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| 1 | A nationwide survey of diabetes education, self-management and glycemic control in patients with type 2 diabetes in China显示文摘 | GUO Xiao-hui YUAN Li LOU Qing-qing SHEN Li SUN Zi-lin ZHAO Fang DAI Xia HUANG Jin YANG Hui-ying | 2012 | Chinese Medical Journal2012，，23： | 74 |
| 2 | Programmable time-domain digital-coding metasurface for non-linear harmonic manipulation and new wireless communication systems显示文摘Optical non-linear phenomena are typically observed in natural materials interacting with light at high intensities, and they benefit a diverse range of applications from communication to sensing. However,controlling harmonic conversion with high efficiency and flexibility remains a major issue in modern optical and radio-frequency systems. Here, we introduce a dynamic time-domain digital-coding metasurface that enables efficient manipulation of spectral harmonic distribution. By dynamically modulating the local phase of the surface reflectivity, we achieve accurate control of different harmonics in a highly programmable and dynamic fashion, enabling unusual responses, such as velocity illusion. As a relevant application, we propose and realize a novel architecture for wireless communication systems based on the time-domain digital-coding metasurface, which largely simplifies the architecture of modern communication systems, at the same time yielding excellent performance for real-time signal transmission. The presented work, from new concept to new system, opens new pathways in the application of metamaterials to practical technology. | Jie Zhao Xi Yang Jun Yan Dai Qiang Cheng Xiang Li Ning Hua Qi Jun Chen Ke Guo Dong Bai Shuo Liu Shi Jin Andrea Alù Tie Jun Cui | 2019 | National Science Review2019，6，2： | 46 |
| 3 | Chinese Trauma Surgeon Association for management guidelines of vacuum sealing drainage application in abdominal surgeries-Update and systematic review显示文摘Vacuum sealing drainage (VSD) is frequently used in abdominal surgeries. However, relevant guidelines are rare. Chin ese Trauma Surge on Associati on orga nized a committee composed of 28 experts across China in July 2017, aiming to provide an evidence-based recommendation for the application of VSD in abdominal surgeries.Eleven questions regarding the use of VSD in abdominal surgeries were addressed:(1) which type of materials should be respectively chosen for the intraperitoneal cavity, retroperitoneal cavity and superficial incisions?(2) Can VSD be preventively used for a high-risk abdominal incision w让h primary suture?(3) Can VSD be used in severely contaminated/infected abdominal surgical sites?(4) Can VSD be used for temporary abdominal cavity closure under some special conditions such as severe abdominal trauma, infection, liver transplantation and intra-abdominal volume increment in abdominal compartment syndrome?(5) Can VSD be used in abdominal organ inflammation, injury, or postoperative drainage?(6) Can VSD be used in the treatment of intestinal fistula and pancreatic fistula?(7) Can VSD be used in the treatment of intra-abdominal and extra-peritoneal abscess?(8) Can VSD be used in the treatment of abdominal wall wounds, wound cavity, and defects?(9) Does VSD in crease the risk of bleeding?(10) Does VSD increase the risk of intestinal wail injury?(11) Does VSD increase the risk of peritoneal adhesion? Focusing on these questions, evidence-based recommendations were given accordingly. VSD was strongly recommended regarding the questions 2-4. Weak recommendations were made regarding questions 1 and 5-11. Proper use of VSD in abdominal surgeries can lower the risk of infection in abdominal incisions with primary suture, treat severely contaminated/infected surgical sites and facilitate temporary abdominal cavity closure. | Yang Li Pei-Yuan Li Shi-Jing Sun Yuan-Zhang Yao Zhan-Fei Li Tao Liu Fan Yang Lian-Yang Zhang Xiang-Jun Bai Jing-Shan Huo Wu-Bing He Jun Ouyang Lei Peng Ping Hu Yan-An Zhu Ping Jin Qi-Feng Shao Yan-Feng Wang Rui-Wu Dai Pei-Yang Hu Hai-Ming Chen Ge-Fei Wang Yong-Gao Wang Hong-Xu Jin Chang-Ju Zhu Qi-Yong Zhang Biao Shao Xi-Guang Sang Chang-Lin Yin | 2019 | Chinese Journal of Traumatology2019，22，1： | 26 |
