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| 1 | Towards 6G wireless communication networks:vision,enabling technologies,and new paradigm shifts显示文摘The fifth generation(5G)wireless communication networks are being deployed worldwide from 2020 and more capabilities are in the process of being standardized,such as mass connectivity,ultra-reliability,and guaranteed low latency.However,5G will not meet all requirements of the future in 2030 and beyond,and sixth generation(6G)wireless communication networks are expected to provide global coverage,enhanced spectral/energy/cost efficiency,better intelligence level and security,etc.To meet these requirements,6G networks will rely on new enabling technologies,i.e.,air interface and transmission technologies and novel network architecture,such as waveform design,multiple access,channel coding schemes,multi-antenna technologies,network slicing,cell-free architecture,and cloud/fog/edge computing.Our vision on 6G is that it will have four new paradigm shifts.First,to satisfy the requirement of global coverage,6G will not be limited to terrestrial communication networks,which will need to be complemented with non-terrestrial networks such as satellite and unmanned aerial vehicle(UAV)communication networks,thus achieving a space-airground-sea integrated communication network.Second,all spectra will be fully explored to further increase data rates and connection density,including the sub-6GHz,millimeter wave(mmWave),terahertz(THz),and optical frequency bands.Third,facing the big datasets generated by the use of extremely heterogeneous networks,diverse communication scenarios,large numbers of antennas,wide bandwidths,and new service requirements,6G networks will enable a new range of smart applications with the aid of artificial intelligence(AI)and big data technologies.Fourth,network security will have to be strengthened when developing 6G networks.This article provides a comprehensive survey of recent advances and future trends in these four aspects.Clearly,6G with additional technical requirements beyond those of 5G will enable faster and further communications to the extent that the boundary between physical and cyber worlds disappears. | Xiaohu YOU Cheng-Xiang WANG Jie HUANG Xiqi GAO Zaichen ZHANG Mao WANG Yongming HUANG Chuan ZHANG Yanxiang JIANG Jiaheng WANG Min ZHU Bin SHENG Dongming WANG Zhiwen PAN Pengcheng ZHU Yang YANG Zening LIU Ping ZHANG Xiaofeng TAO Shaoqian LI Zhi CHEN Xinying MA Chih-Lin I Shuangfeng HAN Ke LI Chengkang PAN Zhimin ZHENG Lajos HANZO Xuemin(Sherman)SHEN Yingjie Jay GUO Zhiguo DING Harald HAAS Wen TONG Peiying ZHU Ganghua YANG Jun WANG Erik GLARSSON Hien Quoc NGO Wei HONG Haiming WANG Debin HOU Jixin CHEN Zhe CHEN Zhangcheng HAO Geoffrey Ye LI Rahim TAFAZOLLI Yue GAO HVincent POOR Gerhard P.FETTWEIS Ying-Chang LIANG | 2021 | Science China(Information Sciences)2021，64，1： | 122 |
| 2 | A Survey on Terahertz Communications显示文摘With the exponential growth of the data traffic in wireless communication systems, terahertz(THz) frequency band is envisioned as a promising candidate to support ultra-broadband for future beyond fifth generation(5G), bridging the gap between millimeter wave(mmWave) and optical frequency ranges. The purpose of this paper is to provide a comprehensive literature review on the development towards THz communications and presents some key technologies faced in THz wireless communication systems. Firstly, despite the substantial hardware problems that have to be developed in terms of the THz solid state superheterodyne receiver, high speed THz modulators and THz antennas, the practical THz channel model and the efficient THz beamforming are also described to compensate for the severe path attenuation. Moreover, two different kinds of lab-level THz communication systems are introduced minutely, named a solid state THz communication system and a spatial direct modulation THz communication system, respectively. The solid state THz system converts intermediate frequency(IF) modulated signal to THz frequency while the direct modulation THz system allows the high power THz sources to input for approving the relatively long distance communications. Finally, we discuss several potential application scenarios as well as some vital technical challenges that will be encountered in the future THz communications. | Zhi Chen Xinying Ma Bo Zhang Yaxin Zhang Zhongqian Niu Ningyuan Kuang Wenjie Chen Lingxiang Li Shaoqian Li | 2019 | China Communications2019，16，2： | 43 |
