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| 1 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
| 2 | Whole-Process Pollution Control for Cost-Effective and Cleaner Chemical Production A Case Study of the Tungsten Industry in China显示文摘In this research,a methodology named whole-process pollution control(WPPC)is demonstrated that improves the effectiveness of process optimization.This methodology considers waste/emission treatment as a step of the whole production process with respect to the minimization of cost and environmental impact for the whole process.The following procedures are introduced in a WPPC process optimization:①a material and energy flow investigation and optimization based on a systematic understanding of the distribution and physiochemical properties of potential pollutants;②a process optimization to increase the utilization efficiency of different elements and minimize pollutant emissions;and③an evaluation to reveal the effectiveness of the optimization strategies.The production of ammonium paratungstate was chosen for the case study.Two factors of the different optimization schemes-namely the cost-effectiveness factor and the environmental impact indicator-were evaluated and compared.This research demonstrates that by considering the nature of potential pollutants,technological innovations,economic viability,environmental impacts,and regulation requirements,WPPC can efficiently optimize a metal production process. | Hongbin Cao He Zhao Di Zhang Chenming Liu Xiao Lin Yuping Li Pengge Ning Jiajun Sun Yi Zhang Zhi Sun | 2019 | Engineering2019，5，4： | 7 |
| 3 | Exosomes with low miR-34c-3p expression promote invasion and migration of non-small cell lung cancer by upregulating integrinα2β1显示文摘Exosomes play critical roles in regulating various physiological and pathological processes,including immune stimulation,immune suppression,cardiovascular diseases,and cancers.Recent studies show that exosomes that transport specific microRNAs(miRNAs)are involved in tumor development.However,the molecular mechanism by which tumor invasion and migration are regulated by exosomes from non-small cell lung cancer(NSCLC)is not well understood.Here,we show that exosomes shuttling low levels of miR-34c-3p are involved in NSCLC progression.Our results showed that exosomes derived from NSCLC cells carrying low levels of miR-34c-3p could be transported into the cytoplasm of NSCLC cells and accelerate NSCLC invasion and migration by upregulating integrinα2β1.A luciferase assay revealed that integrinα2β1 was the direct target of miR-34c-3p,and overexpression of integrinα2β1 could promote the invasion and migration of NSCLC cells.The analysis of exosomes derived from clinical serum samples indicated that the expression of miR-34c-3p was significantly downregulated in exosomes from NSCLC patients compared with that of normal controls.A549-derived exosomes promoted NSCLC cells lung metastases in vivo.Exosomes shuttling low levels of miR-34c-3p were associated with the progression of NSCLC in vitro and in vivo.Our data demonstrate that exosomes shuttling low levels of miR-34c-3p can accelerate the invasion and migration of NSCLC by upregulating integrinα2β1.MiR-34c-3p can be a diagnostic and prognostic marker for NSCLC.High expression of integrinα2β1 is positively related to the migration and metastasis of NSCLC cells. | Wenjing Huang Yanyan Yan Yun Liu Minting Lin Jinxiang Ma Wei Zhang Jianwei Dai Jiajun Li Qiaoru Guo Hubiao Chen Bolat Makabel Hong Liu Chaoyue Su Hong Bi Jianye Zhang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 4 | Optimization of control parameters of droplet density in citrus trees using UAVs and the Taguchi method显示文摘The control parameters of the unmanned aerial vehicle(UAV)should be carefully designed to improve UAV spraying performance on citrus trees.The present study investigated the optimal droplet distribution control parameters in citrus trees using a UAV and the Taguchi method,of which optimal results were observed with an inverted triangle citrus tree canopy shape,a spraying height of 1.40 m,and a flight speed of 1.0 m/s.Among the discussed control parameters,the flight speed presented the most