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| 1 | From concept to reality-A review to the primary test stand and its preliminary application in high energy density physics显示文摘Pulsed power technology,whereas the electrical energy stored in a relative long period is released in much shorter timescale,is an efficient method to create high energy density physics(HEDP)conditions in laboratory.Around the beginning of this century,China Academy of Engineering Physics(CAEP)began to build some experimental facilities for HEDP investigations,among which the Primary Test Stand(PTS),a multi-module pulsed power facility with a nominal current of 10 MA and a current rising time~90 ns,is an important achievement on the roadmap of the electro-magnetically driven inertial confinement fusion(ICF)researches.PTS is the first pulsed power facility beyond 10 TW in China.Therefore,all the technologies have to be demonstrated,and all the engineering issues have to be overcome.In this article,the research outline,key technologies and the preliminary HEDP experiments are reviewed.Prospects on HEDP research on PTS and pulsed power development for the next step are also discussed. | Jianjun Deng Weiping Xie Shuping Feng Meng Wang Hongtao Li Shengyi Song Minghe Xia Ji Ce An He Qing Tian Yuanchao Gu Yongchao Guan Bin Wei Xianbin Huang Xiaodong Ren Jiakun Dan Jing Li Shaotong Zhou Hongchun Cai Siqun Zhang Kunlun Wang Qiang Xu Yujuan Wang Zhaohui Zhang Guilin Wang Shuai Guo Yi He Yiwei Zhou Zhanji Zhang Libing Yang Wenkang Zou | 2016 | Matter and Radiation at Extremes2016，1，1： | 19 |
| 2 | Effects of Saccharomyces cerevisiae fermentation products on performance and rumen fermentation and microbiota in dairy cows fed a diet containing low quality forage显示文摘Background: A possible option to meet the increased demand of forage for dairy industry is to use the agricultural byproducts, such as corn stover. However, nutritional value of crop residues is low and we have been seeking technologies to improve the value. A feeding trial was performed to evaluate the effects of four levels of Saccharomyces cerevisiae fermentation product(SCFP; Original XP; Diamond V) on lactation performance and rumen fermentation in mid-lactation Holstein dairy cows fed a diet containing low-quality forage. Eighty dairy cows were randomly assigned into one of four treatments: basal diet supplemented with 0, 60, 120, or 180 g/d of SCFP per head mixed with 180, 120, 60, or 0 g of corn meal, respectively. The experiment lasted for 10 wks, with the first 2 weeks for adaptation.Results: Dry matter intake was found to be similar(P > 0.05) among the treatments. There was an increasing trend in milk production(linear, P ≤ 0.10) with the increasing level of SCFP supplementation, with no effects on contents of milk components(P > 0.05). Supplementation of SCFP linearly increased(P < 0.05) the N conversion, without affecting rumen pH and ammonia-N(P > 0.05). Increasing level of SCFP linearly increased(P < 0.05) concentrations of ruminal total volatile fatty acids, acetate, propionate, and butyrate, with no difference in molar proportion of individual acids(P > 0.05). The population of fungi and certain cel ulolytic bacteria(Ruminococcus albus, R. flavefaciens and Fibrobacter succinogenes)increased linearly(P < 0.05) but those of lactate-utilizing(Selenomonas ruminantium and Megasphaera elsdeni) and lactate-producing bacteria(Streptococcus bovis) decreased linearly(P ≤ 0.01) with increasing level of SCFP. The urinary purine derivatives increased linearly(P < 0.05) in response to SCFP supplementation, indicating that SCFP supplementation may benefit for microbial protein synthesis in the rumen.Conclusions: The SCFP supplementation was effective in maintaining milk persistency of mid-lactation cows receiving diets containing low-quality forage. The beneficial effect of SCFP could be attributed to improved rumen function; 1)microbial population shift toward greater rumen fermentation efficiency indicated by higher rumen fungi and cel ulolytic bacteria and lower lactate producing bacteria, and 2) rumen microbial fermentation toward greater supply of energy and protein indicated by greater ruminal VFA concentration and increased N conversion. Effects of SCFP were dose-depended and greater effects being observed with higher levels of supplementation and the effect was more noticeable during the high THI environment. | Wen Zhu Zihai Wei Ningning Xu Fan Yang Ilkyu Yoon Yihua Chung Jianxin Liu Jiakun Wang | 2017 | Journal of Animal Science and Biotechnology2017，8，3： | 13 |
