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| 1 | Resistance of Helicobacter pylori to antibiotics from 2000 to 2009 in Shanghai显示文摘AIM: To investigate the resistance of Helicobacter pylori (H. pylori ) to 6 commonly used antibiotics from 2000 to 2009 in Shanghai. METHODS: A total of 293 H. pylori strains were collected from 2000 to 2009 in Shanghai and tested for their susceptibility to metronidazole, clarithromycin, amoxicillin, furazolidone, levofloxacin and tetracycline using agar dilution. RESULTS: The resistant rates of H. pylori to clarithromycin (8.6%, 9.0% and 20.7%) and levofloxacin (10.3%, 24.0% and 32.5%) increased from 2000 to 2009 in Shanghai. The resistant rate of H. pylori to metronidazole remained stable (40%-50%). Only one strain of H. pylori isolated in 2005 was resistant to tetracycline. All strains were sensitive to amoxicillin and furazolidone.The resistant rate of H. pylori to antibiotics was not related with the sex, age and clinical outcome of patients. CONCLUSION: Resistance of H. pylori to antibiotics plays an important role in making treatment strategies against H. pylori -associated diseases. | Qin-Juan Sun Xiao Liang Qing Zheng Wei-Qi Gu WenZhong Liu Shu-Dong Xiao Hong Lu | 2010 | World Journal of Gastroenterology2010，16，40： | 90 |
| 2 | Ridge subduction and porphyry copper-gold mineralization:An overview显示文摘Many large porphyry Cu-Au deposits are connected to adakitic rocks known to be closely associated with ridge subduction. For example, there are several subducting ridges along the east Pacific margin, e.g., in Chile, Peru, and South America, most of which are associated with large porphyry Cu-Au deposits. In contrast, there are much fewer ridge subductions on the west Pacific margin and porphyry Cu-Au deposits are much less there, both in terms of tonnage and the number of deposits. Given that Cu and Au are moderately incompatible elements, oceanic crust has much higher Cu-Au concentrations than the mantle and the continental crust, and thus slab melts with their diagnostic adakitic chemistry have systematically higher Cu and Au, which is favorable for mineralization. Considering the geotherm of subducting slabs in the Phanerozoic, ridge subduction is the most favorable tectonic setting for this. Therefore, slab melting is the likely link in the spatial association between ridge subduction and Cu-Au deposits. Geochemical signatures of slab melting and hence maybe ridge subduction in less eroded regions in eastern China, the central Asian orogenic belt etc. may indicate important exploration targets for large porphyry Cu-Au deposits. | SUN WeiDong LING MingXing YANG XiaoYong FAN WeiMing DING Xing LIANG HuaYing | 2010 | Science China Earth Sciences2010，53，4： | 97 |
| 3 | CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes显示文摘染色体编辑工具例如定期聚类短 palindromic 重复(CRISPR ) 联系了的 interspaced 系统(Cas ) 广泛地被用来包括动物接合子和人的房间在模型系统修改基因,并且为基本研究和临床的应用保持巨大的诺言。迄今为止,严肃的知识差距在人的早胚胎,并且在效率和在人的培植前胚胎使用象 CRISPR/Cas9 那样的技术的潜在的离开目标效果留在我们 DNA 修理机制的理解。在这份报告,我们使用了推进的接合子调查 CRISPR/Cas9-mediated 基因在人的房间编辑的 tripronuclear (3PN ) 。我们发现 CRISPR/Cas9 能有效地劈开内长的 -globin 基因(HBB ) 。然而,相应再结合的效率指导了 HBB 的修理(HDR ) 是低的,编辑胚胎是马赛克。离开目标劈开在由 T7E1 试金并且 whole-exome 定序揭示了的这些 3PN 接合子也是明显的。而且,内长的 delta-globin 基因(HBD ) 对 HBB 相应,与外长的施主 oligos 竞争了充当修理模板,导致倔强的变化。我们的数据也显示在这些胚胎的 HBB 地点的修理通过非转线路 HDR 小径优先地发生了。一起拿,我们的工作加亮紧迫的需要进一步改进 CRISPR/Cas9 平台的忠实和特性,为编辑的 CRSIPR/Cas9-mediated 的任何临床的应用程序的一个前提。 | Puping Liang Yanwen Xu Xiya Zhang Chenhui Ding Rui Huang Zhen Zhang Jie Lv Xiaowei Xie Yuxi Chen Yujing Li Ying Sun Yaofu Bai Zhou Songyang Wenbin Ma Canquan Zhou Junjiu Huang | 2015 | Protein & Cell2015，6，5： | 149 |