| 4 | Outcome and risk factors of early onset severe preeclampsia显示文摘 | GONG Yun-hui JIA Jin LU Dong-hao DAI Li BAI Yi ZHOU Rong | 2012 | Chinese Medical Journal2012，，14： | 23 |
| 5 | Wireless Communications with Programmable Metasurface:Transceiver Design and Experimental Results显示文摘Metasurfaces have drawn significant attentions due to their superior capability in tailoring electromagnetic waves with a wide frequency range, from microwave to visible light. Recently, programmable metasurfaces have demonstrated the ability of manipulating the amplitude or phase of electromagnetic waves in a programmable manner in real time, which renders them especially appealing in the applications of wireless communications. In this paper, we present the fundamental principle of applying programmable metasurface as transmitter for wireless communications. Then, we establish a prototype system of metasurface-based transmitter to conduct several experiments and measurements over the air, which practically demonstrate the feasibility of using programmable metasurfaces in future communication systems. By exploiting the dynamically controllable property of programmable metasurface, the design, implementation and experimental evaluation of the proposed metasurface-based wireless communication system are presented with the prototype, which realizes single carrier quadrature phase shift keying(QPSK) transmission over the air. In the developed prototype, the phase of the reflected electromagnetic wave of programma-ble metasurface is directly manipulated in real time according to the baseband control signal, which achieves 2.048 Mbps data transfer rate with video streaming transmission over the air. In addition, experimental result is provided to compare the performance of the proposed metasurface-based architecture against the conventional one. With the slight increase of the transmit power by 5 dB, the same bit error rate(BER) performance can be achieved as the conventional system in the absence of channel coding. Such a result is encouraging considering that the metasurface-based system has the advantages of low hardware cost and simple structure, thus leading to a promising new architecture for wireless communications. | Wankai Tang Xiang Li Jun Yan Dai Shi Jin Yong Zeng Qiang Cheng Tie Jun Cui | 2019 | China Communications2019，16，5： | 23 |
| 6 | Rapamycin attenuates bleomycin-induced pulmonary fibrosis in rats and the expression of metalloproteinase-9 and tissue inhibitors of metalloproteinase-1 in lung tissue显示文摘 | Jin Xiaoguang | 2014 | Chinese Medical Journal2014，，7： | 20 |
| 7 | Researches and developments of biomimetics in tribology显示文摘动物和植物开发了有通过 10 亿年和变得的模型 fortribological 的进化的优秀 tribologicalcharacteristics 的质地设计的最佳的几何结构,聪明的拓扑的材料和多功能的表面。这篇论文提出简历的定义和臀部模仿的摩擦学,调查地位液体固体接口自我清洗,在动物之间的粘附“脚和固体出现,穿模仿的设计和液体固体上的仿生的设计连接的生物表面和简历的特征。tribologicalbiomimetics 的进一步的开发被讨论。 | DAI Zhendong TONG Jin REN Luquan | 2006 | Chinese Science Bulletin2006，51，22： | 19 |
