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| 1 | Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs显示文摘AIM To investigate the long-term effect of dietary education on a low fermentable oligosaccharide, disaccharide and polyol(FODMAP) diet on irritable bowel syndrome(IBS) symptoms and quality of life(Qo L).METHODS Participants with IBS(Rome III) were randomized to two groups. Group I commenced a low FODMAP diet at baseline. At three months, group II, so far a comparator group, crossed over to a low FODMAP diet while group I started re-challenging foods. All patients completed the IBS SSS(IBS symptom severity scoring system, 0-500 points increasing with severity), IBS Qo L questionnaire(0-100 increasing with Qo L), a FODMAP specific food frequency questionnaire and provided a stool sample at baseline, three and six months for microbiome analysis.RESULTS Fifty participants were enrolled into group I(n = 23) or group II(n = 27). Participants in both groups were similar in baseline values but with more men in group I. There was a significantly lower IBS SSS(275.6 ± 63.6 to 128.8 ± 82.5 vs 246.8 ± 71.1 to 203.6 ± 70.1)(P < 0.0002) and increased Qo L(68.5 ± 18.0 to 83 ± 13.4 vs 72.9 ± 12.8 to 73.3 ± 14.4)(P < 0.0001) in group I vs group II at 3 mo. The reduced IBS SSS was sustained at 6 mo in group I(160 ± 102) and replicated in group II(124 ± 76). Fiber intake decreased on the low FODMAP diet(33 ± 17 g/d to 21 ± 8 g/d)(P < 0.01) and after re-introducing FODMAP containing foods increased again to 27 ± 9 g/d. There was no change seen in the intestinal microbiome when participants adopted a low FODMAP diet.CONCLUSION This study demonstrated that a reduction in FODMAPs improves symptoms in IBS and this improvement can be maintained while reintroducing FODMAPs. | Ruth M Harvie Alexandra W Chisholm Jordan E Bisanz Jeremy P Burton Peter Herbison Kim Schultz Michael Schultz | 2017 | World Journal of Gastroenterology2017，23，25： | 5 |
| 2 | Mutations in filamin 1 Prevent Migration of Cerebral Cortical Neurons in Human Periventricular Heterotopia显示文摘 | Jeremy W Fox Edward D Lamperti Yaman Z Ek?io?lu Susan E Hong Yuanyi Feng Donna A Graham Ingrid E Scheffer William B Dobyns Betsy A Hirsch Rodney A Radtke Samuel F Berkovic Peter R Huttenlocher Christopher A Walsh | 1998 | Neuron1998，，6： | 1 |
| 3 | Seasonal and Inter-Annual Relationships Between Vegetation and Climate in Central New Mexico, USA显示文摘 | JEREMY L W DAVIDS S G JULIA E A | 2004 | Journal of Arid Environments2004，57，4： | 1 |
| 4 | Flavonoids:antioxidants or signaling molecule显示文摘 | ROBERT J W JEREMY P E CATHERINE R E | 2004 | Free Radical Biology andMedicine2004，36，7： | 1 |
| 5 | Integration of the global positioning system and geographical information systems for traffic congestion studies显示文摘 | Taylor M A P Jeremy E W | 2000 | Transportation Research Part C (S0968-090X)2000，，8： | 1 |
| 6 | Growth of Cu2O nanocubes from seeds in microwells 显示文摘 | Jennifer Y Wang Teri W Odom Jeremy E Barton | 2005 | Nanoscape2005，2，1： | 1 |
| 7 | Targeted disruption of the α1,3-galactosytransferase gene in cloned pigs显示文摘 | Todd D V Jeremy B Shu-Hung Chen Carol J P Suyapa B Jeff A M Peter M J Kenneth J M Ashley E Lamborn Jamie L Cowell-Lucero Kevin D W Alan C Irina A P David L A | 2002 | Nat Biotechnology2002，20，3： | 1 |
| 8 | Integration of the global positioning system and geographical information systems for traffic congestion studies显示文摘 | TAYLOR M A P JEREMY E W | 2000 | Transportaion Research Part C2000，8，16： | 1 |
| 9 | Integration of the Global Positioning System and Geographical Information Systems for Traffic Congestion Studies显示文摘 | Michael A P Jeremy E W Rocco Z | 2000 | Transportation Research Part C:Emerging Technologies2000，8，6： | 1 |
| 10 | De- sign, synthesis and evaluation of potent bryostatin ana- logs that modulate PKC translocation selectivity 显示文摘 | PAUL A W JEREMY L B STACEY E B | 2011 | PNAS2011，108，17： | 1 |
| 11 | Seasonal and inter annual relationships between vegetation and climate in Central New Mexico, USA显示文摘 | JEREMY L W DAVIDS S G JULIA E A | 2004 | Journal of Arid Environments2004，57，4： | 1 |
| 12 | Two-color multiphoton in vivo imaging with a femtosecond diamond Raman laser显示文摘Two-color multiphoton microscopy through wavelength mixing of synchronized lasers has been shown to increase the spectral window of excitable fluorophores without the need for wavelength tuning.However,most currently available dual output laser sources rely on the costly and complicated optical parametric generation approach.In this report,we detail a relatively simple and low cost diamond Raman laser pumped by a ytterbium fiber amplifier emitting at 1055 nm,which generates a first Stokes emission centered at 1240 nm with a pulse width of 100 fs.The two excitation wavelengths of 1055 and 1240 nm,along with the effective two-color excitation wavelength of 1140 nm,provide an almost complete coverage of fluorophores excitable within the range of 1000–1300 nm.When compared with 1055 nm excitation,two-color excitation at 1140 nm offers a 90%increase in signal for many far-red emitting fluorescent proteins(for example,tdKatushka2).We demonstrate multicolor imaging of tdKatushka2 and Hoechst 33342 via simultaneous two-color two-photon,and two-color three-photon microscopy in engineered 3D multicellular spheroids.We further discuss potential benefits and applications for two-color three-photon excitation.In addition,we show that this laser system is capable of in vivo imaging in mouse cortex to nearly 1 mm in depth with two-color excitation. | Evan P Perillo Jeremy W Jarrett Yen-Liang Liu Ahmed Hassan Daniel C Fernée John R Goldak Andrei Bonteanu David J Spence Hsin-Chih Yeh Andrew K Dunn | 2017 | Light(Science & Applications)2017，6，1： | 1 |
| 13 | C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease显示文摘 | John D Jeremy G W Gideon MH Shinichi E Gudny E Ann R | 2004 | New England J Medicine2004，350，14： | 1 |
| 14 | 硬膜外麻醉与术后结局显示文摘Wijeysundera及其同事(参见本刊2卷12期“论文摘要”)提出了大量数据质疑硬膜外麻醉对于非心脏手术后结局的影响,因此支持了另一些随机试验和系统性综述的结果。然而,主要的问题是这些数据与较早用于分析的临床数据是否仍具有相关性。 | Henrik Kehlet Jeremy Nightingale Alan Stedman Duminda N Wijeysundero W Scott Beattie Peter C Austin Janet E Huxt Andreas Laupacis 肖颖(译) | 2009 | 世界临床医学2009，，9： | 0 |
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