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| 1 | Mitochondrial calcium uniporter protein MCU is involved in oxidative stress-induced cell death显示文摘Mitochondrial 钙 uniporter (MCU ) 是在在真核细胞的房间的 mitochondrial 的保存 Ca 2+ transporter。然而,在氧化导致压力的房间死亡的 MCU 蛋白质的角色仍然保持不清楚。这里,我们证明宫外地表示的 MCU 是在局部性的 mitochondrial HeLa 和主要小脑的小粒神经原(CGN ) 。内长的 MCU 减少 mitochondrial Ca 2+ 举起追随者组织安刺激击倒并且稀释氧化应力在 HeLa 房间和 CGN 导致的房间死亡。我们也发现 MCU 与 VDAC1 交往并且调停在 CGN 的 VDAC1 导致 overexpression 的房间死亡。这发现证明那 MCU-VDAC1 建筑群调整 mitochondrial Ca 2+ 举起和氧化导致压力的 apoptosis,它可能表示为氧化应力的治疗学的目标联系了疾病。 | Yajin Liao Yumin Hao Hong Chen Qing He Zengqiang Yuan Jinbo Cheng | 2015 | Protein & Cell2015，6，6： | 12 |
| 2 | The Seasonal Variation of Large Volume Airgun Signals in Hutubi,Xinjiang显示文摘In order to study the seasonal variation of large volume airgun signals in Hutubi,Xinjiang,we analyzed 2,936 signals of airgun source excitations during 2015-2016 received by a seismograph on the bank of the excitation pool.Firstly,the RMS value of the signal amplitude and the daily average temperature were compared after linearly superimposing the signal in days,to analyze the influence of the surface ice cover on the excitation energy release of the airgun source.The result shows that the ice cover will reduce the excitation energy,and the thicker the ice cover is,the more obvious the excitation energy reduces.Secondly,the time-frequency analysis method was used to analyze the influence of the surface ice cover on the signal frequency.It is concluded that the existence of the ice cover has little effect on the signal frequency,but it will affect the intensity of the signal around 4 Hz between 1-2 s after excitation.The cause of these phenomena is that the ice cover affects the bubble oscillation,which in turn affects the energy conversion.The study shows that when using the cross-correlation delay method to calculate the wave velocity,the signals can be divided into two periods according to the daily average temperature:with or without ice cover on the upper surface of the excitation pool.This can help eliminate the influence of the source variation and improve the accuracy of the monitoring results. | SU Jinbo WANG Qiong ZHANG Wenxiu WEI Yunyun CHEN Hao WANG Haitao | 2019 | Earthquake Research in China2019，33，2： | 5 |
| 3 | Fast-Suppressor Screening for New Components in Protein Trafficking,Organelle Biogenesis and Silencing Pathway in Arabidopsis thaliana Using DEX-Inducible FREE1-RNAi Plants显示文摘Membrane trafficking is essential for plant growth and responses to external signals.The plant unique FYVE domain-containing protein FREE1 is a component of the ESCRT complex(endosomal sorting complex required for transport).FREE1 plays multiple roles in regulating protein trafficking and organelle biogenesis including the formation of intraluminal vesicles of multivesicular body(MVB),vacuolar protein transport and vacuole biogenesis,and autophagic degradation.FREE1 knockout plants show defective MVB formation,abnormal vacuolar transport,fragmented vacuoles,accumulated autophagosomes,and seedling lethality.To further uncover the underlying mechanisms of FREE1 function in plants,we performed a forward genetic screen for mutants that suppressed the seedling lethal phenotype of FREE1-RNAi transgenic plants.The obtained mutants are termed as suppressors of free1(sof).To date,229 putative sof mutants have been identified.Barely detecting of FREE1 protein with M3plants further identified 84 FREE1-related suppressors.Also145 mutants showing no reduction of FREE1 protein were termed as RNAi-related mutants.Through next-generation sequencing(NGS)of bulked DNA from F2mapping population of two RNAi-related sof mutants,FREE1-RNAi T-DNA inserted on chromosome 1 was identified and the causal mutation of putative sof mutant is being identified similarly.These FREE1-and RNAi-related sof mutants will be useful tools and resources for illustrating the underlying mechanisms of FREE1 function in intracellular trafficking and organelle biogenesis,as well as for uncovering the new components involved in the regulation of silencing pathways in plants. | Qiong Zhao Caiji Gao PoShing Lee Lin Liu Shaofang Li Tangjin Hu Jinbo Shen Shuying Pan Hao Ye Yunru Chen Wenhan Cao Yong Cui Peng Zeng Sheng Yu Yangbin Gao Liang Chen Beixin Mo Xin Liu Shi Xiao Yunde Zhao Silin Zhong Xuemei Chen Liwen Jiang | 2015 | Journal of Genetics and Genomics2015，42，6： | 4 |
