|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Redox regulation in tumor cell epithelial-mesenchymal transition:molecular basis and therapeutic strategy显示文摘Epithelial–mesenchymal transition(EMT)is recognized as a driving force of cancer cell metastasis and drug resistance,two leading causes of cancer recurrence and cancer-related death.It is,therefore,logical in cancer therapy to target the EMT switch to prevent such cancer metastasis and recurrence.Previous reports have indicated that growth factors(such as epidermal growth factor and fibroblast growth factor)and cytokines(such as the transforming growth factor beta(TGF-β)family)are major stimulators of EMT.However,the mechanisms underlying EMT initiation and progression remain unclear.Recently,emerging evidence has suggested that reactive oxygen species(ROS),important cellular secondary messengers involved in diverse biological events in cancer cells,play essential roles in the EMT process in cancer cells by regulating extracellular matrix(ECM)remodeling,cytoskeleton remodeling,cell–cell junctions,and cell mobility.Thus,targeting EMT by manipulating the intracellular redox status may hold promise for cancer therapy.Herein,we will address recent advances in redox biology involved in the EMT process in cancer cells,which will contribute to the development of novel therapeutic strategies by targeting redox-regulated EMT for cancer treatment. | Jingwen Jiang Kui Wang Yan Chen Haining Chen Edouard C Nice Canhua Huang | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 5 |
| 2 | Superhydrophobic diamond-coated Si nanowires for application of anti-biofouling显示文摘The effect of the surface wettability of plasma-modified vertical Si nanowire array on the bio-fouling performance has been investigated.The Si nanowires prepared by a metal-assisted chemical etching technique exhibit a super-hydrophilic surface.The treatment in CH4/H2 gas plasma environment leads to the decoration of graphite and diamond nanoparticles around Si nanowires.The detailed interface between graphite/diamond and Si nanowire was characterized by HRTEM technique.These surface-modified nanowire samples show an increased water contact angle with ultrananocrystalline diamond decorated ones being superhydrophobic.The immersion test in chlorella solution reveals that the diamond-coated Si nanowires possess the least attachment of chlorella in comparison with other Si nanowires.This result confirms that the coating of Si nanowires with diamond nanoparticles shows the best behavior in anti-biofouling.Importantly,this work provides a method fabricated super-hydrophobic surface for the application of biofouling prevention. | Wenjing Long Haining Li Bing Yang Nan Huang Lusheng Liu Zhigang Gai Xin Jiang | 2020 | Journal of Materials Science & Technology2020，47，13： | 1 |
| 3 | Efficient coding schemes with power allocation using space-time-frequency spreading显示文摘An efficient space-time-frequency (ST F) coding strategy for multi-input multi-output orthogonal frequency division multiplexing (MIMO-OFDM) systems is presented for high bit rate data transmission over frequency selective fading channels. The proposed scheme is a new approach to space-time-frequency coded OFDM (COFDM) that combines OFDM with space-time coding, linear precoding and adaptive power allocation to provide higher quality of transmission in terms of the bit error rate performance and power efficiency. In addition to exploiting the maximum diversity gain in frequency, time and space, the proposed scheme enjoys high coding advantages and low-complexity decoding. The significant performance improvement of our design is confirmed by corroborating numerical simulations. | Jiang Haining Luo Hanwen Tian Jifeng Song Wentao Liu Xingzhao | 2006 | Journal of Systems Engineering and Electronics2006，17，2： | 1 |
| 4 | Interface microstructare and reaction in Gr/A1l metal matrix composites显示文摘 | YANG Haining GU Mingyuan JIANG Weiji | 1996 | Journal of Materials Science1996，31，7： | 1 |
| 5 | Design of an Efficient FFT Processor for OFDM Systems 显示文摘 | Jiang Haining Luo Hanwen Tian Jifeng | 2005 | Consumer Electronics2005，4，51： | 1 |
| 6 | Fabrication of cyclodextrin-functionalized superparamagnetic Fe 3 O 4 /amino-silane core–shell nanoparticles via layer-by-layer method显示文摘 | Haining Cao Jiang He Li Deng Xiaoqing Gao | 2009 | Applied Surface Science2009，，18： | 1 |