| 8 | Changes in vitreous VEGF, bFGF and fibrosis in proliferative diabetic retinopathy after intravitreal bevacizumab显示文摘AIM: To evaluate the relationship between intravitreal bevacizumab(IVB) treatment and the levels of vitreous vascular endothelial growth factor(VEGF), basic fibroblast growth factor(b FGF) and vitreous-retina surface fibrosis in patients with proliferative diabetic retinopathy(PDR).·METHODS: This study was a prospective, open-label,controlled, randomized clinical trial. Sixty-eight eyes of PDR patients(n =53) and macular hole patients(n =15)were enrolled in this study. Thirty-four eyes of the PDR patients received IVB before vitrectomy. Twenty-three of the 34 PDR patients received IVB treatment 5d before vitrectomy(subgroup a), and 11 of the 34 PDR patients received IVB treatment greater than 2wk prior to vitrectomy(subgroup b). Nineteen of the PDR patients did not receive IVB treatment at any time prior to vitrectomy. The levels of b FGF and VEGF in vitreous samples were measured using enzyme-linked immunosorbent assay(ELISA) and the degree of vitreoretinal fibrosis was characterized using clinical data and data obtained intra-operatively.·RESULTS: In PDR patients, VEGF and b FGF levels were significantly increased compared to non-PDR(control) subject's eyes(P <0.01). In PDR patients,vitreous VEGF levels were significantly decreased following IVB treatment compared to PDR patients that did not receive IVB treatment(P <0.01). The degree of vitreoretinal fibrosis was significantly increased in subgroup b compared to subgroup a(P <0.05) and to patients that did not receive IVB(P <0.05). Vitreous b FGF levels were significantly greater in subgroup b than subgroup a(P <0.01) or in patients who did not receive IVB treatment(P <0.05). A Spearman's rank correlationtest indicated that higher levels of vitreous b FGF, but not VEGF, correlated with the degree of vitreoretinal fibrosis.·CONCLUSION: We found that b FGF levels increase in PDR patient's vitreous after IVB treatment longer than two weeks prior to vitrectomy and correlated with the degree of fibrosis after IVB treatment. These findings suggest vitreous fibrosis is increased in PDR patients after IVB treatment may be due to increased levels of b FGF. | Jiu-Ke Li Fang Wei Xiao-Hong Jin Yuan-Min Dai Hu-Shan Cui Yu-Min Li | 2015 | International Journal of Ophthalmology(English edition)2015，8，6： | 19 |
| 9 | Preservation of the continence function after intersphincteric resection using a prolapsing technique in the patients with low rectal cancer and its clinical prognosis显示文摘肿瘤的 intersphincteric 切除术的技术与 coloanal 吻合相结合的背景被用来为病人避免永久结肠开口术,直肠的癌症定位了 < 从肛门边缘的 5 厘米。针对用 prolapsing technique.Methods 在 intersphincteric 切除术以后与更低的直肠的癌症估计剩余直肠和病人的临床的预后的克制功能的保藏的这研究这研究与下列包括标准包括了病人:(1 ) 在远侧的边缘以内的直肠的癌症和肿瘤的病理学的证据由外科手术前的内视镜的检查从肛门定位了 5 厘米或更少;(2 ) 不由也的渗入的 MRI 证实外部括约肌, puborectalis 或提肌肌肉;(3 ) 病人与与 well-to-moderate 区别显示出肿瘤的外科手术前的活体检视为 intersphincteric 切除术和更低的 coloanal 吻合是合格的。从 2000 年 1 月,到 6 月 2004,23 日,有低直肠的癌症的病人在这研究被包括。我们使用了标准 abdominoperineal 途径与内部括约肌的 mesorectum 和总数或部分的切除执行肿瘤的激进的切除术。病人为对剩余直肠的功能的评价被跟随,在 operations.Results 以后的癌症复发,从肛门边缘的中部的肿瘤距离是 4.5 (范围 3.5-5.0 ) 厘米和吝啬的远侧的外科的边缘 1.6 (范围 1.0-2.0 ) 厘米。癌症被分类进舞台我(30.4%) ,舞台(47.8%) ,和舞台(21.7%) 根据 TNM 分类。在外科的切除术和 2 个病人(8.7%) 在 coloanal 吻合的地点开发了 anastomotic 苛评的以后的阶段以后,二个病人开发了 anastomotic 管。中部的后续时期是 31.5 个月(范围 12-54 ) , 2 个病人(8.7%) 开发了本地复发。三死亡与远侧的机关转移被联系。二十个病人(87.0%) 维持了胜任在外科以后控制固体或液体凳子和屁克制的能力。在这些病人之中, 2 个病人能控制稳固的凳子并且偶尔失去液体凳子的克制。并且仅仅 1 个病人(4.4%) 在手术以后与稳固的凳子然而并非液体的好克制保留了部分直肠功能。在外科是 13.1,4.7,3.1,2.9,和 3.2 时间 / 天以后,每 3, 6, 12, 24 和 36 个月的天平均澄清的时间。在 intersphincteric 切除术和这个变化在后续的时期期间留下了以后,肛门压力计大小在休息时间期间显示出压力的减少。最大值挤压压力在外科以后在起始的减少以后被改进。在外科以后的更多的剩余直肠功能可以被低直肠癌症的 intersphincteric 切除术保存的结论。同时这种技术在外科以后与很少手术后的复杂并发症和低肿瘤复发是安全的。 | DAI Yong JIANG Jin-bo BI Dong-song JIN Zu-tao SUN Jing-zhong HU San-yuan | 2008 | Chinese Medical Journal2008，，20： | 16 |
