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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial显示文摘 | Caroline AH Klazen Paul NM Lohle Jolanda de Vries Frits H Jansen Alexander V Tielbeek Marion C Blonk Alexander Venmans Willem Jan J van Rooij Marinus C Schoemaker Job R Juttmann Tjoen H Lo Harald JJ Verhaar Yolanda van der Graaf Kaspar J van Everdingen Al | 2010 | 2010 (9746)2010，，9746： | 2 |
| 3 | 5-Hydroxyaloesaponarin, a minor blue pigment in an antinorhodin-negative mutant of Streptomyces coelicolorA3(2)显示文摘 | Leonid V B Jan K H Wim K etal | 1997 | Bioteehnol Biochem1997，26，： | 1 |
| 4 | Dimethylsulfoniopropi- onate cleavage by marine phytoplankton in response to mechani- cal,chemical or dark stress显示文摘 | Gordon V W Suzanne L S Jan L H | 2002 | Journal of Phycology2002，38，： | 1 |
| 5 | Hash functions and triangular mesh reconstruction显示文摘 | JAN H MARTIN K V(A)CLAV S | 2003 | Computers & Geosciences2003，，29： | 1 |
| 6 | Development of human protein reference database as an initial platform for approaching systems biology in humans 显示文摘 | PERI S NAVARRO J D AMANCHY R KRISTIANSEN T Z JONNALAGADDA C K SURENDRANATH V NIRAN JAN V MUTHUSAMY B GANDHI T K GRONBORG M IBARROLA N DESHPANDE N SHANKER K SHIVASHANKAR H N RASHMI B P RAMYA M A ZHAO Z CHANDRIKA K N PADMA N HARSHA H C YATISH A J KAVITHA M P MENEZES M CHOUDHURY D R SURESH S GHOSH N SARAVANA R CHANDRAN S KRISHNA S JoY M ANAND S K MADAVAN V JOSEPH A WONG G W SCHIEMANN W P CONSTANTINESCU S N HUANG L KHOSRAVI-FAR R STEEN H TEWARI M GHAFFARI S BLOBE G C DANG C V GARCIA J G PEVSNER J JENSEN O N ROEPSTORFF P DESHPANDE K S CHINNAIYAN A M HAMOSH A CHAKRAVARTI A PANDEY A | 2003 | Genome Research2003，13，10： | 1 |
| 7 | Different approaches to superhard coatings and nanocomposites显示文摘 | STAN V MARITZA G J V H PAVLA K JAN P | 2005 | Thin Solid Films2005，476，： | 1 |
| 8 | Drivers of trust in relational service exchange : understanding the importance of cross-cultural differences 显示文摘 | Jan H Schumann Florian V W | 2010 | Journal of Service Research2010，13，4： | 1 |
| 9 | Muhibody modeling of varying complexity for modal behavior analysis of wind turbine gearboxes显示文摘 | Jan H Frederik V Ben M | 2011 | Renewable Energy2011，36，： | 1 |
| 10 | Random Forests as a Tool for Ecohydrological Distribution Modelling显示文摘 | Jan P Bernard D B Niko E C V Roeland S Sven D Piet D B Willy H | 2007 | Ecological Modelling2007，207，24： | 1 |
| 11 | Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial显示文摘 | Caroline AH Klazen Paul NM Lohle Jolanda de Vries Frits H Jansen Alexander V Tielbeek Marion C Blonk Alexander Venmans Willem Jan J van Rooij Marinus C Schoemaker Job R Juttmann Tjoen H Lo Harald JJ Verhaar Yolanda van der Graaf Kaspar J van Everdingen Al | 2010 | The Lancet2010，，9746： | 1 |
| 12 | Simultaneous measurement of soilpenetration resistance and water content with a combined penetrometer-TDR moisture probe显示文摘 | Carlos M P V Jan W H | 2001 | Soil science society of America journal2001，65，1： | 1 |
| 13 | A direct PCR detection method for clostridium tyrobutyricum spores in up to 100 Milliliters of raw milk显示文摘 | LIEVE M F H JAN H G E De B GUIDO M A V J W | 1995 | Appl Environ Microbiol1995，12，61： | 1 |
| 14 | High-performance ionexchang chromatography with in-line complexation of bisphosphonates and their quality control in pharmaceutical preparations 显示文摘 | ROLF W S JAN D H PIETER V | 1995 | J Pharm Biomed Anal1995，13，12： | 1 |
| 15 | Detecting trend and seasonal changes insatellite image time series显示文摘 | JAN V ROB H GLENN N | 2010 | Remote Sensing of Environment2010，114，1： | 1 |
| 16 | In vitro reconstitution of the complete Clostridium thermoce- llum cellulosome and synergistic activity on crystalline cellulose 显示文摘 | Jan Krauss Vladimir V Zverlov Wolfgang H Schwarz | 2012 | AppI Environ Microbiol2012，78，12： | 1 |
| 17 | Grafting tomato(Solanum lycopersicum) onto the rootstock of a high-alti- tude accession of Solanum habrochaites improves subopti- mal-temperature tolerance 显示文摘 | Jan H V Boukelien E D Joz'e M B | 2008 | Environ Exp Bot2008，63，： | 1 |
| 18 | Multibody modelling of varying complexity for modal behaviour analysis of wind turbine gearboxes 显示文摘 | Jan H Frederik V Ben M | 2011 | Renewable Energy2011，36，11： | 1 |
| 19 | Interactions between soil development, vegetation and soil fauna during spontaneous succession in post mining sites显示文摘 | Jan Frouz Karel Prach Václav Pi?l Ladislav Háněl Josef Stary Karel Tajovsky Jan Materna Vladimír Balík Ji?í Kal?ík Klára ?ehounková | 2007 | European Journal of Soil Biology2007，，1： | 1 |
| 20 | Role of nitric oxide in the pathogenesis of chronic pulmonary hypertension显示文摘 | Hampl V Jan H | 2000 | Physiol Rev2000，80，4： | 1 |
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