| 4 | A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)显示文摘In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named '2019 novel coronavirus(2019-nCoV)' by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV. | Ying-Hui Jin Lin Cai Zhen-Shun Cheng Hong Cheng Tong Deng Yi-Pin Fan Cheng Fang Di Huang Lu-Qi Huang Qiao Huang Yong Han Bo Hu Fen Hu Bing-Hui Li Yi-Rong Li Ke Liang Li-Kai Lin Li-Sha Luo Jing Ma Lin-Lu Ma Zhi-Yong Peng Yun-Bao Pan Zhen-Yu Pan Xue-Qun Ren Hui-Min Sun Ying Wang Yun-Yun Wang Hong Weng Chao-Jie Wei Dong-Fang Wu Jian Xia Yong Xiong Hai-Bo Xu Xiao-Mei Yao Yu-Feng Yuan Tai-Sheng Ye Xiao-Chun Zhang Ying-Wen Zhang Yin-Gao Zhang Hua-Min Zhang Yan Zhao Ming-Juan Zhao Hao Zi Xian-Tao Zeng Yong-Yan Wang Xing-Huan Wang 无 | 2020 | Military Medical Research2020，7，1： | 161 |
| 5 | The Chinese Society of Clinical Oncology(CSCO):Clinical guidelines for the diagnosis and treatment of gastric cancer,2021显示文摘There exist differences in the epidemiological characteristics,clinicopathological features,tumor biological characteristics,treatment patterns,and drug selections between gastric cancer patients from the Eastern and Western countries.The Chinese Society of Clinical Oncology(CSCO)has organized a panel of senior experts specializing in all sub-specialties of gastric cancer to compile a clinical guideline for the diagnosis and treatment of gastric cancer since 2016 and renews it annually.Taking into account regional differences,giving full consideration to the accessibility of diagnosis and treatment resources,these experts have conducted expert consensus judgment on relevant evidence and made various grades of recommendations for the clinical diagnosis and treatment of gastric cancer to reflect the value of cancer treatment and meeting health economic indexes in China.The 2021 CSCO Clinical Practice Guidelines for Gastric Cancer covers the diagnosis,treatment,follow-up,and screening of gastric cancer.Based on the 2020 version of the CSCO Chinese Gastric Cancer guidelines,this updated guideline integrates the results ofmajor clinical studies from China and overseas for the past year,focused on the inclusion of research data from the Chinese population for more personalized and clinically relevant recommendations.For the comprehensive treatment of non-metastatic gastric cancer,attentions were paid to neoadjuvant treatment.The value of perioperative chemotherapy is gradually becoming clearer and its recommendation level has been updated.For the comprehensive treatment of metastatic gastric cancer,recommendations for immunotherapy were included,and immune checkpoint inhibitors fromthird-line to the first-line of treatment for different patient groups with detailed notes are provided. | Feng-Hua Wang Xiao-Tian Zhang Yuan-Fang Li Lei Tang Xiu-Juan Qu Jie-Er Ying Jun Zhang Ling-Yu Sun Rong-Bo Lin Hong Qiu Chang Wang Miao-Zhen Qiu Mu-Yan Cai QiWu Hao Liu Wen-Long Guan Ai-Ping Zhou Yu-Jing Zhang Tian-Shu Liu Feng Bi Xiang-Lin Yuan Sheng-Xiang Rao Yan Xin Wei-Qi Sheng Hui-Mian Xu Guo-Xin Li Jia-Fu Ji Zhi-Wei Zhou Han Liang Yan-Qiao Zhang Jing Jin Lin Shen Jin Li Rui-Hua Xu | 2021 | Cancer Communications2021，41，8： | 97 |
