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| 1 | Tunicamycin sensitizes human prostate cells to TRAIL-induced apoptosisby upregulation of TRAIL receptors and downregulation of cIAP2显示文摘 | Young-Hwa Jung Eun Lim Jeonghoon Heo Taeg Kwon Young-Ho Kim | 2012 | International Journal of Oncology2012，，6： | 1 |
| 2 | Triptolide inactivates Akt and induces caspase-dependent death in cervicalcancer cells via the mitochondrial pathway显示文摘 | Min Kim Tae Lee Sung Kim Yeon-Joo Choi Jeonghoon Heo Young-Ho Kim | 2010 | International Journal of Oncology2010，，5： | 1 |
| 3 | Sixty‐five gene‐based risk score classifier predicts overall survival in hepatocellular carcinoma显示文摘 | Soo Mi Kim Sun‐Hee Leem In‐Sun Chu Yun‐Yong Park Sang Cheol Kim Sang‐Bae Kim Eun Sung Park Jae Yun Lim Jeonghoon Heo Yoon Jun Kim Dae‐Ghon Kim Ahmed Kaseb Young Nyun Park Xin Wei Wang Snorri S. Thorgeirsson Ju‐Seog Lee | 2012 | Hepatology2012，，5： | 1 |
| 4 | Association of MUC6 -minisatellite variants with susceptibility to rectal carcinoma显示文摘 | Myoung-Hyun Ahn Ki Beom Bae Jeong-Ah Kwon Hong-Jo Choi Se-Ra Lee Si-Hoon Kim Tae Doo Jung Sun Hee Kim Min Sung An Kwan Hee Hong Jeonghoon Heo Tae-Hong Kang Jin Woong Chung Sun-Hee Leem | 2013 | Molecular Biology Reports2013，，1： | 1 |
| 5 | Conditioned secretome of adipose-derived stem cells improves dextran sulfate sodium-induced colitis in mice显示文摘BACKGROUND Inflammatory bowel diseases(IBD)is related to uncontrolled immune response.Currently,there is no successful treatment for significant improvement in IBD.Stem cells display their therapeutic effects through their repopulating capacity or secreting factors.AIM To investigate the effects of conditioned mouse adipose-derived stem cells(mADSCs)secretome on colitis-induced mice.METHODS mADSCs were isolated from adipose tissue of C57BL/6 mice.Conditioned mADSCs secrectome was obtained by culturing of mADSCs with lipopolysaccharides(LPS,1μg/mL)for 24 h.Acute colitis was induced by 2%dextran sulfate sodium(DSS)drinking water for 7 d and then normal drinking water for 4 d.The mice were treated with normal culture medium(NM group),conditioned mADSCs secretome(CM group)or mADSCs(SC group).The length of colon and histopatholgy of colon tissues were evaluated.The mRNA expression levels of inflammatory cytokines in colon tissue and the serum interleukin(IL)-6 levels were determined.RESULTS The isolated mADSCs maintained the mADSCs specific gene expression profiles during experiment.The conditioned mADSCs secretome released by the treatment of mADSCs with LPS contained mainly inflammatory chemokines,colony-stimulating factors and inflammatory cytokines.The loss of body weight and reduction in colon length were ameliorated in the CM group.The conditioned mADSCs secretome reduced the histological score in colon tissue.The expression of IL-1b and IL-6 mRNAs in colon tissues significantly inhibited in the CM group compared to SC group and NM group,respectively.The elevation of serum IL-6 levels was also ameliorated in the CM group.These results indicate that the conditioned mADSCs secretome suppressed the synthesis of inflammatory cytokines in damaged colon tissue and the elevation of serum IL-6 concentration in DSS-induced mice CONCLUSION Conditioned mADSCs secretome might play regenerative roles by the suppression of IL-6 in serum and tissue during acute colitis,and may be more effective than stem cells themselves in the regeneration of colon tissue. | Seunghun Lee Jeonghoon Heo Eun-Kyung Ahn Jae Hyun Kim Young-Ho Kim Hee-Kyung Chang Sang-Joon Lee Jongsik Kim Seun-Ja Park | 2021 | World Journal of Gastroenterology2021，27，23： | 0 |
| 6 | Optimization of adipose tissue-derived mesenchymal stromal cells transplantation for bone marrow repopulation following irradiation显示文摘BACKGROUND Bone marrow(BM)suppression is one of the most common side effects of radiotherapy and the primary cause of death following exposure to irradiation.Despite concerted efforts,there is no definitive treatment method available.Recent studies have reported using mesenchymal stromal cells(MSCs),but their therapeutic effects are contested.AIM We administered and examined the effects of various amounts of adipose-derived MSCs(ADSCs)in mice with radiation-induced BM suppression.METHODS Mice were divided into three groups:Normal control group,irradiated(RT)group,and stem cell-treated group following whole-body irradiation(WBI).Mouse ADSCs(mADSCs)were transplanted into the peritoneal cavity either once or three times at 5×10^(5) cells/200μL.The white blood cell count and the levels of,plasma cytokines,BM mRNA,and BM surface markers were compared between the three groups.Human BM-derived CD34+hematopoietic progenitor cells were co-cultured with human ADSCs(hADSCs)or incubated in the presence of hADSCs conditioned media to investigate the effect on human cells in vitro.RESULTS The survival rate of mice that received one transplant of mADSCs was higher than that of mice that received three transplants.Multiple transplantations of ADSCs delayed the repopulation of BM hematopoietic stem cells.Anti-inflammatory effects and M2 polarization by intraperitoneal ADSCs might suppress erythropoiesis and induce myelopoiesis in sub-lethally RT mice.CONCLUSION The results suggested that an optimal amount of MSCs could improve survival rates post-WBI. | Min-Jung Kim Won Moon Jeonghoon Heo Sangwook Lim Seung-Hyun Lee Jee-Yeong Jeong Sang Joon Lee | 2022 | World Journal of Stem Cells2022，14，3： | 0 |
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