| 3 | Picroside Ⅱ down-regulates matrix metalloproteinase-9 expression following cerebral ischemia/reperfusion injury in rats显示文摘Studies have shown that Picroside II attenuates inflammatory reactions following brain ischemia through the inhibition of the TLR-4-NF-κB signal transduction pathway,and ameliorates cerebral edema through the reduction of aquaporin-4 expression.Matrix metalloproteinase-9 (MMP-9),located downstream of the TLR-4-NF-κB signal transduction pathway,can degrade the neurovascular matrix,damage the blood-brain barrier to induce cerebral edema,and directly result in neuronal apoptosis and brain injury.Therefore,the present study further observed MMP-9 expression in the brain tissues of rats with cerebral ischemia/reperfusion injury following Picroside II treatment.Results demonstrated that Picroside II significantly reduced MMP-9 expression in ischemic brain tissues,as well as neuronal apoptosis and brain infarct volume,suggesting Picroside II exhibits neuroprotection by down-regulating MMP-9 expression and inhibiting cell apoptosis. | Xiang Li Xinying Xu Zhen Li Yunliang Guo Qin Li Xiaodan Li Zhen Zhou | 2010 | Neural Regeneration Research2010，5，18： | 13 |
| 4 | Chang'E-1 Lunar Mission:An Overview and Primary Science Results显示文摘Chang'E-1 is the first lunar mission in China,which was successfully launched on Oct.24th,2007.It was guided to crash on the Moon on March 1,2009,at 52.36°E,1.50°S,in the north of Mare Fecunditatis.The total mission lasted 495 days,exceeding the designed life-span about four months.1.37Terabytes raw data was received from Chang'E-1.It was then processed into 4Terabytes science data at different levels.A series of science results have been achieved by analyzing and applicating these data,especially 'global image of the Moon of China's first lunar exploration mission'.Four scientific goals of Chang'E-1 have been achieved.It provides abundant materials for the research of lunar sciences and cosmochemistry.Meanwhile these results will serve for China's future lunar missions. | Ouyang Ziyuan Li Chunlai Lu Chang Liu Jianzhong Zou Yongliao Zhang Hongbo Jianjun Zuo Wei Su Yah Wen Weibin Bian Wei Zhao Baochang Wang Jianyu Yang Jianfeng Chang Jin Wang Huanyu Zhang Xiaohui Wang Shijin Wang Min Ren Xin Mu Lingli Kong Deqing Wang Xiaoqian Wang Fang Geng Liang Zhang Zhoubin Zheng Lei Zhu Xinying Zheng Yongchun Li Junduo Zou Xiaoduan Xu Chun Shi Shuobiao Gao Yifei Gao Guannan | 2010 | 空间科学学报2010，30，5： | 11 |
| 5 | Characteristics and sedimentary processes of lamina-controlled sand-particle imbricate structure in deposits on Lingshan Island, Qingdao, China显示文摘Imbricate structure is a common sedimentary structure and is well developed in sandy sediments.Here,we report a laminacontrolled fine-sand-particle imbricate structure in a set of very fine grained sedimentary rocks(fine sandstone,siltstone,and mudstone)at the Dockyard and Qianceng Cliff areas of Lingshan Island,Qingdao,Shandong,China.Sets of up to 300 laminae are found in stratigraphic profiles in these areas.The laminae are generally less than 1 mm thick,with most being 0.3–0.4 mm thick and the thinnest being<0.1 mm.The dip angle of the imbricate structure varies widely,between 0°and 90°,with an average dip angle of about 40°–50°,which is higher than that of imbricate riverbed gravels(about 34°).The dip angle is a function of the shape and sorting of the particles,as well as the hydrodynamic conditions under which these fine-grained sediments were