin C.calcium,phosphorus,carbohydrates,fibers,potassium,proteins and lipids content,which can be used in seasoning as an appetizer and also make juices.Seeds contain appreciable quantities of phosphorus,magnesium,zinc,sodium,iron,manganese,whereas they have high levels of lysine,thiamine,calcium and iron.Baobab has numerous biological properties including antimicrobial,anti-malarial,diarrhoea,anaemia,asthma,antiviral,anti-oxidant and anti-inflammatory activities amongst others.Phytochemical investigation revealed the presence of flavonoids.phytosterols.amino acids,fatty acids,vitamins and minerals.The review summarizes the information on various aspects of traditional information,taxonomic description,medicinal properties and importantly nutritional value. | Jitin Rahul Manish Kumar Jain Shishu Pal Singh Rakesh Kant Kama Anuradha Aliya Naz Anup Kumar Gupta Sujeet Kumar Mrityunjay | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，1： | 4 |
| 4 | Protective effect of diosmin against diabetic neuropathy in experimental rats显示文摘OBJECTIVE:The present study was undertaken to evaluate the effect of diosmin in diabetic neuropathy in type 2 diabetic rats.METHODS:Type 2 diabetes was induced in male Sprague-Dawley rats by single intraperitoneal injection of streptozotocin(35 mg/kg) and high-fat diet.Four weeks after the confirmation of diabetes,diabetic rats were treated with diosmin(50 and 100 mg/kg,p.o.) for next 4 weeks.Rats were evaluated for biochemical,behavioral and oxidative stress parameters.Eddy's hot plate and tail immersion test were performed on 6th,7th,8th,9th and 10th weeks of experiment to assess thermal hyperalgesia and cold allodynia respectively.Further,the walking function test was performed for assessing the motor responses at the end of the treatment schedule.RESULTS:Rats were fed with high-fat diet throughout the experiment schedule and administration of low-dose streptozotocin induced significant elevation in blood glucose level and insulin resistance which was confirmed by oral glucose tolerance test.Treatment with diosmin at doses of 50 and 100 mg/kg significantly restored the reduced body weight,elevated blood sugar and lipid profiles.Further the dose-dependent improvement was observed in thermal hyperalgesia,cold allodynia and walking function in diabetic rats treated with diosmin.Elevated levels of malondialdehyde,and nitric oxide and decreased glutathione levels and superoxide dismutase activity in diabetic rats were restored significantly after the 4 weeks of diosmin treatment.CONCLUSION:Diosmin has shown beneficial effect in preventing the progression of early diabetic neuropathy in rats. | Dilpesh Jain Manish Kumar Bansal Rahul Dalvi Aman Upganlawar Rahul Somani | 2014 | Journal of Integrative Medicine2014，12，1： | 4 |
| 5 | Inflammatory cytokine IL-10 polymorphism in patients of ulcerative colitis and irritable bowel syndrome显示文摘 | Manish Kumar Tripathi Ashok Kumar Jain Vinod Kumar Dixit | 2013 | Journal of Clinical and Experimental Hepatology2013，13，1： | 1 |
| 6 | Role of interstitial cells of Cajal in motility disorders of the bowel显示文摘 | Dhanpat Jain Khalid Moussa Manish Tandon Joan Culpepper-Morgan Deborah D Proctor | 2003 | The American Journal of Gastroenterology2003，，3： | 1 |
| 7 | Cloning, Characterization of Pichia etchellsii β-Glucosidase II and Effect of Media Composition and Feeding Strategy on its Production in a Bioreactor显示文摘 | Benu Sethi Monika Jain Manish Chowdhary | 2002 | Biotechnology and Bioprocess Engineering2002，7，： | 1 |
| 8 | Biodegradation of Allethrin, a Pyrethroid Insecticide, by an Acidomonas Sp.显示文摘 | Mandar Paingankar Manish Jain Dileep Deobagkar | 2005 | Biotechnology Letters (-)2005，，23： | 1 |
| 9 | End - to - end estimation of the available bandwidth variation range显示文摘 | Manish Jain Constantinos Dovrolis | 2005 | ACM Press2005，，： | 1 |
| 10 | Pigtail stents: An alternative in the treatment of difficult bile duct stones显示文摘 | Sushil K. Jain Robert Stein Manish Bhuva Michael J. Goldberg | 2000 | Gastrointestinal Endoscopy2000，，4： | 1 |
| 11 | Modeling of electrical energy consumption in Delhi显示文摘 | Manish Ranjan Jain V K | 1999 | Energy1999，24，： | 1 |
| 12 | Electronic structure and spin polarization of Mn-containing dilute magnetic Ⅲ-Ⅴ semiconductors显示文摘 | Jain Manish Kronik Leeor | 2001 | Phys Rev B2001，64，24： | 1 |
