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| 1 | Rational optimization of reprogramming culture conditions for the generation of induced pluripotent stem cells with ultra-high efficiency and fast kinetics显示文摘几个抄写因素的宫外的表示能恢复胚胎的房间命运到有教养的体的房间并且产生导致的 pluripotent 干细胞(iPSCs ) ,揭示到 pluripotency 的一条以前未知的小径。然而,这种技术被低效率,慢动力学和多因素的要求当前限制。这里,我们证明 reprogramming 能被优化文化条件改进并且戏剧性地加速了。首先,我们开发了优化定义媒介, iCD1,它允许 Oct4/Sox2/Klf4 (OSK ) 完成的调停的 reprogramming 超离频效率(~10% 在白天 8 点) 。我们也发现这个优化条件使 Sox2 和 Klf4 变为非必需,尽管这二个因素的消除导致更低的效率和更慢的动力学。我们的研究定义一条弄短的线路,两个在预定和因素要求,向 pluripotency。这个新范例不仅提供一个基本原理进一步改进 iPSC 产生而且由定义因素简化 reprogramming 的概念的理解。 | Jiekai Chen Jing Liu You Chen Jiaqi Yang Jing Chen He Liu Xiangjie Zhao Kunlun Mo Hong Song Lin Guo Shilong Chu Deping Wang Ke Ding Duanqing Pei | 2011 | Cell Research2011，21，6： | 9 |
| 2 | Effect of gas emissions from Tianchi volcano (NE China) on environment and its potential volcanic hazards显示文摘The Tianchi volcano in the Changbai Mountains is located on the boundary between China and North Korea. There are many times of eruptions of the Tianchi volcano during the Holocene. One of its large eruptions occurred around 1000 years ago dated by 14C method and historical records. Composition of products of the largest Tianchi volcanic eruption studied is characterized by comendi- tic Plinian fallout and unwelded ignimbrite, which are mainly distributed in China and North Korea. Caldera is about 4.4 km long and 3.4 km wide, which had filled with water (e.g. Tianchi Lake). The Tianchi volcanic cone is about 2700 m high above sea level. The Tianchi Lake is located on the summit of the volcanic cone, that is also highest peak of the Changbai Mountains in northeastern China. This study analyzed Cl, F, S and H2O concentrations of melt inclusions in the phenocryst min- erals (anorthoclase and quartz) and co-existing matrix glasses using the electron microprobe and estimated environmental effect of Tianchi volcanic gases. The authors proposed a new method to evaluate future eruption of active volcano and estimate potential volcanic hazards based on contents of volatile emissions. Using this method, we made a perspective of future volcanic hazard in this re- gion. | GUO Zhengfu LIU Jiaqi HAN Jingtai HE Huaiyu DAI Guoliang YOU Haitao | 2006 | Science China Earth Sciences2006，49，3： | 9 |
| 3 | Mesoporous Graphene Hosts for Dendrite-Free Lithium Metal Anode in Working Rechargeable Batteries显示文摘Lithium(Li) metal anode has received extensive attentions due to its ultrahigh theoretical capacity and the most negative electrode potential. However, dendrite growth severely impedes the practical applications of the Li metal anode in rechargeable batteries. In this contribution, a mesoporous graphene with a high specific surface area was synthesized to host the Li metal anode. The mesoporous graphene host(MGH) has a high specific surface area(2090 m^2/g), which affords free space and an interconnected conductive pathway for Li plating and stripping, thus alleviating the volume variation and reducing the generation of dead Li during repeated cycles. More importantly, the high specific surface area of MGH efficiently reduces the local current density of the electrode, which favors a uniform Li nucleation and plating behavior, rendering a dendritefree deposition morphology at a low overpotential. These factors synergistically boost the Li utilization(90.1% vs. 70.1% for Cu foil) and life span(150 cycles vs. 100 cycles for Cu foil) with a low polarization of MGH electrode at an ultrahigh current of 15.0 mA/cm^2. The as-prepared MGH can provide fresh insights into the electrode design of the Li metal anode operating at high rates. | He Liu Xinbing Cheng Rui Zhang Peng Shi Xin Shen Xiaoru Chen Tao Li Jiaqi Huang Qiang Zhang | 2020 | Transactions of Tianjin University2020，26，2： | 9 |
