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| 1 | Superoxide dismutase prevents development of adenocarcinoma in a rat model of Barrett's esophagus显示文摘AIM: To test whether antioxidant treatment could prevent the progression of Barrett's esophagus to adenocarcinoma.METHODS: In a rat model of gastroduodenoesophageal reflux by esophagojejunal anastomosis with gastric preservation, groups of 6-10 rats were randomized to receive treatment with superoxide dismutase (SOD) or vehicle and followed up for 4 mo. Rat's esophagus was assessed by histological analysis, superoxide anion and peroxinitrite generation, SOD levels and DNA oxidative damage.RESULTS: All rats undergoing esophagojejunostomy developed extensive esophageal mucosal ulceration and inflammation by mo 4. The process was associated with a progressive presence of intestinal metaplasia beyondthe anastomotic area (9% 1st mo and 50% 4th mo) (94% at the anastomotic level) and adenocarcinoma(11% 1st mo and 60% 4th mo). These changes were associated with superoxide anion and peroxinitrite mucosal generation, an early and significant increase of DNA oxidative damage and a significant decrease in SOD levels (P<0.05). Exogenous administration of SOD decreased mucosal superoxide levels, increased mucosal SOD levels and reduced the risk of developing intestinal metaplasia beyond the anastomotic area (odds ratio = 0.326; 95%CI: 0.108-0.981; P = 0.046),and esophageal adenocarcinoma (odds ratio = 0.243;95%CI: 0.073-0.804; P = 0.021).CONCLUSION: Superoxide dismutase prevents the progression of esophagitis to Barrett's esophagus and adenocarcinoma in this rat model of gastrointestinal reflux, supporting a role of antioxidants in the chemoprevention of esophageal adenocarcinoma. | Elena Piazuelo Carmelo Cebrián Alfredo Escartín Pilar Jiménez Fernando Soteras Javier Ortego Angel Lanas | 2005 | World Journal of Gastroenterology2005，11，47： | 5 |
| 2 | Determinants of percutaneous coronary intervention success in repeat chronic total occlusion procedures following an initial failed attempt显示文摘AIM To investigate the rates and determinants of success of repeat percutaneous coronary intervention(PCI) following an initial failed attempt at recanalising the chronic total occlusions(CTO) percutaneously.METHODS In 445 consecutive first attempt CTO-PCI procedures in our institution,procedural failure occurred in 149(33.5%). Sixty-four re-PCI procedures were performed in 58 patients(39%) all had a single CTO. Procedural and outcome data in the re-PCI population was entered into the institutional database. A retrospective analysis of clinical,angiographic and procedural data was performed. RESULTS Procedural success was achieved in 41(64%) procedures. Univariate analysis of clinical and angiographic characteristics showed that re-PCI success was associated with intravascular ultrasound(IVUS) guidance(19.5% vs 0%,P = 0.042),while failure was associated with severecalcification(30.4% vs 9.7%,P = 0.047) and a JCTO score > 3(56.5% vs 17.1% P = 0.003). Following multiple regression analysis the degree of lesion complexity(J-CTO score > 3),IVUS use,involvement of an experienced CTO operator and LAD CTO location were significant predictors of successful re-PCI. Overall the complication rate was low,with the only MACCE two periprocedural MI's neither of which required intervention. CONCLUSION Re-PCI substantially increases the overall success rate of CTO revascularization. Predictors of re-PCI success included the use of IVUS,the involvement of an experienced CTO operator in the repeat attempt and the location of the CTO. | Cecilia Cuevas Nicola Ryan Alicia Quirós Juan Gustavo Del Angel Nieves Gonzalo Pablo Salinas Pilar Jiménez-Quevedo Luis Nombela-Franco Ivan Nunez-Gil Antonio Fernandez-Ortiz Carlos Macaya Javier Escaned | 2017 | World Journal of Cardiology2017，9，4： | 5 |
| 3 | 美国国家级干旱监测业务产品介绍显示文摘 | Mark Svoboda Doug LeComte Mike Hayes Richard Heim Karin Gleason Jim Angel Brad Rippey Rich Tinker Mike Palecki David Stooksbury David Miskus Scott Stephens 王涓力(译) | 2006 | 干旱气象2006，24，1： | 3 |