| 7 | A practical synthesis of ethyl L-glutaminc ( L-theanine ) 显示文摘 | Gu Haining Jiang Yongxiang Wang Jiong | 2004 | Organic Preparations and Procedures International2004，36，2： | 1 |
| 8 | Design of an Efficient FFT Processor for OFDM Systems显示文摘 | Jiang Haining Luo Hanwen Tian Jifeng | 2005 | IEEE Trans on Consumer Electronics2005，51，4： | 1 |
| 9 | Interface microstructure and reaction in Gr/A1 metal matrix composites显示文摘 | Yang Haining Gu Mingyuan Jiang Weiji | 2006 | J Mater Sci2006，31，： | 1 |
| 10 | Design of an efficient FFT Processor for OFDM systems 显示文摘 | Haining Jiang Hanwen Luodifeng Tian Wentao Song | 2005 | Consumer Electronics IEEE Transactions on Volume 51 Issue 42005，2005，： | 1 |
| 11 | SRS-Net: Training object detectors from scratch for remote sensing images without pretraining显示文摘Most of the current object detection algorithms use pretrained models that are trained on ImageNet and then fine-tuned in the network,which can achieve good performance in terms of general object detectors.However,in the field of remote sensing image object detection,as pretrained models are significantly different from remote sensing data,it is meaningful to explore a train-fromscratch technique for remote sensing images.This paper proposes an object detection framework trained from scratch,SRS-Net,and describes the design of a densely connected backbone network to provide integrated hidden layer supervision for the convolution module.Then,two necessary improvement principles are proposed:studying the role of normalization in the network structure,and improving data augmentation methods for remote sensing images.To evaluate the proposed framework,we performed many ablation experiments on the DIOR,DOTA,and AS datasets.The results show that whether using the improved backbone network,the normalization method or training data enhancement strategy,the performance of the object detection network trained from scratch increased.These principles compensate for the lack of pretrained models.Furthermore,we found that SRS-Net could achieve similar to or slightly better performance than baseline methods,and surpassed most advanced general detectors. | Haining WANG Yang LI Yuqiang FANG Yurong LIAO Bitao JIANG Xitao ZHANG Shuyan NI | 2023 | Chinese Journal of Aeronautics2023，36，8： | 0 |
| 12 | Novel differential unitary space-time modulation schemes for fast fading channels显示文摘 | 田继锋 Jiang Haining Song Wentao Luo Hanwen | 2006 | High Technology Letters2006，12，3： | 0 |
| 13 | Evaluating the Topology Coverage of BGP Monitors显示文摘BGP monitors are currently the main data resource of AS-level topology measurement,and the integrity of measurement result is limited to the location of such BGP monitors.However,there is currently no work to conduct a comprehensive study of the range of measurement results for a single BGP monitor.In this paper,we take the first step to describe the observed topology of each BGP monitor.To that end,we first investigate the construction and theoretical up-limit of the measured topology of a BGP monitor based on the valley-free model,then we evaluate the individual parts of the measured topology by comparing such theoretical results with the actually observed data.We find that:1)for more than 90%of the monitors,the actually observed peer-peer links merely takes a small part of all theoretical visible links;2)increasing the BGP monitors in the same AS may improve the measurement result,but with limited improvement;and 3)deploying multiple BGP monitors in different ASs can significantly improve the measurement results,but non-local BGP monitors can hardly replace the local AS BGP monitors.We also propose a metric for monitor selection optimization,and prove its effectiveness with experiment evaluation. | Shen Su Zhihong Tian Jing Qiu Yu Jiang Yanbin Sun Mohan Li Dunqiu Fan Haining Yu | 2020 | Computers, Materials & Continua2020，，3： | 0 |
| 14 | Research on Cutting Force Modeling and Surface Qualityin the Transition Area of the Mosaic Mold显示文摘Aiming at the problem of tool wear and breakage, the low accuracy of machined surface duringthe milling process of automobile panel splicing dies, the cutting force modeling of micro element is carriedout. The cutting chip thickness of each cutting cycle is built as a function of the cutting angle and the shearforce according to the different hardness of machining materials, and a plow force model are obtained underng angles. By introducing a single degree of freedom italic collision model, the Hopkinsontest is used to obtain the elastic deformation δ of the tool workpiece