deposited.Several profiles show well-developed multiscale,soft-sediment deformation structures.Flute casts,load casts,and groove casts are also common.Fragments of carbon remains occur widely and commonly constitute stringers several millimeters thick and up to 10 cm long,together with fine clasts.Vitrain lenticles are also common.Based on the imbricate structure of the Lingshan Island deposits,it is shown that in addition to paleocurrent analysis,the imbricate structure can be used to infer information about fluid properties,transport characteristics,and sedimentary processes of the depositional environment.A near-bottom underflow,either of authigenic origin or derived from cold river water in winter in a delta interdistributary bay or delta-front environment,is inferred to have provided the hydrodynamic setting in which this imbricate structure formed.The imbricate structure,together with other sedimentary structures and features,shows that the sedimentary rocks on Lingshan Island were deposited in an inland,shallow-water environment,such as a delta,and not in a deep-water or submarine continental-slope environment. | SHAO ZhuFu ZHONG JianHua LI Yong MAO Cui LIU ShengXin NI LiangTian TIAN Yuan CUI XinYing LIU YunTian WANG XiaoNan LI WeiHua LIN GangShan | 2014 | Science China Earth Sciences2014，57，5： | 11 |
| 6 | The record of cultivated rice from archaeobiological evidence in northwestern China 5000 years ago显示文摘Pollen, plant seeds and phytoliths from an AMS dated sediment profile at the Xishanping site indicate that the cultivation of rice might start no later than 5070 cal. a BP in the region of Tianshui, Gansu Province. It continued from 5070 to 4300 cal. a BP. This is so far the oldest and the most northwestern record of cultivated rice in Neolithic China, which extends the known region of prehistoric rice cultivation at least 2° longitude to the west. This finding provides important evidence for reconstructing the cultivation region of rice at 5000 a BP (an important time period), and its spreading history in East Asia, during the Neolithic. | LI XiaoQiang ZHOU XinYing ZHANG HongBin ZHOU Jie SHANG Xue DODSON John | 2007 | Chinese Science Bulletin2007，52，10： | 11 |
| 7 | Early agricultural development and environmental effects in the Neolithic Longdong basin(eastern Gansu)显示文摘Neolithic agricultural development and environmental effects in the Longdong area were reconstructed using a synthetic approach,investigating pollen,charcoal,and seed remains for two cultural layer sections and five flotation sites.Results show that Neolithic agriculture in the Longdong area had a simple organization and was dominated by the production of common millet,especially in the early and middle Yangshao age.After the late Yangshao age,Neolithic agriculture developed into a more complex structure,dominated by both common and foxtail millet and the cultivation of rice and soybeans.The production of foxtail millet gradually increased through the Neolithic period,reaching its highest point during the Qijia culture.Soybeans were first cultivated during the late Yangshao culture,approximately 5000 cal a BP.Rice production began no later than 4800 cal a BP,and continued to exist in the Qijia culture,approximately 4000 cal a BP.Agricultural production in Neolithic Longdong,specifically in the 'Yuan' area of the loess plateau,developed as a shrub and grass dominated landscape.Vegetation in the river valleys was partly covered with Picea,Tusga,and Quercus coniferous and broadleaf mixed forests.Agricultural activity during the Neolithic period caused an increase in farmland on the loess tableland and a decrease in the abundance of shrub and grassland in the Longdong area.When farmlands were abandoned,vegetation recovered with Hippophae-,Rosaceae-,Ephedra-,and Leguminosae-dominated shrublands and Artemisia-dominated grasslands. | ZHOU XinYing LI XiaoQiang ZHAO KeLiang DODSON John SUN Nan YANG Qing | 2011 | Chinese Science Bulletin2011，56，8： | 10 |
