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| 1 | HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation显示文摘N6-methyladenosine(m6A),and its reader protein YTHDF1,play a pivotal role in human tumorigenesis by affecting nearly everystage of RNA metabolism.Autophagy activation is one of the ways by which cancer cells survive hypoxia.However,the possibleinvolvement of m6A modification of mRNA in hypoxia-induced autophagy was unexplored in human hepatocellular carcinoma(HCO).In this study,specific variations in YTHDF1 expression were detected in YTHDF1-overexpressing,knockout,and-knockdownHCC cells,HCC organoids,and HCC patient-derived xenograft(PDX)murine models.YTHDF1 expression and hypoxia inducedautophagy were significantly correlated in vitro;signifhcant overexpression of YTHDF1 in HCC tissues was associated with poorprognosis,Multivariate cox regression analysis identihed YTHDF1 expression as an independent prognostic factor in patients withHCC.Multiple HC models conhrmed that YTHDF1 deficiency inhibited HCC autophagy,growth,and metastasis.Luciferase reporterassays and chromatin immunoprecipitation demonstrated that HlIF-1a regulated YTHDF1 transcription by directly binding to itspromoter region under hypoxia.The results of methylated RNA immunoprecipitation sequencing,proteomics,and polysomeprofling indicated that YTHDF1 contibuted to the translation of autophagy-related genes ATG2A and ATG14 by binding to m6A-modifhed ATG2A and ATG14 mRNA,thus facilitating autophagy and autophagy-related malignancy of HCC.Taken together,HlE-1d-induced YTHDF1 expression was associated with hypoxia-induced autophagy and autophagy-related HCC progression via promoting translation of autophagy-related genes ATG2A and ATG14 in a m6A-dependent manner.Our fndings suggest thatYTHDF1 is a potential prognostic biomarker and therapeutic target for patients with HCC. | Qing Li Yong Ni Liren Zhang Runqiu Jiang Jing Xu Hong Yang Yuanchang Hu Jiannan Qiu Liyong Pu Jinhai Tang Xuehao Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 24 |
| 2 | Biomimetic fabrication and characterization of an artificial rice leaf surface with anisotropic wetting显示文摘In nature,rice leaves exhibit special anisotropic sliding capabilities.Although researchers have succeeded in fabricating artificial rice leaf structures and realizing the wettability function of the leaf surface,these methods used to date are complex and do not allow the fabrication of surfaces with large area.Herein,we adopted a simple technology—two steps soft transfer to fabricate biomimetic rice leaf.The fabricated surface well reproduced the structures of the rice leaf surface and exhibited a static superhydrophobic property similar to that of the real rice leaf surface.In terms of its dynamic wettability,it clearly exhibited an anisotropic sliding property.Systematic measurements showed that the sliding angles parallel and perpendicular with the vein direction were 25° and 40°,respectively.The method was simple and reliable,without the need for expensive instruments and complex technologies,which could be used for the rapid fabrication of large-area artificial rice leaf surfaces.We believe that the artificial rice leaf surface fabricated by this method has great potential applications in biomimetic functional surfaces,microfluidics,and so on. | YAO Jia WANG JianNan YU YanHao YANG Han XU Ying | 2012 | Chinese Science Bulletin2012，57，20： | 11 |
| 3 | Characterization of the neutralizing activity of three anti-human TNF monoclonal antibodies and prediction of their TNF epitopes by molecular modeling and mutant protein approach显示文摘 | Cansheng Zhu Xuesong Liu Jiannan Feng Wei Zhang Beifen Shen Weiming Ou'yang Yunxin Cao Boquan Jin | 2006 | 中国生物学文摘2006，20，1： | 5 |
| 4 | Potent anti-angiogenesis and anti-tumor activity of a nove human anti-VEGF antibody, MIL60显示文摘 | Jing Yang Qun Wang Chunxia Qiao Zhou Lin Xinying Li Yifei Huang Tingting Zhou Yan Li Beifen Shen Ming Lv Jiannan Feng | 2014 | Cellular & Molecular Immunology2014，11，3： | 4 |