| 3 | Optimal Trade-Off Between Regulation and Wind Curtailment in the Economic Dispatch Problem显示文摘Generator regulation and wind power curtailment are two conflicting ways to deal with the inaccurate prediction and volatility of wind power.This study focuses on planning the day-ahead schedule based on optimal trade-off between regulation of generators and wind curtailment.Compared to traditional economic dispatch methods,the proposed schedule is more robust and adaptive to multiple forecast scenarios instead of a single forecast scenario.The works of this paper are as follows:First,an economic dispatch problem based on multiple scenarios is formulated with the objective of minimizing both generator regulation and wind curtailment.Next,a forecast method for wind power scenarios is given.Finally,the proposed model is verified by comparing with other dispatch models that are based on single forecast scenario.The simulation results demonstrate the effectiveness of the proposed method with less wind curtailment,generator regulation,and operational cost.In addition,the penalty factors are set as parameters and the influences on the generators’regulation and wind curtailment are analyzed,providing the reference for system operators with different regulatory purposes. | Jinghua Li Jiakun Fang Jinyu Wen Yi Pan Qiang Ding | 2015 | CSEE Journal of Power and Energy Systems2015，1，4： | 12 |
| 4 | Transient stability risk assessment of power systems incorporating wind farms显示文摘Large-scale wind farm integration has brought several aspects of challenges to the transient stability of power systems.This paper focuses on the research of the transient stability of power systems incorporating with wind farms by utilizing risk assessment methods.The detailed model of double fed induction generator has been established.Wind penetration variation and multiple stochastic factors of power systems have been considered.The process of transient stability risk assessment based on the Monte Carlo method has been described and a comprehensive risk indicator has been proposed.An investigation has been conducted into an improved 10-generator 39-bus system with a wind farm incorporated to verify the validity and feasibility of the risk assessment method proposed. | Lu MIAO Jiakun FANG Jinyu WEN Weihua LUO | 2013 | Journal of Modern Power Systems and Clean Energy2013，1，2： | 7 |
| 5 | Design and Analysis of Double One Out of Two with a Hot Standby Safety Redundant Structure显示文摘In the rail transit system,the running foundation of the computer control system is required to be highly reliable,available and safe.A redundant system structure of double one out of two with a hot standby applied to the safety computer platform of the train control system is proposed in this paper.Considering the common cause failure,fault diagnosis rate,repair rate and switching success rate,the Markovian approach is adopted for modeling four safety redundant structures,including two out of three,double one out of two,one out of two with a hot standby and double one out of two with a hot standby.The calculation of the failure rate and PFH values is carried out with MATLAB to evaluate the reliability,safety and influencing factors of each structure.The final conclusion is that double one out of two with a hot standby structure can be best in the aspect of both reliability and safety with appropriate DC andβparameters. | WEN Jiakun CAO Yuan MA Lianchuan DU Siqi | 2020 | Chinese Journal of Electronics2020，29，3： | 4 |
