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| 1 | Sensitivity-enhanced surface plasmon resonance sensor utilizing a tungsten disulfide (WS_2) nanosheets overlayer显示文摘Tungsten disulfide(WS_2), as a representative layered transition metal dichalcogenide(TMDC) material, possesses important potential for applications in highly sensitive sensors. Here, a sensitivity-enhanced surface plasmon resonance(SPR) sensor with a metal film modified by an overlayer of WS_2 nanosheets is proposed and demonstrated. The SPR sensitivity is related to the thickness of the WS_2 overlayer, which can be tailored by coating a WS_2 ethanol suspension with different concentrations or by the number of times of repeated post-coating.Benefitting from its large surface area, high refractive index, and unique optoelectronic properties, the WS_2 nanosheet overlayer coated on the gold film significantly improves the sensing sensitivity. The highest sensitivity(up to 2459.3 nm∕RIU) in the experiment is achieved by coating the WS_2 suspension once. Compared to the case without a WS_2 overlayer, this result shows a sensitivity enhancement of 26.6%. The influence of the WS_2 nanosheet overlayer on the sensing performance improvement is analyzed and discussed. Moreover, the proposed WS_2 SPR sensor has a linear correlation coefficient of 99.76% in refractive index range of 1.333 to 1.360. Besides sensitivity enhancement, the WS_2 nanosheet overlayer is able to show additional advantages, such as protection of metal film from oxidation, tunability of the resonance wavelength region, biocompatibility, capability of vapor,and gas sensing. | HAO WANG HUI ZHANG JIANGLI DONG SHIQI HU WENGUO ZHU WENTAO QIU HUIHUI LU JIANHUI YU HEYUAN GUAN SHECHENG GAO ZHAOHUI LI WEIPING LIU MIAO HE JUN ZHANG ZHE CHEN YUNHAN LUO | 2018 | Photonics Research2018，6，6： | 8 |
| 2 | Zea mays(L.) P1 locus for cob glume color identified as a post-domestication selection target with an effect on temperate maize genomes显示文摘Artificial selection during domestication and post-domestication improvement results in loss of genetic diversity near target loci. However, the genetic locus associated with cob glume color and the nature of the genomic pattern surrounding it was elusive and the selection effect in that region was not clear. An association mapping panel consisting of 283 diverse modern temperate maize elite lines was genotyped by a chip containing over 55,000 evenly distributed SNPs. Ten-fold resequencing at the target region on 40 of the panel lines and 47 tropical lines was also undertaken. A genome-wide association study(GWAS) for cob glume color confirmed the P1 locus, which is located on the short arm of chromosome 1, with a-log10 P value for surrounding SNPs higher than the Bonferroni threshold(α/n, α < 0.001) when a mixed linear model(MLM) was implemented. A total of 26 markers were identified in a 0.78 Mb region surrounding the P1 locus, including 0.73 Mb and 0.05 Mb upstream and downstream of the P1 gene, respectively. A clear linkage disequilibrium(LD) block was found and LD decayed very rapidly with increasing physical distance surrounding the P1 locus. The estimates of π and Tajima's D were significantly(P < 0.001) lower at both ends compared to the locus. Upon comparison of temperate and tropical lines at much finer resolution by resequencing(180-fold finer than chip SNPs), a more structured LD block pattern was found among the 40 resequenced temperate lines. All evidence indicates that the P1 locus in temperate maize has not undergone neutral evolution but has been subjected to artificial selection during post-domestication selection or improvement. The information and analytical results generated in this study provide insights as to how breeding efforts have affected genome evolution in crop plants. | Chuanxiao Xie Jianfeng Weng Wenguo Liu Cheng Zou Zhuanfang Hao Wenxue Li Minshun Li Xiaosen Guo Gengyun Zhang Yunbi Xu Xinhai Li Shihuang Zhang | 2013 | The Crop Journal2013，1，1： | 6 |
