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| 1 | Geothermal occurrence analysis of Dongying Formation in Tanggu area of Tianjin显示文摘Based on introducing geological structure of Tanggu area,the authors analyzed the sedimentary environment of Paleogene Dongying Formation,and further analyzed its geothermal occurrence. The studied area spans two grade Ⅳ tectonic units which are Beitang depression and Banqiao depression. The studied area is mainly located in the Tanggu nose-like structure which is the secondary structure of Beitang depression. Its existence affects the sedimentary distribution of the part strata of Paleogene. The depositions of Dongying Ⅲ( SQEd3) and DongyingⅡ( SQEd2) are mainly delta front facies and lake sand bars which are propitious to the geothermal fluid enrichment. The favorable enrichment region of geothermal fluid is located in south HetouTanggu. Most of DongyingⅠ( SQEd1) changes into swamp plain deposition,only the northeast part of this area is the distributary riverway facies with developed sand layers. There is the favorable enrichment region of geothermal fluid. The hydraulic connection is weak among the geothermal reservoirs of Dongying Formation and its overlying Guantao and Minghuazhen formations. The underlying Shahejie Formation geothermal reservoir provides a steady stream of fluid supply and ground pressure protection for Dongying Formation geothermal reservoir. | LIU Jiulong JIN Baozhen LI Yuanyuan WANG Jige YUE Liyan WANG Xi | 2014 | Global Geology2014，17，3： | 2 |
| 2 | Radical Heteroarylalkylation of Alkenes via Three-Component Docking-Migration Thioetherification Cascade显示文摘A novel,rational-designed approach to access various heteroaryl-substituted alkyl thioethers was developed via docking-migration cascade process.By utilizing three components involving alkene,dual-function reagent,and thioetherificating reagent,radical heteroarylalkylation of alkenes followed by thiolation of the alkyl radical intermediates proceeded smoothly,manifesting well compatibility of substrates and cascade transformations.Furthermore,this protocol also features mild conditions,broad substrate scope,and wide product diversity. | Tao Niu Jige Liu Xinxin Wu Chen Zhu | 2020 | Chinese Journal of Chemistry2020，38，8： | 2 |
| 3 | Generation of gene-target dogs using CRISPR/Cas9 system显示文摘Dear Editor,Dogs(Canis familiaris)serve as human companions and are raised to herd livestock,aid hunters,guard homes,perform police and rescue work,and guide the blind.Dogs exhibit close similarities to humans in terms of metabolic,physiological,and anatomical characteristics,and thus are ideal genetic and clinical models to study human diseases(Tsai et al.,2007).Gene target technology is a powerful tool to create new strains of animals with favorable traits.However,thus far,gene-target dogs have not been developed due to their unique species-specific reproductive characteristics,which limits the applications of dogs especially in the field of biomedical research.Recently,clustered regularly interspaced short palindromic repeats(CRISPRs)/CRISPR-associated(Cas)9 system was applied to edit specific genes with a high efficiency(Cong et al.,2013;Mali et al.,2013).Here we attempt to explore the feasibility of producing gene knockout(KO)dogs by using this technology.Beagle dog,the most widely used breed in biomedical research,was used as our animal model.Myostatin(MSTN)was chosen as the first gene of interest. | Qingjian Zou Xiaomin Wang Yunzhong Liu Zhen Ouyang Haibin Long Shu Wei Jige Xin Bentian Zhao Sisi Lai Jun Shen Qingchun Ni Huaqiang Yang Huilin Zhong Li Li Minhua Hu Quanjun Zhang Zhidong Zhou Jiaxin He Quanmei Yan Nana Fan Yu Zhao Zhaoming Liu Lin Guo Jiao Huang Guanguan Zhang Jun Ying Liangxue Lai Xiang Gao | 2015 | Journal of Molecular Cell Biology2015，7，6： | 1 |
| 4 | Catalyst-free,radical-mediated intermolecular 1,2-arylheteroarylation of alkenes by cleaving inert C–C bond显示文摘A novel photoinduced intermolecular 1,2-arylheteroarylation of alkenes and the efficient synthesis of valuable polyarylalkanes are reported.The reaction is operationally simple,proceeds under mild conditions and with no additional catalyst and reagents.The strategically designed radical cascade reaction is enabled by electron transfer,and involves cleavage of an inert C–C bond.The process features broad functional group compatibility as well as high product transformability. | Meishan Ji Xinxin Wang Jige Liu Xinxin Wu Chen Zhu | 2021 | Science China Chemistry2021，64，10： | 0 |
| 5 | A practical access to fluoroalkylthio(seleno)-functionalized bicyclo[1.1.1]pentanes显示文摘Rational design of new bioisosteres through introduction of high-value functional groups to bicyclo[1.1.1]pentane(BCP)is of particular use for drug discovery.Disclosed herein is the first access to valuable fluoroalkylthio(seleno)-functionalized BCPs.A range of SCF3,SCF2H,SCFH2,SeCF3,SeC4F9,and SeC8F17 groups are readily incorporated to BCPs under mild conditions.Concomitant installation of a sulfone provides a platform for incorporation of the BCP motif to bioactive molecules.This practical protocol features novel BCP scaffolds,broad substrate scope,excellent atom-economy,simple operation,and gramscale preparation. | Zhen Wu Yaohui Xu Jige Liu Xinxin Wu Chen Zhu | 2020 | Science China Chemistry2020，63，8： | 0 |
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