5篇
您的检索式：作者名="Jeremy Lucas"
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| 1 | Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals显示文摘 | Benjamin R. Carone Lucas Fauquier Naomi Habib Jeremy M. Shea Caroline E. Hart Ruowang Li Christoph Bock Chengjian Li Hongcang Gu Phillip D. Zamore Alexander Meissner Zhiping Weng Hans A. Hofmann Nir Friedman Oliver J. Rando | 2010 | Cell2010，，7： | 1 |
| 2 | Solid Immersion Facilitates Fluorescence Microscopy with Nanometer Resolution and Sub‐?ngstr?m Emitter Localization显示文摘 | Dominik Wildanger Brian R. Patton Heiko Schill Luca Marseglia J. P. Hadden Sebastian Knauer Andreas Sch?nle John G. Rarity Jeremy L. O’Brien Stefan W. Hell Jason M. Smith | 2012 | Adv. Mater2012，，44： | 1 |
| 3 | The LEAFY floral regulator displays pioneer transcription factor properties显示文摘Pioneer transcription factors(TFs)are a special category of TFs with the capacity to bind to closed chromatin regions in which DNA is wrapped around histones and may be highly methylated.Subsequently,pioneer TFs are able to modify the chromatin state to initiate gene expression.In plants,LEAFY(LFY)is a master floral regulator and has been suggested to act as a pioneer TF in Arabidopsis.Here,we demonstrate that LFY is able to bind both methylated and non-methylated DNA using a combination of in vitro genomewide binding experiments and structural modeling.Comparisons between regions bound by LFY in vivo and chromatin accessibility data suggest that a subset of LFY bound regions is occupied by nucleosomes.We confirm that LFY is able to bind nucleosomal DNA in vitro using reconstituted nucleosomes.Finally,we show that constitutive LFY expression in seedling tissues is sufficient to induce chromatin accessibility in the LFY direct target genes APETALA1 and AGAMOUS.Taken together,our study suggests that LFY possesses key pioneer TF features that contribute to launching the floral gene expression program. | Xuelei Lai Romain Blanc-Mathieu Loïc GrandVuillemin Ying Huang Arnaud Stigliani Jeremy Lucas Emmanuel Thevenon Jeanne Loue-Manifel Laura Turchi Hussein Daher Eugenia Brun-Hernandez Gilles Vachon David Latrasse Moussa Benhamed Renaud Dumas Chloe Zubieta François Parcy | 2021 | Molecular Plant2021，14，5： | 0 |
| 4 | Capturing Auxin Response Factors Syntax Using DNA Binding Models显示文摘Auxin is a key hormone performing a wealth of functions throughout the life cycle of plants. It acts largely by regulating genes at the transcriptional level through a family of transcription factors called auxin response factors (ARFs). Even though all ARF monomers analyzed so far bind a similar DNA sequence, there is evidence that ARFs differ in their target genomic regions and regulated genes. Here, we report the use of position weight matrices (PWMs) to model ARF DNA binding specificity based on published DNA affinity purification sequencing (DAP-seq) data. We found that the genome binding of two ARFs (ARF2 and ARF5/ Monopteros [MP]) differ largely because these two factors have different preferred ARF binding site (ARFbs) arrangements (orientation and spacing). We illustrated why PWMs are more versatile to reliably identify ARFbs than the widely used consensus sequences and demonstrated their power with biochemical experiments in the identification of the regulatory regions o1IAA19, an well-characterized auxin-responsive gene. Finally, we combined gene regulation by auxin with ARF-bound regions and identified specific ARFbs configurations that are over-represented in auxin-upregulated genes, thus deciphering the ARFbs syntax functional for regulation. Our study provides a general method to exploit the potential of genome-wide DNA binding assays and to decode gene regulation. | Amaud Stigliani Raquel Martin-Arevalillo Jeremy Lucas Adrien Bessy Thomas Vinos-Poyo Victoria Mironova Teva Vernoux Renaud Dumas Francois Parcy | 2019 | Molecular Plant2019，12，6： | 0 |
| 5 | 将智能融入焊接过程——基于规则的系统、模糊逻辑及神经网络显示文摘Jeremy Smith和Bill Lucas解释基于规则的系统、模糊逻辑及神经网络等的基础,并描述它们在焊接工程中的应用。 | Jeremy Smith Bill Lucas | 2002 | 现代制造2002，，9： | 0 |
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