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| 1 | Sensory-motor responses to mechanical stimulation of the esophagus after sensitization with acid显示文摘AIM: Sensitization most likely plays an important role in chronic pain disorders, and such sensitization can be mimicked by experimental acid perfusion of the esophagus.The current study systematically investigated the sensory and motor responses of the esophagus to controlled mechanical stimuli before and after sensitization.METHODS: Thirty healthy subjects were included.Distension of the distal esophagus with a balloon was performed before and after perfusion with 0.1 mol/L hydrochloric acid for 30 min. An impedance planimetry system was used to measure cross-sectional area,volume, pressure, and tension during the distensions. A new model allowed evaluation of the phasic contractions by the tension during contractions as a function of the initial muscle length before the contraction (comparable to the Frank-Starling law for the heart). Length-tension diagrams were used to evaluate the muscle tone before and after relaxation of the smooth muscle with butylscopolamine.RESULTS: The sensitization resulted in allodynia and hyperalgesia to the distension volumes, and the degree of sensitization was related to the infused volume of acid. Furthermore, a nearly 50% increase in the evoked referred pain was seen after sensitization. The mechanical analysis demonstrated hyper-reactivity of the esophagus following acid perfusion, with an increased number and force of the phasic contractions, but the muscle tone did not change.CONCLUSION: Acid perfusion of the esophagus sensitizes the sensory pathways and facilitates secondary contractions.The new model can be used to study abnormal sensorymotor mechanisms in visceral organs. | Asbjφrn Mohr Drewes Hariprasad Reddy Camilla Staahl Jan Pedersen Peter Funch-Jensen Lars Arendt-Nielsen Hans Gregersen | 2005 | World Journal of Gastroenterology2005，11，28： | 3 |
| 2 | Comparison of Osteoprotegerin to Traditional Atherosclerotic Risk Factors and High-Sensitivity C-Reactive Protein for Diagnosis of Atherosclerosis显示文摘 | Rasmus Mogelvang Sune H. Pedersen Allan Flyvbjerg Mette Bjerre Allan Z. Iversen Soren Galatius Jan Frystyk Jan S. Jensen | 2012 | The American Journal of Cardiology2012，，4： | 3 |
| 3 | Gender Differences in Pain and Biomechanical Responses After Acid Sensitization of the Human Esophagus显示文摘 | Hariprasad Reddy MD Lars Arendt-Nielsen PhD Camilla Staahl MScPharm Jan Pedersen MD PhD Peter Funch-Jensen MD PhD Hans Gregersen MD PhD Asbj?rn Mohr Drewes MD PhD | 2005 | Digestive Diseases and Sciences2005，，11： | 1 |
| 4 | Differences Between Male and Female Responses to Painful Thermal and Mechanical Stimulation of the Human Esophagus显示文摘 | Jan Pedersen Hariprasad Reddy Peter Funch-Jensen Lars Arendt-Nielsen Hans Gregersen Asbj?rn Mohr Drewes | 2004 | Digestive Diseases and Sciences (-)2004，，7： | 1 |
| 5 | Gender Differences in Pain and Biomechanical Responses After Acid Sensitization of the Human Esophagus显示文摘 | Hariprasad Reddy MD Lars Arendt-Nielsen PhD Camilla Staahl MScPharm Jan Pedersen MD PhD Peter Funch-Jensen MD PhD Hans Gregersen MD PhD Asbj?rn Mohr Drewes MD PhD | 2005 | Digestive Diseases and Sciences2005，，11： | 1 |
| 6 | Two-microphone separation of speech mix- tures显示文摘 | Michael Syskind Pedersen Wang Deliang Larsen Jan | 2008 | IEEE Transactions on Neural Networks2008，19，3： | 1 |
