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| 1 | Circulating inflammatory factors associated with worse long-term prognosis in colorectal cancer显示文摘AIM To investigate association of circulating inflammatory factors at the time of colorectal cancer(CRC) surgery with survival.METHODS Plasma levels from 174 CRC patients(69 females and 105 men), with median age 70 years(range 29-90), localized in the colon(n = 105) or rectum(n = 69), with stage Ⅰ(n = 24), stage Ⅱ(n = 54), stage Ⅲ(n = 67) and stage Ⅳ(n = 29) were measured using commercially available Bio-Plex Pro? Human Chemokine Panel 40-Plex, including 40 different chemokines, cytokines and interleukins. The prognostic association of each inflammatory factor was analysed as CRC-specific and total mortality.RESULTS Out of 174 patients, 66 died during the follow-up, 40 because of CRC specific mortality. High tertile levels of 8 factors were significantly associated with increased CRC-specific mortality, of which CCL1, CCL20, CCL24, CX3CL1, IL-4 and TNF-α remained significant in a multivariate Cox regression analysis. High tertile levels of 14 factors were associated with increased total mortality, of which CCL1, CCL15, CCL20, CX3CL1, CXCL13, IFN-γ, IL-2, IL-4 and IL-10 remained significant after adjustment for clinical covariates. For most of the inflammatory factors the association between higher tertile levels and an increased mortality in general appeared two years after surgery. High tertile levels of TNF-α and CCL24 were exclusively associated with CRC-specific mortality. The distribution of these factors were not associated with TNM stage with exception for CCL20.CONCLUSION High plasma levels of inflammatory factors are associated with increased risk of mortality among CRC patients and could be potential biomarkers for revealing prognosis. | Renate S Olsen Johnny Nijm Roland E Andersson Jan Dimberg Dick Wagsater | 2017 | World Journal of Gastroenterology2017，23，34： | 8 |
| 2 | Association of gene and protein expression and genetic polymorphism of CC chemokine ligand 4 in colorectal cancer显示文摘BACKGROUND Leukocytes,such as T cells and macrophages,play an important role in tumorigenesis.CC chemokine ligand(CCL)4,which is produced by lymphocytes and macrophages,has been found to be expressed in the mucosa of the gastrointestinal tract and is a potent chemoattractant for various leukocytes.AIM To examine CCL4 expression and its genetic polymorphism rs10491121 in patients with colorectal cancer(CRC)and evaluate their prognostic significance.METHODS Luminex technology was used to determine CCL4 Levels in CRC tissue(n=98),compared with paired normal tissue,and in plasma from patients with CRC(n=103),compared with healthy controls(n=97).Included patients had undergone surgical resection for primary colorectal adenocarcinomas between 1996 and 2019 at the Department of Surgery,Ryhov County Hospital,Jönköping,Sweden.Reverse transcription quantitative PCR was used to investigate the CCL4 gene expression in CRC tissue(n=101).Paired normal tissue and TaqMan single nucleotide polymorphism assays were used for the CCL4 rs10491121 polymorphism in 610 CRC patients and 409 healthy controls.RESULTS The CCL4 protein and messenger RNA expression levels were higher in CRC tissue than in normal paired tissue(90%,P<0.001 and 45%,P<0.05,respectively).CRC tissue from patients with localized disease had 2.8-fold higher protein expression levels than that from patients with disseminated disease.Low CCL4 protein expression levels in CRC tissue were associated with a 30%lower cancer-specific survival rate in patients(P<0.01).The level of plasma CCL4 was 11%higher in CRC patients than in healthy controls(P<0.05)and was positively correlated(r=0.56,P<0.01)with the CCL4 protein level in CRC tissue.The analysis of CCL4 gene polymorphism rs10491121 showed a difference(P<0.05)between localized disease and disseminated disease in the right colon,with a dominance of allele A in localized disease.Moreover,the rate of the A allele was higher among CRC patients with mucinous cancer than among those with nonmucinous cancer.CONCLUSION The present study indicates that the CRC tissue levels of CCL4 and CCL4 gene polymorphism rs10491121,particularly in the right colon,are associated with clinical outcome in CRC patients. | Levar Shamoun Kalle Landerholm Amanda Balboa Ramilo Roland E Andersson Jan Dimberg Dick Wågsäter | 2021 | World Journal of Gastroenterology2021，27，30： | 2 |
| 3 | An Arbitrary La- grangian-eulerian Finite-volume Method for the Simulation of Rotary Displacement Pump Flow 显示文摘 | Kris Riemslagh Jan Vierendeels Erik Dick | 2000 | Applied Numerical Mathematics2000，，32： | 1 |