significant effect with a contribution percentage of 74.0%.The established multiple regression model predicted an optimal spraying height of 1.27 m and a maximum droplet density of 35.39 droplets/cm2.In addition,the effects of individual control parameter on the droplet density of the lower layer of citrus trees were systematically analyzed,of which inverted triangle shape more significantly affected the droplet density of the lower layer and presented an 82.0%increase in droplet density as compared to the triangle shape.An improvement of 59.6%in the lower layer droplet density was observed at a spraying height of 1.40 m.In addition,the other spraying heights did not present significant differences in their coefficient of variation(CV)values. | Chaojun Hou Yu Tang Shaoming Luo Jintian Lin Yong He Jiajun Zhuang Weifeng Huang | 2019 | International Journal of Agricultural and Biological Engineering2019，12，4： | 4 |
| 5 | Selenium Enrichment in Cambrian Stratabound Gold Deposits in the Western Qinling Mountains显示文摘Stratabound gold deposits in the western Qinling Mountains occur in Cambrian chert formation composed of carbonaceous chert and carbonaceous slate. The distinctive chert formation provides important grounds for the mineralization and controls on the formation of gold deposits. Study shows that Se is exceptionally higher in both host rocks and gold orebodies. It may be recovered as a valuable component in ores for total utilization, and in some localities even independent Se orebodies (which are mined exclusively for Se) may be delineated. In gold ore Se mainly occurs as independent minerals or in the isomorphous form in sulphides and there is a positive correlation between Se and Au. | Liu Jiajun,Open Laboratory of Ore Deposit Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang, Guizhou 550002Zheng Minghua, Chengdu Institute of Technology, Chengdu, Sichuan 610059Liu Jianming, Research Centre of Mineral Resources Exploration, Chinese Academy of Sciences,Beijing 100101Zhou Yufeng, Gu Xuexiang, Zhang Bin, Lin Li, Chengdu Institute of Technology, Chengdu, Sichuan 610059and Lu Wenquan Institute of Comprehensive Utilization of Mineral Resources, Chengdu, Sichuan 610041 | 1997 | Acta Geologica Sinica(English Edition)1997，71，4： | 3 |
| 6 | Study of Texture Segmentation and Classification for Grading Small Hepatocellular Carcinoma Based on CT Images显示文摘To grade Small Hepatocellular Car Cinoma(SHCC)using texture analysis of CT images,we retrospectively analysed 68 cases of Grade II(medium-differentiation)and 37 cases of Grades III and IV(high-differentiation).The grading scheme follows 4 stages:(1)training a Super Resolution Generative Adversarial Network(SRGAN)migration learning model on the Lung Nodule Analysis 2016 Dataset,and employing this model to reconstruct Super Resolution Images of the SHCC Dataset(SR-SHCC)images;(2)designing a texture clustering method based on Gray-Level Co-occurrence Matrix(GLCM)to segment tumour regions,which are Regions Of Interest(ROIs),from the original and SR-SHCC images,respectively;(3)extracting texture features on the ROIs;(4)performing statistical analysis and classifications.The segmentation achieved accuracies of 0.9049 and 0.8590 in the original SHCC images and the SR-SHCC images,respectively.The classification achived an accuracy of 0.838 and an Area Under the ROC Curve(AUC)of 0.84.The grading scheme can effectively reduce poor impacts on the texture analysis of SHCC ROIs.It may play a guiding role for physicians in early diagnoses of medium-differentiation and high-differentiation in SHCC. | Bei Hui Yanbo Liu Jiajun Qiu Likun Cao Lin Ji Zhiqiang He | 2021 | Tsinghua Science and Technology2021，26，2： | 3 |