| 13 | Role of interstitial cells of Cajal in motility disorders of the bowel显示文摘 | Dhanpat Jain Khalid Moussa Manish Tandon Joan Culpepper-Morgan Deborah D Proctor | 2003 | The American Journal of Gastroenterology2003，，3： | 1 |
| 14 | Influence of cohesion on California bearing ratio of clay-gravel mixtures显示文摘An understanding of the behavior of cohesive sediment is required to solve various engineering problems such as scour around bridge elements,mitigation of soil erosion,pavement design,river bed degradation,stable channel design.Pavement foundation designers principally use the California bearing ratio(CBR)to describe the subgrade and subbase materials and their strength.Several laboratory experiments were done to study the variation in the CBR of cohesive mixtures comprised of clay-gravel mixtures.Nine different clay-gravel mixtures were used in which the clay content varies from 10%to 50%by weight.The variation of the CBR with clay percentage,moisture content,and undrained shear strength parameters was studied.The CBR value reduces with the increase in the moisture content and clay fraction in the mixtures and increases with an increase in the dry density of the mixture under unsoaked conditions.The CBR also increases with the increase of the angle of internal friction of clay-gravel mixtures.A functional relation has been identified to estimate the CBR of clay-gravel mixtures.Using multiple linear regression analysis(MLRA),a relation is proposed to estimate the CBR of clay-gravel mixtures under unsoaked conditions.A statistical analysis was done to judge the behavior of the pertinent variables on the CBR.The proposed relation predicts the CBR of clay-gravel mixtures very well.Artificial neural network(ANN)analysis using R programming was also done to determine the effects of the pertinent variables on the CBR.ANN methodology was applied to predict the contribution of each variable.Three different methods:Garson algorithm,Olden algorithm,and Lek's profile model are used to assess the influence of variable parameters.The Olden algorithm and Lek's profile both show positive association of cohesion with CBR in an unsoaked condition.The role of moisture content was found to be marginally negative in the Olden algorithm and Lek's profile results.It is found that both the ANN and MLRA models are accurate in predicting the CBR of clay-gravel mixtures.It was further found that the MLRA and ANN models are reliable and rapid tools for correct assessment of the CBR of cohesive soil mixtures using the basic soil properties. | Rajesh Jain Ketan Timani Manish Pandey | 2023 | International Journal of Sediment Research2023，38，3： | 0 |
| 15 | Tongue thickness in health vs cirrhosis of the liver:Prospective observational study显示文摘BACKGROUNDMalnutrition affects 40%-90% of patients with cirrhosis of the liver. L3 skeletalmuscle index (L3SMI) is presently accepted as the most objective and quantitativemeasure available for sarcopenia, a surrogate marker of malnutrition. L3SMIapplication is, however, limited by non-availability of computed tomographyscanning in remote areas, cost, need for extensive training, and the risk ofexposure to radiation. Therefore, an alternative dependable measure with wideravailability is needed. Malnutrition causes sarcopenia not only in skeletal musclesbut also in other muscular structures such as the psoas muscle, diaphragm andtongue. We therefore hypothesised that the tongue, being easily accessible forinspection and for measurement of thickness using ultrasonography, may be usedto document sarcopenia.AIMTo measure and compare tongue thickness in healthy individuals and in patientswith cirrhosis of the liver and to study its correlation with conventionalprognostic scores for patients with cirrhosis of the liver.METHODSTongue thickness was measured using ultrasonography. One hundred twentysubjects of either gender aged 18 to 65 years were studied, with 30 subjects in eachgroup. The tongue thickness was compared between groups based on “ChildTurcotte Pugh” (CTP) scores. The correlations between measured tonguethickness and “Model for end stage liver disease” (MELD) score and between age and measured tongue thickness were also assessed.RESULTSMean tongue thickness (mean ± SD) in patients with CTP class A, B and C was4.39 ± 0.39 cm, 4.19 ± 0.53 cm, and 3.87 ± 0.42, respectively, and was 4.33 ± 0.49 cmin normal healthy individuals. Significant differences were seen in tonguethickness between