| 4 | Thermal protection mechanism of heat pipe in leading edge under hypersonic conditions显示文摘Sharp local structure, like the leading edge of hypersonic aircraft, confronts a severe aerodynamic heating environment at a Mach number greater than 5. To eliminate the danger of a material failure, a semi-active thermal protection system is proposed by integrating a metallic heat pipe into the structure of the leading edge. An analytical heat-balance model is established from traditional aerodynamic theories, and then thermal and mechanical characteristics of the structure are studied at Mach number 6–8 for three refractory alloys, Inconel 625, C-103, and T-111. The feasibility of this simple analytical method as an initial design tool for hypersonic aircraft is assessed through numerical simulations using a finite element method. The results indicate that both the isothermal and the maximum temperatures fall but the von Mises stress increases with a longer design length of the leading edge. These two temperatures and the stress rise remarkably at a higher Mach number. Under all investigated hypersonic conditions, with a 3 mm leading edge radius and a0.15 m design length, the maximum stress exceeds the yield strength of Inconel 625 at Mach numbers greater than 6, which means a material failure. Moreover, both C-103 and T-111 meet all requirements at Mach number 6–8. | Peng Wengen He Yurong Wang Xinzhi Zhu Jiaqi Han Jiecai | 2015 | Chinese Journal of Aeronautics2015，28，1： | 7 |
| 5 | OsMKKK70 regulates grain size and leaf angle in rice through the OsMKK4-OsMAPK6-OsWRKY53 signaling pathway显示文摘Grain size and leaf angle are key agronomic traits that determine final yields in rice.However,the underlying molecular mechanisms are not well understood.Here we demonstrate that the Oryza sativa Mitogen Activated Protein Kinase Kinase Kinase OsMKKK70 regulates grain size and leaf angle in rice.Overexpressing OsMKKK70 caused plants to produce longer seeds.The osmkkk62/70 double mutant and the osmkkk55/62/70 triple mutant displayed significantly smaller seeds and a more erect leaf angle compared to the wild type,indicating that OsMKKK70 functions redundantly with its homologs Os MKKK62 and Os MKKK55.Biochemical analysis demonstrated that OsMKKK70 is an active kinase and that OsMKKK70 interacts with Os MKK4 and promotes Os MAPK6 phosphorylation.In addition,the osmkkk62/70 double mutant showed reduced sensitivity to Brassinosteroids(BRs).Finally,overexpressing constitutively active Os MKK4,Os MAPK6,and Os WRKY53 can partially complement the smaller seed size,erect leaf,and BR hyposensitivity of the osmkkk62/70 double mutant.Taken together,these findings suggest that OsMKKK70 might regulate grain size and leaf angle in rice by activating Os MAPK6 and that OsMKKK70,Os MKK4,Os MAPK6,and Os WRKY53 function in a common signaling pathway that controls grain shape and leaf angle. | Zhiqi Liu Enyang Mei Xiaojie Tian Mingliang He Jiaqi Tang Min Xu Jiali Liu Lu Song Xiufeng Li Zhenyu Wang Qingjie Guan Qijiang Xu Qingyun Bu | 2021 | Journal of Integrative Plant Biology2021，63，12： | 6 |
| 6 | Decentration and tilt of plate-haptic multifocal intraocular lenses in myopic eyes显示文摘Background:To investigate the decentration and tilt of plate-haptic multifocal intraocular lenses(MfIOLs)in myopic eyes.Methods:Myopic(axial length[AXL]>24.5 mm)and non-myopic(21.0 mm | Jiaqi Meng Wenwen He Xianfang Rong Ao Miao Yi Lu Xiangjia Zhu | 2020 | Eye and Vision2020，7，1： | 5 |
| 7 | An all-round AI-Chemist with a scientific mind显示文摘The realization of automated chemical experiments by robots unveiled the prelude to an artificial intelligence(AI)laboratory.Several AI-based systems or robots with specific chemical skills have been demonstrated,but conducting all-round scientific research remains challenging.Here,we present an all-round AI-Chemist equipped with scientific data intelligence that is capable of performing basic tasks generally required in chemical research.Based on a service platform,the AI-Chemist is able to automatically read the literatures from a cloud database and propose experimental plans accordingly.It can control a mobile robot in-house or online to automatically execute the complete experimental process on 14 workstations,including synthesis,characterization and performance tests.The experimental data can be