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| 1 | Artificial intelligence in gastrointestinal endoscopy:The future is almost here显示文摘Artificial intelligence(AI) enables machines to provide unparalleled value in a myriad of industries and applications. In recent years, researchers have harnessed artificial intelligence to analyze large-volume, unstructured medical data and perform clinical tasks, such as the identification of diabetic retinopathy or the diagnosis of cutaneous malignancies. Applications of artificial intelligence techniques, specifically machine learning and more recently deep learning, are beginning to emerge in gastrointestinal endoscopy. The most promising of these efforts have been in computeraided detection and computer-aided diagnosis of colorectal polyps, with recent systems demonstrating high sensitivity and accuracy even when compared to expert human endoscopists. AI has also been utilized to identify gastrointestinal bleeding, to detect areas of inflammation, and even to diagnose certain gastrointestinal infections. Future work in the field should concentrate on creating seamless integration of AI systems with current endoscopy platforms and electronic medical records, developing training modules to teach clinicians how to use AI tools, and determining the best means for regulation and approval of new AI technology. | Muthuraman Alagappan Jeremy R Glissen Brown Yuichi Mori Tyler M Berzin | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，10： | 14 |
| 2 | Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients显示文摘AIM:To study if HER-2 overexpression by locally advanced esophageal cancers increase the chance of brain metastasis following esophagectomy.METHODS:We retrospectively reviewed the medical records of esophageal cancer patients who underwent esophagectomy at University of Iowa Hospitals and Clinics between 2000 and 2010.Data analyzed consisted of demographic and clinical variables.The brain metastasis tissue was assayed for HER-2 overexpression utilizing the FDA approved DAKO Hercept Test.RESULTS:One hundred and forty two patients were reviewed.Median age was 64 years(36-86 years).Eighty eight patients(62%) received neoadjuvant chemoradiotherapy.Pathological complete and partial responses were achieved in 17(19%) and 71(81%) patients.Cancer relapsed in 43/142(30%) patients.The brain was the first site of relapse in 9/43 patients(21%,95% CI:10%-36%).HER-2 immunohistochemistry testing of the brain metastasis tissue showed that 5/9(56%) cases overexpressed HER-2(3+ staining).CONCLUSION:HER-2 overexpression might be associated with increased risk of brain metastasis in esophageal cancer patients following esophagectomy.Further studies will be required to validate this observation. | Taher Abu Hejleh Barry R DeYoung Eric Engelman Jeremy M Deutsch Bridget Zimmerman Thorvardur R Halfdanarson Daniel J Berg Kalpaj R Parekh William R Lynch Mark D Iannettoni Sudershan Bhatia Gerald Clamon | 2012 | World Journal of Gastrointestinal Oncology2012，4，5： | 5 |
| 3 | Perinatal Listeria monocytogenes susceptibility despite preconceptual priming and maintenance of pathogen-specific CD8^+ T cells during pregnancy显示文摘Listeria monocytogenes (Lm ) 为发展中的胎儿在怀孕和疾病的后果期间是有为全身的母亲的感染的唯一的倾向的一个细胞内部的细菌。给与出生前的 Lm 感染联系的高死亡,为在怀孕的极其脆弱的经期期间扩充保护的免疫的策略着急地被需要。此处,保护由在对随后的剧毒的 Lm 出生前的感染的怀孕被评估以前,管理的稀释 Lm 交谈了。因为显著地更多的细菌从母亲的纸巾被恢复,我们证明对在非怀孕的老鼠的第二等的 Lm 感染的保护严厉地在 allogeneic 怀孕期间被节制,尽管有病原体特定的 CD8 + T 房间的数字、功能的保藏。更重要地,因为各在怀孕和天真的怀孕控制以前与稀释 Lm 接种的老鼠在怀孕期间在 Lm 感染以后从单个 concepti 显示出近完全的胎儿的再吞和病原体恢复, preconceptual priming 不在 utero 侵略或胎儿的消耗量免于。显著地,对有在 allogeneic 怀孕的 preconceptual priming 的出生前的 Lm 感染的保护的缺乏在 syngeneic 怀孕期间被恢复。因此,母亲胎儿的抗原不和在出生前的 Lm 感染以后对胎儿的复杂并发症支配 preconceptual 种痘的低效率,尽管有病原体特定的 CD8 + T 房间的数字、功能的保藏。 | Dayna R Clark Vandana Chaturvedi Jeremy M Kinder Tony T Jiang Lijun Xin James M Ertelt Sing Sing Way | 2014 | Cellular & Molecular Immunology2014，11，6： | 3 |