| 4 | Research on Large Volume Airgun Source Signal Reception in Hutubi, Xinjiang Using Seismic Network Data显示文摘We used data from the Xinjiang Digital Seismic Network and PSD( Power Spectral Density) method to perform noise level assessment for six stations. We calculated the median of the power spectral density to evaluate the noise level of different stations. After the comparison of the power spectral density of different stations and the airgun signal recognition,we found that noise level of stations with recognizable airgun source signals is lower than that of stations without recognizable signals. The largest difference of the power spectral density is 40 d B,and the smallest is 15 d B. Finally,we found that the failure to recognize the signal of airgun sources at some stations is due to the noise level. | Su Jinbo Wang Qiong Wang Haitao Shi Yongjun Chen Xiangjun Feng Lei Chen Hao Zhang Wenxiu | 2016 | Earthquake Research in China2016，30，3： | 4 |
| 5 | Tuning parallel symbolic execution engine for better performance显示文摘 | Anil Kumar KARNA Jinbo DU Haihao SHEN Hao ZHONG Jiong GONG Haibo YU Xiangning MA: Jianjun ZHAO | 2018 | Frontiers of Computer Science2018，12，1： | 3 |
| 6 | CAS FGOALS-g3 Model Datasets for the CMIP6 Scenario Model Intercomparison Project(ScenarioMIP)显示文摘This paper describes the datasets from the Scenario Model Intercomparison Project(ScenarioMIP)simulation experiments run with the Chinese Academy of Sciences Flexible Global Ocean–Atmosphere–Land System Model,GridPoint version 3(CAS FGOALS-g3).FGOALS-g3 is driven by eight shared socioeconomic pathways(SSPs)with different sets of future emission,concentration,and land-use scenarios.All Tier 1 and 2 experiments were carried out and were initialized using historical runs.A branch run method was used for the ensemble simulations.Model outputs were three-hourly,six-hourly,daily,and/or monthly mean values for the primary variables of the four component models.An evaluation and analysis of the simulations is also presented.The present results are expected to aid research into future climate change and socio-economic development. | Ye PU Hongbo LIU Ruojing YAN Hao YANG Kun XIA Yiyuan LI Li DONG Lijuan LI He WANG Yan NIE Mirong SONG Jinbo XIE Shuwen ZHAO Kangjun CHEN Bin WANG Jianghao LI and Ling ZUO | 2020 | Advances in Atmospheric Sciences2020，37，10： | 3 |
| 7 | An Ensemble Detection Method for Shilling Attacks Based on Features of Automatic Extraction显示文摘Faced with the evolving attacks in recommender systems, many detection features have been proposed by human engineering and used in supervised or unsupervised detection methods. However, the detection features extracted by human engineering are usually aimed at some specific types of attacks. To further detect other new types of attacks, the traditional methods have to re-extract detection features with high knowledge cost. To address these limitations, the method for automatic extraction of robust features is proposed and then an Adaboost-based detection method is presented. Firstly, to obtain robust representation with prior knowledge, unlike uniform corruption rate in traditional mLDA(marginalized Linear Denoising Autoencoder), different corruption rates for items are calculated according to the ratings’ distribution. Secondly, the ratings sparsity is used to weight the mapping matrix to extract low-dimensional representation. Moreover, the uniform corruption rate is also set to the next layer in mSLDA(marginalized Stacked Linear Denoising Autoencoder) to extract the stable and robust user features. Finally, under the robust feature space, an Adaboost-based detection method is proposed to alleviate the imbalanced classification problem. Experimental results on the Netflix and Amazon review datasets indicate that the proposed method can effectively detect various attacks. | Yaojun Hao Fuzhi Zhang Jinbo Chao | 2019 | China Communications2019，16，8： | 2 |