| 10 | Generation of B Cell-Deficient Pigs by Highly Efficient CRISPR/Cas9-Mediated Gene Targeting显示文摘Generating B cell-deficient mutant is the first step to produce human antibody repertoires in large animal models. In this study, we applied the clustered regularly interspaced short palindromic repeat(CRISPR)/CRISPR-associated(Cas) system to target the JHregion of the pig Ig M heavy chain gene which is crucial for B cell development and differentiation. Transfection of Ig M-targeting Cas9 plasmid in primary porcine fetal fibroblasts(PFFs) enabled inducing gene knock out(KO) in up to 53.3% of colonies analyzed, a quarter of which harbored biallelic modification, which was much higher than that of the traditional homologous recombination(HR). With the aid of somatic cell nuclear transfer(SCNT) technology, three piglets with the biallelic Ig M heavy chain gene mutation were produced. The piglets showed no antibody-producing B cells which indicated that the biallelic mutation of the Ig M heavy chain gene effectively knocked out the function of the Ig M and resulted in a B cell-deficient phenotype. Our study suggests that the CRISPR/Cas9 system combined with SCNT technology is an efficient genome-editing approach in pigs. | Fengjiao Chen Ying Wang Yilin Yuan Wei Zhang Zijian Ren Yong Jin Xiaorui Liu Qiang Xiong Qin Chen Manling Zhang Xiaokang Li Lihua Zhao Ze Li Zhaoqiang Wu Yanfei Zhang Feifei Hu Juan Huang Rongfeng Li Yifan Dai | 2015 | Journal of Genetics and Genomics2015，42，8： | 15 |
| 11 | Human placenta-derived mesenchymal stem cells loaded on linear ordered collagen scaffold improves functional recovery after completely transected spinal cord injury in canine显示文摘Traumatic spinal cord injury(SCI) is a major challenge in the clinic. In this study, we sought to examine the synergistic effects of linear ordered collagen scaffold(LOCS) and human placenta-derived mesenchymal stem cells(hPMSCs) when transplanted into completely transected beagle dogs. After 36 weeks observation, we found that LOCS+hPMSCs implants promoted better hindlimb locomotor recovery than was observed in the non-treatment(control) group and LOCS group. Histological analysis showed that the regenerated tissue after treatment was well integrated with the host tissue, and dramatically reduced the volume of cystic and chondroitin sulfate proteoglycans(CSPGs) expression. Furthermore, the LOCS+hPMSCs group also showed more neuron-specific βIII-tubulin(Tuj-1)-and NeuN-positive neurons in the lesion area, as well as axonal regeneration, remyelination and synapse formation in the lesion site. Additionally, dogs in the LOCS+hPMSCs group experienced enhanced sprouting of both ascending(CGRP-positive) sensory fibers and descending(5-HT-and TH-positive) motor fibers at the lesion area. All these data together suggested that the combined treatment had beneficial effects on neuronal regeneration and functional improvement in a canine complete transection model. Therefore, LOCS+hPMSCs implantation holds a great promise for bridging the nerve defect and may be clinically useful in the near future. | Sufang Han Zhifeng Xiao Xing Li Huan Zhao Bin Wang Zhixue Qiu Zhi Li Xin Mei Bai Xu Caixia Fan Bing Chen Jin Han Yanzheng Gu Huilin Yang Qin Shi Jianwu Dai | 2018 | Science China(Life Sciences)2018，61，1： | 15 |
| 12 | Inhibitor of fatty acid synthase induced apoptosis in human colonic cancer cells显示文摘INTRODUCTIONThe treatment of human epithelial malignancies islimited by drug resistance and toxic and side effects,which results in the failure in the treatment ofmajority of advanced cancer victims.To seek for anew,and specific antineoplastic therapy willprovide hope for tumor treatment.Althoughdisordered intermediary metabolism in cancer cellshas been known for many years,much of the | Pei Lin Huang Shi Neng Zhu Shi Lun Lu Zhen Sheng Dai Yue Lin Jin | 2000 | World Journal of Gastroenterology2000，6，2： | 13 |