| 8 | Investigation of the ultrastructural characteristics of foxtail and broomcorn millet during carbonization and its application in archaeobotany显示文摘Fossilized caryopses (or grains) of foxtail millet (Setaria italica) and broomcorn millet (Panicum miliaceum) are important archaeobotanical materials for the study of early human agricultural activities.The morphology and ultrastructural characteristics of carbonized modern millets caryopses treated in a drying oven and burning in a field were investigated at different temperatures to study how fossilized millets are formed.The caryopses shrank gradually at temperatures below 200°C,and starch granules in the endosperm retained their crystalline structure.At 250°C the foxtail millet caryopses expanded,whereas the broomcorn millet caryopses were greatly deformed.At this temperature,the structure of the starch granules of both millets became amorphous.At 300°C the caryopses partially turned to ash and became porous,and the ultrastructure of the starch granules was transformed into alveolate cavities.Fossil caryopses from the prehistoric storage cellar at the Beiniu Site retained their crystalline structure and were formed by the dehydrating effect of carbonization,indicating that water molecules were not involved in the starch crystallization.The results of a field burning experiment demonstrated that the ultrastructure of carbonized caryopses placed on the ground under the fire was amorphous.The amorphous ultrastructure of the carbonized caryopses recovered from the archaeological layers is consistent with the expected structure of caryopses that have been carbonized at 250°C.Therefore,we suggest that the recovered caryopses were formed at about 250°C by baking rather than by burning in an open fire. | YANG Qing LI XiaoQiang ZHOU XinYing ZHAO KeLiang JI Ming SUN Nan | 2011 | Chinese Science Bulletin2011，56，14： | 10 |
| 9 | Counteraction of ABA-Mediated Inhibition of Seed Germination and Seedling Establishment by ABA Signaling Terminator in Arabidopsis显示文摘Seed germination and seedling establishment are important for the reproductive success of plants,but seeds and seedlings typically encounter constantly changing environmental conditions.By inhibiting seed germination and post-germinative growth through the PYR1/PYL/RCAR ABA receptors and PP2C co-receptors,the phytohormone abscisic acid(ABA)prevents premature germination and seedling growth under unfavorable conditions.However,little is known about how the ABA-mediated inhibition of seed germination and seedling establishment is thwarted.Here,we report that ABA Signaling Terminator(ABT),a WD40 protein,efficiently switches off ABA signaling and is critical for seed germination and seedling establishment.ABT is induced by ABA in a PYR1/PYL/RCAR-PP2C-dependent manner.Overexpression of ABT promotes seed germination and seedling greening in the presence of ABA,whereas knockout of ABT has the opposite effect.We found that ABT interacts with the PYR1/PYL/RCAR and PP2C proteins,interferes with the interaction between PYR1/PYL4 and ABI1/ABI2,and hampers the inhibition of ABI1/ABI2 by ABA-bound PYR1/PYL4,thereby terminating ABA signaling.Taken together,our results reveal a core mechanism of ABA signaling termination that is critical for seed germination and seedling establishment in Arabidopsis. | Zhijuan Wang Ziyin Ren Chunhong Cheng Tao Wang Hongtao Ji Yang Zhao Zhiping Deng Liya Zhi Jingjing Lu Xinying Wu Shimin Xu Mengmeng Cao Hongtao Zhao Liu Liu Jiankang Zhu Xia Li | 2020 | Molecular Plant2020，13，9： | 10 |