| 7 | Genetic and Environmental Contributions to Back Pain in Old Age: A Study of 2,108 Danish Twins Aged 70 and Older显示文摘 | Jan Hartvigsen Kaare Christensen Henrik Frederiksen Hans Christian Pedersen | 2004 | Spine2004，，8： | 1 |
| 8 | Cardiac Dysfunction Assessed by Echocardiographic Tissue Doppler Imaging Is an Independent Predictor of Mortality in the General Population显示文摘 | Rasmus Mogelvang Peter Sogaard Sune A. Pedersen Niels T. Olsen Jacob L. Marott Peter Schnohr Jens P. Goetze Jan S. Jensen | 2009 | Circulation2009，，20： | 1 |
| 9 | Intraaortic Balloon Pump in Open Heart Operations: 10-Year Follow-up With Risk Analysis 1 1 This article has been selected for the open discussion forum on the STS Web site: http://gffzz06206328a72143f9h0kuqu56ucckq6pwu.ffgz.tsg.suse.edu.cn/annals显示文摘 | Osama E Arafa Thore H Pedersen Jan L Svennevig Erik Fosse Odd R Geiran | 1998 | The Annals of Thoracic Surgery1998，，3： | 1 |
| 10 | Formation of Tablet-Shaped and Ribbonlike Micelles in Mixtures of an Anionic and a Cationic Surfactant 显示文摘 | Magnus Bergstrm Jan Skov Pedersen | 1999 | Langmuir1999，15，7： | 1 |
| 11 | Pain and biomechanical responses to distention of the duodenum in patients with systemic sclerosis显示文摘 | Jan Pedersen Chunwen Gao Henrik Egekvist Peter Bjerring Lars Arendt-nielsen Hans Gregersen Asbj?rn Mohr Drewes | 2003 | Gastroenterology2003，，5： | 1 |
| 12 | Silver nanoparticle formnation in microemulsions acting both as template and reducing agent显示文摘 | Martin Andersson Jan Skov Pedersen Anders E C Palmqvist | 2005 | Langmuir2005，21，11： | 1 |
| 13 | Determination of the optimal dietary threonine:lysine ratio for finishing pigs using three different methods显示文摘 | Carsten Pedersen Jan Erik Lindberg Sigurd Boisen | 2003 | Livestock Production Science2003，82，： | 1 |
| 14 | Genotype-by-nutrient interactions assessed in European obese women显示文摘 | Jose L. Santos Philippe Boutin Camilla Verdich Claus Holst Lesli H. Larsen Soren Toubro Christian Dina Wim H.M. Saris Ellen E. Blaak Johnatan Hoffstedt Moira A. Taylor Jan Polak Karine Clement Dominique Langin Arne Astrup Philippe Froguel Oluf Pedersen Th | 2006 | European Journal of Nutrition2006，，8： | 1 |
| 15 | Epidemiology of Parkinson’s disease显示文摘 | Guido Alves Elin Bjelland Forsaa Kenn Freddy Pedersen Michaela Dreetz Gjerstad Jan Petter Larsen | 2008 | Journal of Neurology2008，，： | 1 |
| 16 | Intake of trans fatty acids from partially hydrogenated vegetable and fish oils and ruminant fat in relation to cancer risk 显示文摘 | LAAKE IDA CARLSEN MONICA H PEDERSEN JAN I | 2013 | International Journal of Canc- er2013，132，6： | 1 |
| 17 | Small-Angle Neutron Scattering Study of the Growth Behavior, Flexibility, and Intermicellar Interactions of Wormlike SDS Micelles in NaBr Aqueous Solutions 显示文摘 | Arleth Lise Bergstroem Magnus Pedersen Jan Skov | 2002 | Langmuir2002，18，14： | 1 |
| 18 | Formation of tablet-shaped and ribbonlike micelles in mixtures of an anionic and a cationic surfactant显示文摘 | Magnus Bergstrom Jan Skov Pedersen | 1999 | Langmuir1999，15，7： | 1 |
| 19 | Small-angle neutron scattering(SANS) study of vesicles and lameller sheets formed from mixtures of an anionic and a cationic surfactant显示文摘 | Magnus Bergstrom Jan Skov Pedersen | 1999 | J Phys Chem1999，3，： | 1 |
| 20 | Fiber-optics probe for noninvasive real-time determina- tion of tissue optical properties at multiple wavelengths 显示文摘 | Jan S Dam Carsten B Pedersen Torben Dalgaard | 2001 | Appl Opt2001，40，7： | 1 |
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