| 7 | An effective spray drift-reducing method for a plant-protection unmanned aerial vehicle显示文摘A spraying system for a plant-protection unmanned aerial vehicle(UAV)was designed to reduce spray drift.A custom low-speed wind tunnel was constructed to generate a wind speed ranging from 0 to 5.92 m/s.The results showed that the wind speed was attenuated with an increase in distance.To compensate for the attenuation,a linear-fitting model was adopted.Then,the relationship between the spraying pressure and atomization rate was analyzed,and a fuzzy algorithm was adopted to adjust the spraying angle and pressure according to the wind speed and its changing rate.Finally,an evaluation of the proposed system in the compensated wind tunnel was conducted,and the drift distance was reduced by 33.7%compared with the system without adjustment of the spraying angle and pressure. | Yayong Chen Chaojun Hou Yu Tang Jiajun Zhuang Jintian Lin Shaoming Luo | 2019 | International Journal of Agricultural and Biological Engineering2019，12，5： | 2 |
| 8 | Source attribution for mercury deposition with an updated atmospheric mercury emission inventory in the Pearl River Delta Region, China显示文摘We used CMAQ-Hg to simulate mercury pollution and identify main sources in the Pearl River Delta (PR.D) with updated local emission inventory and latest regional and global emissions. The total anthropogenic mercury emissions in the PRD for 2014 were 11,939.6 kg. Power plants and industrial boilers were dominant sectors, responsible for 29.4 and 22.7%. We first compared model predictions and observations and the results showed a good performance. Then five scenarios with power plants (PP), municipal solid waste incineration (MSWI), industrial point sources (IP), natural sources (NAT), and boundary conditions (BCs) zeroed out separately were simulated and compared with the base case. BCs was responsible for over 30% of annual average mercury concentration and total deposition while NAT contributed around 15%. Among the anthropogenic sources, IP (22.9%) was dominant with a contribution over 20.0% and PP (18.9%) and MSWI (11.2%) ranked second and third. Results also showed that power plants were the most important emission sources in the central PRD, where the ultra-low emission for thermal power units need to be strengthened. In the northern and western PRD, cement and metal productions were priorities for mercury control. The fast growth of municipal solid waste incineration were also a key factor in the core areas. In addition, a coordinated regional mercury emission control was important for effectively controlling pollution. In the future, mercury emissions will decrease as control measures are strengthened, more attention should be paid to mercury deposition around the large point sources as high levels of pollution are observed. | Jiajun Liu Long Wang Yun Zhu Che-Jen Lin Carey Jang Shuxiao Wang Jia Xing Bin Yu Hui Xu Yuzhou Pan | 2019 | Frontiers of Environmental Science & Engineering2019，13，1： | 2 |
| 9 | Peroxisome proliferator activated receptor-γ ligands induced cell growth inhibition and its influence on matrix metalloproteinase activity in human myeloid leukemia cells显示文摘 | Jiajun Liu Huiling Lu Renwei Huang Dongjun Lin Xiangyuan Wu Qu Lin Xinyao Wu Jing Zheng Xianglin Pan Jun Peng Yuqin Song Maohong Zhang Ming Hou Feng Chen | 2005 | Cancer Chemotherapy and Pharmacology2005，，4： | 1 |
| 10 | Poncidin, an ent-kaerane diterpenoid derived from a constituent of the herbal sup- plement PC-SPES, Rabdosia rubescens, induces apoptosis by activation of capspase-3 and mitochondrial events in lung cancer cells in vitro显示文摘 | Liu Jiajun Huang Renwei Lin Dongiun | 2006 | Cencer Invest2006，24，2： | 1 |
| 11 | Antiproliferation effects of ponicidin on human myeloid leukemia cells in vitro 显示文摘 | Liu Jiajun Huang Renwei Lin Dongjun | 2005 | Oncol Rep2005，13，4： | 1 |
| 12 | Cross-Target Transfer Algorithm Based on the Volterra Model of SSVEP-BCI显示文摘In general, a large amount of training data can effectively improve the classification performance of the Steady-State Visually Evoked Potential(SSVEP)-based Brain-Computer Interface(BCI) system. However, it will prolong the training time and considerably restrict the practicality of the system. This study proposed a SSVEP nonlinear signal model based on the Volterra filter, which could reconstruct stable reference signals using relatively small number of training targets by transfer learning, thereby reducing the training cost of SSVEP-BCI. Moreover,this study designed a transfer-extended Canonical Correlation Analysis(t-eCCA) method based on the model to achieve cross-target transfer. As a result, in a single-target