| 4 | An interactive genetic algorithm-based framework for handling qualitative criteria in design optimization显示文摘 | Alexandra M B Jeremy R Ashutosh T | 2007 | Computers in Industry2007，58，： | 1 |
| 5 | Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial显示文摘 | Jeremy Chataway Nadine Schuerer Ali Alsanousi Dennis Chan David MacManus Kelvin Hunter Val Anderson Charles R M Bangham Shona Clegg Casper Nielsen Nick C Fox David Wilkie Jennifer M Nicholas Virginia L Calder John Greenwood Chris Frost Richard Nicholas | 2014 | The Lancet2014，，： | 1 |
| 6 | Review:the strobilurin fungicides显示文摘 | Dave W B John M C Jeremy R G | 2002 | Pest Management Science2002，58，7： | 1 |
| 7 | Detecting influenza epidemics using search engine query data 显示文摘 | JEREMY G MOHEBBI M H PATEL R S | 2009 | Nature2009，，457： | 1 |
| 8 | Ionic conduction in phosphateester-crosslinked poly(ethylene glycol)s complexed with lithium trifluoromethanesulphonate显示文摘 | Jeremy R M Martin P G | 1986 | Polymer Communications1986，27，12： | 1 |
| 9 | Towards regenerative therapy for cardiac disease显示文摘 | Leon M Ptaszek Moussa Mansour Jeremy N Ruskin Kenneth R Chien | 2012 | 2012 (9819)2012，，9819： | 1 |
| 10 | The strobilurin fungicides 显示文摘 | Bartlett D W Clough J M Jeremy R | 2002 | Pest Manag Sci2002，58，： | 1 |
| 11 | Review the Strobilurin fungicides显示文摘 | Dave W B John M C Jeremy R G | 2002 | Pest Management Science2002，58，7： | 1 |
| 12 | Combinations of microphase separation and terminal multi- ple hydrogen bonding in novel显示文摘 | Koji Yamauchi Jeremy R Lizotte David M Hercules | 2002 | Macromolecules J Am Chem Soc2002，124，29： | 1 |
| 13 | Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity显示文摘 | JEREMY R G BRUCE W K THOMAS M V | 2007 | The Journal of Clinical Investigation2007，117，9： | 1 |
| 14 | Review: The strobilurin fungicides 显示文摘 | DAVE W BARTLETT JOHN M CLOUGH JEREMY R GODWIN | 2002 | Pest Management Science2002，58，： | 1 |
| 15 | A multicenter comparison of intraaortic balloon pump utilization in isolated coronary artery bypass graft surgery显示文摘 | Roger J.F Baskett Gerald T O’Connor Gregory M Hirsch William A Ghali Kathy Sabadosa Jeremy R Morton Cathy S Ross Felix Hernandez William C Nugent Stephen J Lahey Donato A Sisto Lawrence J Dacey John D Klemperer Robert E Helm Andrew Maitland | 2003 | The Annals of Thoracic Surgery2003，，6： | 1 |
| 16 | Combinations of microphase separation and terminal multiple hydrogen bonding in novel显示文摘 | Koji Yamauchi Jeremy R Lizotte David M Hercules | 2002 | Macromolecules J Am Chem Soc2002，124，29： | 1 |
| 17 | RF MEMS switches and switch circuits显示文摘 | Gabriel M R Jeremy B M | 2001 | IEEE Microwave Magazine2001，，2： | 1 |
| 18 | Bone and metal:An orthopaedic perspective on osseointegration of metals显示文摘 | Goriainov V Cook R Jeremy M | 2014 | Acta Biomater2014，10，10： | 1 |
| 19 | NMR visualization of free asparagine in potato tissue using adduct formation with formaldehyde显示文摘 | MASON R P SANDERS JEREMY K M GIDLEY M J | 1986 | Phytochemistry1986，25，7： | 1 |
| 20 | The strobiluin fungicides 显示文摘 | BARTLETt D W CIOUGH J M JEREMY R | 2002 | Pest Management Science2002，，58： | 1 |
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