| 10 | Whole genome sequencing of 10K patients with acute ischaemic stroke or transient ischaemic attack: design, methods and baseline patient characteristics显示文摘Background and purpose Stroke is the second leading cause of death worldwide and the leading cause of mortality and long-term disability in China,but its underlying risk genes and pathways are far from being comprehensively understood.We here describe the design and methods of whole genome sequencing(WGS)for 10914 patients with acute ischaemic stroke or transient ischaemic attack from the Third China National Stroke Registry(CNSR-III).Methods Baseline clinical characteristics of the included patients in this study were reported.DNA was extracted from white blood cells of participants.Libraries are constructed using qualified DNA,and WGS is conducted on BGISEQ-500 platform.The average depth is intended to be greater than 30×for each subject.Afterwards,Sentieon software is applied to process the sequencing data under the Genome Analysis Toolkit best practice guidance to call genotypes of single nucleotide variants(SNVs)and insertion-deletions.For each included subject,21 fingerprint SNVs are genotyped by MassARRAY assays to verify that DNA sample and sequencing data originate from the same individual.The copy number variations and structural variations are also called for each patient.All of the genetic variants are annotated and predicted by bioinformatics software or by reviewing public databases.Results The average age of the included 10914 patients was 62.2±11.3 years,and 31.4%patients were women.Most of the baseline clinical characteristics of the 10914 and the excluded patients were balanced.Conclusions The WGS data together with abundant clinical and imaging data of CNSR-III could provide opportunity to elucidate the molecular mechanisms and discover novel therapeutic targets for stroke. | Si Cheng Zhe Xu Yang Liu Jinxi Lin Yong Jiang Yilong Wang Xia Meng Anxin Wang Xinying Huang Zhimin Wang Guohua Chen Songdi Wu Zhengchang Jia Yongming Chen Xuerong Qiu Jun Wu Binbin Song Weizhong Ji Zhongping An Wenjun Xue Lili Zhao Yu Geng Hongyan Li Hao Li Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 8 |
| 11 | Regional and Global Land Data Assimilation Systems: Innovations,Challenges, and Prospects显示文摘Since the North American and Global Land Data Assimilation Systems(NLDAS and GLDAS) were established in2004, significant progress has been made in development of regional and global LDASs. National, regional, projectbased, and global LDASs are widely developed across the world. This paper summarizes and overviews the development, current status, applications, challenges, and future prospects of these LDASs. We first introduce various regional and global LDASs including their development history and innovations, and then discuss the evaluation, validation, and applications(from numerical model prediction to water resources management) of these LDASs. More importantly, we document in detail some specific challenges that the LDASs are facing: quality of the in-situ observations, satellite retrievals, reanalysis data, surface meteorological forcing data, and soil and vegetation databases; land surface model physical process treatment and parameter calibration; land data assimilation difficulties; and spatial scale incompatibility problems. Finally, some prospects such as the use of land information system software, the unified global LDAS system with nesting concept and hyper-resolution, and uncertainty estimates for model structure,parameters, and forcing are discussed. | Youlong XIA Zengchao HAO Chunxiang SHI Yaohui LI Jesse MENG Tongren XU Xinying WU Baoqing ZHANG | 2019 | Journal of Meteorological Research2019，33，2： | 7 |
| 12 | Analysis of users’ electricity consumption behavior based on ensemble clustering显示文摘Due to the increase in the number of smart meter devices,a power grid generates a large amount of data.Analyzing the data can help in understanding the users’electricity consumption behavior and demands;thus,enabling better service to be provided to them.Performing power load profile clustering is the basis for mining the users’electricity consumption behavior.By examining the complexity,randomness,and uncertainty of the users’electricity consumption behavior,this paper proposes an ensemble clustering method to analyze this behavior.First,principle component analysis(PCA)is used to reduce the dimensions of the data.Subsequently,the