| 3 | Regulation of the inflammatory cycle by a controllable release hydrogel for eliminating postoperative inflammation after discectomy显示文摘Surgery is the final choice for most patients with intervertebral disc degeneration(IDD).Operation-caused trauma will cause inflammation in the intervertebral disc.Serious inflammation will cause tissue defects and induce tissue degeneration,IDD recurrence and the occurrence of other diseases.Therefore,we proposed a scheme to treat recurrence after discectomy by inhibiting inflammation with an aspirin(ASP)-loaded hydrogel to restore the mechanical stability of the spine and relieve local inflammation.ASP-liposomes(ASP-Lips)were incorporated into a photocrosslinkable gelatin-methacryloyl(GelMA)via mixing.This material can effectively alleviate inflammation by inhibiting the release of high mobility group box 1(HMGB1)from the nucleus to the cytoplasm.We further assessed the expression of inflammatory cytokines,such as interleukin 6(IL-6)and tumor necrosis factor-α(TNF-α),and degeneration-related factors,such as type II collagen(COL-2),Aggrecan,matrix metallopeptidases-3(MMP-3),MMP-13,a disintegrin and metalloproteinase with thrombospondin motifs-4(ADAMTS-4)and ADAMTS-5 in rat nucleus pulpous cells.The level of IDD was analyzed through H&E,safranin-O staining and immunohistochemistry in rabbit samples.In vitro,we found that ASP-Lip@GelMA treatment significantly decreased inflammatory cytokines,MMP-3 and-13,and ADAMTS-4 and-5 and up-regulated COL-2 and Aggrecan via the inhibited release of HMGB-1 from the nucleus.In vivo,ASP-Lip@GelMA can effectively inhibit inflammation of local tissue after disc surgery and fill local tissue defects.This composite hydrogel system is a promising way to treat the recurrence of IDD after surgery without persistent complications. | Yu Liu Jiacheng Du Peng Peng Ruoyu Cheng Jiayi Lin Congxin Xu Huilin Yang Wenguo Cui Haiqing Mao Yuling Li Dechun Geng | 2021 | Bioactive Materials2021，6，1： | 6 |
| 4 | Photonic cavity enhanced high-performance surface plasmon resonance biosensor显示文摘Herein we propose a novel strategy to enhance surface plasmon resonance(SPR)by introducing a photonic cavity into a total-internal-reflection architecture.The photonic cavity,which is comprised of a highly reflective photonic crystal(PC),defect layers,and a gold(Au)film,enables Fabry–Perot(FP)resonances in the defect layers and therefore narrows the SPR resonance width in the metallic surface as well as increases the electric field intensity and penetration depth in the evanescent region.The fabricated sensor exhibits a 5.7-fold increase in the figure of merit and a higher linear coefficient as compared with the conventional Au-SPR sensor.The demonstrated PC/FP cavity/metal structure presents a new design philosophy for SPR performance enhancement. | GUI-SHI LIU XIN XIONG SHIQI HU WEICHENG SHI YAOFEI CHEN WENGUO ZHU HUADAN ZHENG JIANHUI YU NUR HIDAYAH AZEMAN YUNHAN LUO ZHE CHEN | 2020 | Photonics Research2020，8，4： | 4 |
| 5 | Orofacial inflammatory pain affects the expression of MT1 and NADPH-d in rat caudal spinal trigeminal nucleus and trigeminal ganglion显示文摘Very little is known about the role of melatonin in the trigeminal system,including the function of melatonin receptor 1.In the present study,adult rats were injected with formaldehyde into the right vibrissae pad to establish a model of orofacial inflammatory pain.The distribution of melatonin receptor 1 and nicotinamide adenine dinucleotide phosphate diaphorase in the caudal spinal trigeminal nucleus and trigeminal ganglion was determined with immunohistochemistry and histochemistry.The results show that there are significant differences in melatonin receptor 1 expression and nicotinamide adenine dinucleotide phosphate diaphorase expression in the trigeminal ganglia and caudal spinal nucleus during the early stage of orofacial inflammatory pain.Our findings suggest that when melatonin receptor 1 expression in the caudal spinal nucleus is significantly reduced,melatonin's regulatory effect on pain is attenuated. | Fang Huang Hongwen He Wenguo Fan Yongliang Liu Hongyu Zhou Bin Cheng | 2013 | Neural Regeneration Research2013，8，32： | 4 |