| 4 | The developing cancer stem-cell model: clinical challenges and opportunities显示文摘 | Louis Vermeulen Felipe de Sousa e Melo Dick J Richel Jan Paul Medema | 2012 | Lancet Oncology2012，，： | 1 |
| 5 | Flow simulations in rotary volumetric pumps and compressors with the fictitous domain method 显示文摘 | John Vande Voorde Jan Vierendeels Erik Dick | 2004 | Journal of Computational and Applied Mathematics2004，，168： | 1 |
| 6 | Model for the spontaneous heating of coal显示文摘 | Schmal Dick Duyzer Jan H Ven Heuven | 1985 | Fuel1985，64，7： | 1 |
| 7 | Bio-deposition of a calcium carbonate layer on degraded limestone by Bacillus species显示文摘 | Jan Dick Wim Windt Bernard Graef Hans Saveyn Paul Meeren Nele Belie Willy Verstraete | 2006 | Biodegradation2006，，4： | 1 |
| 8 | Bio - deposition of a calcium carbonate layer on degraded limestone by Bacillus species 显示文摘 | Jan Dick Wire De Windt | 2006 | Biodegradation2006，17，： | 1 |
| 9 | Gene delivery by cationic lipid vectors: overcoming cellular barriers显示文摘 | Inge S. Zuhorn Jan B. F. N. Engberts Dick Hoekstra | 2007 | European Biophysics Journal (-)2007，，4： | 1 |
| 10 | In Search of a Functional Flora-towards a Greater Integration of Ecology and Taxonomy显示文摘 | PENDRY COLIN A DICK JAN PULLAN MARTIN R | 2007 | Plant Ecology2007，192，： | 1 |
| 11 | Flow simulations in rotary volumetric pumps and compressors with the fictitious domain method显示文摘 | John Vande Voorde Jan Vierendeels Erik Dick | 2003 | Journal of Computational and Applied Mathematics2003，，1： | 1 |
| 12 | A Force-Based Grid Manipulator for ALE Calculations in a Lobe Pump显示文摘In this paper, a time-dependant calculation of flow in a lobe pump is presented. Calculations are performed using the arbitrary Lagrangean Eulerean (ALE) method. A grid manipulator is needed to move the nodes between time steps. The used grid manipulator is based on the pseudo-force idea. This means that each node is fictitiously cormeeted with its 8 neighbours via fictitious springs. The equilibrium of the resulting pseudo spring forces defines the altered position of the nodes. The grid manipulator was coupled with a commercial flow solver and the whole was tested on the flow through a three-lobe lobe pump. Results were obtained for a rotational speed of 460 rpm and incompressible silicon oil as fluid. | John Vande Voorde rug.ac.be Jan Vierendeels rug.ac.be Erik Dick rug.ac.be | 2003 | Journal of Thermal Science2003，12，4： | 1 |
| 13 | An arbitrary Lagrangian–Eulerian finite-volume method for the simulation of rotary displacement pump flow显示文摘 | Kris Riemslagh Jan Vierendeels Erik Dick | 2000 | Applied Numerical Mathematics2000，，4： | 1 |
| 14 | Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia after 36 weeks’ gestation (HYPITAT): a multicentre, open-label randomised controlled trial显示文摘 | Corine M Koopmans Denise Bijlenga Henk Groen Sylvia MC Vijgen Jan G Aarnoudse Dick J Bekedam Paul P van den Berg Karin de Boer Jan M Burggraaff Kitty WM Bloemenkamp Addy P Drogtrop Arie Franx Christianne JM de Groot Anjoke JM Huisjes Anneke Kwee Aren J va | 2009 | The Lancet2009，，9694： | 1 |
| 15 | Effect of the drug transporters ABCG2, Abcg2, ABCB1 and ABCC2 on the disposition, brain accumulation and myelotoxicity of the aurora kinase B inhibitor barasertib and its more active form barasertib-hydroxy-QPA显示文摘 | Serena Marchetti Dick Pluim Monique Eijndhoven Olaf Tellingen Roberto Mazzanti Jos H. Beijnen Jan H. M. Schellens | 2013 | Investigational New Drugs2013，，5： | 1 |
| 16 | Flow simulations in rotary volumetric pumps and compressors with the factitious domain method显示文摘 | John Vande Voorde Jan Vierendeels Erik Dick | 2004 | Journal of Computational and Applied Mathematics2004，，168： | 1 |
| 17 | T sw gene‐based resistance is triggered by a functional RNA silencing suppressor protein of the T omato spotted wilt virus显示文摘 | Dryas Ronde Patrick Butterbach Dick Lohuis Marcio Hedil Jan W. M. Lent Richard Kormelink | 2013 | Molecular Plant Pathology2013，，4： | 1 |
| 18 | Predictions of Spatially Averaged Cadmium Contents in Rice Grains in the Fuyang Valley, P.R. China显示文摘 | Brus Dick J Li Zhibo Song Jing Koopmans Gerwin F Temminghoff Erwin J M Yin Xuebin Yao Chunxia Zhang Haibo Luo Yongming Japenga Jan | 2009 | Journal of Environmental Quality2009，，3： | 1 |
| 19 | Regulation of cardiac long-chain fatty acid and glucose uptake by translocation of substrate transporters显示文摘 | Joost J. F. P. Luiken Susan L. M. Coort Debby P. Y. Koonen Dick J. Horst Arend Bonen Antonio Zorzano Jan F. C. Glatz | 2004 | Pflügers Archiv - European Journal of Physiology2004，，1： | 1 |
| 20 | Expression of CXCL16 in human rectal cancer显示文摘 | Dick W?gs?ter Anders Hugander Jan Dimberg | 2004 | International Journal of Molecular Medicine2004，，1： | 1 |
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