simultaneously analysed by the computational brain of the AI-Chemist through machine learning and Bayesian optimization,allowing a new hypothesis for the next iteration to be proposed.The competence of the AI-Chemist has been scrutinized by three different chemical tasks.In the future,the more advanced all-round AI-Chemists equipped with scientific data intelligence may cause changes to the landscape of the chemical laboratory. | Qing Zhu Fei Zhang Yan Huang Hengyu Xiao LuYuan Zhao XuChun Zhang Tao Song XinSheng Tang Xiang Li Guo He BaoChen Chong JunYi Zhou YiHan Zhang Baicheng Zhang JiaQi Cao Man Luo Song Wang GuiLin Ye WanJun Zhang Xin Chen Shuang Cong Donglai Zhou Huirong Li Jialei Li Gang Zou WeiWei Shang Jun Jiang Yi Luo | 2022 | National Science Review2022，9，10： | 5 |
| 8 | A Bayesian Updating Method for Non-Probabilistic Reliability Assessment of Structures with Performance Test Data显示文摘For structures that only the predicted bounds of uncertainties are available,this study proposes a Bayesianmethod to logically evaluate the nonprobabilistic reliability of structures based on multi-ellipsoid convex model and performance test data.According to the given interval ranges of uncertainties,we determine the initial characteristic parameters of a multi-ellipsoid convex set.Moreover,to update the plausibility of characteristic parameters,a Bayesian network for the information fusion of prior uncertainty knowledge and subsequent performance test data is constructed.Then,an updated multi-ellipsoid set with the maximum likelihood of the performance test data can be achieved.The credible non-probabilistic reliability index is calculated based on the Kriging-based surrogate model of the performance function.Several numerical examples are presented to validate the proposed Bayesian updating method. | Jiaqi He Yangjun Luo | 2020 | Computer Modeling in Engineering & Sciences2020，，11： | 5 |
| 9 | Attribution analysis based on Budyko hypothesis for land evapotranspiration change in the Loess Plateau, China显示文摘Land evapotranspiration(ET) is an important process connecting soil, vegetation and the atmosphere, especially in regions that experience shortage in precipitation.Since 1999, the implementation of a large-scale vegetation restoration project has significantly improved the ecological environment of the Loess Plateau in China.However, the quantitative assessment of the contribution of vegetation restoration projects to long-term ET is still in its infancy.In this study, we investigated changes in land ET and associated driving factors from 1982 to 2014 in the Loess Plateau using Budyko-based partial differential methods.Overall, annual ET slightly increased by 0.28 mm/a and there were no large fluctuations after project implementation.An attribution analysis showed that precipitation was the driving factor of inter-annual variability of land ET throughout the study period;the average impacts of precipitation, potential evapotranspiration, and vegetation restoration on ET change were 61.5%, 11.5% and 26.9%, respectively.These results provide an improved understanding of the relationship between vegetation condition change and climate variation on terrestrial ET in the study area and can support future decision-making regarding water resource availability. | HE Guohua ZHAO Yong WANG Jianhua GAO Xuerui HE Fan LI Haihong ZHAI Jiaqi WANG Qingming ZHU Yongnan | 2019 | Journal of Arid Land2019，11，6： | 5 |
| 10 | Stable interfaces constructed by concentrated ether electrolytes to render robust lithium metal batteries显示文摘Lithium metal batteries(LMBs)are highly considered as promising candidates for next-generation energy storage systems.However,routine electrolytes cannot tolerate the high potential at cathodes and low potential at anodes simultaneously,leading to severe interfacial reactions.Herein,a highly concentrated electrolyte(HCE)region trapped in porous carbon coating layer is adopted to form a stable and highly conductive solid electrolyte interphase(SEI)on Li metal surface.The protected Li metal anode can potentially match the