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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | 诊断性试验和策略的证据质量和推荐强度的分级显示文摘GRADE系统能对诊断性试验或策略的证据质量和推荐强度进行分级。本文旨在阐释在此过程中如何考虑患者的重要结局, | Holger J Schünemann Andrew D Oxman Jan Brozek Paul Glasziou Roman Jaeschke Gunn E Vist John W Williams Jr Regina Kunz Jonathan Craig Victor M Montori Patrick Bossuyt Gordon H Guyatt 李晓 黄程 陈耀龙 李幼平 | 2009 | 中国循证医学杂志2009，9，5： | 7 |
| 3 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 4 | Introduction of laparoscopic gastrectomy for gastric cancer in a Western tertiary referral centre:A prospective cost analysis during the learning curve显示文摘AIM To evaluate the costs of the introduction of a laparoscopic surgery program for gastric cancer in a Western community training hospital and tertiary referral centre for gastric cancer surgery. METHODS All patients who underwent surgery for gastric cancer with curative intent in 2013 and 2014 were prospectively included. Primary outcomes were costs regarding surgery and hospital stay. RESULTS Laparoscopic gastrectomy was used in 52 patients [mean age 68 years(± 9, range 50 to 87) years] and open gastrectomy was used in 25 patients [mean age 70 years(± 10, range 46 to 85)]. Mean costs(in euro's) of surgical instrumentation were significantly higher for laparo-scopic surgery: 2270 ± 670 vs 1181 ± 680 in the open approach(P < 0.001). Costs of theatre use were higher in the laparoscopic group: mean 3818 ± 865 vs 2545± 1268 in the open surgery(P < 0.001). Total costs of hospitalization(i.e., costs of surgery and admission)were not different between laparoscopic and open surgery, 8187 ± 4864 and 6152 ± 2680 respectively(P= 0.729). Mean length of hospital stay was 9 ± 12 d in the laparoscopic group vs 14 ± 14 d in the open group(P= 0.044). CONCLUSION The introduction of laparoscopic gastrectomy for gastric cancer coincided with higher costs for theatre use and surgical instrumentation compared to the open technique. Total costs were not significantly different due to shorter length of stay and less intensive care unit(ICU) admissions and shorter ICU stay in the laparoscopic group. | Juul J Tegels Charlotte E Silvius Frederique E Spauwen Karel W Hulsewé Anton G Hoofwijk Jan H Stoot | 2017 | World Journal of Gastrointestinal Oncology2017，9，5： | 2 |
| 5 | Minimally invasive aortic valve replacement: how does this perform in high-risk patients?显示文摘 | Jan D Schmitto Friedrich W Mohr Lawrence H Cohn | 2011 | Current Opinion in Cardiology2011，，2： | 2 |
| 6 | Development and validation of ultrasound speckle tracking to quantify tendon displacement 显示文摘 | Jan W H K Ruud W S Henk J S | 2012 | Journal of Biomechanics2012，43，7： | 1 |
| 7 | Effect of lameness on the calving- to-conception interval in dairy cows 显示文摘 | Jorge H Jan KS Daniel W W | 2001 | Journal of the American Veterinary Medical Association2001，218，10： | 1 |
| 8 | Contribution of water content and bulk density to field soil penetration resistance as measured by a combined cone penetrometer-TDR probe显示文摘 | Vaz M P C Bassoi H L Hopmans W Jan | 2001 | Soil and Tillage Research2001，60，12： | 1 |
| 9 | Finite element analysis of vortexshedding oscillations from cylinders in the straightchannel 显示文摘 | Jan Y J Sheu W H | 2004 | Computational Mechanics2004，33，2： | 1 |
| 10 | Discrete wavelet approach to multifractality 显示文摘 | Ka Kantelhardt Jan W Roman H Eduardo Greiner | 1995 | Physica A1995，220，34： | 1 |
| 11 | Dimethylsulfoniopropi- onate cleavage by marine phytoplankton in response to mechani- cal,chemical or dark stress显示文摘 | Gordon V W Suzanne L S Jan L H | 2002 | Journal of Phycology2002，38，： | 1 |
| 12 | The role of calci- tonin gene-related peptide (CGRP) in ischemic precondition- ing in isolated rat hearts 显示文摘 | Chai W Mehrotra S Jan Danser A H | 2006 | Eur J Pharmacol2006，531，13： | 1 |
| 13 | Finite Element Analysis of Vortex Shedding Oscillations from Cylinders in the Straight Channel显示文摘 | JAN Y J SHEU W H | 2004 | Computational Mechanics2004，33，2： | 1 |
| 14 | Development of human protein reference database as an initial platform for approaching systems biology in humans 显示文摘 | PERI S NAVARRO J D AMANCHY R KRISTIANSEN T Z JONNALAGADDA C K SURENDRANATH V NIRAN JAN V MUTHUSAMY B GANDHI T K GRONBORG M IBARROLA N DESHPANDE N SHANKER K SHIVASHANKAR H N RASHMI B P RAMYA M A ZHAO Z CHANDRIKA K N PADMA N HARSHA H C YATISH A J KAVITHA M P MENEZES M CHOUDHURY D R SURESH S GHOSH N SARAVANA R CHANDRAN S KRISHNA S JoY M ANAND S K MADAVAN V JOSEPH A WONG G W SCHIEMANN W P CONSTANTINESCU S N HUANG L KHOSRAVI-FAR R STEEN H TEWARI M GHAFFARI S BLOBE G C DANG C V GARCIA J G PEVSNER J JENSEN O N ROEPSTORFF P DESHPANDE K S CHINNAIYAN A M HAMOSH A CHAKRAVARTI A PANDEY A | 2003 | Genome Research2003，13，10： | 1 |
| 15 | Detecting long-range correlations with detrended fluctuation analysis显示文摘 | Kantelhardt Jan W Eva Koscielny-Bunde Rego Henio H A | 2001 | Physica A2001，，295： | 1 |
| 16 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 17 | Detecting long - range correlations with detrended fuctuation analysis 显示文摘 | Jan W Henio H A | 2001 | Physica A2001，，295： | 1 |
| 18 | Electronic and Bonding Structures of Amorphous Si-C-N Thin Films by X-Ray Absorption Spectroscopy 显示文摘 | Tsai H M Jan J C Chiou J W | 2001 | Appl Phys Lett2001，79，15： | 1 |
| 19 | Drivers of trust in relational service exchange : understanding the importance of cross-cultural differences 显示文摘 | Jan H Schumann Florian V W | 2010 | Journal of Service Research2010，13，4： | 1 |
| 20 | Finite Element Analysis of Vortex Shedding Oscillations from Cylinders in the Straight Channel显示文摘 | JAN Y J SHEU T W H | 2004 | Computational Mechancis2004，33，2： | 1 |
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