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| 1 | The American Heart Association’s Get With the Guidelines(GWTG)-Stroke development and impact on stroke care显示文摘The American Heart Association’s Get With the Guidelines(GWTG)-Stroke programme has changed stroke care delivery in the USA since its establishment in 2003.GWTG is a voluntary registry and continuous quality improvement initiative that collects data on patient characteristics,hospital adherence to guidelines and inpatient outcomes.Implementation of the programme saw increased provision of evidence-based care and improved patient outcomes.This review will describe the development of the programme and discuss the impact on stroke outcomes and transformation of stroke care delivery that followed its implementation. | Cora H Ormseth Kevin N Sheth Jeffrey L Saver Gregg C Fonarow Lee H Schwamm | 2017 | Stroke & Vascular Neurology2017，2，2： | 15 |
| 2 | Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up显示文摘AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies. | Ahmed Z Elmaadawi Peter S Jensen L Eugene Arnold Brooke SG Molina Lily Hechtman Howard B Abikoff Stephen P Hinshaw Jeffrey H Newcorn Laurence Lee Greenhill James M Swanson Cathryn A Galanter | 2015 | World Journal of Psychiatry2015，5，4： | 3 |
| 3 | The Integrator complex controls the termination of transcription at diverse classes of gene targets显示文摘包含 INTS3 和 NABP1 或 NABP2 的建筑群开始在 DNA 损坏回答被描绘,但是他们的生物化学的功能仍然保持未知。用亲密关系纯化和 HIV 集成定序目标(HIT-Seq ) ,我们发现这些建筑群是综合者建筑群的部分,它绑 RNA 聚合酶 II 并且调整特定的目标基因。综合者作为他们在亲密地被结合的机制处理到他们的成熟形式的部分劈开 snRNAs 抄写结束。然而, HIT-Seq 表明那个综合者也绑在 3 ′以 polyadenylated 抄本复制依赖者 histones 和倡导者结束基因的近似区域。综合者子单元的弄空导致抄写结束失败, histone mRNA 处理的混乱,和 snRNAs 和 histone mRNAs 的 polyadenylation。而且,倡导者综合者的近似绑定否定地通常调整其抄本是的基因的表示 polyadenylated。到所有三个基因类的综合者招募是 DSIF 依赖的,建议那个综合者作为在 DSIF 依赖的 RNA 聚合酶 II 的结束建筑群工作暂停地点。 | Jeffrey R Skaar Andrea L Ferris Xiaolin Wu Anita Saraf Kum Kum Khanna Laurence Florens Michael P Washburn Stephen H Hughes Michele Pagano | 2015 | Cell Research2015，25，3： | 2 |
| 4 | Synthesis of polysub- stituted indoles and indulines by means of zirconcenne- stabilized benzzyne complexes 显示文摘 | JEFFREY H T STEPHEN L B | 1994 | J Am Chem Soc1994，116，11： | 1 |
| 5 | Leptin and the regulation of body weight in mammals显示文摘 | Jeffrey M F Jeffrey L H | 1998 | Nature1998，395，： | 1 |
| 6 | Temozolomideis Active in Childhood, Progressive, Unresectable,Low-Grade Gliomas 显示文摘 | Kuo D J Weiner H L Jeffrey W | 2003 | J Pediatr Hematol Oncol2003，25，5： | 1 |
| 7 | Regulation of milk protein gene expression显示文摘 | Jeffrey M R Shannon L W Darryl H | 1999 | Annu Rev Nutr1999，19，： | 1 |
| 8 | Weight-reducing effects of the plasma protein encode by the obese gene显示文摘 | Jeffrey L H Ketan S G Margherita M | 1995 | Science1995，269，： | 1 |
| 9 | Role of Streptococcus thermophilus MR-1C Capsular Exopolysaccharide in Cheese Moisture retention显示文摘 | DEBORAH L JEFFREY A AHLGREN D H | 1998 | Appl Environ Microbiol1998，64，6： | 1 |
| 10 | Effects of ref- erence displacement and damage accumulation in wood shear walls 显示文摘 | JEFFREY G L RAKESH G THOMAS H M | 2004 | ASCE Journal of Structural Engineering2004，，130： | 1 |
| 11 | Fabrication and Characterization of Graded Impedance Impactors for Gas Gun Experiments from Tape Cast Metal Powders 显示文摘 | Martin L P Orlikowski Daniel Nguyen Jeffrey H | 2006 | Mater Sci Eng A2006，427，： | 1 |
| 12 | Convergence properties of the Nelder-Mead simplex method in low dimensions显示文摘 | JAMES A R MARGARET H W PAUL E W | 1998 | SIAM Journal of Optimization1998，9，1： | 1 |
| 13 | Ensemble Square Root Filters显示文摘 | Michael K T Jeffrey L A Craig H B | 2002 | Notes and Correspondence2002，25，6： | 1 |
| 14 | Characterization of VolatileCompounds Contributing to Naturally Occurring Fruity FermentedFlavor in Peanuts显示文摘 | L G Jeffrey H S Timothy Mary Anne Drake | 2008 | Agric Food Chem2008，56，： | 1 |
| 15 | Unmanned aerial vehi- cle-based remote sensing for rangeland assessment,moni- toring and management显示文摘 | Albert R Andrea L Jeffrey H | 2009 | Journal of Applied Remote Sens- ing2009，3，1： | 1 |
| 16 | The growth of word trade:Tariffs,transport costs and income similarities显示文摘 | Scott L B Jeffrey H B | | 0，，01： | 1 |
| 17 | Non-line-ofsight single-scatter propagation model显示文摘 | MARK R L JEFFREY H S DAVID M R | 1991 | Journal Optical Society of America1991，8，12： | 1 |
| 18 | Predicting the performance of rescheduling strategies for parallel machine systems显示文摘 | VIEIRA G E JEFFREY W H EDWARD L | 2000 | Journal of Manufacturing Systems2000，19，4： | 1 |
| 19 | Origins and progressing of organic matter in the Ama- zon River as indicated by carbohydrates and amino acids显示文摘 | JOHN I H GREGORY L C JEFFREY E R | 1994 | LimnolOeeanogr1994，39，4： | 1 |
| 20 | Carbon accumu- lation in Colorado ponderosa pine stands显示文摘 | Jeffrey A H Rosemary L S Thomas T V | 2004 | Canadian Journal of Forest Research2004，34，6： | 1 |
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