| 5 | Interaction between uranium and humic acid(Ⅰ):Adsorption behaviors of U(Ⅵ) in soil humic acids显示文摘The adsorption behaviors of uranium on three soil humic acids (HAs), which were extracted from soils of different depths at the same site, were investigated under various experimental conditions. The adsorption results showed that U(Ⅵ) in solutions can be adsorbed by the three soil HAs, with the order of FHA (HA from 5 m depth of soil) >SHA (HA from the surface) >THA (HA from 10 m depth of soil) for adsorption efficiency in each desirable condition, and the adsorption reached equilibrium in about 240 min. Although the maximum adsorption efficiency was achieved at a suitable uranium concentration (10 mg·L-1 U(Ⅵ) for SHA and THA, 20 mg·L-1 U(Ⅵ) for FHA), the adsorption could be described with Langmiur isotherm or Freundlich isotherm equation. The L/S (liquid/solid, mL/g) ratio and pH were important factors influencing the adsorption in our adsorption system besides uranium concentration. The adsorption efficiency decreased with the increase of the L/S ratio and pH at the pH range of 2.0-3.0 for SHA and THA or 2.5-6.0 for FHA. However, no significant difference in adsorption of U(Ⅵ) was observed at the experimental temperature. All the results implied that humic substances have different characteristics in samples even collected at the same site. | WEI Min LIAO Jiali LIU Ning ZHANG Dong KANG Houjun YANG Yuanyou YANG Yong JIN Jiannan | 2007 | Nuclear Science and Techniques2007，18，5： | 4 |
| 6 | Interaction between uranium and humic acid (Ⅱ): complexation, precipitation and migration behavior of U(Ⅵ) in the presence of humic substances显示文摘The complexation, precipitation, and migration behavior of uranium in the presence of humic acid (HA) or fulvic acid (FA) were investigated by cation exchange, ultrafiltration and dynamic experiment, respectively. The results showed that (i) complex equilibrium between the uranium and humic substances was achieved at approximately 72 h, (ii) the coordination number varied from 1:1 to 1:2 ( U(Ⅵ) : humic acid) as pH increased from 3 to 6; and (iii) , while the complex stability constant decreased when temperature increased, but increased with pH value. We found that the precipitation of uranyl could only be observed in presence of HA, and the precipitation was influenced by conditions, such as pH, uranium concentration, temperature, and the HA concentration. The maximum precipitation proportion up to 60% could be achieved in the condition of 40 mg/L HA solution at pH 6. We further observed that the migration behavior of uranium in soil in the presence of humic acid (HA) or fulvic acid (FA) was different from that in the presence of inorganic colloid, and the effect of humic substances (HS) was limited. | LIAO Jiali WEN Wei LI Bing YANG Yuanyou ZHANG Dong KANG Houjun YANG Yong JIN Jiannan LIU Ning | 2013 | Nuclear Science and Techniques2013，24，3： | 3 |
| 7 | Coordination of PSS and FACTS Damping Controllers to Improve Small Signal Stability of Large-scale Power Systems显示文摘This paper presents an approach for designing parameters of power system stabilizer(PSS)and FACTS damping controllers in a large scale practical power system.The objective is maximizing damping ratio of the target mode,and tracking technology(MTT)is used to avoid frequent alternations of target mode in optimization procedures.An improved planted growth simulation algorithm(IPGSA),which has high search efficiency and quick convergence speed,is proposed to optimize controller parameters coordinately.Based on case study of a large-scale power grid,and by using local and interregional low-frequency oscillation modes as target modes,simulation results verify proposed method in this paper.Furthermore,coordination optimization strategy adapted to multi-operating conditions demonstrates that the proposed approach is robust. | Guangzheng Yu Tao Lin Jiannan Zhang Ye Tian Xiu Yang | 2019 | CSEE Journal of Power and Energy Systems2019，5，4： | 2 |
| 8 | Novel sulfonated thin-film composite nanofiltration membranes with improved water flux for treatment of dye solutions显示文摘 | Yang Liu Shuling Zhang Zheng Zhou Jiannan Ren Zhi Geng Jiashuang Luan Guibin Wang | 2012 | Journal of Membrane Science2012，，： | 1 |
| 9 | Thymosin alpha-1-transformed Bifidobacterium promotes T cell proliferation and maturation in mice by oral administration显示文摘 | Congwen Shao Guojun Tian Yuanjian Huang Wenying Liang Hang Zheng Jiannan Wei Cheng Wei Cuilan Yang Hong Wang Weisen Zeng | 2013 | International Immunopharmacology2013，，3： | 1 |