high-voltage cathode in ester electrolytes.Synergistically,this ingenious design promises high-voltage-resistant interfaces at cathodes and stable SEI with abundance of inorganic components at anodes simultaneously in high-voltage LMBs.The feasibility of this interface-regulation strategy is demonstrated in Li|LiFePO_(4) batteries,realizing a lifespan twice as long as the routine cells,with a huge capacity retention enhancement from 46.4%to 88.7%after 100 cycles.This contribution proof-ofconcepts the emerging principles on the formation and regulation of stable electrode/electrolyte interfaces in the cathode and anode simultaneously towards the next-generation high-energy-density batteries. | He Liu Tao Li Xiangqun Xu Peng Shi Xueqiang Zhang Rui Xu Xinbing Cheng Jiaqi Huang | 2021 | Chinese Journal of Chemical Engineering2021，34，9： | 5 |
| 11 | Mushroom Poisoning Outbreaks -China, 2022显示文摘Mushroom poisoning has become a serious food safety issue in China.With the support of the government,over the past decade,China has gradually established a mushroom poisoning prevention and treatment system involving experts in disease prevention and control,clinical diagnosis and treatment,fungal classification,and basic medicine(1–3). | Haijiao Li Yizhe Zhang Hongshun Zhang Jing Zhou Jiaqi Liang Yu Yin Qian He Shaofeng Jiang Yutao Zhang Yuan Yuan Nan Lang Bowen Cheng Mei Wang Chengye Sun | 2023 | China CDC weekly2023，5，3： | 4 |
| 12 | Nature and evolution of the lithospheric mantle revealed by water contents and He-Ar isotopes of peridotite xenoliths from Changbaishan and Longgang basalts in Northeast China显示文摘The nature and evolution of the lithospheric mantle underlying Northeast(NE)China were investigated by assessing the mineral chemistry,water contents,and noble gas(He-Ar)isotopes of peridotite xenoliths captured by Cenozoic basalts from the Changbaishan and Longgang regions.The xenoliths,which have863–1141℃ equilibration temperatures,primarily comprise spinel lherzolites and rare spinel harzburgites.The Mg#(Fo)values of olivine in the peridotite xenoliths vary from 86.9 to 91.3.The clinopyroxenes have high Ti/Eu and low(La/Yb)N,and their chondrite-normalized rare earth elements(REEs)exhibit light REE-depletion to-enrichment patterns,indicating that the mantle underneath the investigated region was predominantly subjected to partial melting(1%–10%)and was metasomatized by silicate melts.The measured3He/4He ratios of the Changbaishan xenoliths have a narrow range from 5.8 Ra to 8.4 Ra with an average of 7.4 Ra.The3He/4He isotopic ratios of the Longgang xenoliths varied from 4.7 Ra to8.1 Ra with an average of 5.9 Ra;slightly lower than the Changbaishan xenoliths.The whole-rock H2Ocontents of the studied peridotite ranged from 9 to 132 ppm.The high H2O contents in excess of50 ppm(up to 132 ppm)might represent newly accreted and cooled asthenospheric materials,while those with H2O contents lower than 50 ppm(as little as 9 ppm)may represent thinned,relic,ancient lithospheric mantle.These geochemical evidences,in combination with published data,indicated that the lithospheric mantle beneath the Changbaishan and Longgang in NE China is dominated by the younger and more fertile lithospheric mantle with a minor ancient and refractory keel.In addition,the lithospheric mantle of this area was metasomatized by melts related to the recent subduction event(e.g.,Pacific oceanic plate).Therefore,the westward-dipping Pacific oceanic plate subduction had an important contribution to the transformation of the lithospheric mantle beneath NE China. | Qinghu Xu Jiaqi Liu Huaiyu He Yunhui Zhang | 2019 | Science Bulletin2019，64，18： | 4 |