| 4 | 在经历 transcatheter 的病人的 atrial 纤维性颤动的临床、预示的含意大动脉的阀门培植显示文摘 AIM: To study a cohort of consecutive patients under-going transcatheter aortic valve implantation (TAVI) and compare the outcomes of atrial fibrillation (AF) patients vs patients in sinus rhythm (SR). METHODS: All consecutive patients undergoing TAVI in our hospital were included. The AF group comprised patients in AF at the time of TAVI or with history of AF, and were compared with the SR group. Procedural, echocardiographic and follow-up variables were compared. Likewise, the CHA 2 DS 2-VASC stroke risk score and HAS-BLED bleeding risk score and antithrombotic treatment at discharge in AF patients were compared with that in SR patients. RESULTS: From a total of 34 patients undergoing TAVI, 17 (50%) were allocated to the AF group, of whom 15 (88%) were under chronic oral anticoagulation. Patients in the AF group were similar to those in the SR group except for a trend (P = 0.07) for a higher logistic EuroSCORE (28% vs 19%), and a higher prevalence of hypertension (82% vs 53%) and chronic renal failure (17% vs 0%). Risk of both stroke and bleeding was high in the AF group (mean CHA 2 DS 2-VASC 4.3, mean HAS-BLED 2.9). In the AF group, treatment at discharge included chronic oral anticoagulation in all except one case, and in association with an antiplatelet drug in 57% of patients. During a mean follow-up of 11 mo (maximum 32), there were only two strokes, none of them during the peri-procedural period: one in the AF group at 30 mo and one in the SR group at 3 mo. There were no statistical differences in procedural success, and clinical outcome (survival at 1 year 81% vs 74% in AF and SR groups, respectively, P = NS). CONCLUSION: Patients in AF undergoing TAVI show a trend to a higher surgical risk. However, in our cohort, patients in AF did not have a higher stroke rate compared to the SR group, and the prognosis was similar in both groups. | Pablo Salinas Raúl Moreno Luis Calvo Santiago Jiménez-Valero Guillermo Galeote Angel Sánchez-Recalde Teresa López-Fernández Sergio Garcia-Blas Diego Iglesias Luis Riera Isidro Moreno-Gómez Jose María Mesa Ignacio Plaza Rocio Ayala Rosa Gonzalez José-Luis López-Sendón | 2012 | World Journal of Cardiology2012，4，1： | 2 |
| 5 | The Impact and Implications of Environmentally Linked Strategies on Competitive Advantage :A Study of Malaysian Companies 显示文摘 | SLATER JIM ISABEL TIRADO ANGEL | 2000 | Journal of Business Research2000，47，1： | 1 |
| 6 | Radiation-induced coronary artery disease: Useful insights from OCT显示文摘 | Juan Caro-Codón Santiago Jiménez-Valero Guillermo Galeote Angel Sanchez-Recalde Raul Moreno | 2016 | International Journal of Cardiology2016，，： | 1 |
| 7 | Drug-Induced Liver Injury: An Analysis of 461 Incidences Submitted to the Spanish Registry Over a 10-Year Period显示文摘 | Raúl J. Andrade M. Isabel Lucena M. Carmen Fernández Gloria Pelaez Ketevan Pachkoria Elena García-Ruiz Beatriz García-Mu?oz Rocio González-Grande Angeles Pizarro José Antonio Durán Manuel Jiménez Luis Rodrigo Manuel Romero-Gomez José María Navarro Ramón P | 2005 | Gastroenterology2005，，2： | 1 |
| 8 | Factors Associated With a High Risk of Recurrence in Patients With Transient Ischemic Attack or Minor Stroke显示文摘 | Angel Ois Meritxell Gomis Ana Rodríguez-Campello Elisa Cuadrado-Godia Jordi Jiménez-Conde Claustre Pont-Sunyer Gracia Cuccurella Jaume Roquer | 2008 | Stroke2008，，6： | 1 |
| 9 | Characterization of Various Magnesium Oxides by XRD and 1HMAS NMR Spectroscopy显示文摘 | María Angeles Aramendía José Antonio Benítez Victoriano Borau César Jiménez José Maria Marinas José Rafael Ruiz and Francisco Urbano | 1999 | J Solid State Chem1999，144，1： | 1 |
| 10 | Carbosilane dendrimers as gene delivery agents for the treatment of HIV infection显示文摘 | Ana Judith Perisé-Barrios José Luis Jiménez Angeles Domínguez-Soto F. Javier de la Mata Angel L. Corbí Rafael Gomez María ángeles Mu?oz-Fernandez | 2014 | Journal of Controlled Release2014，，： | 1 |