patients with CTP class C and those with CTP class A and B (P< 0.05). Patients with CTP class C also had a significantly reduced tonguethickness than normal individuals (P < 0.05). However, no significant differencewas seen in tongue thickness between patients with CTP class A and B andnormal individuals. A statistically significant, negative correlation was foundbetween MELD score and tongue thickness (r = -0.331) (P < 0.001). No correlationwas observed between L3SMI and MELD score (r = 0.074, P = 0.424). L3SMI(mean ± SD) in healthy subjects was 39.66 ± 6.8 and was 38.26 ± 8.88 in patientswith CTP class C, and the difference was not significant. No significant correlationwas found between age of the patients and tongue thickness. Intra-classcorrelation coefficient was used to determine the reliability of the tonguethickness measurements. The intra-class correlation coefficient was 0.984 (95%CI:0.979-0.989) and was indicative of good reliability.CONCLUSIONTongue thickness measured by ultrasonography, correlates significantly with theseverity of liver disease, as assessed by CTP and MELD scores. The patients with aCTP score ≥ 10 have significantly reduced tongue thickness as compared tonormal individuals and those with less severe liver disease and CTP scores of 5-9.No significant difference in tongue thickness was found between healthyindividuals and CTP class A and B patients. | Manish Tandon Harshita Singh Nishant Singla Priyanka Jain Chandra Kant Pandey | 2020 | World Journal of Gastrointestinal Pharmacology and Therapeutics2020，11，3： | 0 |
| 16 | Artificial neural network based modeling of liquid membranes for separation of dysprosium显示文摘In recent years,the liquid membrane process has been widely investigated to remove rare earth metals.However,transport modeling of this process requires the accurate values of several parameters,which are difficult to measure.Thus,the accurate simulation of this process is a challenging task.In this study,the artificial neural network(ANN)based approach is used to model the liquid membrane process for removing dysprosium.Experimental results from a previous study were used to train the ANN.Initially,the number of neurons in the hidden layer was optimized.The minimum mean squared error between experimental results and model predictions is found with ten neurons.Model predictions were successfully validated with experimental results with correlation factor(R)of 0.9987,which confirms the authenticity of the trained network.Trained ANN was then used to study the effects of different operating parameters on transport rate.The higher volume ratio of membrane solution to feed solution(3-4)with 50-60 min of operation,higher feed pH(5),HCl concentration in stripping solution of 2 mol/L,and moderate concentration of carrier species(0.5 mol/L)with 0.5×10^(-4) mol/L dysprosium initial concentration are found to be optimum values of operating conditions for maximizing the transport rate. | Jawad Iqbal Arjun Tyagi Manish Jain | 2023 | Journal of Rare Earths2023，41，3： | 0 |
| 17 | Exciton fine structure in twisted transition metal dichalcogenide heterostructures显示文摘Moirésuperlattices of transition metal dichalcogenide(TMD)heterostructures give rise to rich excitonic phenomena associated with the interlayer twist angle.Theoretical calculations of excitons in such systems are typically based on model moirépotentials that mitigate the computational cost.However,predictive understanding of the electron-hole coupling dominating the excitations is crucial to realize the twist-induced modifications of the optical selection rules.In this work,we use many-body perturbation theory to evaluate the relation between twist angle and exciton properties in TMD heterostructures.We present an approach for unfolding excitonic states from the moiréBrillouin zone onto the separate-layer ones.Applying this method to a large-angle twisted MoS^(2)/MoSe^(2) bilayer,we find that the optical spectrum is dominated by mixed electron–hole transitions with different momenta in the separate monolayers,leading to unexpected hybridization between interlayer and intralayer excitons.Our findings offer a design pathway for exciton layer-localization in TMD heterostructures. | Sudipta Kundu Tomer Amit H.R.Krishnamurthy Manish Jain Sivan Refaely-Abramson | 2023 | npj Computational Materials2023，，1： | 0 |
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