| 13 | Oryza sativa mediator subunit OsMED25 interacts with OsBZR1 to regulate brassinosteroid signaling and plant architecture in rice显示文摘Brassinosteroids(BRs)are plant-specific steroid hormones which regulate plant growth,development,and adaptation.Transcriptional regulation plays key roles in plant hormone signaling.A mediator can serve as a bridge between gene-specific transcription factors and the RNA polymerase machinery,functioning as an essential component in regulating the transcriptional process.However,whether a mediator is involved in BR signaling is unknown.Here,we discovered that Oryza sativa mediator subunit 25(Os MED25)is an important regulator of rice BR signaling.Phenotypic analyses showed that the Os MED25-RNAi and osmed25 mutant presented erect leaves,as observed in BR-deficient mutants.In addition,the Os MED25-RNAi and osmed25 mutant exhibited decreased BR sensitivity.Genetic analysis indicated that Os MED25-RNAi could suppress the enhanced BR signaling phenotype of Osbzr1-D.Further biochemical analysis showed that Os MED25 interacts with Os BZR1 in vivo,and Os MED25 is enriched on the promoter of Os BZR1 target genes.RNA sequencing analysis indicated that Os MED25 affects the expression of approximately 45%of Os BZR1-regulated genes and mainly functions as a corepressor of Os BZR1.Together,these findings revealed that Os MED25 regulates rice BR signaling by interacting with Os BZR1 and modulating the expression of Os BZR1 target genes,thus expanding our understanding of the roles of mediators in plant hormone signaling. | Yuekun Ren Xiaojie Tian Shuyu Li Enyang Mei Mingliang He Jiaqi Tang Min Xu Xiufeng Li Zhenyu Wang Chuanyou Li Qingyun Bu | 2020 | Journal of Integrative Plant Biology2020，62，6： | 3 |
| 14 | Source emissions and climate change impacts on the multimedia transport and fate of persistent organic pollutants,Chaohu watershed,eastern China显示文摘Emission intensity and climate change control the transport flux and fate of persistent organic pollutants(POPs)inmultiple environmental compartments.This study applied amultimedia model(BETR model)to explore alternations in the spatio-temporal trends of concentrations and transport flux of benzopyrene(BaP),phenanthrene(Phe),perfluorooctane sulfonates(PFOS)and polychlorinated biphenyls(PCBs)in the Chaohu watershed,located in the lower reaches of the Yangtze River,China in response to changes in source emissions and climate.The potential historic and future risks of these pollutants also were assessed.The results suggest that current trends in concentrations and transport were similar to that of their emissions between 2005 and 2018.During the next 100 years,temporal trends and spatial patterns were not predicted to change significantly,which is consistent with climate change.Based on sensitivity and correlation analyses,climate change had significant effects on multi-media concentrations and transport fluxes of BaP,Phe,PFOS and PCBs,and rainfall intensity was the predominant controlling factor.Risk quotients(RQs)of BaP and Phe-in soil increased from 0.42 to 0.95 and 0.06 to 0.35,respectively,from 2005 to 2090,indicating potential risks.The RQs of the other examined contaminants exhibited little potential risk in soil,water,or sediment.Based on spatial patterns,it was inferred that the ecosystem around Lake Chaohu is the most at risk.The study provides insights needed for local pollution control of POPs in the Chaohu watershed.In addition,the developed approach can be applied to other watersheds world-wide. | Xianghui Cao Shouliang Huo Hanxiao Zhang Jiaqi Zheng Zhuoshi He Chunzi Ma Shuai Song | 2021 | Journal of Environmental Sciences2021，33，11： | 3 |
| 15 | Urea transport and hydrolysis in the rumen: A review显示文摘Inefficient dietary nitrogen(N)conversion to microbial proteins,and the subsequent use by ruminants,is a major research focus across different fields.Excess bacterial ammonia(NH3)produced due to degradation or hydrolyses of N containing compounds,such as urea,leads to an inefficiency in a host’s ability to utilize nitrogen.Urea is a non-protein N containing compound used by ruminants as an ammonia source,obtained from feed and endogenous sources.It is hydrolyzed by ureases from rumen bacteria to produce NH_(3) which is used for microbial protein synthesis.However,lack of information exists regarding urea hydrolysis in ruminal bacteria,and how urea gets to hydrolysis sites.Therefore,this review describes research on sites of urea hydrolysis,urea transport routes