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| 1 | Objective assessment of bradykinesia in Parkinson’s disease using evolutionary algorithms:clinical validation显示文摘Background:There is an urgent need for developing objective,effective and convenient measurements to help clinicians accurately identify bradykinesia.The purpose of this study is to evaluate the accuracy of an objective approach assessing bradykinesia in finger tapping(FT)that uses evolutionary algorithms(EAs)and explore whether it can be used to identify early stage Parkinson’s disease(PD).Methods:One hundred and seven PD,41 essential tremor(ET)patients and 49 normal controls(NC)were recruited.Participants performed a standard FT task with two electromagnetic tracking sensors attached to the thumb and index finger.Readings from the sensors were transmitted to a tablet computer and subsequently analyzed by using EAs.The output from the device(referred to as'PD-Monitor')scaled from−1 to+1(where higher scores indicate greater severity of bradykinesia).Meanwhile,the bradykinesia was rated clinically using the Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale(MDS-UPDRS)FT item.Results:With an increasing MDS-UPDRS FT score,the PD-Monitor score from the same hand side increased correspondingly.PD-Monitor score correlated well with MDS-UPDRS FT score(right side:r=0.819,P=0.000;left side:r=0.783,P=0.000).Moreover,PD-Monitor scores in 97 PD patients with MDS-UPDRS FT bradykinesia and each PD subgroup(FT bradykinesia scored from 1 to 3)were all higher than that in NC.Receiver operating characteristic(ROC)curves revealed that PD-Monitor FT scores could detect different severity of bradykinesia with high accuracy(≥89.7%)in the right dominant hand.Furthermore,PD-Monitor scores could discriminate early stage PD from NC,with area under the ROC curve greater than or equal to 0.899.Additionally,ET without bradykinesia could be differentiated from PD by PD-Monitor scores.A positive correlation of PD-Monitor scores with modified Hoehn and Yahr stage was found in the left hand sides.Conclusions:Our study demonstrated that a simple to use device employing classifiers derived from EAs could not only be used to accurately measure different severity of bradykinesia in PD,but also had the potential to differentiate early stage PD from normality. | Chao Gao Stephen Smith Michael Lones Stuart Jamieson Jane Alty Jeremy Cosgrove Pingchen Zhang Jin Liu Yimeng Chen Juanjuan Du Shishuang Cui Haiyan Zhou Shengdi Chen | 2018 | Translational Neurodegeneration2018，7，1： | 3 |
| 2 | Exome Resequencing Identifies Potential Tumor‐Suppressor Genes that Predispose to Colorectal Cancer显示文摘 | Christopher G. Smith Marc Naven Rebecca Harris James Colley Hannah West Ning Li Yuan Liu Richard Adams Timothy S. Maughan Laura Nichols Richard Kaplan Michael J. Wagner Howard L. McLeod Jeremy P. Cheadle | 2013 | Human Mutation2013，，7： | 2 |
| 3 | Endoscopic Ultrasound-Guided Radiofrequency Ablation (EUS-RFA) of the Pancreas in a Porcine Model显示文摘 | Monica Gaidhane Ioana Smith Kristi Ellen Jeremy Gatesman Nagy Habib Patricia Foley Christopher Moskaluk Michel Kahaleh Salem Omar | 2012 | Gastroenterology Research and Practice2012，，： | 1 |
| 4 | Vascular development in embryoid bodies: quantification of transgenic intervention and antiangiogenic treatment显示文摘 | Amanda Lisabeth Evans James Bryant Jeremy Skepper Stephen K. Smith Cristin G. Print D. Stephen Charnock-Jones | 2007 | Angiogenesis2007，，3： | 1 |
| 5 | Predictors of depression, anxiety and quality of life in patients with prostate cancer receiving androgen deprivation therapy显示文摘 | Kelly Chipperfield Jane Fletcher Jeremy Millar Joanne Brooker Robin Smith Mark Frydenberg Sue Burney | 2013 | Psycho‐Oncology2013，，10： | 1 |