| 6 | A viral vector expressing hypoxia-inducible factor 1 alpha inhibits hippocampal neuronal apoptosis显示文摘Hypoxia-inducible factor 1(HIF-1) attenuates amyloid-beta protein neurotoxicity and decreases apoptosis induced by oxidative stress or hypoxia in cortical neurons. In this study, we constructed a recombinant adeno-associated virus(rAAV) vector expressing the human HIF-1α gene(rAAV-HIF-1α), and tested the assumption that rAAV-HIF-1α represses hippocampal neuronal apoptosis induced by amyloid-beta protein. Our results confirmed that rAAV-HIF-1α significantly reduces apoptosis induced by amyloid-beta protein in primary cultured hippocampal neurons. Direct intracerebral rAAV-HIF-1α administration also induced robust and prolonged HIF-1α production in rat hippocampus. Single rAAV-HIF-1α administration resulted in decreased apoptosis of hippocampal neurons in an Alzheimer's disease rat model established by intracerebroventricular injection of aggregated amyloid-beta protein(25–35). Our in vitro and in vivo findings demonstrate that HIF-1 has potential for attenuating hippocampal neuronal apoptosis induced by amyloid-beta protein, and provides experimental support for treatment of neurodegenerative diseases using gene therapy. | Xiqing Chai Weina Kong Lingyun Liu Wenguo Yu Zhenqing Zhang Yimin Sun | 2014 | Neural Regeneration Research2014，9，11： | 4 |
| 7 | Preparation and characterization of carbonyl iron/strontium hexaferrite magnetorheological fluids显示文摘The heat transfer oil-based magnetorheological fluid(MRF) was prepared using oleic acid-modified micron carbonyl iron powder as a magnetic dispersed phase and strontium hexaferrite(SrFe_(12)O_(19))nanoparticles as an additive.The sedimentation stability of MRFs was studied.The results indicated that the stability of MRFs was improved remarkably by adding SrFe_(12)O_(19) nanoparticles and the sedimentation ratio was only 0.88 in 20 days when the content of nanoparticles reached 10 wt%.The Theological properties were characterized by a HAAKE rheometer without a magnetic field and a capillary rheometer with and without a magnetic field.The effects of SrFe_(12)O_(19) nanoparticles,the temperature,and magnetic field strength were investigated.In addition,the rheological properties could be predicted well using the improved Herschel-Bulkley model,even under a magnetic field.A theoretical model was also proposed to predict the yield stress based on the microstructure of the MRF under an applied magnetic field. | Jianrong Liu Xianjun Wang Xia Tang Ruoyu Hong Yaqiong Wang Wenguo Feng | 2015 | Particuology2015，13，5： | 3 |
| 8 | Conditioned medium-electrospun fiber biomaterials for skin regeneration显示文摘Conditioned medium(CM)contains variety of factors secreted by cells,which directly regulate cellular processes,showing tremendous potential in regenerative medicine.Here,for the first time,we proposed a novel regenerative therapy mediated by biodegradable micro-nano electrospun fibers loaded with highly active conditioned medium of adipose-derived stem cells(ADSC-CM).ADSC-CM was successfully loaded into the nanofibers with biological protection and controllable sustained-release properties by emulsion electrospinning and protein freeze-drying technologies.In vitro,ADSC-CM released by the fibers accelerated the migration rate of fibroblasts;inhibited the over proliferation of fibroblasts by inducing apoptosis and damaging cell membrane;in addition,ADSC-CM inhibited the transformation of fibroblasts into myofibroblasts and suppressed excessive production of extracellular matrix(ECM).In vivo,the application of CM-biomaterials significantly accelerated wound closure and improved regeneration outcome,showing superior pro-regenerative performance.This study pioneered the application of CM-biomaterials in regenerative medicine,and confirmed the practicability and significant biological effects of this innovative biomaterials. | Lu Chen Liying Cheng Zhen Wang Jianming Zhang Xiyuan Mao Zhimo Liu Yuguang Zhang Wenguo Cui Xiaoming Sun | 2021 | Bioactive Materials2021，6，2： | 2 |