| 8 | Experimental and numerical investigation of the position-dependent growth of carbon nanotube–alumina microparticle hybrid structures in a horizontal CVD reactor显示文摘 | Delong He Hao Li Jinbo Bai | 2011 | Carbon2011，，15： | 1 |
| 9 | Fhermodynamic study on dynamic water and organic vapor sorption on amorphous valnemulin hydrochloride显示文摘 | Jinbo OUYANG | 2015 | Frontiers of Chemical Science and Engineering2015，9，1： | 1 |
| 10 | High coercivity Nd-Ce-Fe-B nanostructured ribbons prepared from melt spinning technique显示文摘The Ce-substituted(Nd1-xCex)12.2 Fe81.6 B6.2(x=0.0, 0.2, 0.4, 0.6) nanocrystalline ribbons were prepared by annealing amorphous ribbons from melt spinning. It is found that all ribbons are in a multiphase state consisting of a-Fe phase, Nd(Ce)-rich phases and RE2 Fe14 B(RE = Nd, Ce) phases. However, the coercivity of all annealed ribbons can reach a considerably high value without doping any heavy rare earth or other coercivity enhanced elements. A strong intergranular exchange coupling appears in these nanocrystalline ribbons. The Nd12.2 Fe81.6 B6.2 ribbons with multiphase have a coercivity of about 11.3 k Oe, and the coercivity decreases slightly with increasing Ce content. A coercivity of 7.5 kOe can be obtained when60 at% of Nd is replaced by Ce(x = 0.6) due to the grain refinement and the strong intergranular exchange coupling. This provides a practical approach of fabricating high coercivity Ce-substituted Nd-Fe-B materials. | Liang Zha Zhou Liu Hao Chen Mingzhu Xue Guanyi Qiao Shilei Ding Xin Wen Meiling Zhang Youfang Lai Wenyun Yang Jingzhi Han Dong Zhou Chenyao Zhu Jinbo Yang | 2019 | Journal of Rare Earths2019，37，10： | 1 |
| 11 | Transition metal embedded in nonmetal-doped T-carbon [110]: A superior synergistic trifunctional electrocatalyst for HER, OER and ORR显示文摘The design of efficient and low-cost multifunctional electrocatalysts for hydrogen evolution reaction(HER), oxygen evolution reaction(OER) and oxygen reduction reaction(ORR) is critical for the development of clean energy. Two-dimensional(2D) carbon-based nano-materials are becoming more and more popular in heterogeneous catalysis due to their cost-effective and multi-scale tunability as single-atom catalysis(SACs) substrates. In this paper, by using first-principles calculation, we designed and demonstrated a novel macropore T-carbon [110](TC) monolayer as 2D electrocatalyst substrate for HER/OER/ORR, and the synergistic modification of the transition metal and nonmetal atoms(TM-X) were investigated to enhance the multifunctional electrocatalytic performance. We screened out the Co embedded in N-doped TC(Co3@N-TC) from 30 TM@X-TC monolayers as a trifunctional electrocatalysts, which exhibits superior performance for HER/ORR/OER on both thermodynamic and kinetic scales, and with excellent thermal and electrochemical stability. Then, the TC monolayer is naturally macropore with a diameter of 5.36 A and exhibits excellent adsorption capacity for the intermediates and products of the redox reactions. Moreover, we revealed the origin of the electrocatalytic activity using the crystal orbital Hamilton population(COHP) and the molecular orbitals(MOs). The d orbital of Co3@N-TC is significantly hybridized with the p orbital of the intermediates, so that the lone electrons initially occupied in the antibonding state pair up and occupy the downward bonding state, allowing *OH to be appropriately adsorbed onto the TC monolayer. This work not only demonstrates that the TM@X-TC monolayer is a superior synergistic trifunctional electrocatalyst, but also reveals a macropore monolayer material with potential applications in electrocatalysis. | Zhengqin Zhao Jinbo Hao Baonan Jia Xinhui Zhang Ge Wu Chunling Zhang Long Li Shuli Gao Yirong Ma Yuanzi Li Pengfei Lu | 2023 | Journal of Energy Chemistry2023，，8： | 0 |