| 6 | 2D CoOOH Sheet-Encapsulated Ni2P into Tubular Arrays Realizing 1000 mA cm^-2-Level-Current-Density Hydrogen Evolution Over 100 h in Neutral Water显示文摘Water electrolysis at high current density(1000 mA cm-2 level)with excellent durability especially in neutral electrolyte is the pivotal issue for green hydrogen from experiment to industrialization.In addition to the high intrinsic activity determined by the electronic structure,electrocatalysts are also required to be capable of fast mass transfer(electrolyte recharge and bubble overflow)and high mechanical stability.Herein,the 2D CoOOH sheet-encapsulated Ni2P into tubular arrays electrocatalytic system was proposed and realized 1000 mA cm-2-levelcurrent-density hydrogen evolution over 100 h in neutral water.In designed catalysts,2D stack structure as an adaptive material can buffer the shock of electrolyte convection,hydrogen bubble rupture,and evolution through the release of stress,which insure the long cycle stability.Meanwhile,the rich porosity between stacked units contributed the good infiltration of electrolyte and slippage of hydrogen bubbles,guaranteeing electrolyte fast recharge and bubble evolution at the high-current catalysis.Beyond that,the electron structure modulation induced by interfacial charge transfer is also beneficial to enhance the intrinsic activity.Profoundly,the multiscale coordinated regulation will provide a guide to design high-efficiency industrial electrocatalysts. | Shucong Zhang Wenbin Wang Feilong Hu Yan Mi Shuzhe Wang Youwen Liu Xiaomeng Ai Jiakun Fang Huiqiao Li Tianyou Zhai | 2020 | Nano-Micro Letters2020，12，10： | 3 |
| 7 | Optimal Scheduling for Combined District Heating and Power Systems Using Subsidy Strategies显示文摘The ongoing development of cogeneration technology has promoted public awareness on the integration of different types of energy systems.Integration of power and heating systems is the most common approach for energy transmission.The heat and power coupling of combined heat and power(CHP)units constrains the improvement of flexibility to accommodate more wind power,especially in winter.To address this problem,electrical boilers(EBs)are utilized as independent heat sources in one heat station to enhance their flexibility.This paper proposes a subsidy based bi-level optimal model.The objective of the upper problem is to minimize the operating cost,while the lower problem is to maximize the benefits of CHP and EBs based on the subsidy signals sent by the power system operator(PSO).The bi-level model is reformulated as a single-level linear problem by Karush Kuhn Turck(KKT)conditions and recast to a mix integer quadratic program using strong duality theory.Numerical results performed on an IEEE six-bus system with a eight-node district heating system validate the proposed model.The results demonstrate that the subsidy strategies can make the EB and CHP units operate according to the system operators’preferences to accommodate more wind power. | Bofu Deng Jiakun Fang Qian Hui Tieyan Zhang Zhe Chen Yun Teng Xiao Xi | 2019 | CSEE Journal of Power and Energy Systems2019，5，3： | 3 |
| 8 | Effects of dwarfing genes on water use efficiency of bread wheat显示文摘Climate change has increased the risk of drought, which significantly limits plant productivity.Various ways of increasing water availability and sustaining growth of crop plants in drought-prone environments are available. Genetic advances in grain yields under rainfed conditions have been achieved with the introduction of dwarfing genes. A thorough understanding of the effects of different dwarfing genes on root growth, coleoptile length, grain yields and water using efficiency(WUE) will provide opportunities to select appropriate Rht genes for breeding high WUE and grain yield cultivars. This review focuses on the mechanism involved in Rht genes that reduce plant height and affect root and coleoptile length, their consequent effects on grain yields and WUE, and suggests that for rainfed and irrigation-limited environments, combining GAR and GAI dwarfing genes in breeding may help boost WUE and yields, and more materials from different parental sources should be collected to assess opportunities for potential comprehensive application of specific Rht genes. | Jiakun YAN Suiqi ZHANG | 2017 | Frontiers of Agricultural Science and Engineering2017，4，2： | 3 |
| 9 | Review on bio-inspired flight systems and bionic aerodynamics显示文摘Humans’initial desire for flight stems from the imitation of flying creatures in nature.The excellent flight performance of flying animals will inevitably become a source of inspiration for researchers.Bio-inspired flight systems have become one of the most exciting disruptive aviation technologies.This review is focused on the recent progresses in bio-inspired flight systems and bionic aerodynamics.First,the development path of Biomimetic Air Vehicles(BAVs)for bio-inspired flight systems and the latest mimetic progress are summarized.The advances of the flight principles of several natural creatures are then introduced,from the perspective of bionic aerodynamics.Finally,several new challenges of bionic aerodynamics are proposed for the autonomy and intelligent development trend of the bio-inspired smart aircraft.This review will provide an important insight in designing new biomimetic air vehicles. | Jiakun HAN Zhe HUI Fangbao TIAN Gang CHEN | 2021 | Chinese Journal of Aeronautics2021，34，7： | 3 |