| 6 | 加快大型数据中心服务的可重构结构显示文摘数据中心的工作负载要求高计算能力、灵活性、能效和低成本。同时改善所有这些因素非常具有挑战性。为了推进数据中心超出商用服务器设计可以提供的能力,我们设计并构建了一个可组合、可重构的结构,来加速部分大型软件服务。结构的每个实例都由嵌入48台机器的半机架6×8二维环面高端Stratix V FPGA组成。每台服务器中都放置了一个FPGA,可以通过PCIe来访问,并用成对的10 Gb SAS电缆直接连接到其他FPGA。在本文中,我们描述了这种结构在1,632台服务器组(bed)的中等规模的部署,并测量了其在加快Bing搜索引擎方面的功效。我们描述了系统的要求和架构,详细介绍了关键技术挑战,以及使系统在出现故障情况下保持鲁棒性所需的解决方案,还有根据排名候选文档测量的系统性能、功率和弹性。在高负载时,一定范围内的可重构结构提高了每台服务器固定延迟分布的吞吐量排名95%——或在保持等效吞吐量时,减少29%的尾延迟。 | Andrew Putnam Adrian M.Caulfield Eric S.Chung Derek Chiou Kypros Constantinide John Demme Hadi Esmaeilzadeh Jeremy Fowers Gopi Prashanth Gopal Jan Gray Michael Haselman Scott Hauck Stephen Heil Amir Hormati Joo-Young Kim Sitaram Lanka James Larus Eric Peterson Simon Pope Aaron Smith Jason Thong Phillip Yi Xiao Doug Burger | 2015 | 中国集成电路2015，24，1： | 1 |
| 7 | A Global Profile of Germline Gene Expression in C. elegans显示文摘 | Valerie Reinke Harold E. Smith Jeremy Nance John Wang Carrie Van Doren Rebecca Begley Steven J.M. Jones Elizabeth B. Davis Stewart Scherer Samuel Ward Stuart K. Kim | 2000 | Molecular Cell2000，，3： | 1 |
| 8 | bohemi-a and lschemia Tolerance in the Brain显示文摘 | Jeremy L Smith Mathew J reeves | 2006 | Int J Cexebrovasc Dis2006，14，3： | 1 |
| 9 | FinancialMarketinDevel-opmentandtheDevelopmentofFinancialMarkets显示文摘 | Jeremy G Smith B | | 0，，： | 1 |
| 10 | Sex steroid control of hypothalamic Kiss1 expression in sheep and rodents: Comparative aspects显示文摘 | Jeremy T. Smith | 2008 | Peptides2008，，1： | 1 |
| 11 | Financial markets in development, and the development of financial markets 显示文摘 | Greenwood Jeremy Smith | 1997 | Journal of Economic Dynamics and Control1997，21，1： | 1 |
| 12 | Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates显示文摘 | Jeremy A. Miller Jason Nathanson Daniel Franjic Sungbo Shim Rachel A. Dalley Sheila Shapouri Kimberly A. Smith Susan M. Sunkin Amy Bernard Jeffrey L. Bennett Chang-Kyu Lee Michael J. Hawrylycz Allan R. Jones David G. Amaral Nenad Sestan Fred H. Gage Ed S. | 2013 | Development2013，，22： | 1 |
| 13 | Venous Invasion in Colorectal Cancer: Impact of an Elastin Stain on Detection and Interobserver Agreement Among Gastrointestinal and Nongastrointestinal Pathologists显示文摘 | Richard Kirsch David E. Messenger Robert H. Riddell Aaron Pollett Megan Cook Sahar Al-Haddad Catherine J. Streutker Dimitrios X. Divaris Rajani Pandit Ken J. Newell Jimin Liu Russell G. Price Sharyn Smith Jeremy R. Parfitt David K. Driman | 2013 | The American Journal of Surgical Pathology2013，，2： | 1 |
| 14 | Apochromatie lenses for near-infrared astronomical instruments 显示文摘 | REND Q JEREMY SMITH J R | 1999 | Optical Engineer- ing1999，38，3： | 1 |
| 15 | Measuring genetic diversity in ecological studies显示文摘 | Meghan L. Avolio Jeremy M. Beaulieu Eugenia Y. Y. Lo Melinda D. Smith | 2012 | Plant Ecology2012，，7： | 1 |
| 16 | Fragrance materials in asthma: a pilot study using a surrogate aerosol product显示文摘 | Dilini Vethanayagam Harissios Vliagoftis Dennell Mah Jeremy Beach Ladd Smith Redwan Moqbel | 2013 | Journal of Asthma2013，，9： | 1 |
| 17 | Ferrate (Ⅵ) oxidation of hydrogen sulfide显示文摘 | VIRENDER K SHARMA JEREMY O SMITH FRANK J MILLERO | 1997 | Environ Sci & Teehnoi1997，31，9： | 1 |
| 18 | Ferrate (Ⅵ) oxidation of aqueous cyanide显示文摘 | VIRENDER K SHARMA WAYNE RIVERA JEREMY O SMITH | 1998 | Environ Sci & Technol1998，32，17： | 1 |
| 19 | On the Tempo of Genome Size Evolution in Angiosperms显示文摘 | Jeremy M. Beaulieu Stephen A. Smith Ilia J. Leitch Jan Suda | 2010 | Journal of Botany2010，，： | 1 |
| 20 | The U.S. Acid Rain Program: Key Insights from the Design, Operation, and Assessment of a Cap-and-Trade Program显示文摘 | Sam Napolitano Jeremy Schreifels Gabrielle Stevens Maggie Witt Melanie LaCount Reynaldo Forte Kenon Smith | 2007 | The Electricity Journal2007，，7： | 1 |
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