| 10 | C-terminus of TRAP in Staphylococcus can enhance the activity of lysozyme and lysostaphin显示文摘在葡萄球菌 aureus,激活蛋白质(陷井) 的 RNAIII 的目标是其 C 终点能被用作一支疫苗对 staphylococcal 感染提供保护的联系膜的蛋白质。这里,我们由表面电浆子第一次证明回声和套住的连接酶的 immunosorbent 试金能明确地通过它的 C 终点(氨基酸 155-167 ) 绑溶解酵素和 lysostaphin 并且在 vitro 提高 lysozomal 活动。陷井异种紧张对 lysostaphin 更抵抗比,这也被发现野类型。我们的以前的数据证明陷井力量的 C 终点是细胞外的。我们的结果因此建议陷井的 C 终点能对 S 作为 lysozyme/lysostaphin 的特定的指向蛋白质起作用。aureus 房间墙和相互作用的生物意义可能是便于 lysozyme/lysostaphin-mediated 房间细胞溶解。 | Guang Yang Yaping Gao Jiannan Feng Yong Huang Shaohua Li Yu Liu Chuan Liu Ming Fan Beifen Shen Ningsheng Shao | 2008 | Acta Biochimica et Biophysica Sinica2008，40，5： | 1 |
| 11 | Bidirectional differentiation of BMSCs induced by a biomimetic procallus based on a gelatin-reduced graphene oxide reinforced hydrogel for rapid bone regeneration显示文摘Developmental engineering strategy needs the biomimetic composites that can integrate the progenitor cells,biomaterial matrices and bioactive signals to mimic the natural bone healing process for faster healing and reconstruction of segmental bone defects.We prepared the gelatin-reduced graphene oxide(GOG)and constructed the composites that mimicked the procallus by combining the GOG with the photo-crosslinked gelatin hydrogel.The biological effects of the GOG-reinforced composites could induce the bi-differentiation of bone marrow stromal cells(BMSCs)for rapid bone repair.The proper ratio of GOG in the composites regulated the composites’mechanical properties to a suitable range for the adhesion and proliferation of BMSCs.Besides,the GOG-mediated bidirectional differentiation of BMSCs,including osteogenesis and angiogenesis,could be activated through Erk1/2 and AKT pathway.The methyl vanillate(MV)delivered by GOG also contributed to the bioactive signals of the biomimetic procallus through priming the osteogenesis of BMSCs.During the repair of the calvarial defect in vivo,the initial hypoxic condition due to GOG in the composites gradually transformed into a well-vasculature robust situation with the bi-differentiation of BMSCs,which mimicked the process of bone healing resulting in the rapid bone regeneration.As an inorganic constituent,GOG reinforced the organic photo-crosslinked gelatin hydrogel to form a double-phase biomimetic procallus,which provided the porous extracellular matrix microenvironment and bioactive signals for the bi-directional differentiation of BMSCs.These show a promised application of the bio-reduced graphene oxide in biomedicine with a developmental engineering strategy. | Delong Jiao Ao Zheng Yang Liu Xiangkai Zhang Xiao Wang Jiannan Wu Wenjun She Kaige Lv Lingyan Cao Xinquan Jiang | 2021 | Bioactive Materials2021，6，7： | 1 |
| 12 | Autographa Californica Multiple Nucleopolyhedrovirus P48(Ac103) Is Required for the Efficient Formation of Virus-Induced Intranuclear Microvesicles显示文摘Our previous study has shown that the Autographa californica multiple nudeopolyhedrovirus(AcMNPV)p48(acl03)gene is essential for the nuclear egress of nucleocapsids and the formation of occlusion-derived virions(ODVs).However,the exact role of p48 in the morphogenesis of ODVs remains unknown.In this study,we demonstrated that p48 was required for the efficient formation of intranuclear microvesicles.To further understand its functional role in intranuclear microvesicle formation,we characterized the distribution of the P48 protein,which was found to be associated with the nucleocapsid and envelope fractions of both budded virions and ODVs.In AcMNPV-infected cells,P48 was predominantly localized to nucleocapsids in the virogenic stroma and the nucleocapsids enveloped in ODVs,with a limited but discernible distribution in the plasma membrane,nuclear envelope,intranuclear microvesicles,and ODV envelope.Furthermore,coimmunoprecipitation assays showed that among the viral proteins required for intranuclear microvesicle formation,F48 associated with Ac93 in the absence of viral infection. | Yan Wang Qingyun Cai Jiannan Chen Zhihong Huang Wenbi Wu Meijin Yuan Kai Yang | 2019 | Virologica Sinica2019，34，6： | 1 |
| 13 | pH-dependent deg- radation of acid orange Ⅱ by zero-valent iron in presence of oxygen 显示文摘 | He Chun Yang Jiannan Zhu Linfei | 2013 | Separation and Purification Technology2013，117，： | 1 |