impact under different spindle speeds,sults showforce on the tool in the transition area is obtained. Combining above models together,of milling force in the transition area can be obtained. Experiment and simulation reconslstendirections is studied. Fromcythto prove the accuracy of the model. The surface quality under different feede analysis results of machined surface quality, surfacedifference between workpieces, it is concluded that better surface quality can be obtaineness and heightness and low hardness workpiece. The results provide theoretical support for the optimizationing process in the splicing die of the automobile panel highof the milling process in the splicing die of the automobile panel. | LIU Xianli GAO Haining YUE Caixu JIANG Nan | 2018 | 振动.测试与诊断2018，38，3： | 0 |
| 15 | Molecular Marker Techniques Using Single Primers and Their Advances显示文摘Molecular marker techniques have been widely applied in the fields of genetic diversity analysis,germplasm resources identification,molecular fingerprint and genetic linkage map construction,QTL mapping and molecular assisted breeding.On the basis of stating the concept of molecular marker techniques based on single primer amplification reactions,this study focused on the sorting and induction of single-primer molecular marker techniques,and expounded their derivative development.Finally,the application prospect and future expectation of single-primer molecular marker techniques were described in detail.The purpose of this study was to clarify the types of molecular marker techniques based on single primer amplification reactions,so that researchers can quickly and conveniently select molecular marker techniques according to their own specific scientific research conditions. | Junxian LIU Jing LIU Jing JIANG Zhuqiang HAN Xiumei TANG Lihang QIU Ruichun ZHONG Liangqiong HE Haining WU Zhipeng HUANG Ronghua TANG Faqian XIONG | 2021 | Agricultural Biotechnology2021，10，2： | 0 |
| 16 | Polo样激酶1通过PLK1-Myc反馈激活信号环路稳定癌蛋白Myc并促进肿瘤细胞生长存活显示文摘癌基因MYCN(编码N-Myc)在癌症中出现扩增突变预示不良预后和复发耐药。众多细胞水平和模式动物研究表明,干预癌蛋白N-Myc的表达或活性能够显著甚至完全抑制肿瘤发生和发展。 | Daibiao Xiao Ming Yue Hexiu Su Ping Ren Jue Jiang Feng Li Yufeng Hu Haining Du Hudan Liu 卿国良 | 2017 | 科学新闻2017，19，4： | 0 |
| 17 | Geographically Distinct Expression Profile of Host Defense Peptides in the Skin of the Chinese Odorous Frog, Odorrana margaretae显示文摘Odorrana margaretae(Anura: Ranidae) is widely distributed in the southern provinces of China. Previously, 72 antimicrobial peptides(AMPs) belonging to 21 families were identified from the skin of O. margaretae, which were captured in the Hunan province. In the present study, five O. margaretae frogs were captured from the Guizhou province and a total of 28 cDNAs encoding 17 host defense peptides(HDPs) belonging to 14 families were cloned from the skin cDNA library of O. margaretae. Among the 17 HDPs, only one(brevinin-1-Omar5) had been characterized. The distinct HDP expression profiles for O. margaretae in the previous and present study may be attributed to the environmental differences between the sampling locations and the genetic divergence among O. margaretae populations. Besides, 11 of the 17 HDPs identified in the present study were novel for ranids. In order to understand their roles in host defense reactions, three HDPs(odorranain-H-OM1, odorranain-M-OM and ranatuerin-2-OM), which possess low sequence similarity with the known amphibian HDPs, were selected for further chemical synthesis and functional analysis. Odorranain-H-OM1 showed direct antimicrobial activity against bacteria and fungi. Odorranain-M-OM exhibited concentration-dependent anti-oxidant activity. Ranatuerin-2-OM showed lectin-like activity and could strongly hemagglu-tinate human intact erythrocytes with or without the presence of Ca2+. The diverse activities of HDPs implied that they may play different roles in host defense reactions of O. margaretae. | Guiying LING Li LI Jiuxiang GAO Haining YU Yipeng WANG Jiang ZHOU | 2013 | Asian Herpetological Research2013，4，4： | 0 |