| 13 | Accurate and broadband manipulations of harmonic amplitudes and phases to reach 256 QAM millimeter-wave wireless communications by time-domain digital coding metasurface显示文摘We propose a theoretical mechanism and new coding strategy to realize extremely accurate manipulations of nonlinear electromagnetic harmonics in ultrawide frequency band based on a time-domain digital coding metasurface(TDCM).Using the proposed mechanism and coding strategy,we design and fabricate a millimeter-wave(mmWave) TDCM,which is composed of reprogrammable meta-atoms embedded with positive-intrinsic-negative diodes.By controlling the duty ratios and time delays of the digital coding sequences loaded on a TDCM,experimental results show that both amplitudes and phases of different harmonics can be engineered at will simultaneously and precisely in broad frequency band from 22 to33 GHz,even when the coding states are imperfect,which is in good agreement with theoretical calculations.Based on the fabricated high-performance TDCM,we further propose and experimentally realize a large-capacity mmWave wireless communication system,where 256 quadrature amplitude modulation,along with other schemes,is demonstrated.The new wireless communication system has a much simpler architecture than the currently used mmWave wireless systems,and hence can significantly reduce the hardware cost.We believe that the proposed method and system architecture can find vast application in future mmWave and terahertz-wave wireless communication and radar systems. | Ming Zheng Chen Wankai Tang Jun Yan Dai Jun Chen Ke Lei Zhang Cheng Zhang Jin Yang Lianlin Li Qiang Cheng Shi Jin Tie Jun Cui | 2022 | National Science Review2022，9，1： | 13 |
| 14 | De novo mutation in ATP6V1B2 impairs lysosome acidification and causes dominant deafness-onychodystrophy syndrome显示文摘 | Yongyi Yuan Jianguo Zhang Qing Chang Jin Zeng Feng Xin Jianjun Wang Qingyan Zhu Jing Wu Jingqiao Lu Weiwei Guo Xukun Yan Hui Jiang Binfei Zhou Qi Li Xue Gao Huijun Yuan Shiming Yang Dongyi Han Zixu Mao Ping Chen Xi Lin Pu Dai | 2014 | Cell Research2014，24，11： | 13 |
| 15 | Spatial Interaction and Network Structure Evolvement of Cities in Terms of China's Rail Passenger Flows显示文摘Cities separated in space are connected together by spatial interaction (SI) between them. But the studies focusing on the SI are relatively few in China mainly because of the scarcity of data. This paper deals with the SI in terms of rail passenger flows, which is an important aspect of the network structure of urban agglomeration. By using a data set consisting of rail O-D (origin-destination) passenger flows among nearly 200 cities, intercity rail distance O-D matrixes, and some other indices, it is found that the attenuating tendency of rail passenger is obvious. And by the analysis on dominant flows and spatial structure of flows, we find that passenger flows have a trend of polarizing to hubs while the linkages between hubs upgrade. However, the gravity model reveals an overall picture of convergence process over time which is not in our expectation of integration process in the framework of globalization and economic integration. Some driven factors for the re-organization process of the structure of urban agglomeration, such as technique advance, globalization, etc. are discussed further based on the results we obtained. | DAI Teqi JIN Fengjun | 2008 | Chinese Geographical Science2008，18，3： | 11 |
| 16 | Evaluation of recombinant endostatin in the treatment of atherosclerotic plaques and neovascularization in rabbits显示文摘Objective:Atherosclerotic plaques and neovascularization play an important role in the course of coronary atherosclerosis.This study evaluated the effect of recombinant endostatin on experimental atherosclerotic plaques and neovascularization in rabbits.Methods:Eighteen healthy male rabbits were divided into three groups:control group,atherosclerotic model group,and recombinant endostatin treated group.The atherosclerotic model was established via a high-cholesterol