| 9 | Phosphorus reduction behavior of high-phosphate iron ore during hydrogen-rich sintering显示文摘High-phosphorus iron ore resource is considered a refractory iron ore because of its high-phosphorus content and complex ore phase structure. Therefore, the development of innovative technology to realize the efficient utilization of high-phosphorus iron ore resources is of theoretical and practical significance. Thus, a method for phosphorus removal by gasification in the hydrogen-rich sintering process was proposed. In this study, the reduction mechanism of phosphorus in hydrogen-rich sintering, as well as the reduction kinetics of apatite based on the non-isothermal kinetic method, was investigated. Results showed that, by increasing the reduction time from 20 to 60 min, the dephosphorization rate increased from 10.93%to 29.51%. With apatite reduction, the metal iron accumulates, and part of the reduced phosphorus gas is absorbed by the metal iron to form stable iron-phosphorus compounds, resulting in a significant reduction of the dephosphorization rate. Apatite reduction is mainly concentrated in the sintering and burning zones, and the reduced phosphorus gas moves downward along with flue gas under suction pressure and is condensed and adsorbed partly by the sintering bed when passing through the drying zone and over the wet zone. As a result, the dephosphorization rate is considerably reduced. Based on the Ozawa formula of the iso-conversion rate, the activation energy of apatite reduction is 80.42 kJ/mol. The mechanism function of apatite reduction is determined by a differential method (i.e., the Freeman-Carroll method) and an integral method (i.e., the Coats-Redfern method). The differential form of the equation is f(α)=2(1-α)^(1/2), and the integral form of the equation is G(α)=1-(1-α)^(1/2). | Yanbiao Chen Wenguo Liu Haibin Zuo | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，10： | 2 |
| 10 | Age-dependent loss of cholinergic neurons in learning and memory-related brain regions and impaired learning in SAMP8 mice with trigeminal nerve damage显示文摘The tooth belongs to the trigeminal sensory pathway.Dental damage has been associated with impairments in the central nervous system that may be mediated by injury to the trigeminal nerve.In the present study,we investigated the effects of damage to the inferior alveolar nerve,an important peripheral nerve in the trigeminal sensory pathway,on learning and memory behaviors and structural changes in related brain regions,in a mouse model of Alzheimer's disease.Inferior alveolar nerve transection or sham surgery was performed in middle-aged(4-monthold) or elderly(7-month-old) senescence-accelerated mouse prone 8(SAMP8) mice.When the middle-aged mice reached 8 months(middle-aged group 1) or 11 months(middle-aged group 2),and the elderly group reached 11 months,step-down passive avoidance and Y-maze tests of learning and memory were performed,and the cholinergic system was examined in the hippocampus(Nissl staining and acetylcholinesterase histochemistry) and basal forebrain(choline acetyltransferase immunohistochemistry).In the elderly group,animals that underwent nerve transection had fewer pyramidal neurons in the hippocampal CA1 and CA3 regions,fewer cholinergic fibers in the CA1 and dentate gyrus,and fewer cholinergic neurons in the medial septal nucleus and vertical limb of the diagonal band,compared with sham-operated animals,as well as showing impairments in learning and memory.Conversely,no significant differences in histology or behavior were observed between middle-aged group 1 or group 2 transected mice and age-matched sham-operated mice.The present findings suggest that trigeminal nerve damage in old age,but not middle age,can induce degeneration of the septal-hippocampal cholinergic system and loss of hippocampal pyramidal neurons,and ultimately impair learning ability.Our results highlight the importance of active treatment of trigeminal nerve damage in elderly patients and those with Alzheimer's disease,and indicate that tooth extraction should be avoided in these populations. | Yifan He Jihong Zhu Fang Huang Liu Qin Wenguo Fan Hongwen He | 2014 | Neural Regeneration Research2014，9，22： | 2 |