single clustering method is used,and the majority is selected for integrated clustering.As a result,the users’electricity consumption behavior is classified into different modes,and their characteristics are analyzed in detail.This paper examines the electricity power data of 19 real users in China for simulation purposes.This manuscript provides a thorough analysis along with suggestions for the users’weekly electricity consumption behavior.The results verify the effectiveness of the proposed method. | Qi Zhao Haolin Li Xinying Wang Tianjiao Pu Jiye Wang | 2019 | Global Energy Interconnection2019，2，6： | 7 |
| 13 | Holocene vegetation succession and responses to climate change in the northern sector of Northeast China显示文摘Sediment pollen samples from the Huola Basin in the northern sector of northeast China, and surface pollen samples from its environs, were analyzed to reconstruct accurately the historical response of vegetation to climate change since 9100 cal yr BP. Pollen analysis of the Huola Section indicates that vegetation experienced a transformation from early-mid Holocene warm-cold mixed vegetation to late Holocene cold-temperate vegetation. From 9100 to 6000 cal yr BP, the study area was warmer and moister than at present, developing Corylus, Carpinus, Pinus, Picea, Betula and Larix-dominated forests. Two cooling events at 6000–5000 and 3500–2500 cal yr BP led to a decrease in Corylus, Carpinus and other warmth-loving vegetation, whereas cold temperate forests composed of Larix and Betula expanded. After 2500 cal yr BP, Larix and Betula dominated cold-temperate vegetated landscapes. The Holocene warm period in NE China(9100–6000 cal yr BP) suggests that such warming could have resulted in a strengthening of the influence from East Asian Summer Monsoon on northernmost NE China and would have benefited the development of warm-temperate forest vegetation and an improved plant load, which also provides the similarity model for the possible global warming in the future. | ZHAO Chao LI XiaoQiang ZHOU XinYing ZHAO KeLiang YANG Qing | 2016 | Science China Earth Sciences2016，59，7： | 7 |
| 14 | The optional long 5'-untranslated region of human ACAT1 mRNAs impairs the production of ACAT1 protein by promoting its mRNA decay显示文摘我们以前报导了人的 ACAT1 mRNAs 用 AUG13971399 开始 codon 生产 50 kDa 蛋白质,并且另外一个未成年者用在上游的在里面框架 GGC12741276 开始 codon 的 56 kDa isoform。GGC12741276 codon 在可选的长 5-untranslated 区域被定位(5-UTR, nt 11396 ) mRNAs。相应于这 5-UTR 的 DNA 序列位于二个不同染色体, 7 和 1。在当前的工作,我们报导可选的长 5-UTR 显著地损害从 AUG13971399 codon 开始的人的 ACAT1 蛋白质的生产,主要由支持它的 mRNA 腐烂。西方的污点分析显示可选的长 5-UTR potently 损害了从 AUG13971399 codon 开始的不同蛋白质的生产,意味着这损害效果没被 3-UTR 或 ACAT1 mRNA 的编码顺序影响。反向的抄写量的聚合酶链反应的结果证明这 5-UTR 戏剧性地减少了它的连接 mRNAs 的内容。到 mRNA 比率的蛋白质的分析证明这 5-UTR 主要减少了它的 mRNA 稳定性而非改变它的翻译效率。我们下次执行了 plasmid transfection 实验并且使用了放线菌素 D 禁止抄写。结果证明这 5-UTR 支持了它的 mRNA 腐烂。用在 vitro 准备的 RNA 的另外的 transfection 和 nucleofection 实验说明了那,在细胞质和房间的原子核,没有连接,可选的长 5-UTR-linked mRNAs 比那些快腐烂了。总的来说,我们的学习在抄写以后的水平把新卓见带到人的 ACAT1 基因表示的规定。 | Xiaonan Zhao Jia Chen Lei Lei Guangjing Hu Ying Xiong Jiajia Xu Qin Li Xinying Yang Catherine C.Y. Chang Baoliang Song Tayuan Chang Boliang Li | 2009 | Acta Biochimica et Biophysica Sinica2009，41，1： | 6 |
| 15 | Atorvastatin attenuates surgery-induced BBB disruption and cognitive impairment partly by suppressing NF-κB pathway and NLRP3 inflammasome activation in aged mice显示文摘In clinic,perioperative neurocognitive disorder is becoming a common complication of surgery in old patients.Neuroinflammation and blood-brain barrier(BBB)disruption are important contributors for cognitive impairment.Atorvastatin,as a strong HMG-CoA reductase inhibitor,has been widely used in clinic.However,it remains unclear whether atorvastatin could prevent anesthesia and surgery-induced BBB disruption and cognitive injury by its anti-inflammatory property.In this study,aged C57BL/6J mice were used to address this question.Initially,the mice were subject to atorvastatin treatment for 7 days(10 mg/kg).After a simple laparotomy