| 14 | Analysis of the MISR LAI/FPAR product for spatial and temporal coverage, accuracy and consistency显示文摘 | Jiannan Hu Yin Su Bin Tan Dong Huang Wenze Yang Mitchell Schull Michael A. Bull John V. Martonchik David J. Diner Yuri Knyazikhin Ranga B. Myneni | 2006 | Remote Sensing of Environment2006，，1： | 1 |
| 15 | INNOVATION IN THE CHINESE PUBLIC SECTOR: TYPOLOGY AND DISTRIBUTION显示文摘 | JIANNAN WU LIANG MA YUQIAN YANG | 2013 | Public Administration2013，，2： | 1 |
| 16 | Impact history and origin of lunar meteorite Northwest Africa 15528显示文摘No samples from the Moon’s far side have been returned to Earth.Thus,lunar meteorite study can deepen the understanding of the Moon’s far side(if we can identify which lunar meteorites came from the Moon’s far side).The Northwest Africa(NWA)15528 meteorite is a lunar feldspathic regolith breccia meteorite and we speculated it might originate from the Feldspathic Highlands Terrane(FHT)on the far side of the Moon.Here,we report detailed petrography,major and trace elements,and noble gas(He,Ne,and Ar)isotopes for the clasts and matrix,respectively.The results show that the NWA 15528 lunar meteorite contains diverse clasts,including anorthosite,granulite,basalt,and impact melt clasts.The coarse,wellcrystallized,uniform chemical composition minerals may come from intrusive plutonic rocks.Among the anorthosite clasts,the norite/olivine clasts originate from the deep lunar crust,whereas the other anorthosite clasts are from lunar highlands.The Sm concentrations in NWA 15528 were similar to those in the fourth group of Apollo 16 melt samples,demonstrating that NWA 15528 has a typical plagioclase highland meteorite composition.Compared with the Apollo sample data and remote sensing results,the chemical composition of NWA 15528 indicated strong affinities with the FHT area and ferroan anorthosite(FAN)material from the far side of the Moon.The noble gas isotopic composition of NWA 15528 is consistent with a binary mixture of solar wind and cosmogenic components;during stepwise pyrolytic extractions,we observed that the abundance of cosmogenic components decreased,whereas that of solar wind components increased with increasing temperature.The average cosmic-ray exposure(CRE)age of the matrix and granulite is 42±6 Ma,with a shielding depth in the same range of 10-20 g cm^(−2).The gas retention age of NWA 15528 is 2.14 Ga,and the antiquity age of NWA 15528 is(0.69-0.74)±0.2 Ga(considering 50%40Arm is 40Artrap)which indicates the different clasts of NWA 15528 are assembled after 0.69-0.74 Ga. | Runchuan LIU Huaiyu HE Thomas SMITH Hanqing YE Huapei WANG Xuhang ZHANG Fei SU Ziheng LIU Wei GUO Peng YANG Chuantong ZHANG Dingshuai Xue Ting CAO Jiannan LI Xuelong JIANG Ye HE Chao LU | 2023 | Science China Earth Sciences2023，66，6： | 0 |
| 17 | A common variant in AAK1 reduces risk of noise-induced hearing loss显示文摘Noise-induced hearing loss(NIHL)is one of the most common types of hearing loss and contributes to significant morbidity worldwide,as well as being the major cause of age-related hearing loss and tinnitus.The World Health Organization(WHO)estimates that 10%of the world's population is exposed to sound levels that could potentially cause NIHL[1].It has been widely accepted that NIHL is a multifactorial genetic disorder with estimated heritability of 36%to 40%[2].Ideally,identification of the modifying genetic variants would help protect individuals at high risk of NIHL.For decades,many geneticists have searched for genes that either predispose or protect from NIHL.Howeve r,the majority of genetic studies for NIHL were conducted in independent known candidate genes[3]. | Qixuan Wang Xueling Wang Tao Yang Lu Yang Huihui Liu Yihang Zheng Guixian Jiang Hongchao Liu Chenhui Huang Juan Chen Zhentao Wang Zhaoyan Wang Wei Zhao Jiannan Lin Xuejie Zhang Junbo Shi Kun Han Xingyu Le Yan Ren Yun Li Yingying Hong Wentao Shi Dongqi Cui Minfei Qian Jun Xu Xiaofei Zheng Yunge Gao Chen Li James Lin Zhiwu Huang Hao Wu | 2023 | National Science Review2023，10，7： | 0 |