| 12 | Bilayer tellurene-metal interfaces显示文摘Tellurene, an emerging two-dimensional chain-like semiconductor, stands out for its high switch ratio, carrier mobility and excellent stability in air. Directly contacting the 2D semiconductor materials with metal electrodes is a feasible doping means to inject carriers. However, Schottky barrier often arises at the metal–semiconductors interface, impeding the transport of carriers. Herein, we investigate the interfacial properties of BL tellurene by contacting with various metals including graphene by using ab initio calculations and quantum transport simulations. Vertical Schottky barriers take place in Ag, Al, Au and Cu electrodes according to the maintenance of the noncontact tellurene layer band structure. Besides, a p-type vertical Schottky contact is formed due to the van der Waals interaction for graphene electrode. As for the lateral direction, p-type Schottky contacts take shape for bulk metal electrodes(hole Schottky barrier heights(SBHs) ranging from 0.19 to 0.35 eV). Strong Fermi level pinning takes place with a pinning factor of 0.02. Notably, a desirable p-type quasi-Ohmic contact is developed for graphene electrode with a hole SBH of 0.08 eV. Our work sheds light on the interfacial properties of BL tellurene based transistors and could guide the experimental selections on electrodes. | Hua Pang Jiahuan Yan Jie Yang Shiqi Liu Yuanyuan Pan Xiuying Zhang Bowen Shi Hao Tang Jinbo Yang Qihang Liu Lianqiang Xu Yangyang Wang Jing Lv | 2019 | Journal of Semiconductors2019，40，6： | 0 |
| 13 | Plant Rho GTPase signaling promotes autophagy显示文摘The roles of Rho family guanosine triphosphatases(GTPases)of plants(ROPs)in modulating plant growth and development have been well characterized.However,little is known about the roles of ROP signaling pathways in regulating plant autophagy and autophagosome formation.In this study,we identify a unique ROP signaling mechanism,which mediates developmental to autophagic transition under stress conditions in the model plant Arabidopsis.Loss-of-function mutants of ROP8 showed stress-induced hypersensitive phenotypes and compromised autophagic flux.Similar to other ROPs in the ROP/RAC family,ROP8 exhibits both plasma membrane and cytosolic punctate localization patterns.Upon autophagic induction,active ROP8 puncta colocalize with autophagosomal markers and are degraded inside the vacuole.In human cells,RalB,an RAS subfamily GTPase,engages its effector Exo84 for autophagosome assembly.However,a RalB counterpart is missing in the plant lineage.Intriguingly,we discovered that plant ROP8 promotes autophagy via its downstream effector Sec5.Live-cell super-resolution imaging showed that ROP8 and Sec5 reside on phagophores for autophagosome formation.Taken together,our findings highlight a previously unappreciated role of an ROP8-Sec5 signaling axis in autophagy promotion,providing new insights into how plants utilize versatile ROP signaling networks to coordinate developmental and autophagic responses depending on environmental changes. | Youshun Lin Yonglun Zeng Ying Zhu Jinbo Shen Hao Ye Liwen Jiang | 2021 | Molecular Plant2021，14，6： | 0 |
| 14 | A novel molecular classification method for osteosarcoma based on tumor cell differentiation trajectories显示文摘Subclassification of tumors based on molecular features may facilitate therapeutic choice and increase the response rate of cancer patients.However,the highly complex cell origin involved in osteosarcoma(OS)limits the utility of traditional bulk RNA sequencing for OS subclassification.Single-cell RNA sequencing(sc RNA-seq)holds great promise for identifying cell heterogeneity.However,this technique has rarely been used in the study of tumor subclassification.By analyzing sc RNA-seq data for six conventional OS and nine cancellous bone(CB)samples,we identified 29 clusters in OS and CB samples and discovered three differentiation trajectories from the cancer stem cell(CSC)-like subset,which allowed us to classify OS samples into three groups.The classification model was further examined using the TARGET dataset.Each subgroup of OS had different prognoses and possible drug sensitivities,and OS cells in the three differentiation branches showed distinct interactions with other clusters in the OS microenvironment.In addition,we verified the classification model through IHC staining in 138 OS samples,revealing a worse prognosis for Group B patients.Furthermore,we describe the novel transcriptional program of CSCs and highlight the activation of EZH2 in CSCs of OS.These findings provide a novel subclassification method based on sc RNA-seq and shed new light on the molecular features of CSCs in OS and may serve as valuable references for precision treatment for and therapeutic development in OS. | Hao Zhang Ting Wang Haiyi Gong Runyi Jiang Wang Zhou Haitao Sun Runzhi Huang Yao Wang Zhipeng Wu Wei Xu Zhenxi Li Quan Huang Xiaopan Cai Zaijun Lin Jinbo Hu Qi Jia Chen Ye Haifeng Wei Jianru Xiao | 2023 | Bone Research2023，11，1： | 0 |