under 1.5%isoflurane anesthesia,Morris water maze was performed to assess spatial learning and memory.Western blot analysis,immunohistochemistry,and enzyme-linked immunosorbent assay were used to examine the inflammatory response,BBB integrity,and cell apoptosis.Terminal-deoxynucleotidyl transferase mediated nick end labeling assay was used to assess cell apoptosis.The fluorescein sodium and transmission electron microscopy were used to detect the permeability and structure of BBB.The results showed that anesthesia and surgery significantly injured hippocampal-dependent learning and memory,which was ameliorated by atorvastatin.Atorvastatin could also reverse the surgery-induced increase of systemic and hippocampal cytokines,including IL-1β,TNF-α,and IL-6,accompanied by inhibiting the nuclear factor kappa-B(NF-κB)pathway and Nucleotide-Binding Oligomerization Domain,or Leucine Rich Repeat and Pyrin Domain Containing 3(NLRP3)inflammasome activation,as well as hippocampal neuronal apoptosis.In addition,surgery triggered an increase of BBB permeability,paralleled by a decrease of the ZO-1,occludin,and Claudin 5 proteins in the hippocampus.However,atorvastatin treatment could protect the BBB integrity from the impact of surgery,by up-regulating the expressions of ZO-1,occludin,and Claudin 5.These findings suggest that atorvastatin exhibits neuroprotective effects on cognition in aged mice undergoing surgery. | Pengfei Liu Quansheng Gao Lei Guan Yanting Hu Jingwen Jiang Teng Gao Weixuan Sheng Xinying Xue Hui Qiao Tianzuo Li | 2021 | Acta Biochimica et Biophysica Sinica2021，53，5： | 6 |
| 16 | Potent anti-angiogenesis and anti-tumor activity of a nove human anti-VEGF antibody, MIL60显示文摘 | Jing Yang Qun Wang Chunxia Qiao Zhou Lin Xinying Li Yifei Huang Tingting Zhou Yan Li Beifen Shen Ming Lv Jiannan Feng | 2014 | Cellular & Molecular Immunology2014，11，3： | 4 |
| 17 | Xiyanping injection therapy for children with mild hand foot and mouth disease:a randomized controlled trial显示文摘OBJECTIVE: To evaluate the clinical effects of Xiyan-ping injection intervention in pediatric patients with mild hand foot and mouth disease(HFMD).METHODS: A total of 329 patients were stratified and block-randomized for symptomatic treatment of HFMD and assigned to one of the following groups: Western Medicine(group A, n = 103), Xiyanping injection(group B, n = 109), or Xiyanping injection and symptomatic treatment using Western Medicine(group C, n = 117). During the trial, fever,rash, ulcers of the mouth were observed among participants in each group before and after treatment, and conversion rates from mild to severe HFMD were measured.RESULTS: After 3-7 days' treatment, no significant differences in the conversion rates from mild to severe HFMD were observed among the three groups(P > 0.05). There was a significantly low number of patients with the onset time of antifebrile effect,vanished time of hand and foot rashes and cumulative time for the ulcers in the mouth vanished,among the three groups(P < 0.05, P < 0.01). The onset time of antifebrile effect of patients in groups B and C were markedly shorter compared with those in group A(P < 0.05, P < 0.01); there was no statically significant difference observed between groups B and C(P > 0.05). No significant differences were observed in the time for body temperature recovery among the three groups(P > 0.05). There were no significant differences in adverse effects among the three groups(P > 0.05).CONCLUSION: Xiyanping injection together with use of Western Medicine is most effective for symptomatic treatment of mild HFMD. No severe adverse reactions were observed. | Zhang Guoliang He Liyun Tang Liuping Yang Tong Zou Xinying Zhu Qingxiong Yan Shiyan Hou Yong Huang Baoju Zhao Jindong Li Yan Huang Jihan | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 4 |