| 10 | Baicalin inhibits inflammation of lipopolysaccharide-induced acute lung injury via toll like receptor-4/myeloid differentiation primary response 88/nuclear factor-kappa B signaling pathway显示文摘OBJECTIVE:To explore the effect and mechanism of baicalin in the treatment of acute lung injury(ALI)by in vivo and in vitro experiments.METHODS:ALI was induced by instilling 10 mg/m L lipopolysaccharide(LPS)into the airway of rats.Different doses of baicalin(50 and 100 mg·kg^(-1)·d^(-1 ))were administered by gavage one day before modeling.RESULTS:Baicalin significantly reduced the permeability of the alveolocapillary membrane,alleviated tissue injury and inflammatory infiltration,and inhibited the secretion of inflammatory factors and the infiltration of neutrophils.The decline in these inflammations was related to the inhibition of the toll like receptor-4(TLR4)/myeloid differentiation factor 88(My D88)/nuclear factor-kappa B(NF-κB)/nod-like receptor pyrin containing 3(NLRP3)signaling pathway and the mitogen-activated protein kinase(MAPK)signaling pathway.CONCLUSIONS:Baicalin inhibits the secretion of inflammatory factors by inhibiting the TLR4-My D88-NF-κB/NLRP3 pathway and the MAPK signaling pathway.Thus,it reduces lung bronchial epithelial layer,alveolar damage,and pulmonary edema as detected in the in vivo and in vitro experiments.Therefore,baicalin may be a potential preventive and therapeutic drug for ALI. | ZHU Changle FENG Cuiling FENG Feng Yao Xiaoqin WANG Guishu SHI Liangtian ZHENG Jiakun | 2022 | Journal of Traditional Chinese Medicine2022，42，2： | 3 |
| 11 | The different root apex zones contribute to drought priming induced tolerance to a reoccurring drought stress in wheat显示文摘Drought priming is a promising approach to improve tolerance to further drought in wheat.The root apex plays important roles in drought however,its contribution to drought priming remains unknown.To provide mechanistic insights into this process,the transcriptomes and proteomes at three different zones along the root axis under drought stress were analyzed.Physiological assessment of root growth indicated that priming augmented roots growth in response to drought and also the levels of protective proline and glycine betaine.Scanning across the proximal to the distal zones of the root apex indicated increases the transcription of genes involved in primary and secondary metabolism.Conversely,genes related to translation,transcription,folding,sorting and degradation,replication and repair were increased in the apex compared to the proximal zone.A single drought episode suppressed their expression but prior drought priming served to maintain expression with recurrent drought stress.The differentially primed responses genes were mainly involved in the pathways related to plant hormone signaling,stress defense and cell wall modification.The prediction of regulatory hubs using Cytoscape implicated signaling components such as the ABA receptor PYL4 as influencing antioxidant status and the cell cycle.Based our integrative transcriptomic-proteomic assessments we present a model for drought priming protected plant hormone signaling transduction pathways to drive the cell cycle and cell wall loosening to confer beneficial effects on roots to counter the effects of drought.This model provides a theoretical basis for improvement of drought tolerance in wheat,via an increased understanding of drought priming induced drought tolerance. | Xiao Wang Jing Chen Jiakun Ge Mei Huang Jian Cai Qin Zhou Tingbo Dai Luis Alejandro Jose Mur Dong Jiang | 2021 | The Crop Journal2021，9，5： | 2 |