| 15 | Modulating p-type doping of two-dimensional material palladium diselenide显示文摘The van der Waals heterostructures have evolved as novel materials for complementing the Si-based semiconductor technologies.Group-10 noble metal dichalcogenides(e.g.,PtS_(2),PtSe_(2),PdS_(2),and PdSe_(2))have been listed into two-dimensional(2D)materials toolkit to assemble van der Waals heterostructures.Among them,PdSe_(2) demonstrates advantages of high stability in air,high mobility,and wide tunable bandgap.However,the regulation of p-type doping of PdSe_(2) remains unsolved problem prior to fabricating p–n junction as a fundamental platform of semiconductor physics.Besides,a quantitative method for the controllable doping of PdSe_(2) is yet to be reported.In this study,the doping level of PdSe_(2) was correlated with the concentration of Lewis acids,for example,SnCl_(4),used for soaking.Considering the transfer characteristics,the threshold voltage(the gate voltage corresponding to the minimum drain current)increased after SnCl_(4) soaking treatment.PdSe_(2) transistors were soaked in SnCl_(4) solutions with five different concentrations.The threshold voltages from the as-obtained transfer curves were extracted for linear fitting to the threshold voltage versus doping concentration correlation equation.This study provides in-depth insights into the controllable p-type doping of PdSe_(2).It may also push forward the research of the regulation of conductivity behaviors of 2D materials. | Jiali Yang Yu Liu En-Yang Wang Jinbo Pang Shirong Huang Thomas Gemming Jinshun Bi Alicja Bachmatiuk Hao Jia Shu-Xian Hu Chongyun Jiang Hong Liu Gianaurelio Cuniberti Weijia Zhou Mark H Rümmeli | 2024 | Nano Research2024，17，4： | 0 |
| 16 | Vertical β-Ga_(2)O_(3) power electronics显示文摘β-Ga_(2)O_(3) possesses a highly promising critical electric field of 8 MV/cm,allowing devices with improved perfor-mance compared with other wide bandgap materials[1,2].The 4-inch wafers grown from a melt and over 10μm of the epitax-ial layers grown by Halide vapor phase epitaxy(HVPE)with highly controllable doping concentration,are commercially available,paving the way of vertical power devices.Theβ-Ga_(2)O_(3) community has consistently elevated the average criti-cal electric field superior to SiC or GaN,which is suitable for medium/high voltage infrastructures demanding over 900 V[1].Verticalβ-Ga_(2)O_(3) power electronics have made a tremendous progress in recent years,such as various surface/interface engineering,diverse edge termination,quasi-inversion vertical transistor,etc. | Guangwei Xu Feihong Wu Qi Liu Zhao Han Weibing Hao Jinbo Zhou Xuanze Zhou Shu Yang Shibing Long | 2023 | Journal of Semiconductors2023，44，7： | 0 |
| 17 | A Comparative Study on the Excitation of Large Volume Airgun Source with Different Combinations in Hutubi,Xinjiang,China显示文摘In order to study the excitation of large-volume airgun source with different combinations in Hutubi,Xinjiang,China,we conducted a targeted experiment.The method of timefrequency analysis is used to study the signals recorded by a seismometer on the shore of the excited pool,and it is concluded that different gun combinations will lead to different frequency of bubble pulse signals.Besides,linear combination method is used to analyze the signal-to-noise ratios of signals excited by different gun combinations which was recorded by seismic stations around the airgun source.In order to improve the signal-tonoise ratios,it is more effective to increase the activation energy(the number of excited guns at the same time)than to stack the excited signals with smaller energy repeatedly. | SU Jinbo WANG Qiong CHEN Hao WEI Yunyun ZHANG Wenxiu WANG Haitao | 2019 | Earthquake Research in China2019，33，4： | 0 |
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