| 18 | Excess TNF-α in the blood activates monocytes with the potential to directly form cholesteryl ester-laden cells显示文摘肿瘤坏死因素 --(TNF-) 并且 monocytic 房间在动脉粥样硬化的发展起一个关键作用,它是冠的心疾病(CHD ) 的主要原因。在这个工作,我们在血在单核白血球上调查了过量 TNF- 的效果并且发现从 CHD 病人的血单核白血球有潜力直接形成 cholesteryl 酉旨(CE ) 沉重的房间在下面在里面有 oxLDL 的 vitro 孵化。proinflammatory cytokines 的血浆层次例如 TNF- , interleukin 6 (IL-6 ) ,并且 C 反应蛋白质(CRP ) ,在 CHD,病人们是比在控制的那些显著地高级的健康志愿者。然而, TNF- ,然而并非 IL-6 或 CRP 的仅仅血浆水平,断然与血单核白血球的潜力被相关直接形成 CE 沉重的房间。由使用人的血单核白血球和 monocytic THP-1 房间, CE 沉重的房间的形成上的 TNF- 的激活的效果被表明,它能被 anti-TNF- 抗体明确地堵住。而且, TNF- 能由分别地提高功能的粘附分子和 scavenger 受体的表示增加粘附和单核白血球的 oxLDL 举起,这也被揭示。最后,结果在 vivo 并且在 vitro,与一个老鼠模型一起的实验证实在血的过量 TNF- 与潜力激活单核白血球直接形成 CE 沉重的房间。这些数据证明在血的过量 TNF- 是为动脉粥样硬化和 CHD 的开发的主要扳机。 | Ming Zhu Lei Lei Zhenhua Zhu Qin Li Dongqing Guo Jiajia Xu Jia Chen Huifang Sha Xiaowei Zhang Xinying Yang Baoliang Song Boliang Li Yan Yan Ying Xiong | 2015 | Acta Biochimica et Biophysica Sinica2015，47，11： | 4 |
| 19 | Selection and characterization of the novel anti-human PD-1 FV78 antibody from a targeted epitope mammalian cell-displayed antibody library显示文摘Currently,display-based methods are well established and widely used in antibody engineering for affinity maturation and structural stability improvement.We obtained a novel anti-human programmed death 1(PD-1)antibody using computer-aided design and a mammalian cell display technology platform.We used computer-aided modeling and distance geometry methods to predict and assign the key residues that contributed to the binding of human PD-L1 to PD-1.Then,we analyzed the sequence of nivolumab(an anti-human PD-1 antibody,referred to as MIL75 in the article)to determine the template for antibody design and library construction.We identified a series of potential substitutions on the obtained template and constructed a virtual epitope-targeted antibody library based on the physicochemical properties and each possible location of the assigned key residues.The virtual antibody libraries were displayed on the surface of mammalian cells as the antigen-binding fragments of full-length immunoglobulin G.Then,we used flow cytometry and sequencing approaches to sort and screen the candidates.Finally,we obtained a novel anti-human PD-1 antibody named FV78.FV78 competitively recognized the PD-1 epitopes that interacted with MIL75 and possessed an affinity comparable to MIL75.Our results implied that FV78 possessed equivalent bioactivity in vitro and in vivo compared with MIL75,which highlighted the probability and prospect of FV78 becoming a new potential antibody therapy. | Longlong Luo Shi Wang Xiaoling Lang Tingting Zhou Jing Geng Xinying Li Chunxia Qiao Jiannan Feng Beifen Shen Ming Lv Yan Li | 2018 | Cellular & Molecular Immunology2018，15，2： | 4 |
| 20 | Characterization of particle size distribution of mainstream cigarette smoke generated by smoking machine with an electrical low pressure impactor显示文摘Cigarette smoking is a particle-related exposure. Studying the characteristics of the particle size distribution of cigarette smoke can aid in providing knowledge of smoke aerosol attributes. We used an electrical low pressure impactor(ELPI) to measure the particle size distribution of mainstream cigarette smoke generated by a smoking machine and provided a continuum of particle sizes of cigarette smoke from a whole cigarette. The results showed that the aerodynamic diameters(D, geometric mean of a channel) of particles ranged from 0.021 to 1.956 μm, and the number concentrations were on the order of 105–109cm-3for different sizes of particles. The particle number of the size category below 0.1 μm approximated that of the category 0.1–2.0 μm, and the particles in the size category of 0.1–2.0 μm contributed extremely heavily to total particulate mass. In addition, the results with small samples indicated that the tar yields normalized per milligram of nicotine showed an approximately linear increase with increasing concentration of total particles. | Xiang Li Haohui Kong Xinying Zhang Bin Peng Cong Nie Guanglin Shen Huimin Liu | 2014 | Journal of Environmental Sciences2014，26，4： | 4 |
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