| 6 | Discovery of ultrahigh-pressure magnesite-bearing garnet lherzolite (>3.8 GPa) in the Altyn Tagh, Northwest China显示文摘Magnesite-bearing garnet Iherzolite from the Altyn Tagh, associated with garnet pyroxenite, and garnet-bearing felsic gneiss, crops out as lenses in Proterozoic gneiss about 100 km east of the Jianggelasayi River. The garnet Iherzolite, together with the eclogite in western Jianggelasayi, composes a high-pressure to ultrahigh-pressure metamorphic belt in the southern margin of the Altyn Tagh. Parageneses of minerals from magnesite-bearing garnet Iherzolite indicate that the rock evolved a multi-stage metamorphism. The peak-stage metamorphism produces an assemblage of Grt+Ol+Opx+Cpx±Mgs, in which A12O3 content of Opxis very low (0.30-0.66wt%). The calculated P-T condition of the peak stage is 3.8-5.lGPa and 880-970°C, some exsolution rods of clinopyroxene and rutile occur in the Grt and magnesite is rimed by dolomite and orthopyroxene, all implying that the peak stage was a UHP metamorphic process. Together with regional geological studies, isotopic dating and the discovery of coesite inclusions in | LIU Liang, SUN Yong, XIAO Peixi, CHE Zicheng, LUO Jinhai, CHEN Danling, WANG Yan, ZHANG Anda, CHEN Liang & WANG YongheKey Laboratory of Continental Dynamics of the Ministry of Education, Northwest University, Xi’an 710069, China The Northwest Institute of | 2002 | Chinese Science Bulletin2002，47，11： | 69 |
| 7 | Analysis of in vivo patterns of caspase 3 gene expression in primary hepatocellular carcinoma and its relationship to p21^(WAF1) expression and hepatic apoptosis显示文摘AIM To detect the expression of caspase 3gene in primary human hepatocellular carcinoma(HCC)and investigate its relationship to p21WAF1gene expression and HCC apoptosis.METHODS In situ hybridization was employedto determine caspase 3 and p21WAF1expression inHCC.In situ end-labeling was used to detecthepatocytic apoptosis in HCC.RESULTS Twenty-one of 39(53.8%)cases ofHCC were found to express caspase 3transcripts,while 45.2% of HCC failed toexpress caspase 3.Non-cancerous adjacent livertissues showed more positive caspase 3(87.5%,7/8)as compared with HCC(P<0.05).The expression of caspase 3 is correlated withHCC differentiation,72.2%(13/18)ofmoderately to highly differentiated HCC showedcaspase 3 transcripts positive,while only 38.1%of poorly differentiated HCC harbored caspase 3transcripts(P<0.05).No relationship wasfound between caspase 3 expression and tumorsize or grade or metastasis,although 52.5%(5/8)of HCC with metastasis were caspase 3positive and a little higher than that with nometastasis(51.6%,P>0.05).Expression of caspase 3 alone did not affect the apoptosisindex(AI)of HCC.The AI was 7.12%o in caspase3-positive tumors(n=21),while in caspase 3-negative cases(n=18)6.59%0(P>0.05).Expression of caspase 3 clearly segregated withp21WAF1positive tumors as compared withp21WAF1-negative cases(16 of 23,69.6% versus5 of 16,31.3%)with statistical significance(P=0.017).In the cases with positive caspase 3and negative p21WAF1,the Al was found slightlyhigher,but with no statistical significance,thanthat with expression of p21WAF1and caspase 3(7.21‰ vs 6.98‰,P>0.05).CONCLUSION Loss of caspase 3 expressionmay contribute to HCC carcinogenesis,althoughthe expression of caspase 3 does not correlatewell with cell apoptosis in HCC.p21WAF1may bemerely one of the inhibitors which can reducecaspase 3 mediated cell apoptosis in HCCs. | Bao Hua Sun Jun Zhang Bao JǜWang Xi Ping Zhao You Kun Wang Zhi Qun Yu Dong Liang Yang Lian Jie Hao Department of Clinical Immunology,Tongji Hospital,Tongji Medical University,Wuhan 430030,Hubei Province,China | 2000 | World Journal of Gastroenterology2000，6，3： | 65 |