towards these sites,the role and structure of urea transporters in rumen epithelium and bacteria,the composition of ruminal ureolytic bacteria,mechanisms behind urea hydrolysis by bacterial ureases,and factors influencing urea hydrolysis.This review explores the current knowledge on the structure and physiological role of urea transport and ureolytic bacteria,for the regulation of urea hydrolysis and recycling in ruminants.Lastly,underlying mechanisms of urea transportation in rumen bacteria and their physiological importance are currently unknown,and therefore future research should be directed to this subject. | Samson Hailemariam Shengguo Zhao Yue He Jiaqi Wang | 2021 | Animal Nutrition2021，，4： | 3 |
| 16 | SP1 governs primordial folliculogenesis by regulating pregranulosa cell development in mice显示文摘Establishment of the primordial follicle(PF)pool is pivotal for the female reproductive lifespan;however,the mechanism of primordial folliculogenesis is poorly understood.Here,the transcription factor SP1 was shown to be essential for PF formation in mice.Our results showed that SP1 is present in both oocytes and somatic cells during PF formation in the ovary.Knockdown of Sp1 expression,especially in pregranulosa cells,significantly suppressed nest breakdown,oocyte apoptosis,and PF formation,suggesting that SP1 expressed by somatic cells functions in the process of primordial folliculogenesis.We further demonstrated that SP1 governs the recruitment and maintenance of Forkhead box L2-positive(FOXL2^+)pregranulosa cells using an Lgr5-EGFP-IRES-CreER^T2(Lgr5-KI)reporter mouse model and a FOXL2^+ cell-specific knockdown model.At the molecular level,SP1 functioned mainly through manipulation of NOTCH2 expression by binding directly to the promoter of the Notch2 gene.Finally,consistent with the critical role of granulosa cells in follicle survival in vitro,massive loss of oocytes in SP1 knockdown ovaries was evidenced before puberty after the ovaries were tranSP1anted under the renal capsules.Conclusively,our results reveal that SP1 controls the establishment of the ovarian reserve by regulating pregranulosa cell development in the mammalian ovary. | Han Cai Bingying Liu Huarong Wang Guanghong Sun Lizhao Feng Ziqi Chen Jiaqi Zhou Jiawei Zhang Tuo Zhang Meina He Tingting Yang Qirui Guo Zhen Teng Qiliang Xin Bo Zhou Hua Zhang Guoliang Xia Chao Wang | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 17 | Ultrabroadband and multiband infrared/terahertz photodetectors with high sensitivity显示文摘Broadband response is pursued in both infrared(IR)and terahertz(THz)detection technologies,which find their applications in both terrestrial and astronomical realms.Herein,we report an ultrabroadband and multiband IR/THz detector based on blocked-impurity-band detecting principle.The detectors are prepared by implanting phosphorus into germanium(Ge:P),where photoresponses with a P impurity band,a self-interstitial defect band,and a vacancy-P(V-P)pair defect band are realized simultaneously.The response spectra of the detectors show ultrabroad and dual response bands in a range of 3-28μm(IR band)and 40-165μm(THz band),respectively.Additionally,a tiny mid-IR(MIR)band within 3-4.2μm is embedded in the IR band.The THz band arises from the P impurity band,whereas the IR and the MIR bands are ascribed to the two defect bands.At150 m V and 4.5 K,the peak detectivities of the three bands are obtained as 2.9×10^(12) Jones(at 3.9μm),6.8×10^(12) Jones(at 16.3μm),and 9.9×10^(12) Jones(at 116.5μm),respectively.The impressive coverage andsensitivity of the detectors are promising for applications in IR and THz detection technologies. | JIAQI ZHU HE ZHU MENGJUAN LIU YAO WANG HANLUN XU NASIR ALI HUIYONG DENG ZHIYONG TAN JUNCHENG CAO NING DAI HUIZHEN WU | 2021 | Photonics Research2021，9，11： | 2 |
