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| 1 | 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions显示文摘 | Glenn N. Levine Eric R. Bates James C. Blankenship Steven R. Bailey John A. Bittl Bojan Cercek Charles E. Chambers Stephen G. Ellis Robert A. Guyton Steven M. Hollenberg Umesh N. Khot Richard A. Lange Laura Mauri Roxana Mehran Issam D. Moussa Debabrata Mu | 2011 | Circulation2011，，23： | 3 |
| 2 | AMP-Activated Protein Kinase Induces a p53-Dependent Metabolic Checkpoint显示文摘 | Russell G. Jones David R. Plas Sara Kubek Monica Buzzai James Mu Yang Xu Morris J. Birnbaum Craig B. Thompson | 2005 | Molecular Cell2005，，3： | 3 |
| 3 | Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)显示文摘 | Han Cho James Mu Jason K | 2001 | Science2001，292，5522： | 1 |
| 4 | Reinstalling antitumor immunity by inhibiting tumor-derived immunosuppressive molecule IDO through RNA interferencel显示文摘 | Zheng XF James K Mu Li | 2006 | J Immunol2006，177，： | 1 |
| 5 | Nanoparticle-based monitoring of cell therapy显示文摘 | Chenjie Xu Luye Mu Isaac Roes David Miranda-Nieves Matthias Nahrendorf James A Ankrum Weian Zhao Jeffrey M Karp | 2011 | Nanotechnology2011，，49： | 1 |
| 6 | Prevalence of Dry Eye Among the Elderly显示文摘 | OLIVER D. SCHEIN BEATRIZ MU?Oz JAMES M. TIELSCH KAREN BANDEEN-Roche SHEILA WEST | 1997 | American Journal of Ophthalmology1997，，6： | 1 |
| 7 | Impact of selected combinations of non-thermal processing technologies on the quality of an apple and cranberry juice blend显示文摘 | Irene M. Caminiti Francesco Noci Arantxa Mu?oz Paul Whyte Desmond J. Morgan Denis A. Cronin James G. Lyng | 2010 | Food Chemistry2010，，4： | 1 |
| 8 | 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions显示文摘 | Glenn N. Levine Eric R. Bates James C. Blankenship Steven R. Bailey John A. Bittl Bojan Cercek Charles E. Chambers Stephen G. Ellis Robert A. Guyton Steven M. Hollenberg Umesh N. Khot Richard A. Lange Laura Mauri Roxana Mehran Issam D. Moussa Debabrata Mu | 2011 | Circulation2011，，23： | 1 |
| 9 | Chronic inhibition of dipeptidylpeptidase-4 with a sitagliptin analog preserves pancreatic, p-cell mass and function in a rodent model of type 2 diabetes显示文摘 | James MU John W Yun PZ | 2006 | Diabetes2006，55，6： | 1 |
| 10 | Common Variants in Epithelial Sodium Channel Genes Contribute to Salt Sensitivity of Blood Pressure: The GenSalt Study显示文摘 | Qi Zhao Dongfeng Gu James E. Hixson De-Pei Liu Dabeeru C. Rao Cashell E. Jaquish Tanika N. Kelly Fanghong Lu Jixiang Ma Jianjun Mu Lawrence C. Shimmin Jichun Chen Hao Mei L. Lee Hamm Jiang He | 2011 | Circulation: Cardiovascular Genetics2011，，4： | 1 |
| 11 | Genetic variants in the renin–angiotensin–aldosterone system and salt sensitivity of blood pressure显示文摘 | Dongfeng Gu Tanika N Kelly James E Hixson Jing Chen Depei Liu Ji-chun Chen Dabeeru C Rao Jianjun Mu Jixiang Ma Cashell E Jaquish Treva K Rice Charles Gu Lee Hamm Paul K Whelton Jiang He | 2010 | Journal of Hypertension2010，，6： | 1 |
| 12 | Mutations in the Myosin VIIA Gene Cause a Wide Phenotypic Spectrum, Including Atypical Usher Syndrome显示文摘 | Xue-Zhong Liu Carolyn Hope James Walsh Valerie Newton Xiao Mei Ke Chuan Yu Liang Li Ron Xu Jiu Mu Zhou Dorothy Trump Karen P. Steel Sarah Bundey Steve D.M. Brown | 1998 | The American Journal of Human Genetics1998，，3： | 1 |
| 13 | Chronic inhibition of dipepti- dyl peptidase-4 with a sitagliptin analog preserves pancreatic β - cell mass and function in a rodent model of type 2 diabetes 显示文摘 | Mu James Woods J Zhou YP | 2006 | Di- abetes2006，55，： | 1 |
| 14 | Genetic variants in the renin–angiotensin–aldosterone system and blood pressure responses to potassium intake显示文摘 | Jiang He Dongfeng Gu Tanika N. Kelly James E. Hixson Dabeeru C. Rao Cashell E. Jaquish Jing Chen Qi Zhao Chi Gu Jianfeng Huang Lawrence C. Shimmin Ji-Chun Chen Jianjun Mu Xu Ji De-Pei Liu Paul K. Whelton | 2011 | Journal of Hypertension2011，，9： | 1 |
| 15 | AMP-Activated Protein Kinase Induces a p53-Dependent Metabolic Checkpoint显示文摘 | Russell G. Jones David R. Plas Sara Kubek Monica Buzzai James Mu Yang Xu Morris J. Birnbaum Craig B. Thompson | 2005 | Molecular Cell2005，，3： | 1 |
| 16 | Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2(PKBbeta)显示文摘 | Han Cho James Mu Janson K | 2001 | Science2001，，： | 1 |
| 17 | Reinstalling anti-tumor immunity by inhibiting tumor-deived immunosuppressive molecule IDO through RNA interferencel显示文摘 | ZHENG X F JAMES K MU L I | 2006 | J Immunol2006，17，7： | 1 |
| 18 | Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic β cell mass and function in a rodent model of type 2 diabetes显示文摘 | Mu James Woods J Zhou YP | | 0，，： | 1 |