| 8 | RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings显示文摘在有前列腺癌症的不同赛跑的病人之中有显著不同;然而,位于这差别下面的机制仍然保持不清楚。这里,我们在场 transcriptome 的一处全面风景用 RNA-seq,越过关于基因熔化的前列腺癌症 transcriptomes 的揭示巨大的差异,长 noncoding RNA (长 ncRNA ) ,其他的拼接和体的变化从中国人口 14 主要前列腺癌症和他们的配对的正常对应物介绍。14 个肿瘤(21.4%) 中的三个在中国病人怀有 TMPRSS2 尔格熔化,和这熔化的低流行进一步在一个另外的肿瘤集合(10/54=18.5%) 被证实。尤其是,二新奇基因熔化, CTAGE5-KHDRBS3 (20/54=37%) 和 USP9Y-TTTY15 (19/54=35.2%) ,在我们的耐心的队经常发生了。介绍的进一步系统的 transcriptional 识别了是在肿瘤表示的差别的众多的长 ncRNAs。在长 ncRNA 和基因的表示之间的关联的分析建议长 ncRNAs 可以在 transcriptional 规定以外有功能。这研究在中国人口产出新卓见进前列腺癌症的致病。 | Shancheng Ren Zhiyu Peng Jian-Hua Mao Yongwei Yu Changjun Yin Xin Gao Zilian Cui Jibin Zhang Kang Yi Weidong Xu Chao Chen Fubo Wang Xinwu Guo Ji Lu Jun Yang Min Wei Zhijian Tian Yinghui Guan Liang Tang Chuanliang Xu Linhui Wang Xu Gao Wei Tian Jian Wang Huanming Yang Jun Wang Yinghao Sun | 2012 | Cell Research2012，22，5： | 66 |
| 9 | Remediation of Heavy Metal-Polluted Agricultural Soils Using Clay Minerals: A Review显示文摘Heavy metal contamination of agricultural soils poses risks and hazards to humans. The remediation of heavy metal-polluted soils has become a hot topic in environmental science and engineering. In this review, the application of clay minerals for the remediation of heavy metal-polluted agricultural soils is summarized, in terms of their remediation effects and mechanisms, influencing factors,and future focus. Typical clay minerals, natural sepiolite, palygorskite, and bentonite, have been widely utilized for the in-situ immobilization of heavy metals in soils, especially Cd-polluted paddy soils and wastewater-irrigated farmland soils. Clay minerals are able to increase soil p H, decrease the chemical-extractable fractions and bioavailability of heavy metals in soils, and reduce the heavy metal contents in edible parts of plants. The immobilization effects have been confirmed in field-scale demonstrations and pot trials. Clay minerals can improve the environmental quality of soils and alleviate the hazards of heavy metals to plants. As main factors affecting the immobilization effects, the p H and water condition of soils have drawn academic attention. The remediation mechanisms mainly include liming, precipitation, and sorption effects. However, the molecular mechanisms of microscopic immobilization are unclear. Future studies should focus on the long-term stability and improvement of clay minerals in order to obtain a better remediation effect. | XU Yi LIANG Xuefeng XU Yingming QIN Xu HUANG Qingqing WANG Lin SUN Yuebing | 2017 | Pedosphere2017，27，2： | 66 |
| 10 | Natural herbal medicine Lianhuaqingwen capsule anti-influenza A (H1N1) trial: a randomized, double blind, positive controlled clinical trial显示文摘背景 2009 流行性感冒 A (H1N1 ) 病毒感染与严重复杂并发症的高风险被联系并且比另外的报导季节的流行性感冒在整个 wodd 更快正在传播。试图评估在病人的草药的药 Lianhuaqingwen 囊( LHC )与 16-65 年的 244 个病人的一个总数由实时 RT-PCR 与流行性感冒 A ( H1N1 )病毒感染证实了的流行性感冒 A ( H1N1 ) virus.Methods 感染了的性质的功效和安全的这研究被使随机化到之一二治疗各 122 组织病人。每个组分配了收到 LHC 或 Oseltamivir 五天和观察七天。如果他们有 37.4 并且与至少一下列症状的腋的温度,病人在 36 小时病发作以内被注册:鼻音阻塞,流鼻涕的鼻子,咳嗽,酸的喉咙,疲劳,头疼,肌痛,寒冷并且出汗。主要结束点是 244 个病人,的 illness.Results 的持续时间 240 (98.36 ) 有 21 年完成了的中部的年龄的病人在 10 月 24,2009 日和 2009 年 11 月 23 日之间的学习。对待的 LHC 之间没有重要全面差别, Oseltamivir 在病(LHC 69 小时对 Oseltamivir 85 小时 P 0.05 ) 的中部的持续时间或病毒的流的中部的持续时间对待病人(LHC 103 小时对 Oseltamivir 96 小时, P 0.05 ) 。然而,注意 LHC 显著地包括发烧,咳嗽,酸的喉咙,和疲劳(P 0.05 ) 减少了病和症状的持续时间的严厉是值得的。两学习药很好被容忍。没有药联系了严肃的不利事件与 Oseltamivir 相比发生在 study.Conclusions 期间, LHC 完成了病的持续时间和病毒的流的持续时间的类似的治疗学的有效性减小。因此, LHC 可能是为流行性感冒 A (H1N1 ) 病毒感染的一项其他的治疗学的措施。(临床的试用数字:ChiCTR-TRC-00000589 ) 。 | DUAN Zhong-ping JIA Zhen-hua ZHANG Jian LIU Shuang CHEN Yu LIANG Lian-chun ZHANG Chang-qing ZHANG Zong SUN Yan ZHANG Shu-qin WANG Yong-yan WU Yi-ling | 2011 | Chinese Medical Journal2011，，18： | 55 |
