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| 1 | Optical observations of LIGO source GW 170817 by the Antarctic Survey Telescopes at Dome A,Antarctica显示文摘The LIGO detection of gravitational waves(GW) from merging black holes in 2015 marked the beginning of a new era in observational astronomy. The detection of an electromagnetic signal from a GW source is the critical next step to explore in detail the physics involved. The Antarctic Survey Telescopes(AST3),located at Dome A, Antarctica, is uniquely situated for rapid response time-domain astronomy with its continuous night-time coverage during the austral winter. We report optical observations of the GW source(GW 170817) in the nearby galaxy NGC 4993 using AST3. The data show a rapidly fading transient at around 1 day after the GW trigger, with the i-band magnitude declining from 17:23 ± 0:13 magnitude to 17:72 ± 0:09 magnitude in ~1:8 h. The brightness and time evolution of the optical transient associated with GW 170817 are broadly consistent with the predictions of models involving merging binary neutron stars. We infer from our data that the merging process ejected about ~10^(-2) solar mass of radioactive material at a speed of up to 30% the speed of light. | lei hu xuefeng wu igor andreoni michael c.b.ashley jeff cooke xiangqun cui fujia du zigao dai bozhong gu yi hu haiping lu xiaoyan li zhengyang li ensi liang liangduan liu bin ma zhaohui shang tianrui sun n.b.suntzeff charling tao syed a.uddin lifan wang xiaofeng wang haikun wen di xiao jin xu ji yang shihai yang xiangyan yuan hongyan zhou hui zhang jilin zhou zonghong zhu | 2017 | Science Bulletin2017，62，21： | 6 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | The Scorpion Venom Peptide Smp76 Inhibits Viral Infection by Regulating Type-Ⅰ Interferon Response显示文摘Dengue virus(DENV) and Zika virus(ZIKV) have spread throughout many countries in the developing world and infect millions of people every year, causing severe harm to human health and the economy. Unfortunately, there are few effective vaccines and therapies available against these viruses. Therefore, the discovery of new antiviral agents is critical.Herein, a scorpion venom peptide(Smp76) characterized from Scorpio maurus palmatus was successfully expressed and purified in Escherichia coli BL21(DE3). The recombinant Smp76(rSmp76) was found to effectively inhibit DENV and ZIKV infections in a dose-dependent manner in both cultured cell lines and primary mouse macrophages. Interestingly,rSmp76 did not inactivate the viral particles directly but suppressed the established viral infection, similar to the effect of interferon(IFN)-b. Mechanistically, rSmp76 was revealed to upregulate the expression of IFN-b by activating interferon regulatory transcription factor 3(IRF3) phosphorylation, enhancing the type-Ⅰ IFN response and inhibiting viral infection.This mechanism is significantly different from traditional virucidal antimicrobial peptides(AMPs). Overall, the scorpion venom peptide Smp76 is a potential new antiviral agent with a unique mechanism involving type-Ⅰ IFN responses,demonstrating that natural AMPs can enhance immunity by functioning as immunomodulators. | Zhenglin Ji Fangfang Li Zhiqiang Xia Xingchen Guo Minjun Gao Fang Sun Yuting Cheng Yingliang Wu Wenxin Li Syed Abid Ali Zhijian Cao | 2018 | Virologica Sinica2018，33，6： | 2 |
| 4 | Interleukin-17 increases the expression of Toll-like receptor 3 via the STAT3 pathway in rheumatoid arthritis fibroblast-like synoviocytes显示文摘 | Lee SY Yoon BY Kim JI | 2014 | Immunology2014，141，3： | 1 |
| 5 | Interleukin-17 increasesthe expression of Toll -like receptor 3 via the STAT3pathway in rheumatoid arthritis fibroblast -like synovio-cytes 显示文摘 | Lee SY Yoon BY Kim JI | 2014 | Immunology2014，141，3： | 1 |
| 6 | Regional and seasonal variations in facial sebum secretions:a proposal for the defi-nition of combination skin type显示文摘 | Youn SW Na JI Choi SY | 2005 | Skin Res Technol2005，11，3： | 1 |
| 7 | lntrasellar Cavernous Hemangioma显示文摘 | Seong CJ Jin SY Ji HYY | | 0，，： | 1 |
| 8 | Effect of tranexamic acid on melasma: a clinical trial with histological evaluation 显示文摘 | Na JI Choi SY Yang SH | 2013 | J EurAcad Dermatol Venereol2013，27，8： | 1 |
| 9 | Fetus in fetu:two case reports and literature review显示文摘 | Ji Y Chen SY Zhong L et si | 2014 | BMC Pediatr2014，14，1： | 1 |
| 10 | Vascular endothelial growth factor-induced angiogenic gene therapy in patients with peripheral artery disease显示文摘 | Jang SY Park JI | 2004 | Exp Mol Med2004，36，： | 1 |
| 11 | Cardioprotective effects of Astragali Ra- dix against isoproterenol-induced myocardial injury in rats and its possible mechanism 显示文摘 | Xu XL Ji H Gu SY et ai | 2008 | Phytother Res2008，22，3： | 1 |
| 12 | New Insights into biological roles of relaxin and relaxin-related peptides 显示文摘 | Park JI Chang CL Hsu SY | 2005 | Rev Endocr Metab Dis- ord2005，6，4： | 1 |
| 13 | Cardioproteetive effects of Astragali Radix against Isoproterenol - induced myocardial injury in rats and its possible mechanism 显示文摘 | Xu XL Ji H Gu SY | 2008 | J Phytother Res2008，22，3： | 1 |
| 14 | SPARC deficiency leads to early onset cataractogenesis显示文摘 | Clark JI Syed NA | 1998 | Invest Ophthalmol Vis Sci1998，39，： | 1 |
| 15 | Uhrasound-targeted transfection of tissue-type plasminogen activator gene carried by albumin nanoparticles to dog my- ocardium to prevent thrombosis after heart mechanical valve replacement 显示文摘 | Ji J Ji SY Yang JA | 2012 | Int Journal of Nanomedicine2012，7，1： | 1 |
| 16 | Catheter ablation of atrial fibrillation in patients with chronic lung disease 显示文摘 | Roh SY Choi JI Lee JY | 2011 | Circ Arrhythm Electrophysiol2011，4，6： | 1 |
| 17 | A retrospective analysis of second-line chemotherapy in patients with advanced gastric cancer显示文摘 | Ji SH Lira do H Yi SY | 2009 | BMC Cancer2009，9，： | 1 |
| 18 | Study on construction of nano t-PA plas- mid to prevent thrombosis after mechanical valve peplacement in dogs 显示文摘 | Ji SY Jun J Xiaohan Y | 2011 | J Surg Res2011，168，1： | 1 |
| 19 | Reactive oxygen species enhance differentiation of human embryonic stem cells into mesendodermal lineage显示文摘 | Ji AR Ku SY Cho MS | 2010 | Exp Mol Med2010，42，： | 1 |
| 20 | Glutathione prevented dopamine-induced apoptosis of melanocytes and its signaling显示文摘 | Park ES Kim SY Na JI | 2007 | J Dermatol Sci2007，47，： | 1 |
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