| 19 | Adapting the endoplasmic reticulum proteostasis rescues epilepsy-associated NMDA receptor variants显示文摘The GRIN genes encoding N-methyl-D-aspartate receptor(NMDAR)subunits are remarkably intolerant to variation.Many pathogenic NMDAR variants result in their protein misfolding,inefficient assembly,reduced surface expression,and impaired function on neuronal membrane,causing neurological disorders including epilepsy and intellectual disability.Here,we investigated the proteostasis maintenance of NMDARs containing epilepsy-associated variations in the GluN2A subunit,including M705V and A727T.In the transfected HEK293T cells,we showed that the two variants were targeted to the proteasome for degradation and had reduced functional surface expression.We demonstrated that the application of BIX,a known small molecule activator of an HSP70 family chaperone BiP(binding immunoglobulin protein)in the endoplasmic reticulum(ER),dose-dependently enhanced the functional surface expression of the M705V and A727T variants in HEK293T cells.Moreover,BIX(10μM)increased the surface protein levels of the M705V variant in human iPSC-derived neurons.We revealed that BIX promoted folding,inhibited degradation,and enhanced anterograde trafficking of the M705V variant by modest activation of the IRE1 pathway of the unfolded protein response.Our results suggest that adapting the ER proteostasis network restores the folding,trafficking,and function of pathogenic NMDAR variants,representing a potential treatment for neurological disorders resulting from NMDAR dysfunction. | Pei-pei Zhang Taylor M.Benske Lucie Y.Ahn Ashleigh E.Schaffer James C.Paton Adrienne W.Paton Ting-wei Mu Ya-juan Wang | 2024 | Acta Pharmacologica Sinica2024，45，2： | 0 |
| 20 | A spatially distributed,deterministic approach to modeling Typha domingensis(cattail)in an Everglades wetland显示文摘Introduction:The emergent wetland species Typha domingensis(cattail)is a native Florida Everglades monocotyledonous macrophyte.It has become invasive due to anthropogenic disturbances and is out-competing other vegetation in the region,especially in areas historically dominated by Cladium jamaicense(sawgrass).There is a need for a quantitative,deterministic model in order to accurately simulate the regional-scale cattail dynamics in the Everglades.Methods:The Regional Simulation Model(RSM),combined with the Transport and Reaction Simulation Engine(TARSE),was adapted to simulate ecology.This provides a framework for user-defineable equations and relationships and enables multiple theories with different levels of complexity to be tested simultaneously.Five models,or levels,of increasing complexity were used to simulate cattail dynamics across Water Conservation Area 2A(WCA2A),which is located just south of Lake Okeechobee,in Florida,USA.These levels of complexity were formulated to correspond with five hypotheses regarding the growth and spread of cattail.The first level of complexity assumed a logistic growth pattern to test whether cattail growth is density dependent.The second level of complexity built on the first and included a Habitat Suitability Index(HSI)factor influenced by water depth to test whether this might be an important factor for cattail expansion.The third level of complexity built on the second and included an HSI factor influenced by soil phosphorus concentration to test whether this is a contributing factor for cattail expansion.The fourth level of complexity built on the third and included an HSI factor influenced by(a level 1–simulated)sawgrass density to determine whether sawgrass density impacted the rate of cattail expansion.The fifth level of complexity built on the fourth and included a feedback mechanism whereby the cattail densities influenced the sawgrass densities to determine the impact of inter-species interactions on the cattail dynamics.Results:All the simulation results from the different levels of complexity were compared to observed data for the years 1995 and 2003.Their performance was analyzed using a number of different statistics that each represent a different perspective on the ecological dynamics of the system.These statistics include box-plots,abundance-area curves,Moran’s I,and classified difference.The statistics were summarized using the Nash-Sutcliffe coefficient.The results from all of these comparisons indicate that the more complex level 4 and level 5 models were able to simulate the observed data with a reasonable degree of accuracy.Conclusions:A user-defineable,quantitative,deterministic modeling framework was introduced and tested against various hypotheses.It was determined that the more complex models(levels 4 and 5)were able to adequately simulate the observed patterns of cattail densities within the WCA2A region.These models require testing for uncertainty and sensitivity of their various parameters in order to better understand them but could eventually be used to provide insight for management decisions concerning the WCA2A region and the Everglades in general. | Gareth Lagerwall Gregory Kiker Rafael Muñoz-Carpena Matteo Convertino Andrew James Naiming Wang | 2012 | Ecological Processes2012，1，1： | 0 |
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