| 11 | The regulation of the Treg/Th 17 balance by mesenchyma stem cells in human systemic lupus erythematosus显示文摘 | Dandan Wang Saisai Huang Xinran Yuan Jun Liang Renju Xu Genhong Yao Xuebing Feng Lingyun Sun | 2017 | Cellular & Molecular Immunology2017，14，5： | 44 |
| 12 | Identification and mapping of genes for improving yield from Chinese common wild rice (O.rufipogon Griff.) using advanced backcross QTL analysis显示文摘To identify useful genes from wild rice which have been lost or weakened in cultivated rice has become more and more important for modern breeding strategy. In this study, a BC4 population derived from 94W1, an accession of common wild rice (Oryza rufipogon Griff.) from Dongxiang in Jiangxi Province of China, as the donor, and a high-yielding Indica cultivar (O. sativa L.), 'Guichao 2', as the recipient, was used to identify quantitative trait loci (QTL) associated with yield and its components. Based on the analysis for the genotype of BC4F1 population with 87 SSR markers distributed throughout the genome and investigation of the plant height, yield and yield components of BC4F2, a total of 52 QTLs, were detected. Of 7 QTLs associated with grain yield per plant, 2 QTLs on chromosome 2 and chromosome 11 for grain yield, explaining 16% and 11% of the phenotypic variance respectively, were identified. The alleles from Dongxiang common wild rice in those two loci could increase the yield of 'Guichao 2' by | Dejun Li Chuanqing Sun Yongcai Fu Cheng Li Zuofeng Zhu Liang Chen Hongwei Cai Xiangkun Wang | 2002 | Chinese Science Bulletin2002，47，18： | 39 |
| 13 | Risk factors of infected pancreatic necrosis secondary to severe acute pancreatitis显示文摘BACKGROUND: Severe acute pancreatitis(SAP) remains a clinical challenge with considerable morbidity and mortality.An early identification of infected pancreatic necrosis(IPN), a life-threatening evolution secondary to SAP, is obliged for a more preferable prognosis. Thus, the present study was conducted to identify the risk factors of IPN secondary to SAP. METHODS: The clinical data of patients with SAP were retrospectively analyzed. Univariate and multivariate logistic regression analyses were sequentially performed to assess the associations between the variables and the development of IPN secondary to SAP. A receiver operating characteristic(ROC) curve was created for each of the qualified independent risk factors. RESULTS: Of the 115 eligible patients, 39(33.9%) progressed to IPN, and the overall in-hospital mortality was 11.3%(13/115).The early enteral nutrition(EEN)(P=0.0092, OR=0.264), maximum intra-abdominal pressure(IAP)(P=0.0398, OR=1.131)and maximum D-dimer level(P=0.0001, OR=1.006) in the first three consecutive days were independent risk factors associated with IPN secondary to SAP. The area under ROC curve(AUC) was 0.774 for the maximum D-dimer level in the first three consecutive days and the sensitivity was 90% and the specificity was 58% at a cut-off value of 933.5 μg/L; the AUC was 0.831 for the maximum IAP in the first three consecutive days and the sensitivity was 95% and specificity was 58%at a cut-off value of 13.5 mm Hg. CONCLUSIONS: The present study suggested that the maximum D-dimer level and/or maximum IAP in the first three consecutive days after admission were risk factors of IPN secondary to SAP; an EEN might be helpful to prevent the progression of IPN secondary to SAP. | Liang Ji Jia-Chen Lv Zeng-Fu Song Mai-Tao Jiang Le Li Bei Sun | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，4： | 38 |