| 18 | A Simulation Study on the Clouds Microphysical Processes of Heavy Precipitation in Hebei Area Caused by'Lekima'显示文摘During the period of the super typhoon'Lekima'(No.1909)landed on the coast of North China,a high-resolution numerical simulation study was carried out with the WRF model on the clouds microphysical process of heavy precipitation.The results showed that(1)the water vapor convergence tended to develop and strengthen on the way forward of typhoon center,and the evolution of water vapor convergence zone was closely related to the development of typhoon asymmetric structure,and had a good corresponding relationship with the falling zone of the rainstorm.(2)The eastern coast of Hebei was located in the big-value area of water vapor transport belt in the northwest quadrant of the typhoon.Below 850 hPa,northeast wind appeared,and warm humid water vapor was transported from marine area to terrestrial by typhoon.Affected by upper-level westerly trough,westerly wind was dominated above 700 hPa,and water vapor convergence was transported from low level to upper level,and several rainstorm center appeared.(3)In the spiral rain bands of typhoon,the big-value center of graupel particles cooperated with the warm cloud enriched with water content,and the ground would produce a center of heavy precipitation,and the precipitation center of pure warm cloud appeared in 117.5°E.This phenomenon rarely occurred during continental cloud precipitation.Therefore,the contribution of warm cloud precipitation mechanism to the typhoon spiral rain belt should be emphasized. | Min PENG Wenxia YANG Zhihui WU Jiannan ZHANG Yang YANG Shaoyu HOU | 2023 | Meteorological and Environmental Research2023，14，4： | 0 |
| 19 | Reverse engineering a predictive signature characterized by proliferation,DNA damage,and immune escape from stage I lung adenocarcinoma recurrence显示文摘Identifying early-stage cancer patients at risk for progression is a major goal of biomarker research.This report describes a novel 19-gene signature(19-GCS)that predicts stage I lung adenocarcinoma(LAC)recurrence and responseto therapy and performs comparably in pancreatic adenocarcinoma(PAC),which shares LAC molecular traits.Kaplan-Meier,Cox regression,and cross-validation analyses were used to build the signature from training,test,and validation sets comprising 831 stage I LAC transcriptomes from multiple independent data sets.A statistical analysis was performed using the R Ianguage.Pathway and gene set enrichment were used to identify underlying mechanisms.19-GCS strongly predicts overall survival and recurrence-free survival in stage I LAC(P=0.002 and P<0.001,respectively)and in stage l-ll PAC(P<0.0001 and Pv0.0005,respectively).A multivariate cox regression analysis demonstrated the independence of 19-GCS from significant clinical factors.Pathway analyses revealed that 19-GCS high-risk LAC and PAC tumors are characterized by increased proliferation,enhanced sternness,DNA repair deficiency,and compromised MHC class I and II antigen presentation along with decreased immune infiltration.Importantly,high-risk LAC patients do not appear to benefit from adjuvant cisplatin while PAC patients derive additi onal ben efit from FOLFIRINOX compared with gemcitabi ne-based regimens.Whe n validated prospectively,this proof-of-c on cept biomarker may con tribute to tailoring treatment,recurrence reduction,and survival improvements in early-stage lung and pancreatic cancers. | Jiannan Yao Xinying Xue Dongfeng Qu C.Benedikt Westphalen Yang Ge Liyang Zhang Manyu Li Tianbo Gao Parthasarathy Chandrakesan Kenneth J.Vega Jun Peng Guangyu An Nathaniel Weygant | 2020 | Acta Biochimica et Biophysica Sinica2020，52，6： | 0 |
| 20 | TMEM181:a key mediator of cytolethal distending toxin required for Wnt signaling activity显示文摘Wnt signaling pathway plays critical roles in a variety of embryonic developmental processes and also controls homeostatic selfrenewal in a number of adult tissues(Flaherty and Dawn,2008;Nusse and Clevers,2017).At the cell membrane,Wnt ligands bind to the seven transmembrane receptors of Frizzled family and the co-receptors to activate intracellular signaling pathway,including theβ-catenin-dependent canonical Wnt signaling pathway,the noncanonical planar cell polarity(PCP)pathway and the Wnt/calcium pathway(Flaherty and Dawn,2008).In mammals,WNT4,WNT5A. | Jiannan Zhang Xueqin Yang Shicheng Zhu Zhong-Min Dai Xiao-Jing Zhu | 2023 | Journal of Genetics and Genomics2023，50，1： | 0 |
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