diet after balloon catheter injury.The subject weights,serum total cholesterol,creatine kinase-myocardial band fraction(CKMB),and matrix metalloproteinase-2(MMP-2) were measured.Six weeks after treatment,the aortic roots were taken for pathological assay.The thickness ratio of the intima to media was measured by hematoxylin and eosin(HE) staining,and the number of neovessels was measured by immunohistochemistry via monoclonal antibody CD31 staining.Results:The weight,plasma total cholesterol,and CKMB were not significantly different between the atherosclerotic model group and the recombinant endostatin treated group,but much higher than those of the control group(P<0.05).The thickness ratio of the intima to media in the recombinant endostatin treated group was distinctly less than that in the atherosclerotic model group(P<0.05).The number of neovessels decreased dramatically(P<0.05) and the content of MMP-2 decreased slightly without statistical difference(P>0.05) in the recombinant endostatin treated group,compared to the atherosclerotic model group.Conclusions:Recombinant endostatin is able to inhibit the growth of neovascularization in the atherosclerotic plaque and the development of plaque. | Wei MAO Jing KONG Jin DAI Zhao-quan HUANG Dong-zhi WANG Gui-bao NI Min-li CHEN | 2010 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010，11，8： | 11 |
| 17 | The historical and current research progress on jujube–a superfruit for the future显示文摘Jujube(Ziziphus jujuba Mill.),or Chinese date,is the most important species of Rhamnaceae,a large cosmopolitan family,and is one of the oldest cultivated fruit trees in the world.It originates from the middle and lower reaches of the Yellow River,the‘mother river’of the Chinese people.It is distributed in at least 48 countries on all continents except Antarctica and is becoming increasingly important,especially in arid and semiarid marginal lands.Based on a systematic analysis of the unique characteristics of jujube,we suggest that it deserves to be recognized as a superfruit.We summarized historical research achievements from the past 3000 years and reviewed recent research advances since 1949 in seven fields,including genome sequencing and application,germplasm resources and systematic taxonomy,breeding and genetics,cultivation theory and techniques,pest control,postharvest physiology and techniques,and nutrition and processing.Based on the challenges facing the jujube industry,we discuss eight research aspects to be focused on in the future. | Mengjun Liu Jiurui Wang Lili Wang Ping Liu Jin Zhao Zhihui Zhao Shengrui Yao Florin Stănică Zhiguo Liu Lixin Wang Changwei Ao Li Dai Xiansong Li Xuan Zhao Chunxiang Jia | 2020 | Horticulture Research2020，7，1： | 10 |
| 18 | Laparoscopic splenectomy by secondary pedicle division strategy: a highly cost-effective method显示文摘背景:Laparoscopic 脾切除术(LS ) 除了高费用与开的外科相比显示出许多优点。这研究被瞄准与高划算推荐第二等的小花梗部门策略为一个方法。方法:从 2003 年 1 月到 2005 年 6 月, 14 个连续病人经历了 laparoscopic 脾切除术。脾的小花梗被第二等的小花梗部门策略在另外的 6 个盒子中在 8 种情况中并且由 Endo-GIA 控制。回顾的研究被执行评估起作用的时间,失血,节食的时间,起作用的病态,手术后的停留,和起作用的费用。结果:LS 总共 14 个盒子的成功地被执行。在在起作用的时间,失血,节食的时间,起作用的病态和手术后的停留的二策略之间没有有效差量。第二等的小花梗部门策略的起作用的费用组织(RMB 8354.38 +/- 752.10 ) 比 Endo-GIA 组的显著地低(RMB 11053.33 +/- 602.27 )(P <
0.01 ) 。结论:由第二等的小花梗部门策略的 Laparoscopic 脾切除术是有在开发国家的通俗化的价值的一个安全、有效、节俭的过程。 | CAI Xiu-jun SHEN Bo YU Hong LIANG Xiao ZHU Lin-hua WANG Yi-fan DAI Yi YANG Jin | 2008 | Chinese Medical Journal2008，，2： | 9 |