| 14 | Does Helicobacter pylori infection play a role in iron deficiency anemia? A meta-analysis显示文摘AIM:To perform a meta-analysis of observational studies and randomized controlled trials(RCTs)on the association between Helicobacter pylori(H.pylori)and iron deficiency anemia(IDA).METHODS:A defined search strategy was used to search Medline,Embase,the Cochrane Library,Clinical Trials,Cochrane Central Register of Controlled Trials,Premedline and Healthstar.Odds ratio(OR)was used to evaluate observational epidemiology studies,and weighted mean difference(WMD)was used to demonstrate the difference between control and intervention groups.RESULTS:Fifteen observational studies and 5 RCTs were identified and used for calculation.The pooled OR for observational studies was 2.22(95%CI:1.52-3.24,P<0.0001).The WMD for hemoglobin(HB) was 4.06 g/L(95%CI:-2.57-10.69,P=0.01),and the WMD for serum ferritin(SF)was 9.47μg/L(95%CI:-0.50-19.43,P<0.0001).Results were heterogeneous for all comparisons.CONCLUSION:This meta-analysis on observational studies suggests an association between H.pylori and IDA.In RCTs,eradication of H.pylori can improve HB and SF levels but not significantly. | Qu, Xin-Hua Huang, Xiao-Lu Xiong, Ping Zhu, Cui-Ying Huang, You-Liang Lu, Lun-Gen Sun, Xu Rong, Lan Zhong, Liang Sun, Da-Yu Lin, Hai Cai, Ming-Ci Chen, Zhi-Wei Hu, Bing Wu, Lian-Ming Jiang, Yi-Bin Yan, Wei-Li | 2010 | World Journal of Gastroenterology2010，16，7： | 34 |
| 15 | Correction of β-thalassemia mutant by base editor in human embryos显示文摘 | Puping Liang Chenhui Ding Hongwei Sun Xiaowei Xie Yanwen Xu Xiya Zhang Ying Sun Yuanyan Xiong Wenbin Ma Yongxiang Liu Yali Wang Jianpei Fang Dan Liu Zhou Songyang Canquan Zhou Junjiu Huang | 2017 | Protein & Cell2017，8，11： | 34 |
| 16 | Microsatellite analysis of genetic diversity and population structure of Chinese mitten crab (Eriocheir sinensis)显示文摘中国露指手套螃蟹(Eriocheir sinensis ) 在中国比 Eriocheir 的任何另外的种类作为食物来源有更高商业的价值。为了评估细菌原生质资源并且在不同的水系统,二张股票和二张耕作人口描绘基因差异和螃蟹的人口结构,与在公共场合可得到的 25 多态的 microsallite loci 被估计 GenBank。基本统计证明一般水准观察了杂合现象(惊讶) 在人口之中从 0.5789 ~ 0.6824 。然而,使近交的显著存在和异质接合体缺乏被观察。到分析人口结构,配对系数从露指手套螃蟹人口的分向仅仅 10.3% 可变性解释了的明智的 FST,留下的可变性在潜水艇人口以内源自分。尽管四张人口有细微区别,不同突变而产生之遗传的频率导致了不同人口结构。二张股票和股票耕作人口一起被聚类到 Yangtze 螃蟹的种系发生的分支,与 95% 的一个近似会员。而,另一张耕作人口单身地被聚类到 Liaohe 螃蟹的种系发生的分支,与 97.1% 的一个会员。为单个混合的测试证明那只 Yangtze 螃蟹可能从另外的水系统与个人一起被污染了。在人口之间的基因关系也支持了尽管有一样的种类的起源,那只 Yangtze 螃蟹和 Liaohe 螃蟹有不同基因库的结论。 | Yumei Chang Liqun Liang Haitao Ma Jianguo He Xiaowen Sun | 2008 | Journal of Genetics and Genomics2008，35，3： | 29 |
| 17 | Variability and reduction of atmospheric pollutants in Beijing and its surrounding area during the Beijing 2008 Olympic Games显示文摘The Beijing-Tianjin-Hebei Atmospheric Environment Monitoring Network was established by the Institute of Atmospheric Physics,Chinese Academy of Sciences.The goals of the network were to monitor and provide warnings of the atmospheric quality in Beijing and its surrounding area during the Beijing 2008 Olympic Games.The results showed that the atmospheric complex pollution exhibited high concentrations of ozone and fine particles and oxidation in summer,with a ubiquitous regional source.The regional mean concentrations of SO2,PM2.5,NO2,and O3_8h max(the maximum daily 8 h mean) and Ox were 22±11,90±40,25±5,136±35 and 112±21 μg/m3 in summer,respectively.During the Olympic Games,the mean concentration of SO2,PM2.5,NO2,O3_8h max,and Ox were 12.5±4,56±28,23±4,114±29,95±17 μg/m3 