|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Exercise-induced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism显示文摘Irisin is a polypeptide hormone derived from the proteolytic cleavage of fibronectin-type III domaincontaining 5(FNDC5) protein. Once released to circulation upon exercise or cold exposure, irisin stimulates browning of white adipose tissue(WAT) and uncoupling protein 1(UCP1) expression, leading to an increase in total body energy expenditure by augmented UCP1-mediated thermogenesis. It is currently unknown whether irisin is secreted by bone upon exercise or whether it regulates bone metabolism in vivo. In this study, we found that 2 weeks of voluntary wheel-running exercise induced high levels of FNDC5 messenger RNA as well as FNDC5/irisin protein expression in murine bone tissues. Increased immunoreactivity due to exercise-induced FNDC5/irisin expression was detected in different regions of exercised femoral bones,including growth plate, trabecular bone, cortical bone, articular cartilage, and bone–tendon interface. Exercise also increased expression of osteogenic markers in bone and that of UCP1 in WAT, and led to bodyweight loss. Irisin intraperitoneal(IP) administration resulted in increased trabecular and cortical bone thickness and osteoblasts numbers, and concurrently induced UCP1 expression in subcutaneous WAT. Lentiviral FNDC5 IP administration increased cortical bone thickness. In vitro studies in bone cells revealed irisin increases osteoblastogenesis and mineralization, and inhibits receptor activator of nuclear factor-k B ligand(RANKL)-induced osteoclastogenesis. Taken together, our findings show that voluntary exercise increases irisin production in bone, and that an increase in circulating irisin levels enhances osteogenesis in mice. | Jin Zhang Paloma Valverde Xiaofang Zhu Dana Murray Yuwei Wu Liming Yu Hua Jiang Michel M Dard Jin Huang Zhiwei Xu Qisheng Tu Jake Chen | 2017 | Bone Research2017，5，1： | 23 |
| 2 | Resistance to Aspergillus flavus in maize and peanut:Molecular biology, breeding, environmental stress,and future perspectives显示文摘The colonization of maize(Zea mays L.) and peanut(Arachis hypogaea L.) by the fungal pathogen Aspergillus flavus results in the contamination of kernels with carcinogenic mycotoxins known as aflatoxins leading to economic losses and potential health threats to humans. The regulation of aflatoxin biosynthesis in various Aspergillus spp. has been extensively studied, and has been shown to be related to oxidative stress responses. Given that environmental stresses such as drought and heat stress result in the accumulation of reactive oxygen species(ROS) within host plant tissues, host-derived ROS may play an important role in cross-kingdom communication between host plants and A. flavus. Recent technological advances in plant breeding have provided the tools necessary to study and apply knowledge derived from metabolomic, proteomic, and transcriptomic studies in the context of productive breeding populations. Here, we review the current understanding of the potential roles of environmental stress, ROS, and aflatoxin in the interaction between A.flavus and its host plants, and the current status in molecular breeding and marker discovery for resistance to A. flavus colonization and aflatoxin contamination in maize and peanut. We will also propose future directions and a working model for continuing research efforts linking environmental stress tolerance and aflatoxin contamination resistance in maize and peanut. | Jake C.Fountain Pawan Khera Liming Yang Spurthi N.Nayak Brian T.Scully Robert D.Lee Zhi-Yuan Chen Robert C.Kemerait Rajeev K.Varshney Baozhu Guo | 2015 | The Crop Journal2015，3，3： | 3 |
| 3 | Temperature Responses to Infrared-Loading and Water Table Manipulations in Peatland Mesocosms显示文摘We initiated a multi-factor global change experiment to explore the effects of infrared heat loading (HT) and water table level (WL) treatment on soil temperature (T) in bog and fen peatland mesocosms.We found that the temperature varied highly by year,month,peatland type,soil depth,HT and WL manipulations.The highest effect of HT on the temperature at 25 cm depth was found in June for the bog mesocosms (3.34–4.27 ?C) but in May for the fen mesocosms (2.32–4.33 ?C) over the 2-year study period.The effects of WL in the bog mesocosms were only found between August and January,with the wet mesocosms warmer than the dry mesocosms by 0.48–2.03 °C over the 2-year study period.In contrast,wetter fen mesocosms were generally cooler by 0.16–3.87 °C.Seasonal changes of temperatures elevated by the HT also varied by depth and ecosystem type,with temperature differences at 5 cm and 10 cm depth showing smaller seasonal fluctuations than those at 25 cm and 40 cm in the bog mesocosms.However,increased HT did not always lead to warmer soil,especially in the fen mesocosms.Both HT and WL manipulations have also changed the length of the non-frozen season. | Jiquan Chen Scott Bridgham Jason Keller John Pastor Asko Noormets Jake F.Weltzin | 2008 | Journal of Integrative Plant Biology2008，50，11： | 2 |