| 19 | Selection of candidates for surgery as local therapy among early-stage small cell lung cancer patients: a population-based analysis显示文摘Background:Surgery and radiotherapy are considered local therapies for small cell lung cancer(SCLC).The present study aimed to select candidates for surgery as local therapy among patients with stage I or II SCLC,based on the eighth edition of the TNM classification for lung cancer.Methods:Patients diagnosed with SCLC between 2004 and 2013 were selected from the Surveillance,Epidemiology,And End Results database.The TNM stage of SCLC in these patients was re-classified according to the eighth edition of the TNM classification for lung cancer.Patients with stage I or II SCLC were included in the present study.Overall survival(OS)and lung cancer-specific survival(LCSS)were separately compared in the different TNM stages between patients who received surgery and radiotherapy as local therapy.Multivariate analysis was applied to evaluate multi-ple factors associated with survival.Results:Among the 2129 patients included in the present study,387(18.2%)received surgery,1032(48.5%)under-went radiotherapy as local therapy,154(7.2%)underwent surgery and radiotherapy,and 556(26.1%)did not undergo either surgery or radiotherapy.Among patients with T1-2N0(tumor size≤50 mm without positive lymph nodes)dis-ease,patients who underwent surgery had higher 5-year OS and LCSS rates than patients who received radiotherapy(T1N0:46.0%vs.23.8%,P<0.001,and 58.4%vs.36.4%,P<0.001,respectively;T2N0:42.6%vs.24.7%,P=0.004,and 48.8%vs.31.3%,P=0.011,respectively).Multivariate analysis results revealed that surgery was associated with low risk of death.However,among T3N0 or T1-2N1(stage IIB)SCLC patients,patients who underwent surgery did not have higher 5-year OS and LCSS rates than patients who received radiotherapy(T3N0:16.2%vs.26.5%,P=0.085,and 28.7%vs.30.9%,P=0.372,respectively;T1-2N1:20.3%vs.29.0%,P=0.146,and 25.6%vs.35.5%,P=0.064,respectively).Conclusions:Based on the assumption that the overwhelming majority of stage I or II SCLC patients who underwent surgery or radiotherapy also received certain types of systemic therapy,only patients with T1-2N0 SCLC may benefit from surgery as local therapy.Patients with T3N0 or T1-2N1 SCLC may consider radiotherapy as local therapy. | Kaiqi Jin Kaixuan Zhang Feng Zhou Jie Dai Peng Zhang Gening Jiang | 2018 | Cancer Communications2018，38，1： | 9 |
| 20 | Association between large artery stenosis,cerebral small vessel disease and risk of ischemic stroke显示文摘We aimed to assess the associations of large artery stenosis(LAS)and cerebral small vessel disease(CSVD)with the risk of ischemic stroke and to investigate their respective and combined contributions.In the prospective population-based Shunyi Study,1,082 stroke-free participants aged 55.9±9.1 years were included.Participants were followed for incident stroke throughout the study period(2013-2019).Total small vessel disease score was used to measure CSVD burden.Cervico-cerebral large artery stenosis was evaluated via brain magnetic resonance angiography and carotid ultrasound.We estimated the risk of ischemic stroke in relation to LAS and CSVD with Cox regression models.During a mean follow-up of 4.2 years,34 participants(3.1%)experienced at least one ischemic stroke.Severe LAS(≥50% stenosis versus no stenosis:HR=3.27(95%CI:1.31-8.18))and high CSVD burden(total small vessel disease score 2-4 versus 0 point:HR=12.73(4.83-33.53))were associated with increased stroke risk independently.In multivariate models,CSVD burden(7.72%)explained a larger portion of the variation in stroke risk than severity of LAS(3.49%).Our findings identified that both LAS and CSVD were associated with future ischemic stroke in asymptomatic subjects,while those with high CSVD burden deserve more attention in primary prevention of stroke. | Fei Han Ding-Ding Zhang Fei-Fei Zhai Jun Xue Jiang-Tao Zhang Shuang Yan Li-Xin Zhou Jun Ni Ming Yao Meng Yang Ming-Li Li Zheng-Yu Jin Qing Dai Shu-Yang Zhang Li-Ying Cui Yi-Cheng Zhu | 2021 | Science China(Life Sciences)2021，64，9： | 9 |
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