| 11 | Corrigendum to‘Conditioned medium-electrospun fiber biomaterials for skin regeneration’[Bioact.Mater.6(2021)361-374]显示文摘 | Lu Chen Liying Cheng Zhen Wang Jianming Zhang Xiyuan Mao Zhimo Liu Yuguang Zhang Wenguo Cui Xiaoming Sun | 2021 | Bioactive Materials2021，6，9： | 2 |
| 12 | Process operation performance of PDMS membrane pervaporation coupled with fermentation for efficient bioethanol production显示文摘There would be strong product inhibition on ethanol fermentation process if ethanol is not removed in situ from broth. PDMS membrane pervaporation coupled with fermentation is a promising process for efficient bioethanol production since ethanol inhibition is relieved or eliminated. From the perspective of process operation, membrane separation performance, ethanol fermentation performance and the subsequent processing on membrane downstream are the three key issues. This review aims at contributing a comprehensive overview on the operation performance of the integrated process. The state-of-the-art of the three key issues related to the operation performance is focused. Finally, the tentative perspective on the possible future prospects of the integrated process is briefly presented. | Senqing Fan Jingyun Liu Xiaoyu Tang Wenguo Wang Zeyi Xiao Boya Qiu YuyangWang Shizhao Jian Yangmei Qin Yinan Wang | 2019 | Chinese Journal of Chemical Engineering2019，27，6： | 2 |
| 13 | Molecular cloning and characterization of a jasmonate biosynthetic pathway gene for allene oxide cyclase from Jatropha curcas显示文摘 | Bin Liu Wenguo Wang Jihai Gao Fang Chen Shenghua Wang Ying Xu Lin Tang Yongjiong Jia | 2010 | Acta Physiologiae Plantarum2010，，3： | 1 |
| 14 | Programmable immune activating electrospun fibers for skin regeneration显示文摘Immune cells play a crucial regulatory role in inflammatory phase and proliferative phase during skin healing.How to programmatically activate sequential immune responses is the key for scarless skin regeneration.In this study,an“Inner-Outer”IL-10-loaded electrospun fiber with cascade release behavior was constructed.During the inflammatory phase,the electrospun fiber released a lower concentration of IL-10 within the wound,inhibiting excessive recruitment of inflammatory cells and polarizing macrophages into anti-inflammatory phenotype“M2c”to suppress excessive inflammation response.During the proliferative phase,a higher concentration of IL-10 released by the fiber and the anti-fibrotic cytokines secreted by polarized“M2c”directly acted on dermal fibroblasts to simultaneously inhibit extracellular matrix overdeposition and promote fibroblast migration.The“Inner-Outer”IL-10-loaded electrospun fiber programmatically activated the sequential immune responses during wound healing and led to scarless skin regeneration,which is a promising immunomodulatory biomaterial with great potential for promoting complete tissue regeneration. | Lu Chen Liucheng Zhang Hongbo Zhang Xiaoming Sun Dan Liu Jianming Zhang Yuguang Zhang Liying Cheng Hélder A.Santos Wenguo Cui | 2021 | Bioactive Materials2021，6，10： | 1 |
| 15 | Controlled growth of superhydrophobic films by sol–gel method on aluminum substrate显示文摘 | Shixiang Lu Yiling Chen Wenguo Xu Wei Liu | 2010 | Applied Surface Science2010，，20： | 1 |
| 16 | A Study on Microwave Induced Plasma Ionization Detector for Gas Chromatograph显示文摘Among various ionization detectors for gas chromatography(GC), the most promising one is perhaps the nonradioactive ionization detector which makes use of a microwave induced plasma(MIP). The use of MIP for gas chromatography was first studied by McCormack, et al. in 1965, Freeman developed a photoionization detector utilizing helium microwave discharge. In 1971, we developed a | Yu Aimin, Xu Wenguo, Wang Fendi, Wang Xu, Liu Yun and Jin Qinhan (Department of Chemistry, Jilin University, Changchun) | 1991 | Chemical Research in Chinese Universities1991，7，4： | 1 |
| 17 | Extracellular domain of 4-1BBL enhanced the antitumoral efficacy of peripheral blood lymphocytes mediated by anti-CD3<ce:hsp sp='0.25'/>×<ce:hsp sp='0.25'/>anti-Pgp bispecific diabody against human multidrug-resistant leukemia显示文摘 | Hongxing Guo Wenguo Jiang Wenge Liu Yingdai Gao Ming Yang Yuan Zhou Jinhong Wang Jing Qi Xin Cheng Zhenping Zhu Chunzheng Yang Dongsheng Xiong | 2008 | Cellular Immunology2008，，2： | 1 |