| 12 | Biomarker and pathway analyses of urine metabolomics in dairy cows when corn stover replaces alfalfa hay显示文摘Background: Alfalfa hay and corn stover are different type of forages which can significantly impact a cow's lactation performance, but the underlying metabolic mechanism has been poorly studied. We used biomarker and pathway analyses to characterize related biomarkers and pathways based on urine metabolomics data from different forage treatments. Urine was col ected from 16 multiparous Holstein dairy cows fed alfalfa hay(AH, high-quality forage, n = 8) and corn stover(CS, low-quality forage, n = 8) respectively. Gas chromatography–time of flight/mass spectrometry(GC-TOF/MS) was performed to identify metabolites in urine and the metaboanalyst online platform was used to do biomarker and pathway analysis.Results: Hippuric acid(HUA) and N-methyl-glutamic(NML-Glu) indicated the most significant difference between the two diets, when statistical y validated by biomarker analysis. HUA was also validated by standard compound quantitative method and showed significant higher concentration in CS group than AH group(2.8282 vs. 0.0005 mg/mL; P < 0.01).The significant negative correlation between milk yield and HUA(R^2= 0.459; P < 0.01) and significant positive correlation between milk yield and NML-Glu(R^2= 0.652; P < 0.01) were characterized. The pathway analysis revealed that these different metabolites were involved in 17 pathways including 7 influential pathways(pathway impact value > 0): Tyr metabolism, starch and sucrose metabolism, amino sugar and nucleotide sugar metabolism, galactose metabolism,Phe, Tyr and Try biosynthesis, purine metabolism, and glycerolipid metabolism. Based on the metabolome view map,the Phe, Tyr and Try biosynthesis pathway exhibited the highest impact value(0.50), and the Holm-Bonferroni multiple testing-based analysis revealed the most significant difference in the Tyr metabolism pathway(Holm P = 0.048).Conclusions: The identified HUA and NML-Glu may serve as potential biomarkers for discriminating CS and AH diets and could be used as candidates for milk yield related mechanistic investigations. Integrated network pathways associated with related metabolites provide a helpful perspective for discovering the effectiveness of forage quality in lactation performance and provides novel insights into developing strategies for better utilization of CS and other low-quality forage in China. | Huizeng Sun Bing Wang Jiakun Wang Hongyun Liu Jianxin Liu | 2017 | Journal of Animal Science and Biotechnology2017，8，1： | 2 |
| 13 | Use of electrosense in the feeding behavior of sturgeons显示文摘The electro-receptive lateral line system appeared early in the evolutionary history of fish.Sturgeons,members of the primitive Chondrostei group,are known for their electroreceptors(ampullae of Lorenzini)on the head,which are thought to be sensitive to weak electric fields in aquatic environments and involved in feeding,mating and migration.Here,we report the results of a set of behavioral and electrophysiological experiments designed to determine the function and characteristics of the electrosense in cultured sturgeons.The results showed Sibe-rian sturgeon(Acipenser baerii Brandt,1869)feeding striking at bio-electric fields produced by living feed-fish enclosed in a gel chamber and at the corrosion field produced by metal rods.With an electric stimulus that mim-ics the bio-electric fields produced by living prey,the relative discharge rate of electrosensory neurons in the dorsal octavolateralis nucleus(DON)was modulated by and phase-locked to sinusoidal stimulus and some units showed selectivity for dipolar direction in white sturgeon(Acipenser transmontanus Richardson,1836).This is the first study to provide the empirical evidence correlating with electrosensory behaviors and electrophysiolog-ical responses in cultured sturgeons,and suggesting that electrosense does play an innate role in feeding behav-ior of sturgeon.We believe this will have important implications for protecting sturgeons in the wild. | Xuguang ZHANG Jiakun SONG Chunxin FAN Hongyi GUO Xiaojie WANG Horst BLECKMANN | 2012 | Integrative Zoology2012，7，1： | 2 |