SSVEP experiment with 16 stimulus frequencies,t-eCCA obtained an average accuracy of 86.96%˙12.87% across 12 subjects using only half of the calibration time,which exhibited no significant difference from the representative training classification algorithms, namely, extended canonical correlation analysis(88.32%±13.97%) and task-related component analysis(88.92%±14.44%), and was significantly higher than that of the classic non-training algorithms, namely, Canonical Correlation Analysis(CCA) as well as filter-bank CCA. Results showed that the proposed cross-target transfer algorithm t-eCCA could fully utilize the information about the targets and its stimulus frequencies and effectively reduce the training time of SSVEP-BCI. | Jiajun Lin Liyan Liang Xu Han Chen Yang Xiaogang Chen Xiaorong Gao | 2021 | Tsinghua Science and Technology2021，26，4： | 1 |
| 13 | Crosslinking and functionalization of acellular patches via the self-assembly of copper@tea polyphenol nanoparticles显示文摘Decellularization is a promising technique to produce natural scaffolds for tissue engineering applications.However,non-crosslinked natural scaffolds disfavor application in cardiovascular surgery due to poor biomechanics and rapid degradation.Herein,we proposed a green strategy to crosslink and functionalize acellular scaffolds via the self-assembly of copper@tea polyphenol nanoparticles(Cu@TP NPs),and the resultant nanocomposite acellular scaffolds were named as Cu@TP-dBPs.The crosslinking degree,biomechanics,denaturation temperature and resistance to enzymatic degradation of Cu@TP-dBPs were comparable to those of glutaraldehyde crosslinked decellularized bovine pericardias(Glut-dBPs).Furthermore,Cu@TP-dBPs were biocompatible and had abilities to inhibit bacterial growth and promote the formation of capillary-like networks.Subcutaneous implantation models demonstrated that Cu@TP-dBPs were free of calcification and allowed for host cell infiltration at Day 21.Cardiac patch graft models confirmed that Cu@TP-dBP patches showed improved ingrowth of functional blood vessels and remodeling of extracellular matrix at Day 60.These results suggested that Cu@TP-dBPs not only had comparable biomechanics and biostability to Glut-dBPs,but also had several advantages over Glut-dBPs in terms of anticalcification,remodeling and integration capabilities.Particularly,they were functional patches possessing antibacterial and proangiogenic activities.Thesematerial properties and biological functionsmade Cu@TP-dBPs a promising functional acellular patch for cardiovascular applications. | Qin Li Yuan Gao Jiajun Zhang Yangfeng Tang Yangyong Sun Lujia Wu Hao Wu Meifang Shen Xiaohong Liu Lin Han Zhiyun Xu | 2022 | Regenerative Biomaterials2022，9，1： | 1 |
| 14 | Noise estimation based on time-frequency correlation for speech enhancement显示文摘 | Yuan Wenhao Lin Jiajun An Wei | 2013 | Applied Acoustics2013，74，5： | 1 |
| 15 | Hydrogel bioadhesives harnessing nanoscale phase separation for Achilles tendon repairing显示文摘Repairing Achilles tendon has emerged as a long-standing challenge in the orthopaedic surgeries.Although suture is the gold standard for re-attaching and repairing the fractured Achilles tendons in clinical surgeries,it is still subjected to numerous adverse side-effects,including chronic inflammatory,tendon tissue re-rupture,scar formation,and post-surgical peritendinous adhesion.In this work,we develop a class of hydrogel bioadhesives with tailored nanoscale phase separation for Achilles tendon repairing.To address the existing limitations of sutures,our hydrogel bioadhesives encompass three core functionalities:(i)instant and tough adhesion to Achilles tendon tissues,(ii)extraordinary long-term adhesion robustness under wet and dynamic in vivo conditions,and(iii)anti-postsurgical peritendinous adhesion.Combining our hydrogel bioadhesives with sutures,such kind of integrated approach enables a conformable yet robust biointerface with the tendon tissues,and prevents the fibroblast migration and formation of connective tissues,thus facilitating the tendon repairing.The hydrogel bioadhesives reported here open up new opportunities for the repairing of fractured Achilles tendons in diverse and complicated clinical scenarios. | Jun Zhang Xingmei Chen Jingseng Lin Pei Zhang Iek Man Lei Yue Tao Jiajun Zhang Tian Luo Ji Liu | 2024 | Nano Research2024，17，2： | 1 |