in the region,respectively,and fell by 51.0%,43.7%,13%,20.2%,and 18.9%,respectively,compared to the prophase mean before the Olympic Games.The concentration of atmospheric pollutants declined significantly and achieved the 'Green Olympics' control goal of air quality.After the Olympic Games,SO2,PM2.5 and NOx increased significantly as the temporary atmospheric pollution control measures were terminated. | XIN JinYuan WANG YueSi TANG GuiQian WANG LiLi SUN Yang WANG YingHong HU Bo SONG Tao JI DongSheng WANG WeiFeng LI Liang LIU GuangRen | 2010 | Chinese Science Bulletin2010，55，18： | 30 |
| 18 | Identification and characterization of microRNAs in raw milk during different periods of lactation, commercial fluid, and powdered milk products显示文摘最近的婴儿的公式奶粉污染事件证明了在牛奶质量控制的经典标记或标准在识别鈥渕a nipulated 鈥 ? 是不够的差质量的牛奶。在现在的学习,我们第一次证明奶牛牛奶包含大量 microRNAs ( miRNAs )并且牛奶特定的 miRNAs 的唯一的表示侧面能为未加工的牛奶和牛奶相关的商业产品的质量控制用作新奇指示物和可能的新标准,例如液体牛奶和粉状的公式牛奶。用定序的 Solexa,首先,我们系统地在未加工的牛奶屏蔽了 miRNA 表示并且在未加工的牛奶识别了 245 miRNAs 的一个总数。不同于层次在哺乳的不同时期是其表达式将近相同的另外的经典 biomarkers,单个 miRNAs 能显著地在哺乳过程期间被改变,含有那 miRNAs 可以是更精确的指示物反映牛奶的优秀改变。第二,使用 TaqMan 基于探查的 miRNA 量的 RT-PCR ,我们进一步识别了七 miRNAs 重要地在整个哺乳过程,和更多有相对一致的表情,这七牛奶特定的 miRNAs 的表示侧面能为区别用作理想的 biomarker 差质量或从纯未加工的牛奶的 鈥渕a nipulated 鈥?牛奶,象为商业乳制品的质量控制一样,例如液体,牛奶和粉状的公式挤。一起,我们的调查结果为为决定未加工的牛奶或牛奶相关的商业产品的质量理解牛奶 miRNAs 和一个新潜在的标准的生理的角色提供一个基础。 | Xi Chen Chao Gao Haijin Li Lei Huang Qi Sun Yanye Dong Chunliang Tian Shengpu Gao Hailin Dong Danping Guan Xiaoyun Hu Shujian Zhao Liang Li Lin Zhu Qiao Yan Junfeng Zhang Ke Zen Chen-Yu Zhang | 2010 | Cell Research2010，20，10： | 29 |
| 19 | Modelling of multi-bodies in close proximity under water waves——Fluid resonance in narrow gaps显示文摘Viscous fluid model and potential flow model with and without artificial damping force(f=-μV,μ the damping coefficient and V the local averaging flow velocity) are employed in this work to investigate the phenomenon of fluid resonance in narrow gaps between multi-bodies in close proximity under water waves.The numerical results are compared with experimental data available in the literature.The comparison demonstrates that both the viscous fluid model and the potential flow model are able to predict the resonant frequency reasonably well.However the conventional potential flow model(without artificial damping term) significantly over-predicts the wave height in narrow gaps around the resonant frequency.In order to calibrate the appropriate damping coefficient used for the potential model and make it work as well as the viscous fluid model in predicting the resonant wave height in narrow gaps but with little computational efforts,the dependence of damping coefficient μ on the body geometric dimensions is examined considering the parameters of gap width Bg,body draft D,body breadth ratio Br and body number n(n = 2,3),where Br = BB/BA for the case of two bodies(Body A and Body B) with different breadths of BA and BB,respectively.It was confirmed that the damping coefficient used for the potential flow model is not sensitive to the geometric dimensions and spatial arrangement.It was found that μ∈ [0.4,0.5] may guarantee the variation of Hg/H0 with kh to be generally in good agreement with the experimental data and the results of viscous fluid model,where Hg is the excited wave height in narrow gaps under various dimensionless incident wave frequencies kh,H0 is the incident wave height,k = 2π/L is the wave number and h is the water depth. | LU Lin1,2,TENG Bin3,CHENG Liang 4,SUN Liang5 & CHEN XiaoBo6 1 Center for Deepwater Engineering,Dalian