| 18 | Pigeon-inspired optimization and extreme learning machine via wavelet packet analysis for predicting bulk commodity futures prices显示文摘In this paper, a hybrid approach consisting of pigeon-inspired optimization(PIO) and extreme learning machine(ELM) based on wavelet packet analysis(WPA) is presented for predicting bulk commodity futures prices. Firstly, WPA is applied to decompose the original futures prices into a set of lower-frequency subseries. Secondly, the PIO algorithm is used to optimize the parameters of ELM and then the optimized ELM is utilized to forecast the subseries. Finally, we adopt the hybrid method to calculate the final forecasting outcomes of futures prices. In order to further test the predictive ability of the hybrid forecasting model on bulk commodity futures prices, we use the prices of West Texas Intermediate crude oil futures and Chicago Board of Trade soybean futures to make one-step, two-step and four-step ahead predictions. In comparison with complete ensemble empirical mode decomposition with adaptive noise, empirical mode decomposition and singular spectrum analysis, WPA is the most suitable for decomposing bulk commodity futures prices.The experimental outcomes show that the hybrid WPA-PIO-ELM model has better performance on horizontal precision, directional precision and robustness. | Feng JIANG Jiaqi HE Zhigang ZENG | 2019 | Science China(Information Sciences)2019，62，7： | 2 |
| 19 | Near-infrared light-controllable bufalin delivery from a black phosphorus-hybrid supramolecular hydrogel for synergistic photothermal-chemo tumor therapy显示文摘Bufalin is efficacious in treating various tumors, however, the clinical application of which is restricted by the myocardial toxicity. Developing a smart synergetic delivery system is widely considered as a promising therapeutic strategy. To address this issue, a black phosphorus hybrid polypeptides hydrogel was designed to highly load bufalin, and achieved near-infrared (NIR)-controllable drug release with synergistic photothermal-chemo therapeutic effect. Black phosphorus nanosheets (BPNSs) and bufalin were co-loaded in temperature-sensitive supramolecular hydrogel to receive smart hybridization (BP-bufalin@SH). With NIR irradiation (1 W·cm−2), BP-bufalin@SH exhibited a rapid and large temperature increase and released bufalin via light-controllable manner, with which the side effects of bufalin were greatly decreased. Combined with photothermal-chemo therapeutic effect, BP-bufalin@SH could collapse the mitochondrial transmembrane potential resulting in the irreversible apoptosis of tumor cells, and realize a highly efficient in vivo tumor elimination with good biosafety and biocompatibility. This work provides a new hydrogel platform for controlling bufalin release, and thus further promotes the practical application on antitumor therapy. | Jiaqi He Guoqin Chen Peng Zhao Caiwen Ou | 2021 | Nano Research2021，14，11： | 2 |
| 20 | Performance of silicone rubber composites using boron nitride to replace alumina tri‐hydrate显示文摘Boron nitride(BN)has attracted increasing attention as a filler using in insulating ma-terials.In this work,by using an equal amount of BN to replace alumina tri‐hydrate(ATH),various SR/BN/ATH composites were prepared,and for comparison,vinyl tri‐methoxysilane(VTMS)was added to prepare SR/BN/ATH‐VTMS composites.With the increasing BN content,Shore A hardness,breakdown strength and thermal conductivity of the silicone rubber(SR)composites increased despite the tensile strength slightly reduced.By replacing all the ATH with BN,the SR composite showed a∼47%increase in breakdown strength,reaching 33.8 kV mm1.The lower dielectric constant and dielectric loss were found for the SR composites with higher BN content,while the decreased dielectric loss and increased dielectric constant were achieved by the intro-duction of VTMS.Owing to the improved filler‐rubber interfacial interactions by adding VTMS,with the same BN content,all the SR/BN/ATH‐VTMS composites exhibited better property than the SR/BN/ATH composites.The best thermal conductivity of the SR composite reached 0.448 Wm1 K1,∼156%higher than that of the ATH filled SR composite. | Xin Chen Jiaqi Wang Chong Zhang Wei Yang Jun Lin Xingming Bian Shaojian He | 2021 | High Voltage2021，6，3： | 2 |
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