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| 1 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 2 | Winter wheat mapping using a random forest classifier combined with multi-temporal and multi-sensor data显示文摘Wheat is a major staple food crop in China.Accurate and cost-effective wheat mapping is exceedingly critical for food production management,food security warnings,and food trade policy-making in China.To reduce confusion between wheat and non-wheat crops for accurate growth stage wheat mapping,we present a novel approach that combines a random forest(RF)classifier with multi-sensor and multi-temporal image data.This study aims to(1)determine whether an RF combined with multi-sensor and multi-temporal imagery can achieve accurate winter wheat mapping,(2)to find out whether the proposed approach can provide improved performance over the traditional classifiers,and(3)examine the feasibility of deriving reliable estimates of winter wheat-growing areas from medium-resolution remotely sensed data.Winter wheat mapping experiments were conducted in Boxing County.The experimental results suggest that the proposed method can achieve good performance,with an overall accuracy of 92.9%and a kappa coefficient(κ)of 0.858.The winter wheat acreage was estimated at 33,895.71 ha with a relative error of only 9.3%.The effectiveness and feasibility of the proposed approach has been evaluated through comparison with other image classification methods.We conclude that the proposed approach can provide accurate delineation of winter wheat areas. | Jiantao Liu Quanlong Feng Jianhua Gong Jieping Zhou Jianming Liang Yi Li | 2018 | International Journal of Digital Earth2018，11，8： | 3 |
| 3 | Comparison of the graphic and moment methods for analyzing grainsize distributions:A case study for the Chinese inner continental shelf seas显示文摘Sediment grain-size distributions provide key information on sediment sources,transport,and deposition.The Folk and Ward graphic method and the Friedman moment method are generally used for rapid analysis of the qualitative and quantitative properties of sediment samples;whether the two methods yield the same results for any given sediment sample is not yet known.Little research attention has been paid to comparison of the descriptive terms used in both methods,although some work has been done on comparison of the numerical values.In the current study,sediment samples from six areas of the Chinese inner continental seas were investigated.The mean and sorting values obtained using the two methods are well correlated(0.821≤R^(2)≤0.998),but the skewness and kurtosis vary among study areas(0.035≤R^(2)≤0.816),which is consistent with previous studies where R^(2) is the coefficient of determination.The two methods yield significant differences for skewness(84.78%-98.04%of samples)and kurtosis(40.59%-67.29%of samples).The main reasons for these differences are variations in the grainsize distribution curves of the sediment samples and differences in the weighting applied to specified cumulative percentile values by the two methods.These results demonstrate that the differences between the two methods should be taken into account when analyzing sedimentary environments and studying historical data. | Gaocong Li Rihong Du Jieping Tang Zhiqiang Li Qiong Xia Benwei Shi Liang Zhou Yang Yang Wenxiang Zhang | 2022 | International Journal of Sediment Research2022，37，6： | 1 |
| 4 | Multiplex and optimization of dCas9-TV-mediated gene activation in plants显示文摘Synthetic gene activators consisting of nucleasedead Cas9(dCas9)for single-guide RNA(sgRNA)-directed promoter binding and a transcriptional activation domain(TAD)represent new tools for gene activation from endogenous genomic locus in basic and applied plant research.However,multiplex gene coactivation by d Cas9-TADs has not been demonstrated in whole plants.There is also room to optimize the performance of these tools.Here,we report that our previously developed gene activator,dCas9-TV,could simultaneously upregulate OsGW7 and OsER1 in rice by up to 3,738 fold,with one sg RNA targeting to each promoter.The gene coactivation could persist to at least the fourth generation.Astonishingly,thepolycistronictRNA-sgRNAexpression under the maize ubiquitin promoter,a Pol II promoter,could cause enormous activation of these genes by up to>40,000-fold in rice.Moreover,the yeast GCN4 coiled coil-mediated dCas9-TV dimerization appeared to be promising for enhancing gene activation.Finally,we successfully introduced a self-amplification loop for dCas9-TV expression in Arabidopsis to promote the transcriptional upregulation of AtFLS2,a previously characterized dCas9-TV-refractory gene with considerable basal expression.Collectively,this work illustrates the robustness of dCas9-TV in multigene coactivation and provides broadly useful strategies for boosting transcriptional activation efficacy of dCas9-TADs in plants. | Xiangyu Xiong Jieping Liang Zhenxiang Li Ben-Qiang Gong Jian-Feng Li | 2021 | Journal of Integrative Plant Biology2021，63，4： | 1 |
| 5 | Canonical correlation analysis for multi-label classification: a least-squares formula- tion, extensions, and analysis显示文摘 | Sun Liang Ji Shuiwang Ye Jieping | 2011 | IEEE Transactions on Pattern Analysis and Machine Intelligence2011，33，1： | 1 |
| 6 | The Application Status of Horticultural Therapy in the Study of College Students’Physical and Mental Health显示文摘Horticultural therapy,as a new medical method,has a good effect on human physical,mental health and society.This study focused on the significance of horticultural therapy in college students,the research of experimental content and the problems encountered in the specific implementation,fully understood the application status of horticultural therapy on college students’physical and mental health,and proposed that agricultural colleges and universities could take advantage of their own advantages to actively carry out relevant research,in order to provide technical support for the comprehensive development of horticultural therapy in college students. | WEI Meng LIU Yi LIANG Fahui HUANG Jieping XIA Rui | 2020 | Journal of Landscape Research2020，12，3： | 0 |
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