| 14 | A simple daily dynamic feeding regimen for reducing phosphorus consumption and excretion in laying hens显示文摘Phosphorus metabolism in laying hens is a highly dynamic process over the course of the 24 h egg-laying cycle.Adjusting the phosphorus feeding regimen according to the daily egg-laying cycle may help to improve phosphorus utilization efficiency.Hy-Line Brown layers(n=120;70 wk old)were offered 4different phosphorus daily regimens:(1)RR,fed regular phosphorus at both 09:00 and 17:00;(2)RL,fed regular phosphorus at 09:00 and low phosphorus at 17:00;(3)LR,fed low phosphorus at 09:00 and regular phosphorus at 17:00;(4)LL,fed low phosphorus at both 09:00 and 17:00.The regular and low phosphorus diets contained 0.32% and 0.14% non-phytate phosphorus,respectively.The feeding trial lasted for 12 wk.As a result,layers on the RL regimen had decreased laying rate(P<0.05;5 to 8,9 to 12,and 1 to 12 wk)when compared to all other regimens.Layers on the LL regimen had decreased eggshell thickness and specific gravity(P<0.05;wk 8)when compared to all other regimens,and had decreased egg shell strength(P<0.05;wk 8)when compared to RL and LR regimens.When compared to the RR regimen(a common practice in the industry),layers on the LR regimen had:(1)identical laying performance and egg quality(P>0.05);(2)decreased phosphorus excretion(P<0.05)during the period of09:00 to 17:00;(3)increased jejunal calbindin D28k protein expression(P<0.05)2 h after feeding in the morning;(4)decreased serum fibroblast growth factor 23 and calcitriol levels(P<0.05),decreased jejunal type Ⅲ sodium-phosphate cotransporter 2 gene and protein expression(P<0.05),and decreased renal type Ⅲ sodium-phosphate cotransporter 1 protein expression(P<0.05),2 h after feeding in the afternoon.In summary,when dietary phosphorus was supplemented in accordance with daily serum phosphorus rhythms(i.e.,the LR regimen),laying performance and egg quality were well supported whilst significantly decreasing phosphorus consumption and excretion.Thus,serum phosphorus rhythms will need to be carefully maintained when developing dietary phosphorus-reduction strategies in laying hens. | Xujie Liao Jiakun Yan Jionghao Chen Zhenyu Huang Tianshuai Xiao Changqing Li Chong Pan Xin Yang Yanli Liu Thomas D.Crenshaw Xiaojun Yang Zhouzheng Ren | 2022 | Animal Nutrition2022，，4： | 2 |
| 15 | Testing final closure time of the Paleo-Asian Ocean along the Solonker suture by a transition of compressional and extensional setting显示文摘The giant Central Asian Orogenic Belt is an extensive accretionary orogen,of which the Solonker suture,as a major regional suture,coincides closely with an early Permian paleobiogeographical boundary.This suture is considered to mark the location of the final closure of the Paleo-Asian Ocean between the North China Craton and the Mongolian Terrane.Although the closure time of the Paleo-Asian Ocean along the Solonker suture has generally been regarded as Late Permian-Early Triassic,uncertainty remains because of a lack of typical collisionrelated features(e.g.,high-grade regional metamorphism and well-developed fold-thrust structures)and a scarcity of outcrops.The present study reports Early Permian foliated gabbros and dikes(288-275 Ma)and Middle-Late Permian undeformed layered gabbros,strongly peraluminous granites,and I-type granites(265-254 Ma)in the Xinhure area along the northern margin of the North China Craton.The Early Permian foliated intrusions have a subduction-related geochemical signature and were derived from partial melting of lithospheric mantle modified by subduction-related melts or fluids at the active margin of the North China Craton.In contrast,the Late Permian undeformed layered gabbros and strongly peraluminous granites were derived from partial melting of lithospheric mantle and middle-upper crust,respectively,triggered by asthenospheric upwelling.Therefore,a transition from an end-compressional to an extensional environment according to a transition from collision termination to postcollision of the North China Craton and Mongolian Terrane may have occurred between 275 Ma and 262 Ma.This time span can be considered as the final closure time of the Paleo-Asian Ocean along the Solonker suture. | Haidong Zhang Jianchao Liu Jinkun Yang Jiakun Ge Jinya Wang Zhen Li | 2020 | Geoscience Frontiers2020，11，6： | 2 |
