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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Complicatons of ERCP 显示文摘 | J Shawn Mallery Todd H Baron Jason A Kom initz | 2003 | American Society For Gastrointestinal Endoscopy2003，57，6： | 1 |
| 3 | Solar Forcing of Drought Frequency in the Maya Lowlands 显示文摘 | David A Hodell Mark Brenner Jason H Curtis | 2001 | SCIENCE2001，292，18： | 1 |
| 4 | Determination of the oxidation states of manganese in brain, liver, and heart mitochondria 显示文摘 | Thomas E G Lisa M M Claire E G Roman E Jason S Linas B Andrei A Sean H Karlene K G | 2004 | Journal of Neuroehemistry2004，88，： | 1 |
| 5 | Effect of electrogram characteristics on the relationship of dominant frequency to atrial activation rate in atrial fibrillation显示文摘 | Jason Ng Kadish A H Goldberger J J | 2006 | Heart Rhythm2006，3，10： | 1 |
| 6 | Protein microarray technology显示文摘 | David A H Jason P Michael S | 2007 | Mech Ageing Dev2007，128，1： | 1 |
| 7 | Possible role of climate in the collapse of classic Maya civilization 显示文摘 | David A H Jason H C Mark B | 1995 | Nature1995，375，： | 1 |
| 8 | Climate variability on the Yucatan peninsula (Mexico) during the past 3500 years, andimplications for Maya cultural evolution 显示文摘 | Jason H C Danvid A H | 1996 | Quaternary Research1996，46，： | 1 |
| 9 | Evidence for multiple mechanisms of toxicity in larval rainbow trout(Oncorhynchus mykiss)cotreated with retene and α-naphthoflavone显示文摘 | Jason A S Peter V H | 2008 | Aquatic Toxicology2008，28，3： | 1 |
| 10 | Greenland ice sheet surface mass balance variability (1998-2004) from calibrated polar MM5 output显示文摘 | Jason E B David H B Bruce A | 2006 | Journal of Climate2006，19，： | 1 |
| 11 | Dissolved carbohydrates in seawater-Apricise spectrophotometric analysis for monasaccharides 显示文摘 | JASON H SEE DEBORAH A BRONK | 2005 | Marine Chemistry2005，5，1： | 1 |
| 12 | Electrospun polyacrylonitrile nanofibers containing a high concentration of well-aligned multiwall carbon Nanotubes 显示文摘 | Hou H Q Jason J Ge Zeng J Li Q Reneker D H Greiner A Cheng S Z D | 2005 | Chem Mater2005，17，： | 1 |
| 13 | Image segmentation evaluation: A survey of unsupervised methods 显示文摘 | Zhang H Jason E Fritts Sally A Goldman | 2007 | Computer Vision and Image Understanding2007，110，2： | 1 |
| 14 | Mobile stroke care expedites intravenous thrombolysis and endovascular thrombectomy显示文摘Background The number of mobile stroke programmes has increased with evidence,showing they expedite intravenous thrombolysis.Outstanding questions include whether time savings extend to patients eligible for endovascular therapy and impact clinical outcomes.Objective Our mobile stroke unit(MSU),based at an academic medical centre in upstate New York,launched in October 2018.We reviewed prospective observational data sets over 26 months to identify MSU and non-MSU emergency medical service(EMS)patients who underwent intravenous thrombolysis or endovascular thrombectomy for comparison of angiographic and clinical outcomes.Results Over 568 days in service,the MSU was dispatched 1489 times(2.6/day)and transported 300 patients(20%of dispatches).Intravenous tissue plasminogen activator(tPA)was administered to 57 MSU patients and the average time from 911 call-to tPA was 42.5 min(±9.2),while EMS transported 73 patients who received tPA at 99.4 min(±35.7)(p<0.001).Seven MSU patients(12%)received tPA from 3.5 hours to 4.5 hours since last known well and would likely have been outside the window with EMS care.Endovascular thrombectomy was performed on 21 MSU patients with an average 911 call-to groin puncture time of 99.9 min(±18.1),while EMS transported 54 patients who underwent endovascular thrombectomy(ET)at 133.0 min(±37.0)(p=0.0002).There was no difference between MSU and traditional EMS in modified Rankin score at 90-day clinic follow-up for patients undergoing intravenous thrombolysis or endovascular thrombectomy,whether assessed as a dichotomous or ordinal variable.Conclusions Mobile stroke care expedited both intravenous thrombolysis and endovascular thrombectomy.There is an ongoing need to show improved functional outcomes with MSU care. | Matthew T Bender Thomas K Mattingly Redi Rahmani Diana Proper Walter A Burnett Jason L Burgett Joshua LEsperance Jeremy T Cushman Webster H Pilcher Curtis G Benesch Adam G Kelly Tarun Bhalla | 2022 | Stroke & Vascular Neurology2022，7，3： | 1 |
| 15 | X-Ray Absorp-tion Fine Structure Characterization of the Local Structure ofFe in Fe-ZSM-5 显示文摘 | Sun H C Benjamin R W Jason A R | 2003 | J Phys Chem B2003，107，11： | 1 |
| 16 | Rural drinking water at supply and household levels: Quality and management显示文摘 | Bilqis A Kelly H Jason L | 2006 | International Journal of Hygiene and EnvironmentalHealth2006，209，5： | 1 |
| 17 | Endothelin-induced increases in Ca^2+ entry mechanisms of vascular contraction are enhanced during high-sah diet 显示文摘 | LEAH S JASON A P MON H S | 2003 | Hypertension2003，41，2： | 1 |
| 18 | Solid-supported cyclohexane-1,3-dione (CHD):A' capture and release'reagent for thesynthesis of amides and novel scavenger resin显示文摘 | Cara E H Morag A M E Jason P T et a l | 2003 | Org Lett2003，5，6： | 1 |
| 19 | Retained surgical sponge simulating a pancreatic mass 显示文摘 | Jason R S Chisolm A Lubetsky H W | 1979 | J Natl Med Assoc1979，71，5： | 1 |
| 20 | Peanuts, peanut oil, and fat free peanut flour reduced cardiovascular disease risk factors and the development of atherosclerosis in syrian golden hamsters 显示文摘 | Amanda M Stephens Lisa L Dean Jack P Davis Jason A Osborne Timothy H Sanders | 2010 | Journal of Food Science2010，75，4： | 1 |
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