| 18 | Charge Transport through Peptides in Single-Molecule Electrical Measurements显示文摘Charge transport across the peptide chains is one of the vital processes in the biological systems,so understanding their charge transport properties is an indispensable prerequisite to explain the complex biochemical phenomenon.Here,we review the charge transport mechanism,the influence of the special groups and the experimental conditions on the charge transport through the peptide backbone by employing the single-molecule electrical measurements.Besides,we further review the recent progresses in charge transport properties of supramolecular interaction among the adjacent peptide chains.Finally,we discuss some experimental and theoretical contradictions existing in the charge transport through peptides and provide new inspiration for the future development of the bioelectronics at the single-molecule scale. | Haining Zheng Feng Jiang Runze He Yang Yang Jia Shi Wenjing Hong | 2019 | Chinese Journal of Chemistry2019，37，10： | 0 |
| 19 | A Non-toxic and Efficient Method for Extracting DNA and RNA from Peanut显示文摘[Objectives]To establish a non-toxic and efficient method for extracting DNA and total RNA from peanuts and laying a solid foundation for the molecular biology study of peanuts.[Methods]Based on the principle and method of purifying nucleic acids by silica gel adsorption at high salt and low pH condition,a non-toxic and efficient method to extract peanut DNA and total RNA using cetyltrimethyl ammonium bromide(CTAB)extraction solution was designed.The quality and purity of nucleic acids were detected by agarose gel electrophoresis and nucleic acids protein analyzer,respectively.The quality of DNA was further verified by enzyme digestion and PCR amplification using molecular marker techniques.The quality of total RNA was further verified by reverse transcription(RT)-PCR of actin gene and cDNA-SCoT gene differential display technique.[Results]The agarose gel electrophoresis test showed that the peanut DNA extracted by a low-toxic and effective method is free of contamination and degradation.Through the detection by the nucleic acid protein analyzer,the DNA concentration,yield,A260/A280 and A260/A230 of 5 peanut varieties were 419.6-498.2 ng/μL,20.98-24.91μg/g,1.89-1.96 and 2.03-2.28,respectively.The DNA was of high quality and can be completely digested by EcoRI restriction enzymes,and also can be used for SCoT and SRAP molecular marker technology analysis.The RNA extracted from different tissues of peanuts showed no visible DNA bands by non-denaturing agarose gel electrophoresis.The separated 28S bands were brighter than 18S.The ratio of A260/A280 and A260/A230 showed that the RNA quality was good and can be used for reverse transcription,RT-PCR of actin gene and amplification of cDNA-SCoT gene differential display technique.[Conclusions]This experiment established a low-toxic and effective method for extracting DNA and total RNA from peanuts.Compared with traditional methods,this method is more time-saving and cheaper than commercial kits.The most important point is that this method does not use toxic reagents such as phenol,chloroform and isopropanol.Thus,it is expected to be widely applied in molecular biology research. | Jing LIU Congcong WANG Jing JIANG Zhuqiang HAN Xiumei TANG Lihang QIU Liangqiong HE Ruichun ZHONG Zhipeng HUANG Haining WU Ronghua TANG Junxian LIU Faqian XIONG | 2021 | Asian Agricultural Research2021，13，1： | 0 |
| 20 | Red list assessments of Chinese higher plants显示文摘Based on the two most recent assessments of Chinese higher plants in 2013 and 2020,of 34,450 and 39,330 species,respectively,we analysed the threatened status of Chinese higher plants.In 2020,around 4,088(10.39%)of the assessed species in China are threatened,2,875(7.31%)Near Threatened,27,593(70.16%)not currently threatened and categorised as Least Concern and 4,752(12.08%)categorised as Data Deficient.While in 2013,3,767(10.93%)of the assessed higher plants in China are threatened,2,723(7.90%)Near Threatened,24,296(70.53%)Least Concern and 3,612(10.48%)Data Deficient.Estimates of the Red List Index in the two years show different patterns when using different weighting methods with the equal steps weighting method showing a slight decrease(0.91675-0.91495)and the extinction risk weighting method showing a slight increase(0.98792-0.98797).We inferred that China's threatened plant species were likely/relatively effectively protected.However,attention should also be given to the non-threatened species in the future as an additional strategy for their conservation,to maintain their non-threatened status. | Liping Li Haining Qin Eimear Nic Lughadha Yaomin Zheng Huawei Wan Jack Plummer Melanie-Jayne R.Howes Huiyuan Liu Yangming Jiang Tuo Wang Huihui Zhao Zhanfeng Shen Huiping Huang | 2023 | International Journal of Digital Earth2023，16，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员