University of Technology,Dalian 116024,China 2 State Key Laboratory of Structural Analysis for Industrial Equipment,Dalian University of Technology,Dalian 116024,China 3 State Key Laboratory of Coastal and Offshore Engineering,Dalian University of Technology,Dalian 116024,China 4 School of Civil and Resource Engineering,The University of Western Australia,Crawly 6003,Australia 5 Centre for Offshore Research and Engineering,Department of Civil Engineering,National University of Singapore,117576,Singapore 6 Research Department,Bureau Veritas,Neuilly-Sur-Seine,92570,France | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，1： | 29 |
| 20 | Clinical research linking Traditional Chinese Medicine constitution types with diseases:a literature review of 1639 observational studies显示文摘OBJECTIVE:To analyze clinical studies on correlations between Traditional Chinese Medicine(TCM)body constitution types and diseases published in the past 10 years,and to provide an evidence base to support the use of such correlations for health maintenance and disease prevention.METHODS:We searched five databases for the period April 2009 to December 2019:China National Knowledge Infrastructure Database,Wanfang Database,China Science and Technology Journal Database,PubMed and Embase.Three types of observational studies on correlation between constitution types and diseases were included:cross-sectional,case-control and cohort studies.Descriptive statistical methods were employed for data analysis.RESULTS:A total of 1639 clinical studies were identified:1452(88.59%)cross-sectional studies,115(7.02%)case-control studies and 72(4.39%)cohort studies covering 30 regions of China and five other countries(Malaysia,South Korea,Singapore,Thailand and France).The collection of studies comprised 19 disease categories and 333 different diseases.The 10 most commonly studied diseases were hypertension,diabetes,stroke,coronary atherosclerotic heart disease(CAHD),sleep disorders,neoplasm of the breast,dysmenorrhea,fatty liver disease,chronic viral hepatitis B and dyslipidemia.We found high distributions for each biased constitution type in different patient populations as follows:Qi-deficiency constitution in stroke,diabetes,chronic obstructive pulmonary disease,acquired immunodeficiency syndrome and hypertension;Yang-deficiency constitution in female infertility,osteoporosis,irritable bowel syndrome,gonarthrosis and dysmenorrhea;Yin-deficiency constitution in hypertension,diabetes,constipation,female climacteric states and osteoporosis;phlegm-dampness constitution in hypertension,stroke,fatty liver disease,diabetes and metabolic syndrome;damp-heat constitution in acne,chronic gastritis,chronic viral hepatitis B,human papillomavirus infection and hyperuricemia;blood-stasis constitution in CAHD,endometriosis and stroke;Qi-stagnation constitution in hyperplasia and neoplasms of the breast,insomnia,depression and thyroid nodules;and inherited-special constitution in asthma and allergic rhinitis.CONCLUSION:Eight biased TCM constitutions were closely related to specific diseases,and could be used to guide individualized prevention and treatment.More rigorously designed studies are recommended to further verify the constitution-disease relationship. | Liang Xue Wang Qi Jiang Zeqiang Li Zhuqing Zhang Mengxing Yang Peiying Wang Xin Wang Yanqiu Qin Yuehua Li Tianxing Zhang Tianyi Wang Yi Sun Jianxiang Li Yusi Luo Hui Li Lingru | 2020 | Journal of Traditional Chinese Medicine2020，40，4： | 29 |
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