| 16 | Poly-β-hydroxybutyrate alleviated diarrhea and colitis via Lactobacillus johnsonii biofilm-mediated maturation of sulfomucin显示文摘Maintainance of sulfomucin is a key end point in the treatment of diarrhea and inflammatory bowel disease(IBD).However,the mechanisms underlying the microbial sense to sulfomucin are poorly understood,and to date,there are no therapies targeting the secretion and maturation of sulfomucin in IBD.Herein,we biosynthesized poly-β-hydroxybutyrate(PHB)and found that PHB could alleviate inflammation caused by diarrhea and colitis by enhancing the differentiation of sulfomucin.Microbiota transplantation and clearance together demonstrate that PHB promoting sulfomucin is mediated by Lactobacillus johnsonii(L.johnsonii).Further studies revealed that PHB provides a favorable niche for L.johnsonii biofilm formation to resist disturbance and support its growth.L.johnsonii-biofilm alleviates colitis by regulating fucose residues to promote goblet cell differentiation and subsequent sulfomucin maturation.Importantly,PHB alleviates colitis by enhancing sulfomucin secretion and maturation in a L.johnsonii-dependent manner.PHB represents a class of guardians,acting as a safe probiotic-biofilm delivery system that significantly promotes probiotic proliferation.Altogether,this study adds weight to the possible role of probiotics and functional materials in the treatment of intestinal inflammation.The application of PHB and biofilm self-coating L.johnsonii carries high translational potential and may be of clinical relevance. | Ning Ma Pingting Guo Jingyu Chen Zengkai Qi Chunchen Liu Jiakun Shen Yiwei Sun Xiyue Chen Guo-Qiang Chen Xi Ma | 2023 | Science China(Life Sciences)2023，66，7： | 2 |
| 17 | Association between thyroid hormone levels and frailty in the community-dwelling oldest-old: a cross-sectional study显示文摘Background:Changes in thyroid hormone levels are commonly recognized characters among the elderly,which were reported to potentially influence incident frailty.Therefore,we examined the cross-sectional associations of thyroid hormones(THs)with frailty as well as the five components characterizing frailty(fatigue,resistance,ambulation,number ofillnesses,and loss of weight)among the oldest-old.Methods:Four hundred and eighty-seven community-dwelling oldest-old from a local community in Haidian District,Beijing,participated in our recruitment campaign between April 2019 and May 2020.The primary outcomes were a definitive diagnosis of frailty according to the FRAIL scale(Fatigue,Resistance,Ambulation,Illnesses,Loss of weight)and a positive score for each frailty subdomain.Demographic information(age,sex,marital status,and educational status),comorbidities,and details on the participants lifestyles were recorded.Serum THs including free triodothyronin(fT3),triiodothyronine(T3),free thyroxine(fT4),and thyroxine(T4)and thyroid stimulating hormone(TSH)levels were also measured at the beginning of our study.Logistic regressions were conducted to screen for potential risk factors for frailty and its subdomains.Results:Among the total 487 subjects at enrollment,60(12.23%)of them were diagnosed with subclinical hypothyroidism and 110(22.59%)of the total population scored positive for frailty.Logistic regression analyses adjusted for all potential confounders,showed that frailty was significantly associated with the serum TSH concentration(odds ratio[OR]:1.06),fT3 concentration(OR:0.54),and subclinical hypothyroidism score(OR:2.18).The association between fT4 and frailty was absent in our observational study.The fT3/fT4 ratio characterizing peripheral hormone conversion was also tested to be correlated with frailty.Conclusion:Subclinical hypothyroidism,higher TSH level,lower fT3 level,and decreased fT3/fT4 ratio were all associated with frailty assessed by the FRAIL scale among the community-dwelling oldest-old,suggesting a relevant role of thyroid function in aging.Future longitudinal studies are warranted to determine the casual relationship between thyroid dysfunction and frailty in the oldest-old. | Bo Guan Jiakun Luo Xin Huang Fan Tian Shasha Sun Yufei Ma Yan Yu Ruihan Liu Jian Cao Li Fan | 2022 | Chinese Medical Journal2022，135，16： | 2 |