| 18 | A computational and experimental investigation of the interaction between the template molecule and the functional monomer used in the molecularly imprinted polymer显示文摘 | Wenguo Dong Ming Yan Minlian Zhang Zheng Liu Yanmei Li | 2005 | Analytica Chimica Acta2005，542，： | 1 |
| 19 | Oil Production Optimization by Means of a Combined“Plugging,Profile Control,and Flooding”Treatment:Analysis of Results Obtained Using Computer Tomography and Nuclear Magnetic Resonance显示文摘Due to long-term water injection,often oilfields enter the so-called medium and high water cut stage,and it is difficult to achieve good oil recovery and water reduction through standard methods(single profile control and flooding measures).Therefore,in this study,a novel method based on“plugging,profile control,and flooding”being implemented at the same time is proposed.To assess the performances of this approach,physical simulations,computer tomography,and nuclear magnetic resonance are used.The results show that the combination of a gel plugging agent,a polymer microsphere flooding agent,and a high-efficiency oil displacement agent leads to better results in terms of oil recovery with respect to the situation in which these approaches are used separately(the oil recovery is increased by 15.37%).Computer tomography scan results show that with the combined approach,a larger sweep volume and higher oil washing efficiency are obtained.The remaining oil in the cluster form can be recovered in the middle and low permeability layer,increasing the proportion of the columnar and blind end states of the oil.The nuclear magnetic resonance test results show that the combined“plugging,profile control,and flooding”treatment can also be used to control more effectively the dominant channels of the high permeability layer and further expand the recovery degree of the remaining oil in the pores of different sizes in the middle and low permeability layers.However,for the low permeability layer(permeability difference of 20),the benefits in terms of oil recovery are limited. | Yanyue Li Changlong Liu Wenbo Bao Baoqing Xue Peng Lv Nan Wang Hui Li Wenguo Ma | 2022 | Fluid Dynamics & Materials Processing2022，18，3： | 1 |
| 20 | Honeycomb-Like Hydrogel Microspheres for 3D Bulk Construction of Tumor Models显示文摘A two-dimensional(2D)cell culture-based model is widely applied to study tumorigenic mechanisms and drug screening.However,it cannot authentically simulate the threedimensional(3D)microenvironment of solid tumors and provide reliable and predictable data in response to in vivo,thus leading to the research ilusionis and failure of drug screening.In this study,honeycomb-like gelatin methacryloyl(GelMA)hydrogel microspheres are developed by synchronous photocrosslinking microluidic technique to construct a 3D model of osteosarcoma.The in vitro study shows that ostcosarcoma cells(K7M2)culured in 3D GelMA microspheres have stronger tumorous stemness。proliferation and migration abilitics,more osteoclastogenetic ability,and reistance to chemotherapeutic drugs(DOX)than that of cells in 2D cultures.More imporantly,the 3D-cultured K7M2 cells show more tumorigenicity in immunologically sound mice,characterized by shorter tumorigenesis time,larger tumor volumc,severe bone destruction,and higher mortality.In conclusion,honeycomb like porous microsphere scaffolds are constructed with uniform structure by micofluidic technology to massively produce tumor cells with original phenotypes.Those microspheres could recapitulate the physiology microenvironment of tumors.maintain ell-cell and cell-extracellular matrix interactions,and thus provide an efective and convenient strategy for tumor pathogenesis and drug screening research. | Jiachen He Chichi Chen Liang Chen Ruoyu Cheng Jie Sun Xingzhi Liu Lin Wang Can Zhu Sihan Hu Yuan Xue Jian Lu Huiling Yang Wenguo Cui Qin Shi | 2022 | Research2022，，2： | 1 |
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