| 4 | Critical-size calvarial bone defects healing in a mouse model with silk scaffolds and SATB2-modified iPSCs显示文摘 | Jin-Hai Ye Yuan-Jin Xu Jun Gao Shi-Guo Yan Jun Zhao Qisheng Tu Jin Zhang Xue-Jing Duan Cesar A. Sommer Gustavo Mostoslavsky David L. Kaplan Yu-Nong Wu Chen-Ping Zhang Lin Wang Jake Chen | 2011 | Biomaterials2011，，22： | 1 |
| 5 | The Effects of Infrared Loading and Water Table on Soil Energy Fluxes in Northern Peatlands显示文摘 | Asko Noormets Jiquan Chen Scott D. Bridgham Jake F. Weltzin John Pastor Brad Dewey James LeMoine | 2004 | Ecosystems2004，，5： | 1 |
| 6 | 小鼠诱导性多能干细胞诱导成骨分化的初步研究显示文摘目的:研究小鼠诱导性多能干细胞(induced pluripotent stem cells,i PSCs)向成骨细胞分化的能力,并观察Osterix对i PSCs成骨分化能力的影响。方法:利用体外细胞培养和病毒转染的方法,结合定量RT-PCR以及组织化学的方法检测在成骨诱导的条件下,i PSCs中成骨相关基因、蛋白的表达变化。结果:小鼠i PSCs经悬滴培养可以形成拟胚体,在成骨诱导条件下可以向成骨细胞分化。病毒转染并不影响i PSCs的多向分化潜能;与对照组相比,转染Osterix的i PSCs形成的矿化结节、碱性磷酸酶活性、成骨相关基因的表达均有明显增加(P<0.05)。结论:在成骨诱导液培养条件下,小鼠i PSCs可以作为种子细胞向成骨细胞分化,并且过表达转录因子Osterix可以进一步促进i PSCs的成骨分化。 | 钱浩 徐增琦 李杨 徐镭 程杰 江宏兵 吴煜农 Jake Chen 叶金海 | 2015 | 口腔生物医学2015，6，4： | 1 |
| 7 | Peak‐fitting analysis of cotton fiber powder X-ray diffraction spectra显示文摘 | Chen R Jakes K A Foreman D W | 2004 | Journal of Applied Polymer Science2004，93，5： | 1 |
| 8 | HCV Infection Induces a Unique Hepatic Innate Immune Response Associated With Robust Production of Type III Interferons显示文摘 | Emmanuel Thomas Veronica D. Gonzalez Qisheng Li Ankit A. Modi Weiping Chen Mazen Noureddin Yaron Rotman T. Jake Liang | 2012 | Gastroenterology2012，，4： | 1 |
| 9 | Peak-fitting analysis of cotton fiber powder X-ray diffraction spectra显示文摘 | R Chen K A Jakes D W Foreman | 2004 | Journal of Applied Polymer Science2004，93，： | 1 |
| 10 | Pathway and network analysis in proteomics显示文摘 | Xiaogang Wu Mohammad Al Hasan Jake Yue Chen | 2014 | Journal of Theoretical Biology2014，，： | 1 |
| 11 | Peak-fitting analysis of cotton fiber powder X-ray diffraction spectra显示文摘 | CHEN R JAKES K A FOREMAN D W | 2004 | Journal of Applied Polymer Science2004，，93： | 1 |
| 12 | A ribosomal gene panel predicting a novel synthetic lethality in non-BRCAness tumors显示文摘Poly(ADP-ribose)polymerase(PARP)inhibitors are one of the most exciting classes of targeted therapy agents for cancers with homologous recombination(HR)deficiency.However,many patients without apparent HR defects also respond well to PARP inhibitors/cisplatin.The biomarker responsible for this mechanism remains unclear.Here,we identified a set of ribosomal genes that predict response to PARP inhibitors/cisplatin in HR-proficient patients.PARP inhibitor/cisplatin selectively eliminates cells with high expression of the eight genes in the identified panel via DNA damage(ATM)signaling-induced pro-apoptotic ribosomal stress,which along with ATM signaling-induced pro-survival HR repair constitutes a new model to balance the cell fate in response to DNA damage.Therefore,the combined examination of the gene panel along with HR status would allow for more precise predictions of clinical response to PARP inhibitor/cisplatin.The gene panel as an independent biomarker was validated by multiple published clinical datasets,as well as by an ovarian cancer organoids library we established.More importantly,its predictive value was further verified in a cohort of PARP inhibitor-treated ovarian cancer patients with both RNA-seq and WGS data.Furthermore,we identified several marketed drugs capable of upregulating the expression of the genes in the panel without causing HR deficiency in PARP inhibitor/cisplatin-resistant cell lines.These drugs enhance PARP inhibitor/cisplatin sensitivity in both intrinsically resistant organoids and cell lines with acquired resistance.Together,our study identifies a marker gene panel for HR-proficient patients and reveals a broader application of PARP inhibitor/cisplatin in cancer therapy. | Chao Zhang Qiang Guo Lifeng Chen Zheming Wu Xiao-Jian Yan Chengyang Zou Qiuxue Zhang Jiahong Tan Tian Fang Qunxian Rao Yang Li Shizhen Shen Min Deng Liewei Wang Huanyao Gao Jia Yu Hu Li Cheng Zhang Somaira Nowsheen Jake Kloeber Fei Zhao Ping Yin Chunbo Teng Zhongqiu Lin Kun Song Shuzhong Yao Liangqing Yao Lingying Wu Yong Zhang Xiaodong Cheng Qinglei Gao Jian Yuan Zhenkun Lou Jin-San Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 13 | Special topic-Fisheries monitoring:Eyes in the ocean:Innovative and multidimensional solutions to monitor fisheries显示文摘In the era of climate change,the visibility of environmental changes dictates public attention.Pictures of untamable bushfires,intense hurricanes,collapsing ice sheets are all gripping images that alarm us and urge us to take action.The ocean,however,gives us less such visuals;the changes that are taking place there are often abstract and hidden.However,the environmental challenges in the ocean are less visible but no less grave;they come from multiple sources:pollution,plastic waste,ocean surface warming,ocean acidification(IPCC,2019).But the most direct and age-old impact we exert on the ocean and its ecosystems is overfishing(FAO,2018). | Bowen Chang Shu Su Chongliang Zhang Yiping Ren Xiujuan Shan Jake Kritzer Yong Chen | 2020 | Aquaculture and Fisheries2020，5，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员