| 16 | The epidemic status and genetic diversity of 14 highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) isolates from China in 2009显示文摘 | Zhi Zhou Jianqiang Ni Zhen Cao Xue Han Yingju Xia Zhanchao Zi Kun Ning Qi Liu Lin Cai Peng Qiu Xiaoyu Deng Dongmei Hu Qian Zhang Yunfeng Fan Jiajun Wu Lilin Wang Miaojie Zhang Xiuling Yu Xinyan Zhai Kegong Tian | 2011 | Veterinary Microbiology2011，，3： | 1 |
| 17 | Experiments on Exploration of Shallow Fine Structures and the Construction of the 1-D Velocity Model in the Pingtan Island,Fujian显示文摘112 short-period seismographs were set up in the 400 km^2 area of Pingtan Island and its surrounding areas in Fujian.The combined observations of the airgun source and ambient noise source were carried out using a dense array to receive the 387 airgun signals excited around the island and one month of continuous ambient noise recording.The 1-D P-wave and S-wave shallow velocity model of Pingtan Island is obtained by the inversion of the airgun body wave’s first arrival time data,and the reliability of the velocity model is verified by using the surface wave phase velocity dispersion curve,which can provide initial model for subsequent 3-D imaging.The experimental results show that this experiment is a successful demonstration of local scale green non-destructive detection,which can provide basic data for shallow surface structure research and strong vibration simulation of the Pingtan Island. | GUO Yang XU Jiajun LIN Chen JIN Xing YAO Huajian YANG Hongfeng CAI Huiteng | 2019 | Earthquake Research in China2019，33，2： | 1 |
| 18 | Improved monaural speech segregation based on computational auditory scene analysis 显示文摘 | Wang Yu Lin Jiajun Chen Ning | 2013 | EURASIP Journal on Audio Speech and Music Processing2013，2013，2： | 1 |
| 19 | Pathologically triggered in situ aggregation of nanoparticles for inflammation-targeting amplification and therapeutic potentiation显示文摘Uncontrolled and persistent inflammation is closely related to numerous acute and chronic diseases.However,effective targeting delivery systems remain to be developed for precision therapy of inflammatory diseases.Herein we report a novel strategy for engineering inflammationaccumulation nanoparticles via phenolic functionalization.Different phenol-functionalized nanoparticles were first developed,which can undergo in situ aggregation upon triggering by the inflammatory/oxidative microenvironment.Phenolic compound-decorated poly(lactide-co-glycolide)nanoparticles,in particular tyramine(Tyr)-coated nanoparticles,showed significantly enhanced accumulation at inflammatory sites in mouse models of colitis,acute liver injury,and acute lung injury,mainly resulting from in situ cross-linking and tissue anchoring of nanoparticles triggered by local myeloperoxidase and reactive oxygen species.By combining a cyclodextrin-derived bioactive material with Tyr decoration,a multifunctional nanotherapy(TTN)was further developed,which displayed enhanced cellular uptake,antiinflammatory activities,and inflammatory tissue accumulation,thereby affording amplified therapeutic effects in mice with colitis or acute liver injury.Moreover,TTN can serve as a bioactive and inflammation-targeting nanoplatform for site-specifically delivering a therapeutic peptide to the inflamed colon post oral administration,leading to considerably potentiated in vivo efficacies.Preliminary studies also revealed good safety of orally delivered TTN.Consequently,Tyr-based functionalization is promising for inflammation targeting amplification and therapeutic potentiation of nanotherapies. | Qiang Nie Chenwen Li Yu Wang Yi Hu Wendan Pu Qixiong Zhang Jiajun Cai Yongyao Lin Gang Li Chenping Wang Lanlan Li Yin Dou Jianxiang Zhang | 2023 | Acta Pharmaceutica Sinica B2023，13，1： | 1 |
| 20 | HVS-based Imperceptibility Evalu- ation for Steganography显示文摘 | Ma Xiuying Lin Jiajun | 2009 | Social Informatics and Telecomm- unications Engineering2009，18，1： | 1 |
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