| 18 | Inhibiting manganese(Ⅱ)from catalyzing electrolyte decomposition in lithium-ion batteries显示文摘A once overlooked source of electrolyte degradation incurred by dissolved manganese(Ⅱ)species in lithium-ion batteries has been identified recently.In order to deactivate the catalytic activity of such manganese(II)ion,1-aza-12-crown-4-ether(A12C4)with cavity size well matched manganese(Ⅱ)ion is used in this work as electrolyte additive.Theoretical and experimental results show that stable complex forms between A12C4 and manganese(II)ions in the electrolyte,which does not affect the solvation of Li ions.The strong binding effect of A12C4 additive reduces the charge density of manganese(II)ion and inhibits its destruction of the PF_(6)^(-)structure in the electrolyte,leading to greatly improved thermal stability of manganese(II)ions-containing electrolyte.In addition to bulk electrolyte,A12C4 additive also shows capability in preventing Mn^(2+) from degrading SEI on graphite surface.Such bulk and interphasial stability introduced by A12C4 leads to significantly improved cycling performance of LIBs. | Xuehuan Luo Lidan Xing Jenel Vatamanu Jiawei Chen Jiakun Chen Mingzhu Liu Cun Wang Kang Xu Weishan Li | 2022 | Journal of Energy Chemistry2022，31，2： | 2 |
| 19 | Effect of dietary soybean oil and antioxidants on fatty acids and volatile compounds of tail subcutaneous and perirenal fat tissues in fattening lambs显示文摘Background: Fat is the primary source of the volatiles that determine the characteristic flavors of animal products.Because unsaturated fatty acids(UFAs) contribute to changes in flavor as a result of the oxidation process, a feeding trial was performed to investigate the effects of dietary soybean oil or antioxidants on the fatty acid and volatile profiles of the tail subcutaneous(SF) and perirenal fat tissues(PF) of fattening lambs. Thirty-six Huzhou lambs were assigned to four dietary treatments in a randomized block design. The lambs' diets were supplemented with soybean oil(0 or 3 % of DM) or antioxidants(0 or 0.025 % of DM).Results: Neither soybean oil nor antioxidant supplementation had an effect on lamb growth(P > 0.05). In regard to tail SF, soybean oil supplementation increased the 18:2n6t(P < 0.05) and the total amount of volatile acids,whereas antioxidant supplementation increased the content of C18:2n6c and C18:3n3(P < 0.05) but had no effect on the volatiles profile. In regard to PF, dietary soybean oil supplementation increased the C18:0 content(P < 0.01);decreased the C18:1(P = 0.01), C22:1 n9(P < 0.01) and total UFA(P = 0.03) contents; and tended to decrease the E-2-octenal(P = 0.08), E, E-2, 4-decadienal(P = 0.10), 2-undecenal(P = 0.14) and ethyl 9-decenoate(P = 0.10) contents.Antioxidant supplementation did not affect either the fatty acid content or the volatiles profile in the PF.Conclusions: Tail SF and PF responded to dietary soybean oil and antioxidant supplementation in different ways. For SF, both soybean oil and antioxidant supplementation increased the levels of unsaturated fatty acids but triggered only a slight change in volatiles. For PF, soybean oil supplementation decreased the levels of unsaturated fatty acids and oxidative volatiles, but supplementation with antioxidants had little effect on PF fatty acids and the volatiles profile. | Yongjia Peng Jiakun Wang Jia Lin Jianxin Liu | 2016 | Journal of Animal Science and Biotechnology2016，7，3： | 2 |
| 20 | Remote-controlled flexible pose measurement system and method for a moving target in wind tunnel显示文摘The measurement of position and attitude parameters for the isolated target from a highspeed aircraft is a great challenge in the field of wind tunnel simulation technology.This paper proposes a remote-controlled flexible pose measurement system in wind tunnel conditions for the separation of a target from an aircraft.The position and attitude parameters of a moving object are obtained by utilizing a single camera with a focal length and camera orientation that can be changed based on different measurement conditions.Using this proposed system and method, both the flexibility and efficiency of the pose measurement system can be enhanced in wind tunnel conditions to meet the measurement requirements of different objects and experiments, which is also useful for the development of an intelligent position and attitude measurement system.The position and the focal length of the camera also can be controlled remotely during measurements to enlarge both the vertical and horizontal measurement range of this system.Experiments are conducted in the laboratory to measure the position and attitude of moving objects with high flexibility and efficiency,and the measurement precision of the measurement system is also verified through experiments. | Wei LIU Xin MA Ling CHEN Zhenyuan JIA Weixiao LIU Xiao LI Jiakun ZHANG Jiwen LU | 2018 | Chinese Journal of Aeronautics2018，31，1： | 2 |
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