| 11 | New cements for the 21st century: The pursuit of an alternative to Portland cement显示文摘 | Caijun Shi A. Fernández Jiménez Angel Palomo | 2011 | Cement and Concrete Research2011，，7： | 1 |
| 12 | Drug-Induced Liver Injury: An Analysis of 461 Incidences Submitted to the Spanish Registry Over a 10-Year Period显示文摘 | Raúl J. Andrade M. Isabel Lucena M. Carmen Fernández Gloria Pelaez Ketevan Pachkoria Elena García-Ruiz Beatriz García-Mu?oz Rocio González-Grande Angeles Pizarro José Antonio Durán Manuel Jiménez Luis Rodrigo Manuel Romero-Gomez José María Navarro Ramón P | 2005 | Gastroenterology2005，，2： | 1 |
| 13 | Effects of increasing blood hemoglobin levels on systemic hemodynamics of acutely anemic cirrhotic patients显示文摘 | J.Ignasi Elizalde Eduardo Moitinho Joan Carles García-Pagán Isabel Cirera Angels Escorsell Juan Carlos Bandi Wladimiro Jiménez Jaume Bosch Josep M. Piqué Joan Rodés | 1998 | Journal of Hepatology1998，，5： | 1 |
| 14 | Meckel's diverticulum diagnosis by video capsule endoscopy: A case report and review of literature显示文摘BACKGROUND Meckel's diverticulum(MD) occurs predominantly in children and adolescents. It is rarely diagnosed in adults. Preoperative diagnosis is difficult due to low sensitivity of the radiological imaging studies. The role of video capsule endoscopy(VCE) in the diagnosis of MD is unknown, and the endoscopic patterns are not defined. We will describe four of our cases of MD evaluated with VCE and make a review of the literature focusing on the endoscopic characteristics.CASE SUMMARY We present four cases of MD confirmed by surgery. They were all adult males with ages going from 18 to 50 years, referred to our service from 2004 to 2018, due to obscure gastrointestinal bleeding(OGIB). Theyhad a history of 1 mo to 10 years of overt and occult bleeding episodes. Laboratory blood test showed an iron-deficiency anemia from 4 to 9 g/dL of hemoglobin that required multiple hospitalizations and blood transfusions in all cases. Repeated upper digestive endoscopies and colonoscopies were negative. Small bowel was examined with VCE, which revealed double lumen images in all cases, one with polyps and three with circumferential ulcers in the diverticulum. However, based on VCE findings, preoperative diagnosis of MD was suggested only in two patients. Capsule was retained in one patient, which was recovered with surgery. The anatomopathological report revealed ulcerated ectopic gastric mucosa in all cases.CONCLUSION VCE is useful for the diagnosis of MD. However, endoscopic characteristics must be recognized in order to establish preoperative diagnosis. | Diego García-Compeán Alan R Jiménez-Rodríguez Angel N Del Cueto-Aguilera Gilberto Herrera-Quinones José A González-González Héctor J Maldonado-Garza | 2018 | World Journal of Clinical Cases2018，6，14： | 0 |
| 15 | Analysis of Querétaro-Celaya Highway Applying Queueing Theory显示文摘Querétaro-Celaya highway is the obligatory road to the center of Mexico;the establishment of new companies in the area has generated the need to study the dynamics of the vehicular flow that transits this route.Given that the flow of traffic on a highway is a stochastic phenomenon,it is necessary to apply tools that take into account the randomness of the system to measure performance.Queueing theory models capture the random nature of the phenomenon and provide direct information about the relationship between the variables of the system.In this work,the flow of vehicles on the Querétaro-Celaya highway is analyzed with a macroscopic approach and using analytical models of queueing theory;it is concluded that currently the flow on this road is non-congested.The method is an alternative for institutions that do not have specialized packages to carry out studies of this nature. | Gabriel Guzmán-Sáenz Salvador Hernández-González JoséAlfredo Jiménez-García Vicente Figueroa-Fernández Miguel Angel Melchor-Navarro | 2018 | Journal of Traffic and Transportation Engineering2018，6，2： | 0 |
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